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  • 1
    Online Resource
    Online Resource
    Efficient Derivation and Concise Gene Expression Profiling of Human Embryonic Stem Cell-Derived Mesenchymal Progenitors (EMPs)
    SAGE Publications ; 2011
    In:  Cell Transplantation Vol. 20, No. 10 ( 2011-11), p. 1529-1545
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 20, No. 10 ( 2011-11), p. 1529-1545
    Abstract: New potential sources of stem cells for clinical application include bone marrow mesenchymal stem cells (BMMSCs), human embryonic stem cells (hESCs), and induced pluripotent stem cells (iPS). However, each source is not without its own concerns. While research continues in an effort to overcome these problems, the generation of mesenchymal progenitors from existing hESC lines may circumvent many of these issues. We report here a simple and efficient method of generating hESC-derived mesenchymal progenitors (EMPs) and transcriptome profiling using a concise, custom-designed, oligomnucleotide gene expression microarray. Characterization of EMPs shows that these cells are similar to BMMSCs in terms of differentiation capacity as well as cell surface marker expression. In addition, EMPs express several ESC markers and HLA-G, a nonclassical MHC class I molecule with immunomodulatory properties. Morevoer, EMPs possess significantly enhanced proliferative ability over BMMSCs during which karyotypic stability was maintained. Although derived from hESCs, EMPs do not form any tumors in immunocompromised mice. To efficiently profile gene expression in multiple samples, we designed an oligoarray to probe just over 11,000 genes highly expressed in stem cells. We found that the transcriptome of EMPs is more similar to BMMSCs than hESCs. Both cell types highly express genes involved in processes related to the cytoskeleton, extracellular matrix, and cell adhesion, but EMPs show higher expression of genes involved in cell proliferation whereas BMMSCs showed higher expression of immune-related genes. Based on our data, EMPs may be an accessible source of mesenchymal progenitor for therapeutic use.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368910X564067
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2020466-8
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  • 2
    Online Resource
    Online Resource
    Implementing horizontal-to-vertical Fourier spectral ratios and spatial correlation in a ground-motion prediction equation to predict site effects
    SAGE Publications ; 2021
    In:  Earthquake Spectra Vol. 37, No. 2 ( 2021-05), p. 827-856
    Details
    In: Earthquake Spectra, SAGE Publications, Vol. 37, No. 2 ( 2021-05), p. 827-856
    Abstract: We propose a methodology to implement horizontal-to-vertical Fourier spectral ratios (HVRs) evaluated from strong ground motion induced by earthquake (EHVRs) or ambient ground motion observed from microtremor (MHVRs) individually and simultaneously with the spatial correlation (SC) in a ground-motion prediction equation (GMPE) to improve the prediction accuracy of site effects. We illustrated the methodology by developing an EHVRs-SC-based model which supplements Vs30 and Z1.0 with the SC and EHVRs collected at strong motion stations, and a MHVRs-SC-based model that supplements Vs30 and Z1.0 with the SC and MHVRs observed from microtremors at sites which were collocated with strong motion stations. The standard deviation of the station-specific residuals can be reduced by up to 90% when the proposed models are used to predict site effects. In the proposed models, the spatial distribution of the predicted station terms for peak ground acceleration (PGA) from MHVRs at 3699 sites is consistent with that of the predicted station terms for PGA from EHVRs at 721 strong motion stations. Prediction accuracy for stations with inferred Vs30 is similar to that of stations with measured Vs30 with the proposed models. This study provides a methodology to simultaneously implement SC and EHVRs, or SC and MHVRs in a GMPE to improve the prediction accuracy of site effects for a target site with available EHVRs or MHVRs information.
    Type of Medium: Online Resource
    ISSN: 8755-2930 , 1944-8201
    URL: Article
    DOI: 10.1177/8755293020952449
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2183411-8
    SSG: 16,13
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  • 3
    Online Resource
    Online Resource
    Antiviral Therapy Reduces Risk of Haemorrhagic Stroke in Patients with HCV Infection: A Nationwide Cohort Study
    SAGE Publications ; 2018
    In:  Antiviral Therapy Vol. 23, No. 1 ( 2018-01), p. 43-52
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 23, No. 1 ( 2018-01), p. 43-52
    Abstract: The tendency for haemorrhagic stroke in patients with chronic HCV infection has emerged recently but the finding may be confounded by comorbidities. Proving the causality between HCV infection and haemorrhagic stroke is mandatory. Our study was designed to investigate the incidence of intracranial haemorrhage in HCV-infected patients with and without treatment. Methods In the 11-year and population-based retrospective study, we acquired data from the Taiwan National Health Insurance Research Database. The patients with major comorbidities were excluded and 97,198 HCV-infected patients were included for analysis. Treated and untreated cohorts were matched with propensity score to make the confounding factors in two groups comparable. Cox proportional hazard regression analysis was performed to evaluate the hazard ratio of haemorrhagic stroke in the cohorts. We applied survival analysis to compare the cumulative incidence of outcome events between the two cohorts. Results After matching, the incidence density (ID) of haemorrhagic stroke in the untreated cohort is significantly higher than in the treated cohort (ID: 1.0 versus 0.6 events per 1,000 person-years; P=0.0014). The adjusted hazard ratio (aHR) of haemorrhagic stroke is significantly reduced in the treated group ( P 〈 0.05). Cumulative incidence of haemorrhagic stroke is significantly lower in the treated group than in the untreated group ( P=0.013). Conclusions The study demonstrates that antiviral therapy significantly reduces the events of intracranial haemorrhage in HCV-infected patients and consolidates the novel concept that chronic HCV infection is a risk factor for haemorrhagic stroke.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP3172
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Validity of Visual and Auditory Attention Tests for Detecting ADHD
    SAGE Publications ; 2021
    In:  Journal of Attention Disorders Vol. 25, No. 8 ( 2021-06), p. 1160-1169
    Details
    In: Journal of Attention Disorders, SAGE Publications, Vol. 25, No. 8 ( 2021-06), p. 1160-1169
    Abstract: Objective: This investigation examines the discriminative validity of visual and auditory attention tests for differentiating patients with ADHD from healthy control participants. Method: A total of 107 ADHD patients and 58 healthy control participants were recruited. Visual and auditory attention profiles were obtained using the Conners’ Continuous Performance Test 3rd Edition (CPT3) and Conners’ Continuous Auditory Test of Attention (CATA), respectively. Results: We found that ADHD patients underperformed healthy controls on all CPT3 and CATA indexes, except Response Style and Hit Reaction Time. The CPT3, CATA, and CPT3 plus CATA all significantly differentiate ADHD patients and controls. CPT3 plus CATA had a greater sensitivity (82.6%), specificity (76%), positive predictive value (88.8%), negative predictive value (65.5%), and overall correct classification rate (80.6%) than CPT3 or CATA alone. Conclusion: Neuropsychological tests CPT3 and CATA provide objective information about cases of ADHD and should be used routinely for clinical assessment.
    Type of Medium: Online Resource
    ISSN: 1087-0547 , 1557-1246
    URL: Article
    DOI: 10.1177/1087054719887433
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2188086-4
    SSG: 5,2
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  • 5
    Online Resource
    Online Resource
    Gram-Negative and Polymicrobial Peritonitis Are Associated with Subsequent Fungal Peritonitis in CAPD Patients
    SAGE Publications ; 2006
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 26, No. 5 ( 2006-09), p. 607-608
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 26, No. 5 ( 2006-09), p. 607-608
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.1177/089686080602600518
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2075957-5
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  • 6
    Online Resource
    Online Resource
    Tai Chi Intervention Increases Progenitor CD34 + Cells in Young Adults
    SAGE Publications ; 2014
    In:  Cell Transplantation Vol. 23, No. 4-5 ( 2014-05), p. 613-620
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 23, No. 4-5 ( 2014-05), p. 613-620
    Abstract: Tai Chi has been shown to have many great health benefits. However, few research attempts have been made to explore the effects of practicing TCC on life span. This study provides direct evidence of Tai Chi's antiaging effects. We conducted a retrospective cross-sectional study to compare the rejuvenating and antiaging effects among Tai Chi group (TCC) and brisk walking group (BW) and no exercise habit group (NEH). Thirty-two participants were selected out of a possible 60 based on a survey, and they were separated into three groups: the TCC group (practicing for more than 1 year), the BW group (practicing for more than 1 year), and the NEH group. The CD34 + cell counts in peripheral blood of the participants was determined, and the Kruskal–Wallis test was used to evaluate and compare the antiaging effects of the three groups. Of the 32 participants in this study, the participants in the TCC group ( N = 10) outperformed the NEH group ( N = 12) with respect to the number of CD34 + progenitor cells. No significant difference was found between the TCC group and the BW group. TCC practice sustained for more than 1 year may be an intervention against aging as effective as BW in terms of its benefits on the improvement of CD34 + number.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368914X678355
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2020466-8
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  • 7
    Online Resource
    Online Resource
    Cortical thickness and diffusion tensor imaging in patients with neuropsychiatric systemic lupus erythematosus, with normal structure on brain MRI
    SAGE Publications ; 2023
    In:  Lupus Vol. 32, No. 4 ( 2023-04), p. 489-499
    Details
    In: Lupus, SAGE Publications, Vol. 32, No. 4 ( 2023-04), p. 489-499
    Abstract: Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with adverse outcomes; however, imaging abnormalities are only detectable by conventional brain magnetic resonance imaging (MRI) in up to 50% of patients. This study investigated the variability in cortical thickness and diffusion tensor imaging (DTI) parameters among patients with NPSLE whose brain morphology appeared normal on conventional MRI. Methods This retrospective study enrolled 27 female patients with NPSLE (median age: 41.0 years, range: 22–63 years) and 34 female healthy controls (median age: 37.0 years, range: 24–55 years). None exhibited evident abnormalities on conventional MRI. Regional volumes, cortical thickness, and DTI parameters, including fractional anisotropy (FA) and mean diffusivity (MD), were compared. Age-adjusted multivariable logistic regression analysis was conducted to detect significant NPSLE-associated differences. Results No significant differences in grey or white matter volume fractions were observed between the groups. However, the NPSLE group demonstrated significant cortical thinning in the right pars opercularis (2.45 vs 2.52 mm, p = 0.007), reduced FA values in the fornix (0.35 vs 0.40, p = 0.001) and left anterior limb of internal capsule (0.50 vs 0.52, p = 0.012), and increased MD in the fornix (1.71 vs 1.48, p = 0.009) and left posterior corona radiata (0.80 vs 0.76, p = 0.005) compared with those of healthy controls. Conclusions Cortical thickness measurements and DTI analyses can be used to detect differential variations in patients with NPSLE who exhibit an otherwise normal brain structure on conventional MRI, indicating the existence of subtle changes despite the absence of obvious macrostructural central nervous system involvement of lupus.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/09612033231155848
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2008035-9
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  • 8
    Online Resource
    Online Resource
    Transplantation of Human Wharton's Jelly-Derived Stem Cells Alleviates Chemically Induced Liver Fibrosis in Rats
    SAGE Publications ; 2010
    In:  Cell Transplantation Vol. 19, No. 11 ( 2010-11), p. 1451-1463
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 19, No. 11 ( 2010-11), p. 1451-1463
    Abstract: There is currently no effective treatment method available for liver fibrosis. We therefore evaluated the use of Wharton's jelly stem cells (WJSCs; the major umbilical cord stem cell population) to treat chemically induced liver fibrosis via intraperitoneal injection of thioacetamide. WJSCs were transplanted into liver-damaged rats via the portal vein and the treatment was evaluated by assessing serum biochemistry and histopathology. Transplanted WJSCs were distributed in the fibrotic area and around blood vessels, and hepatic recovery was accelerated. Serum prothrombin time significantly recovered, and serum albumin also improved at 21 days posttransplantation; collagen accumulation also decreased at 14 days. Thus, human WJSCs promoted recovery after chronic liver damage. Using immunohistochemical analyses, we determined that transplanted WJSCs produce albumin, hepatocyte growth factor (HGF), and metalloproteinase (MMP) after transplantation to chemically injured liver, indicating that WJSC may help to decrease liver collagen and thus may be useful for treating liver fibrosis.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368910X514198
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2020466-8
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