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  • 1
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    Online Resource
    Therapeutic effect of mesenchymal stem cells in an animal model of Alzheimer’s disease evaluated by β-amyloid positron emission tomography imaging
    SAGE Publications ; 2020
    In:  Australian & New Zealand Journal of Psychiatry Vol. 54, No. 9 ( 2020-09), p. 883-891
    Details
    In: Australian & New Zealand Journal of Psychiatry, SAGE Publications, Vol. 54, No. 9 ( 2020-09), p. 883-891
    Abstract: We evaluated the effects of bone marrow–derived mesenchymal stem cells in a model of Alzheimer’s disease using serial [ 18 F]Florbetaben positron emission tomography. Methods: 3xTg Alzheimer’s disease mice were treated with intravenously injected bone marrow–derived mesenchymal stem cells, and animals without stem cell therapy were used as controls. Serial [ 18 F]Florbetaben positron emission tomography was performed after therapy. The standardized uptake value ratio was measured as the cortex standardized uptake value divided by the cerebellum standardized uptake value. Memory function and histological changes were observed using the Barnes maze test and β-amyloid-reactive cells. Results: Standardized uptake value ratio decreased significantly from day 14 after stem cell administration in the bone marrow–derived mesenchymal stem cells–treated group ( n = 28). In contrast, there was no change in the ratio in control mice ( n = 25) at any time point. In addition, mice that received bone marrow–derived mesenchymal stem cell therapy also exhibited significantly better memory function and less β-amyloid-immunopositive plaques compared to controls. Conclusion: The therapeutic effect of intravenously injected bone marrow–derived mesenchymal stem cells in a mouse model of Alzheimer’s disease was confirmed by β-amyloid positron emission tomography imaging, memory functional studies and histopathological evaluation.
    Type of Medium: Online Resource
    ISSN: 0004-8674 , 1440-1614
    URL: Article
    DOI: 10.1177/0004867420917467
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2003849-5
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  • 2
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    Exploiting Multiple Channels for Low Latency and Semireliable Broadcasting in Cognitive Wireless Sensor Networks
    SAGE Publications ; 2015
    In:  International Journal of Distributed Sensor Networks Vol. 2015 ( 2015), p. 1-16
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 2015 ( 2015), p. 1-16
    Abstract: In Wireless Sensor Networks (WSNs), disaster management is a crucial issue that focuses on disaster relief and recovery. Mobile sensor nodes support disaster relief and recovery by means of real-time bidirectional communication. For its high data rate requirement, IEEE 802.11 specification can be used for the radio interface of sensor nodes, and the nodes can be equipped with multiple 802.11 radios to utilize multiple channels and link data rates. Channel assignment algorithms can be applied in cognitive radio enabled networks which performs dynamic channel configuration for utilizing multiple channels. For efficient and semireliable broadcast in cognitive radio WSNs, we focus on reducing broadcast latency and achieving 100% delivery percentage. To realize these goals, in this study, we present our design for a novel Channel Assignment Algorithm for a Collision-Reduced Broadcast Tree (CA-CBT). Fundamentally, CA-CBT builds a broadcast tree and then uses several heuristic procedures to allocate collision-free channels to links on the tree. If CA-CBT fails to allocate collision-free channels due to a limited number of available channels, it allocates non-collision-free channels with the smallest number of interfering nodes. Through extensive simulations, we demonstrated that CA-CBT supports lower broadcast latency and higher delivery percentages compared with existing broadcast algorithms.
    Type of Medium: Online Resource
    ISSN: 1550-1329 , 1550-1477
    URL: Article
    DOI: 10.1155/2015/241208
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2192922-1
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  • 3
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    Posterior Cerebral Artery Occlusion After Mycoplasma pnuemoniae Infection Associated With Genetic Defect of MTHFR C677T
    SAGE Publications ; 2009
    In:  Journal of Child Neurology Vol. 24, No. 7 ( 2009-07), p. 891-894
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 24, No. 7 ( 2009-07), p. 891-894
    Abstract: Cerebral artery occlusion in childhood, particularly in the posterior circulation, is a rare neurological complication of Mycoplasma pneumoniae infection. A genetic defect in the methylenetetrahydrofolate reductase gene could result in hyperhomocysteinemia and increased risk of stroke. We report a patient with posterior cerebral artery occlusion after Mycoplasma pneumoniae infection associated with a homozygous, methylenetetrahydrofolate reductase gene mutant type.
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/0883073808331081
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2068710-2
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  • 4
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    Thoracic epithelioid hemangioendothelioma: imaging and pathologic features
    SAGE Publications ; 2011
    In:  Acta Radiologica Vol. 52, No. 2 ( 2011-03), p. 161-166
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 52, No. 2 ( 2011-03), p. 161-166
    Abstract: The purpose of this article is to review the imaging features of thoracic epithelioid hemangioendotheliomas with pathologic correlation. The thoracic manifestation of epithelioid hemangioendotheliomas is one of three different CT patterns: multiple pulmonary nodules, multiple pulmonary reticulonodular opacities, or diffuse infiltrative pleural thickening. Without any evidence of histological malignancy, malignant features (multiplicity of pulmonary nodules, hepatic or bone involvement, lymphangitic tumor spread, and infiltrative pleural masses) are characteristic of these infrequent tumors.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1258/ar.2010.100292
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2024579-8
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  • 5
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    Exploiting channel and interface heterogeneity for rate separating channel assignment in IEEE 802.11 wireless multimedia sensor networks
    SAGE Publications ; 2016
    In:  International Journal of Distributed Sensor Networks Vol. 12, No. 7 ( 2016-07), p. 155014771665860-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 12, No. 7 ( 2016-07), p. 155014771665860-
    Abstract: In wireless multimedia sensor networks (WMSNs), disaster control and public safety are crucial issues that focus on emergency management, rescue, and emergency medical services. For high data rate requirement of WMSNs, the IEEE 802.11 specification can be used for the radio interface of sensor nodes, and the nodes can be equipped with multiple 802.11 radios to utilize multiple channels and link data rates. In practical IEEE 802.11 WMSNs, a link shows different link qualities depending on the operating channels and interfaces between two nodes, called channel and interface heterogeneity. In multirate WMSNs, low-rate links severely degrade the capacity of high-rate links, known as rate anomaly. In this article, we propose a novel channel assignment protocol, heterogeneity-aware mesh (HMesh), to address both rate anomaly mitigation and the channel and interface heterogeneity in real IEEE 802.11 WMSNs. HMesh constructs a tree-based WMSN using the proposed channel assignment and routing metric and the heuristic channel assignment algorithm. With the metric and heuristic algorithm, HMesh separates different data rate links by considering the channel and interface heterogeneity. Through extensive simulations and experiments on our IEEE 802.11 WMSN test bed, we demonstrate that HMesh significantly outperforms existing channel assignment protocols in IEEE 802.11 WMSNs.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1177/1550147716658600
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2192922-1
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  • 6
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    Andersen Cardiodysrhythmic Periodic Paralysis With KCNJ2 Mutations: A Novel Mutation in the Pore Selectivity Filter Residue
    SAGE Publications ; 2010
    In:  Journal of Child Neurology Vol. 25, No. 4 ( 2010-04), p. 490-493
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 25, No. 4 ( 2010-04), p. 490-493
    Abstract: Andersen cardiodysrhythmic periodic paralysis or Andersen-Tawil syndrome includes the distinct clinical features of periodic paralysis, cardiac arrhythmia, and facial and skeletal dysmorphisms and exhibits autosomal dominant inheritance. Mutations in the KCNJ2 gene, which encodes the human inward rectifier potassium channel Kir2.1, have been identified in the majority of cases. Despite well-established clinical and molecular characteristics, treatment is still case oriented, and timely diagnosis could be delayed because of the low incidence and phenotypic heterogeneity of this disease. This article describes the clinical and molecular features of 3 cases of Andersen-Tawil syndrome in 2 families. One of the mutations (G144D) was located in the pore selectivity filter residue (which is mutated recurrently) and was considered novel. Intermittent muscle weakness in childhood warrants careful evaluation of cardiac dysrhythmia and skeletal anomalies.
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/0883073809357937
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2068710-2
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  • 7
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    Is routine preoperative spirometry necessary in elderly patients undergoing laparoscopy-assisted gastrectomy?
    SAGE Publications ; 2013
    In:  Journal of International Medical Research Vol. 41, No. 4 ( 2013-08), p. 1301-1309
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 41, No. 4 ( 2013-08), p. 1301-1309
    Abstract: To identify predictors of postoperative pulmonary complications (PPCs) in patients aged ≥60 years who underwent laparoscopy-assisted gastrectomy (LAG), and to examine the value of preoperative spirometry to predict PPCs. Methods Patients with preoperative spirometric results who underwent LAG were retrospectively studied. Spirometry included four parameters: forced expiratory volume in 1 s; functional vital capacity; mean forced expiratory flow during middle of functional vital capacity; peak expiratory flow rate. Results Of 213 patients, overall incidence of PPCs was 19.2%. Abnormal spirometry findings were not identified as an independent predictor of PPCs using multivariate logistic regression analysis. Age was found to be the only independent predictor of PPCs out of all variables evaluated. Separate assessment of individual spirometric parameters using receiver-operating curve analyses indicated poor diagnostic accuracy. Conclusions Preoperative spirometry was not reliably predictive of PPCs, either as combined or individual parameters, in patients aged ≥60 years who underwent LAG. These results do not support routine use of spirometry to stratify risk of PPCs in this surgical population.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060513489470
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2082422-1
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  • 8
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    Effectiveness of a personalized digital exercise and nutrition-based rehab program for patients with gastric cancer after surgery: Study protocol for a randomized controlled trial
    SAGE Publications ; 2023
    In:  DIGITAL HEALTH Vol. 9 ( 2023-01)
    Details
    In: DIGITAL HEALTH, SAGE Publications, Vol. 9 ( 2023-01)
    Abstract: Patients with gastric cancer often encounter impaired quality of life and reduced tolerability to adjuvant treatments after surgery. Weight preservation is crucial for the overall prognosis of these patients, and exercise and supplemental nutrition play the main role. This study is the first randomized clinical trial to apply personalized, treatment stage-adjusted digital intervention with wearable devices in gastric cancer rehabilitation intervention for 12 months, commencing immediately after surgery. Methods This is a prospective, multicenter, two-armed, randomized controlled trial and aims to recruit 324 patients from two hospitals. Patients will be randomly allocated to two groups for 1 year of rehabilitation, starting immediately after the operation: a personalized digital therapeutic (intervention) group and a conventional education-based rehabilitation (control) group. The primary objective is to clarify the effect of mobile applications and wearable smart bands in reducing weight loss in patients with gastric cancer. The secondary outcomes are quality of life measured by the EORTC-QLQ-C30 and STO22; nutritional status by mini nutrition assessment; physical fitness level measured by grip strength test, 30-s chair stand test and 2-min walk test; physical activity measured by IPAQ-SF; pain intensity; skeletal muscle mass; and fat mass. These measurements will be performed on enrollment and at 1, 3, 6, and 12 months thereafter. Conclusions Digital therapeutic programs include exercise and nutritional interventions modified by age, body mass index, surgery type and postoperative days. Thus, expert intervention is pivotal for precise and safe calibration of this program. Trial registration Clinicaltrials.gov identifier: NCT04907591 (registration date: June 11, 2020; https://clinicaltrials.gov/ct2/show/NCT04907591 ).
    Type of Medium: Online Resource
    ISSN: 2055-2076 , 2055-2076
    URL: Article
    DOI: 10.1177/20552076231187602
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2819396-9
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  • 9
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    Gastric cancer: development and validation of a CT-based model to predict peritoneal metastasis
    SAGE Publications ; 2020
    In:  Acta Radiologica Vol. 61, No. 6 ( 2020-06), p. 732-742
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 61, No. 6 ( 2020-06), p. 732-742
    Abstract: The sensitivity of computed tomography (CT) for the detection of peritoneal metastasis (PM) of advanced gastric cancer (AGC) is relatively low. Purpose To develop a predictive model to improve the sensitivity of PM detection and to externally validate this model. Material and Methods We analyzed data from 78 patients with PM, who had undergone preoperative CT and subsequent surgery between January 2012 and December 2014, and 101 controls to form a derivation set, retrospectively. The following CT findings were evaluated: tumor size; Bormann type 4; enlarged lymph node; indirect findings of PM (peritoneal thickening, fat stranding, plaques or nodules on the peritoneum, and ascites); and definitive findings of PM (omental cake and rectal shelf). A predictive model was created using multivariate logistic regression. Receiver operating characteristic (ROC) analyses were performed to assess the diagnostic performance of the model. The accuracy was externally validated at other hospitals on 31 patients with PM and 48 patients without PM. Results Tumor size 〉 5.2 cm, Bormann type 4, enlarged lymph node, peritoneal plaques or nodules, and ascites were independently associated with PM. It was able to predict PM with a higher area under the ROC curve (AUC) and sensitivity than definitive findings of PM (AUC 0.903 vs. 0.647, sensitivity 92.3% vs. 38.3%). External validation confirmed the predictive power with good inter-observer agreement. Conclusion The CT-driven model shows higher AUC and sensitivity for prediction of PM and may help decision-making with the aim of improving care for patients with AGC.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185119882662
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2024579-8
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  • 10
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    Effects of gait training with a cane and an augmented pressure sensor for enhancement of weight bearing over the affected lower limb in patients with stroke: a randomized controlled pilot study
    SAGE Publications ; 2015
    In:  Clinical Rehabilitation Vol. 29, No. 2 ( 2015-02), p. 135-142
    Details
    In: Clinical Rehabilitation, SAGE Publications, Vol. 29, No. 2 ( 2015-02), p. 135-142
    Abstract: The purpose of this study was to examine the effect of gait training when using a cane with an augmented pressure sensor for enhancement of weight-bearing over the affected lower limb on the peak pressure force of the cane, muscle activation, and gait in patients with stroke. Design: Randomized controlled pilot study. Setting: Inpatient rehabilitation center. Participants: A total of 22 hemiparetic stroke patients were recruited and randomly divided into an experimental group ( n = 11) and control group, which later had a drop-out ( n = 10). Interventions: Subjects in the experimental group participated in gait training with auditory feedback for 30 minutes, five times a week for four weeks, whereas those in the control group received gait training without auditory feedback for the same amount of time. Main measures: The peak force of cane, muscle activation of gluteus medius, and vastus medialis oblique, single limb support phase of the affected leg, and gait speed before and after training were collected. Results: Significant improvement in the peak force of cane, muscle activation of gluteus medius and vastus medialis oblique, single limb support phase of the affected leg, and gait speed were observed in the experimental group (13.5 ±9.5 cm/s) compared with the control group (3.7 ±8.4 cm/s) ( p 〈 0.05). Conclusion: Gait training using a cane with an augmented pressure sensor to enhance weight bearing over the affected lower limb is beneficial and effective in improving the peak force of cane, muscle activation, and gait in stroke patients.
    Type of Medium: Online Resource
    ISSN: 0269-2155 , 1477-0873
    URL: Article
    DOI: 10.1177/0269215514540923
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2028323-4
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