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  • 1
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    Endostar, a novel human recombinant endostatin, attenuates liver fibrosis in CCl 4 -induced mice
    SAGE Publications ; 2014
    In:  Experimental Biology and Medicine Vol. 239, No. 8 ( 2014-08), p. 998-1006
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 239, No. 8 ( 2014-08), p. 998-1006
    Abstract: Decreasing hepatic fibrosis remains one of the major therapeutic challenges in hepatology. The present study aims to evaluate the effect of Endostar on both CCl 4 -induced liver fibrosis in mice and a hepatic stellate cell (HSC) line. Two main models were studied: (i) a liver fibrosis model was induced in BALB/c mice using CCl 4 by intraperitoneal injection for six weeks. Six animal groups were studied: group 1: normal animals; group 2: CCl 4 -induced liver fibrosis; group 3: CCl 4  + Endostar 20 mg/kg/d, six weeks; group 4: CCl 4  + Endostar 10 mg/kg/d, six weeks; group 5: CCl 4  + Endostar 20 mg/kg/d, four weeks; group 6: CCl 4  + Endostar 10 mg/kg/d, four weeks corresponded to different Endostar doses and duration of administration. Liver fibrosis was evaluated by histopathological staining and liver hydroxyproline content. Expressions of collagen type I, α-smooth muscle actin ( α-SMA), TGF-β1 and VEGFR were measured by real-time polymerase chain reaction (PCR). (ii) A liver cell model. HSC-T6 cells were cultured with or without Endostar for 12 h or 24 h. Expressions of collagen type I, α-SMA, and TGF-β1 were measured by real-time PCR. Collagen I and transforming growth factor β1 (TGF-β1) contents in cell supernatant were measured by enzyme-linked immunosorbent assay. As compared to the group without Endostar, liver fibrosis scores and hydroxyproline content were decreased in both Endostar groups ( P  〈  0.05). Moreover, Endostar inhibited the hepatic expression of α-SMA, TGF-β1, Collagen-1, VEGFR1, and VEGFR2 mRNA ( P  〈  0.05). In the HSC-T6 cell line model, Endostar profoundly inhibited the expression of α-SMA, Collagen-1, and TGF-β1 mRNA. Expressions of Collagen-1 and TGF-β1 protein were decreased in the Endostar group as compared to the normal controls in the supernatant of HSC-T6 cells ( P  〈  0.05). Endostar decreased both liver fibrosis in CCl 4 -induced mice and collagen synthesis in HSCs in vitro. Therefore, this recombinant human endostatin is a promising compound for counteracting liver fibrosis.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370214532595
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2020856-X
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  • 2
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    A Systematic Review and Meta-Analysis of Immune-Related Adverse Events of Anti-PD-1 Drugs in Randomized Controlled Trials
    SAGE Publications ; 2020
    In:  Technology in Cancer Research & Treatment Vol. 19 ( 2020-01-01), p. 153303382096745-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 19 ( 2020-01-01), p. 153303382096745-
    Abstract: We aimed to evaluate immune-related adverse events occurring in clinical trials of anti-programmed cell death 1 (PD-1) drugs, compared with control treatments, including chemotherapy, targeted drugs, or placebo. Further we compared the occurrence of immune -related events in patients treated with different anti-PD-1 drugs. Data Sources: Randomized controlled trial (RCT) data were sourced from PubMed, Embase, and the Cochrane Central Register of Controlled Trials combined with https://clinicaltrials.gov . Methods: Randomized controlled trial of anti-PD-1 drugs compared with control treatments published between January 1, 1970 and March 1,2019, were searched and data on trial patient characteristics, and adverse events extracted, reviewed, and subjected to meta-analysis. Results: Eighteen Randomized controlled trials were included in our study. The Randomized controlled trials compared nivolumab (n = 12), pembrolizumab (n = 6), with chemotherapy (n = 13), targeted drugs (n = 2), or placebo (n = 3). Compared with the control group, the risk of any immune-related adverse events in patients treated with anti-PD-1 drugs was increased (RR, 2.65; 95% confidence interval, 1.84–3.83; P 〈 0.00001). Of the immune-related adverse events, the risk rates of pneumonitis (risk ratio, 2.10; 95% CI, 0.85-5.18), colitis (2.96;1.62-5.38), hypophysitis(4.79;1.54-14.89), hypothyroidism(7.87;5.36-11.57), hyperthyroidism (7.03;4.35-11.34), rash (1.58;0.98-2.54), pruritus (2.28; 1.38-3.76), and hepatitis (9.31;2.18-39.85) were increased by anti-PD-1 drugs. Further, the risk of immune-related adverse events was similar for patients treated with pembrolizumab and nivolumab ( P = 0.14). Conclusions: In addition to previously reported organ-specific immune-related adverse events, we found that the risk of hyperthyroidism was also increased, in anit-PD-1-treated patients, relative to control treatments. The risk of total immune-related adverse events, was similar for pembrolizumab and nivolumab.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033820967454
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 3
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    Prednisone plus IVIg compared with prednisone or IVIg for immune thrombocytopenia in pregnancy: a national retrospective cohort study
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Hematology Vol. 13 ( 2022-01), p. 204062072210952-
    Details
    In: Therapeutic Advances in Hematology, SAGE Publications, Vol. 13 ( 2022-01), p. 204062072210952-
    Abstract: The responses of intravenous immunoglobulin (IVIg) or corticosteroids as the initial treatment on pregnancy with ITP were unsatisfactory. This study aimed to assess the safety and effectiveness of prednisone plus IVIg versus prednisone or IVIg in pregnant patients with immune thrombocytopenia (ITP). Methods: Between 1 January 2010 and 31 December 2020, 970 pregnancies diagnosed with ITP at 19 collaborative centers in China were reviewed in this observational study. A total of 513 pregnancies (52.89%) received no intervention. Concerning the remaining pregnancies, 151 (33.04%) pregnancies received an initial treatment of prednisone plus IVIg, 105 (22.98%) pregnancies received IVIg alone, and 172 (37.64%) pregnancies only received prednisone. Results: Regarding the maternal response to the initial treatment, no differences were found among the three treatment groups (41.1% for prednisone plus IVIg, 33.1% for prednisone, and 38.1% for IVIg). However, a significant difference was observed in the time to response between the prednisone plus IVIg group (4.39 ± 2.54 days) and prednisone group (7.29 ± 5.01 days; p   〈  0.001), and between the IVIg group (6.71 ± 4.85 days) and prednisone group ( p  〈  0.001). The median prednisone duration in the monotherapy group was 27 days (range, 8–195 days), whereas that in the combination group was 14 days (range, 6–85 days). No significant differences were found among these three treatment groups in neonatal outcomes, particularly concerning the neonatal platelet counts. The time to response in the combination treatment group was shorter than prednisone monotherapy. The duration of prednisone application in combination group was shorter than prednisone monotherapy. The combined therapy showed a lower predelivery platelet transfusion rate than IVIg alone. Conclusion: These findings suggest that prednisone plus IVIg may represent a potential combination therapy for pregnant patients with ITP.
    Type of Medium: Online Resource
    ISSN: 2040-6207 , 2040-6215
    URL: Article
    DOI: 10.1177/20406207221095226
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2585183-4
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  • 4
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    The effects of perceptions of flagshipness and iconicity on word of mouth for attractions and destinations
    SAGE Publications ; 2020
    In:  Journal of Vacation Marketing Vol. 26, No. 1 ( 2020-01), p. 96-107
    Details
    In: Journal of Vacation Marketing, SAGE Publications, Vol. 26, No. 1 ( 2020-01), p. 96-107
    Abstract: Many destination loyalty studies have explored the antecedents of loyalty and the related relationships. Few studies have attempted to show how the specific attributes of a destination, such as visitor attractions, affect destination loyalty. This study fills the gap by investigating how word of mouth about a destination, a meaningful surrogate of loyalty in the international tourism market, can be developed through perceptions of the destination’s tourist attractions. Further, a new way of differentiating attractions through the perception of flagshipness and iconicity is identified. Using Macao as the research context, this study shows how perceptions of attraction flagshipness and iconicity can help Macao formulate marketing strategies and position itself as a choice destination, both regionally and globally. The results indicate the sophisticated relationships between attraction flagshipness and iconicity and word of mouth about attractions and destinations. It also enriches knowledge and discussion by discussing the theoretical and practical implications for destination marketing and management.
    Type of Medium: Online Resource
    ISSN: 1356-7667 , 1479-1870
    URL: Article
    DOI: 10.1177/1356766719867387
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2093798-2
    SSG: 3,2
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  • 5
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    Safety and Application of Transumbilical Single-Incision Laparoscopic Gastrectomy for GIST : SILS in Benign Gastric Disease
    SAGE Publications ; 2013
    In:  Surgical Innovation Vol. 20, No. 4 ( 2013-08), p. 365-369
    Details
    In: Surgical Innovation, SAGE Publications, Vol. 20, No. 4 ( 2013-08), p. 365-369
    Abstract: Background. The authors report a new technique of umbilical single-incision laparoscopic surgery (SILS) in the treatment of gastrointestinal stromal tumors (GISTs) of the stomach using conventional laparoscopic instruments. Methods. Preliminary experience with umbilical SILS operation in 13 patients with GIST was introduced. Results. Umbilical SILS operation for GISTs was feasible with conventional laparoscopic instruments. No intraoperative or postoperative complications, such as secondary hemorrhage, anastomotic leakage, or obstruction, were recorded. The patients fully recovered and the single umbilical scar healed well. Conclusion. SILS for GISTs is a feasible and safe technique when performed by experienced laparoscopic surgeons. With advanced surgical technology and technique, truly minimally invasive surgical procedures, such as SILS, are feasible.
    Type of Medium: Online Resource
    ISSN: 1553-3506 , 1553-3514
    URL: Article
    DOI: 10.1177/1553350612455224
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2233576-6
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  • 6
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    The CUSUM Analysis of the Learning Curve for Endoscopic Thyroidectomy by the Breast Approach
    SAGE Publications ; 2014
    In:  Surgical Innovation Vol. 21, No. 2 ( 2014-04), p. 221-228
    Details
    In: Surgical Innovation, SAGE Publications, Vol. 21, No. 2 ( 2014-04), p. 221-228
    Abstract: Objectives. To evaluate the learning curve for endoscopic thyroidectomy by the breast approach (ETBBA) based on the cumulative summation (CUSUM) technique. Methods. The study included 110 consecutive patients who underwent ETBBA by a single surgeon between January 2009 and May 2012 at the Xiangya Hospital of Central South University, Changsha, China. The learning curve was evaluated using the CUSUM technique. The patients were chronologically arranged into 3 phases by the CUSUM analysis for operative time. Demographic data and operative parameters were also analyzed. Results. The mean operative time (OT) was 125.3 minutes. The conversion rate for technical difficulties and the definitive complication rate were 6.4% and 10%, respectively. The learning curve was analyzed mainly by OT using the CUSUM technique. There was a significant improvement in the average OT ( P 〈 .05) after the first 27 patients and again after the first 67 patients ( P 〈 .05). A downward trend in OT was found up to the last patient. There were similarities in gender, tumor size, extent of surgery, blood loss, histology, hospital stay, conversion rate, and complications among the 3 phases. Comparison of 2 neighboring phases also showed no significant differences in age. Conclusions. ETBBA performed by surgeons has a remarkable learning curve. There were 27 cases in the early stage of the learning curve, whereas mastery level could be achieved with 67 cases.
    Type of Medium: Online Resource
    ISSN: 1553-3506 , 1553-3514
    URL: Article
    DOI: 10.1177/1553350613500722
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
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  • 7
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    Consensus statement on diagnosis and treatment of cervical ossification of posterior longitudinal ligament from Asia Pacific Spine Society (APSS) 2020
    SAGE Publications ; 2020
    In:  Journal of Orthopaedic Surgery Vol. 28, No. 3 ( 2020-05-01), p. 230949902097521-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 28, No. 3 ( 2020-05-01), p. 230949902097521-
    Abstract: The study aimed to develop an evidence-based expert consensus statement on diagnosis and treatment of cervical ossification posterior longitudinal ligament (OPLL). Method: Delphi method was used to perform such survey, and the panel members from Asia Pacific Spine Society (APSS) 2020 were invited to answer the open-ended questions in rounds 1 and 2. Then the results were summarized and developed into a Likert-style questionnaire for voting in round 3, and the level of agreement was defined as 80%. In the whole process, we conducted a systematic literature search on evidence for each statement. Results: Cervical OPLL can cause various degrees of neurological symptoms, an it’s thought to be more common in Asia population. CT reconstruction is an important imaging examination to assist diagnosis and guide surgical choice. Segmental, continuous, mixed, and focal type is the most widely used classification system. The non-surgical treatment is recommended for patients with no or mild clinical symptoms, or irreversible neurological damage, or failed surgical decompression, or condition cannot tolerant surgery, or refusing surgery. As OPLL may continue to develop gradually, surgical treatment would be considered in their course inevitably. The surgical choice should depend on various conditions, such as involved levels, thickness, and type of OPLL, skill-experiences of surgeons, which are listed and discussed in the article. Conclusion: In this statement, we describe the clinical features, classifications, and diagnostic criteria of cervical OPLL, and review various surgical methods (such as their indications, complications), and provide a guideline on their choice strategy.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499020975213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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  • 8
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    Influence of basketball shoe midsole inserts featuring different mechanical rebound properties on biomechanical loading and subjective perception during a side-cutting maneuver
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology Vol. 236, No. 1 ( 2022-03), p. 24-35
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology, SAGE Publications, Vol. 236, No. 1 ( 2022-03), p. 24-35
    Abstract: This study examined the influence of basketball shoe midsole inserts with different forefoot and rearfoot rebound properties on biomechanical loading and subjective perception during a side-cutting maneuver. Eleven male basketball players executed side cutting in four shoe conditions mechanically characterized for their rearfoot/forefoot rebound: compliant/compliant, springy/springy, compliant/springy, and springy/compliant. Lower extremity kinetics and kinematics (normalized to body mass), as well as subjective perception, were measured. During the weight-acceptance phase, there were no differences between shoes in all biomechanical variables, except a slightly greater ankle range of motion (1.2° greater than the other three shoes) in the frontal plane for shoe compliant/springy. During the push-off phase, shoe springy/springy led to a greater ankle plantarflexion moment (1.21 Nm/kg greater than the other three shoes, p  〈  0.001) and knee internal rotation moment (0.09 Nm/kg greater than the other three shoes, p = 0.012), while shoe compliant/springy resulted in a greater ankle range of motion in the frontal plane (1.4° greater than the other three shoes, p  〈  0.001). Perception data showed no statistically significant difference among any shoes. In conclusion, springy inserts of basketball shoe midsoles induced a biomechanical loading effect. Perception of players being unaffected indicates the importance of biomechanical evaluation to examine the effects of the given shoe modifications during side cutting.
    Type of Medium: Online Resource
    ISSN: 1754-3371 , 1754-338X
    URL: Article
    DOI: 10.1177/1754337120901984
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2433576-9
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  • 9
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    The efficiency analysis and spatial implications of health information technology: A regional exploratory study in China
    SAGE Publications ; 2020
    In:  Health Informatics Journal Vol. 26, No. 3 ( 2020-09), p. 1700-1713
    Details
    In: Health Informatics Journal, SAGE Publications, Vol. 26, No. 3 ( 2020-09), p. 1700-1713
    Abstract: The new adoption of healthcare information technology is costly, and effects on healthcare performance can be questionable. This nationwide study in China investigated the efficient performance of healthcare information technology and examined its spatial correlation. Panel data were extracted from the Annual Investigation Report on Hospital Information in China and the China Health Statistics Yearbook for 2007 through 2015 (279 observations). Stochastic frontier analysis was employed to estimate the technical efficiency of healthcare information technology performance and related factors at the regional level. Healthcare information technology performance was positively associated with electronic medical records, total input, and cost of inpatient stay, while picture archiving and communication systems and net assets were negatively related. Local Indicators of Spatial Association showed that there existed significant spatial autocorrelation. Governmental policies would best make distinctions among different forms of healthcare information technology, especially between electronic medical records and picture archiving and communication systems. Policies should be formulated to improve healthcare information technology adoption and reduce regional differences.
    Type of Medium: Online Resource
    ISSN: 1460-4582 , 1741-2811
    URL: Article
    DOI: 10.1177/1460458219889794
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2070802-6
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  • 10
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    Toxic effects of T-2 toxin on reproductive system in male mice
    SAGE Publications ; 2010
    In:  Toxicology and Industrial Health Vol. 26, No. 1 ( 2010-02), p. 25-31
    Details
    In: Toxicology and Industrial Health, SAGE Publications, Vol. 26, No. 1 ( 2010-02), p. 25-31
    Abstract: The present study was conducted to evaluate the effects of T-2 toxin on semen quality, fertility and serum testosterone concentration in mice. Adult male mice were mated with sexually mature untreated female mice after being exposed to intraperitoneal injection of T-2 toxin at 0, 5, 10 or 15 mg/kg body weight daily for 7 successive days. Semen quality, serum testosterone concentration and fertility of treated mice were assessed. The results showed that the number of abnormal spermatozoa increased significantly and a significant decrease in spermatozoa with integrated acrosome was observed in males treated with T-2 toxin at all doses, As well, the amount of live spermatozoa decreased significantly in mice treated with 10 and 15 mg/kg body weight T-2 toxin. Low pregnancy rate and high fetal resorption rate were observed when females were mated with T-2 toxin—exposed males. Testicular and cauda epididymal sperm counts, efficiency of sperm production and serum testosterone concentration were significantly reduced in mice treated with T-2 toxin at all doses in a dose-dependent manner. In conclusion, these findings indicated that T-2 toxin presented toxic effects on reproductive system of adult male mice.
    Type of Medium: Online Resource
    ISSN: 0748-2337 , 1477-0393
    URL: Article
    DOI: 10.1177/0748233709354554
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2010891-6
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