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  • SAGE Publications  (6)
  • 1
    Online Resource
    Online Resource
    Mood disorders increase mortality mainly through dementia: A community-based prospective cohort study
    SAGE Publications ; 2022
    In:  Australian & New Zealand Journal of Psychiatry Vol. 56, No. 8 ( 2022-08), p. 1017-1024
    Details
    In: Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 56, No. 8 ( 2022-08), p. 1017-1024
    Abstract: The effects of mood disorders on mortality may be mediated by their effects on the risk of dementia, and interventions to reduce the occurrence of dementia may reduce their overall mortality. This study aimed to investigate the direct effects of depressive and bipolar disorders on the 6-year risk of mortality and also their indirect effects on mortality due to their effect on the risk of dementia. Methods: A total of 5101 Koreans were selected from a community-based prospective cohort study, and 6-year risks of mortality and dementia in participants with depressive and bipolar disorders were estimated by Cox proportional hazard analysis. The direct and indirect effects of depressive and bipolar disorders on the risk of mortality were estimated using structural equation modeling. Results: The depressive and bipolar disorder groups showed 51% and 85% higher 6-year mortality, and 82% and 127% higher risk of dementia, respectively, compared to euthymic controls. The effects of depressive and bipolar disorders on mortality were mainly mediated by their effects on the risk of dementia in a structural equation model. The direct effects of each mood disorder on mortality were not significant. Conclusion: Both depressive and bipolar disorders increased the risks of mortality and dementia, and the effects of mood disorders on mortality were mainly mediated through dementia. As dementia occurs later in life than mood disorders, measures to prevent it may effectively reduce mortality in individuals with a history of mood disorders, as well as being more feasible than attempting to control other causes of death.
    Type of Medium: Online Resource
    ISSN: 0004-8674 , 1440-1614
    URL: Article
    DOI: 10.1177/00048674211041937
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2003849-5
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  • 2
    Online Resource
    Online Resource
    Chronic subsyndromal depression and risk of dementia in older adults
    SAGE Publications ; 2021
    In:  Australian & New Zealand Journal of Psychiatry Vol. 55, No. 8 ( 2021-08), p. 809-816
    Details
    In: Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 55, No. 8 ( 2021-08), p. 809-816
    Abstract: Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its effect on the risk of dementia has barely been investigated. This study is aimed to investigate the effect of subsyndromal depression on dementia risk in cognitively normal older adults and patients with mild cognitive impairment. Methods: Data were collected from a nationwide, population-based, prospective cohort study on a randomly sampled Korean elderly population aged 60 years or older, which has been followed every 2 years. Using 6-year follow-up data of 4456 non-demented elderly, the authors examined the risk of dementia associated with late-onset subsyndromal depression using multivariate Cox proportional hazard models. After standardized diagnostic interviews, subsyndromal depression and dementia were diagnosed by the operational diagnostic criteria and Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria, respectively. Results: Subsyndromal depression tripled the risk of dementia in non-demented elderly individuals (hazard ratio = 3.02, 95% confidence interval = [1.56, 5.85], p  〈  0.001). In subgroup analyses, subsyndromal depression was associated with the risk of dementia in cognitively normal participants only (hazard ratio = 4.59, 95% confidence interval = [1.20, 17.54], p = 0.026); chronic/recurrent subsyndromal depression with increasing severity during the follow-up period was associated with the risk of dementia (hazard ratio = 15.34, 95% confidence interval = [4.19, 56.18] , p  〈  0.001). Conclusion: Late-onset subsyndromal depression is a potential predictor of incident dementia when it is chronic or recurrent with increasing severity in cognitively normal older adults.
    Type of Medium: Online Resource
    ISSN: 0004-8674 , 1440-1614
    URL: Article
    DOI: 10.1177/0004867420972763
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2003849-5
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  • 3
    Online Resource
    Online Resource
    Epidemiological characteristics of subsyndromal depression in late life
    SAGE Publications ; 2020
    In:  Australian & New Zealand Journal of Psychiatry Vol. 54, No. 2 ( 2020-02), p. 150-158
    Details
    In: Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 54, No. 2 ( 2020-02), p. 150-158
    Abstract: Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its epidemiological characteristics have barely been investigated. The aim of this prospective cohort study is to compare the prevalence, incidence and risk factors of subsyndromal depression with those of syndromal depression including major and minor depressive disorders in community-dwelling elderly individuals. Methods: In a nationwide community-based study of randomly sampled Korean elderly population aged 60 years or older ( N = 6640), depression was assessed with standardized diagnostic interviews. At baseline and at 2-year and 4-year follow-ups, the authors diagnosed subsyndromal depression by the operational criteria and syndromal depression by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) diagnostic criteria. Multivariate logistic regression analyses were conducted to identify the risk factors for incident depression. Results: The age- and gender-adjusted prevalence rate of subsyndromal depression was 9.24% (95% confidence interval = [8.54, 9.93]), which was 2.4-fold higher than that of syndromal depression. The incidence rate of subsyndromal depression was 21.70 per 1000 person-years (95% confidence interval = [19.29, 24.12] ), which was fivefold higher than that of syndromal depression. The prevalence to incidence ratio of subsyndromal depression was about half that of syndromal depression. The risk for subsyndromal depression was associated with female gender, low socioeconomic status, poor social support and poor sleep quality, while that of syndromal depression was associated with old age and less exercise. Conclusion: Subsyndromal depression should be validated as a clinical diagnostic entity, at least in late life, since it has epidemiological characteristics different from those of syndromal depression.
    Type of Medium: Online Resource
    ISSN: 0004-8674 , 1440-1614
    URL: Article
    DOI: 10.1177/0004867419879242
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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  • 4
    Online Resource
    Online Resource
    The effectiveness of a couple-based intervention for people living with mild Alzheimer’s disease and their spousal caregivers in Korea
    SAGE Publications ; 2021
    In:  Dementia Vol. 20, No. 3 ( 2021-04), p. 831-847
    Details
    In: Dementia, SAGE Publications, Vol. 20, No. 3 ( 2021-04), p. 831-847
    Abstract: We evaluated the effectiveness of a Korean version of the Couples Life Story Approach (CLSA-K), a structured life-review program originally developed in the U.S. to help older adults with dementia and their spousal caregivers engage with each other and improve their quality of life. Research design and methods: Fifty mild people living with mild Alzheimer’s disease and their spouses were recruited and 37 couples completed the five-week CLSA-K program. Data on psychosocial outcomes—i.e., depressive symptoms, talkativeness, mutuality (for both caregivers and care recipients) and burden (for caregivers)—were collected one week prior to (Time 1) and one week after the intervention (Time 2). Using repeated measures generalized linear models, we examined the differences in the amounts and patterns of the changes in outcomes according to age, gender, and the care-recipients’ level of cognitive impairment. Results Some participants benefited from the CLSA-K program, while others did not. For caregivers, mental health, and marital quality remained stable, while caregiver burden increased among those with spouses who had moderate levels of cognitive impairment. For care-recipients, younger and male participants showed increased talkativeness. Discussion and implications CLSA-K appears to be promising for specific subgroups of participants in Korea. Multi-component or other approaches may be more beneficial for other couples. Cultural differences as well as social positions may play a role in the acceptability and efficacy of the couple-based intervention.
    Type of Medium: Online Resource
    ISSN: 1471-3012 , 1741-2684
    URL: Article
    DOI: 10.1177/1471301218811547
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2084045-7
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  • 5
    Online Resource
    Online Resource
    Long-Term Outcomes of Nasoseptal Perforation Repair Using Anterior Maxillary Sinus Wall as an Interpositional Graft
    SAGE Publications ; 2022
    In:  American Journal of Rhinology & Allergy Vol. 36, No. 2 ( 2022-03), p. 238-244
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 36, No. 2 ( 2022-03), p. 238-244
    Abstract: Various graft materials have been used to repair nasoseptal perforation, but there is no standardized treatment method. The anterior maxillary sinus wall is flattened in appearance and can be easily obtained in a sufficient amount for a large-sized nasoseptal perforation. Objectives The aim of this study is to determine whether the anterior maxillary sinus wall is suitable as an interpositional graft in the surgical repair of septal or nasoseptal perforation. Methods This is a retrospective review of 21 patients who underwent repair of nasoseptal perforation using anterior maxillary sinus wall as an interpositional graft. The etiology, pre- and post-operative NOSE and GBI score, and perforation size were reviewed. The surgical outcome was considered successful if total closure was achieved after postoperative follow-up. Results 19 of the 21 perforations were successfully repaired with anterior maxillary sinus wall. Failure of the repair was found in 2 patients. Causal etiology of perforation was previous septoplasty in 10 patients, and electrocautery in 1 case, but not identified in 10 cases. The largest size was 2.7 × 2.2 cm. The most common symptoms were epistaxis, crusting, and nasal obstruction. Closure of septal perforation resulted in improved subjective symptoms and quality of life which were evaluated with NOSE and GBI score. Conclusion Anterior maxillary sinus wall as interpositional graft between mucoperichondrial flaps can be used to reliably repair nasoseptal perforations.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.1177/19458924211049608
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2554548-6
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  • 6
    Online Resource
    Online Resource
    Cognitive impairment differs between neuromyelitis optica spectrum disorder and multiple sclerosis
    SAGE Publications ; 2016
    In:  Multiple Sclerosis Journal Vol. 22, No. 14 ( 2016-12), p. 1850-1858
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 22, No. 14 ( 2016-12), p. 1850-1858
    Abstract: To compare the frequency and pattern of cognitive impairment (CI) between patients with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Methods: A total of 82 NMOSD patients, 58 MS patients, and 45 healthy controls (HCs) underwent a neuropsychological assessment. Results: CI was observed in 29% of NMOSD and 50% of MS patients ( p  〈  0.001); CI was considered present if a patient scored lower than the fifth percentile compared with HCs in at least three domains. A lower frequency of CI was consistently found when CI was indicated by at least two failed tests ( p  〈  0.001). MS patients performed worse than did NMOSD patients on verbal learning and verbal and visual memory tests. Levels of education and depression and the interval from disease onset to treatment were associated with a negative influence on cognition in patients with NMOSD. Conclusion: CI in patients with NMOSD may be not as common as in patients with MS. MS patients exhibited severe impairment, particularly on learning and memory tests, compared with NMOSD patients. Differential prevalence and patterns of CI between NMOSD and MS patients suggest that the two diseases have different mechanisms of brain injury.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458516636246
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2008225-3
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