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  • SAGE Publications  (120)
  • 1
    Online Resource
    Online Resource
    Fragile X carrier screening in Korean women of reproductive age
    SAGE Publications ; 2013
    In:  Journal of Medical Screening Vol. 20, No. 1 ( 2013-03), p. 15-20
    Details
    In: Journal of Medical Screening, SAGE Publications, Vol. 20, No. 1 ( 2013-03), p. 15-20
    Abstract: To estimate the distribution of the FMR1 alleles and the prevalence of the premutaion (PM) and full mutation (FM) of the FMR1 gene in Korean women of reproductive age. Methods Using polymerase chain reaction and Southern blot, 5829 women of reproductive age were screened (low-risk group n = 5470 and high-risk group n = 359) and 11 prenatal diagnoses were completed between September 2003 and December 2011. Results Of the 5829 women screened, normal FMR1 alleles (11,607) had a bimodal distribution with most alleles having 29 (37.87%) and 30 (31.87%) CGG repeats. Of the 5470 women in the low-risk group, 7 PM were identified, giving a PM carrier frequency of 1:781; none of the women had Fragile X syndrome. We also identified 38 intermediate alleles, with a reported incidence of 1:143. Of the 11 prenatal diagnoses, five were normal, five had a premutation, and one had a full mutation allele. Conclusions The carrier frequency is 1/781 (0.13%) in Korean women of reproductive age. This is lower than among Caucasians, but relatively higher than in other Asian populations. Although there may be a founder effect, these results might be valuable in understanding Fragile X syndrome in Koreans and Asians as a whole.
    Type of Medium: Online Resource
    ISSN: 0969-1413 , 1475-5793
    URL: Article
    DOI: 10.1177/0969141313488364
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2058901-3
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  • 2
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    Pleomorphic Leiomyosarcoma in the Hind Leg of a Taiwanese Macaque ( Macaca Cyclopis )
    SAGE Publications ; 2009
    In:  Journal of Veterinary Diagnostic Investigation Vol. 21, No. 4 ( 2009-07), p. 564-567
    Details
    In: Journal of Veterinary Diagnostic Investigation, SAGE Publications, Vol. 21, No. 4 ( 2009-07), p. 564-567
    Abstract: An adult, captive Taiwanese monkey ( Macaca cyclopis) presented clinically with a large, rapidly growing mass located in the crus of the left hind leg. The overlying skin was severely ulcerated and necrotic. Radiographs suggested an invasive neoplasm in soft tissue with no bone involvement. The animal's clinical condition progressively worsened over the next 3 months until it died. Necropsy revealed that the mass infiltrated the surrounding skeletal muscle with no evidence of distant metastasis. Microscopically, the mass was highly cellular and composed of round to spindle cells with frequent rhabdoid cells characterized by abundant eosinophilic glassy cytoplasmic inclusions and large, bizarre nuclei. Phosphotungstic acid hematoxylin staining failed to reveal distinct cross-striations within the neoplastic cells. Neoplastic cells were strongly positive for smooth muscle actin and vimentin but were negative for sarcomeric actin, myoglobin, desmin, cytokeratin, S100, and lysozyme. The gross, microscopic, and immunohistochemical findings supported the diagnosis of pleomorphic leiomyosarcoma.
    Type of Medium: Online Resource
    ISSN: 1040-6387 , 1943-4936
    URL: Article
    DOI: 10.1177/104063870902100426
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2265211-5
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  • 3
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    The effects of prearrival direct notification call to interventional cardiologist on door-to-balloon time in patients who required secondary diversion with ST-elevation myocardial infarction for primary percutaneous coronary intervention
    SAGE Publications ; 2019
    In:  Hong Kong Journal of Emergency Medicine Vol. 26, No. 3 ( 2019-05), p. 165-173
    Details
    In: Hong Kong Journal of Emergency Medicine, SAGE Publications, Vol. 26, No. 3 ( 2019-05), p. 165-173
    Abstract: Rapid door-to-balloon times in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention are associated with favorable outcomes. Objectives: We evaluated the effects of prearrival direct notification calls to interventional cardiologists on door-to-balloon time for ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Methods: A 24-h hotline was created to allow prearrival direct notification calls to interventional cardiologists when transferring ST-elevation myocardial infarction patients. In an urban, tertiary referral center, patients who visited via inter-facility or the emergency department directly were included. Clinical parameters, time to reperfusion therapy, and in-hospital mortality were compared between patients with and without prearrival notifications. Results: Of 228 ST-elevation myocardial infarction patients, 95 (41.7%) were transferred with prearrival notifications. In these patients, door-to-balloon time was shorter (50.0 vs 60.0 min, p = 0.010) and the proportion of patients with door-to-balloon time  〈  90 min was higher (89.5% vs 75.9%, p = 0.034) than patients without notifications. These improvements were more pronounced during “off-duty” hours (52.0 vs 78.0 min, p = 0.001; 88.3% vs 72.3%, p = 0.047, respectively) than during “on-duty” hours (37.5 vs 43.5 min, p = 0.164; 94.4% vs 79.4%, p = 0.274, respectively). In addition, door-to-activation time (–39 vs 11 min, p  〈  0.001) and door-to-catheterization laboratory arrival time (33 vs 42 min, p = 0.007) were shorter in patients with prearrival notifications than those without. However, in-hospital mortality was similar between the two groups (6.3% vs 6.8%, p = 0.892). Conclusion: Prearrival direct notification calls to interventional cardiologists significantly improved the door-to-balloon time and the proportion of patients with door-to-balloon time 〈  90 min through rapid patient transport in primary percutaneous coronary intervention scheduled hospital and readiness of the catheterization laboratory.
    Type of Medium: Online Resource
    ISSN: 1024-9079 , 2309-5407
    URL: Article
    DOI: 10.1177/1024907918794782
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2917387-5
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  • 4
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    Two New Meroterpenoid Derivatives From Sargassum macrocarpum With Their Anti-Oxidant Activities
    SAGE Publications ; 2023
    In:  Natural Product Communications Vol. 18, No. 8 ( 2023-08)
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 18, No. 8 ( 2023-08)
    Abstract: Objective: The purpose of this study was to search for novel secondary metabolites present in the marine brown alga, Sargassum macrocarpum C. Agardh. Methods: The methanolic extract of S. macrocarpum was partitioned and fractionated using a silica gel column, medium pressure liquid chromatography, and preparative-high performance liquid chromatography to obtain four compounds (1-4). These structures were elucidated using nuclear magnetic resonance spectroscopic and high resolution-electrospray ionization-mass spectroscopy methods. The isolated compounds were evaluated for their anti-oxidant activities using 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Result: Two undescribed meroterpenoid derivatives (1 and 2), together with two known racemic meroterpenoids (3 and 4) were isolated from the methanolic extract of S. macrocarpum. All compounds were confirmed to be meroterpenoid derivatives. All these compounds exhibited ABTS and DPPH radical scavenging activities. Conclusions: The four meroterpenoids (1-4) were isolated from S. macrocarpum. Compound 3 showed the most anti-oxidant effect with IC 50 values of 9.9 (ABTS radical) and 22.4 μM (DPPH radical), respectively.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X231191857
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 5
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    Sargassumin C, a Novel Butenolide from Sargassum micracanthum
    SAGE Publications ; 2022
    In:  Natural Product Communications Vol. 17, No. 11 ( 2022-11), p. 1934578X2211374-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 17, No. 11 ( 2022-11), p. 1934578X2211374-
    Abstract: Objective: In our ongoing effort to search for the novel secondary metabolites from the marine algae, chemical investigation of a methanolic extract of Sargassum micracanthum led to the isolation of a novel butenolide (1) and a known compound (2). Methods: The methanolic extract of S. micracanthum was partitioned and subjected to medium pressure column chromatography and preparative-HPLC to yield two compounds (1 and 2). Their structures were established based on comprehensive spectroscopic data (1D NMR, 2D NMR, and HRESIMS). These compounds (1 and 2) were evaluated for the production of the NO in lipopolysaccharide (LPS)-induced RAW264.7 cells and pro-inflammatory cytokines such as IL-6, IL-1 β, TNF- α, and IL-10. Results: A new compound (1) was determined to be a new butenolide derivative, and a known compound (2) were identified as 2-hydroxy-(5 E,9 E)-6,10,14-trimethylpentadeca-5,9-dien-12-one. Compounds 1 and 2 showed inhibitory activities in a dose-dependent manner on LPS-induced NO production in RAW264.7 cells and pro-inflammatory cytokines. Conclusion: A new butenolide, sargassumin C (1), and 2-hydroxy-(5 E,9 E)-6,10,14-trimethylpentadeca-5,9-dien-12-one (2) were isolated from the brown alga, S. micracanthum. Compound 2 was more effective than 1 on NO production and pro-inflammatory cytokines.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X221137411
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2430442-6
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  • 6
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    Free antibodies-to-infliximab are biomarker for predicting the effect of dose intensification in pediatric Crohn’s disease patients with secondary loss of response
    SAGE Publications ; 2023
    In:  Therapeutic Advances in Gastroenterology Vol. 16 ( 2023-01), p. 175628482311709-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 16 ( 2023-01), p. 175628482311709-
    Abstract: Immunogenicity to antitumor necrosis factor alpha agents, such as infliximab (IFX), may lead to therapeutic failure. Objectives: This study evaluated the relationship between free and total antibodies-to-infliximab (ATIs), trough levels (TLs) of IFX, and the response to dose intensification. Design: We performed a prospective, observational study including pediatric patients with Crohn’s disease (CD) receiving IFX maintenance therapy without dose intensification. Methods: We compared clinical and laboratory outcomes according to the presence of free and total ATIs. Factors associated with response to IFX dose intensification were investigated by analyzing IFX TLs and free and total ATIs. Results: Of the 98 patients, 9 patients had detectable free ATIs and 38 patients had total ATIs. Patients with free ATIs had significantly lower TLs (0.7 versus 5.1 µg/mL, p  〈  0.001) than patients without free ATIs. However, there was no difference in the IFX TLs according to the presence of total ATIs ( p = 0.2523). Analysis of the 38 samples with total ATIs showed that response to dose intensification was significantly lower in patients with free ATIs than those without free ATIs (22.2% versus 65.5%, p  〈  0.001). In addition, free ATIs were the only factor with poor response to dose intensification [odds ratio (OR): 14.15, 95% confidence interval (CI): 1.31–151.97, p = 0.0140]. According to the receiver operating characteristic analysis, the optimal cutoff level indicating non-response to IFX dose intensification was 30.0 AU/mL for free ATIs concentration (area under curve, 0.792; 95% CI: 0.590–0.942; sensitivity, 60.0%; specificity, 96.7%; p = 0.0241). Conclusion: Free ATIs, but not total ATIs, have a negative impact on the course of CD. Free ATIs are potential reliable biomarker for predicting the effect of dose intensification in patients with loss of response to IFX. Future studies based on serial and proactive therapeutic drug monitoring are required in the future.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/17562848231170948
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2440710-0
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  • 7
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    The Efficacy of Intraoperative Frozen Section Analysis during Breast-Conserving Surgery for Patients with Ductal Carcinoma in Situ
    SAGE Publications ; 2016
    In:  Breast Cancer: Basic and Clinical Research Vol. 10 ( 2016-01), p. BCBCR.S40868-
    Details
    In: Breast Cancer: Basic and Clinical Research, SAGE Publications, Vol. 10 ( 2016-01), p. BCBCR.S40868-
    Abstract: Recently, the incidence of ductal carcinoma in situ (DCIS), a noninvasive breast malignancy, has increased. This has resulted in an increase in the incidence of breast-conserving surgery (BCS). Numerous studies have suggested that intraoperative frozen section analysis (IFSA) could reduce the rate of additional excisions required to obtain adequate resection margins. However, DCIS is a known risk factor for positive margin status during BCS. Furthermore, some authors have concluded that IFSA may not be reliable for the detection of DCIS. Aim The aim of this study was to evaluate the safety and efficacy of IFSA in patients with DCIS. Methods The operative and pathological reports of patients with DCIS, who underwent BCS at our institute between 2006 and 2015, were retrospectively reviewed. The results of IFSA and the pathological findings of final reanalyzed frozen tissue specimens were analyzed. Results In total, 25 patients were included in our analysis. None of the patients required additional operations. The correct diagnosis rate for IFSA was 89.6%, with a sensitivity and specificity of 60.0% and 95.8%, respectively. Conclusion IFSA could be beneficial for determining safety resection margins in patients with DCIS.
    Type of Medium: Online Resource
    ISSN: 1178-2234 , 1178-2234
    URL: Article
    DOI: 10.4137/BCBCR.S40868
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2423804-1
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  • 8
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    An automatic video instillator for intratracheal instillation in the rat
    SAGE Publications ; 2010
    In:  Laboratory Animals Vol. 44, No. 1 ( 2010-01), p. 20-24
    Details
    In: Laboratory Animals, SAGE Publications, Vol. 44, No. 1 ( 2010-01), p. 20-24
    Abstract: Intratracheal instillation (ITI) of a test compound is an alternative method to inhalation methods that require complex aerosol generation, exposure chambers and airflow monitoring instruments for exposing the lungs of animals to a test compound. For ITI in the rat, a laryngoscope is generally used for endotracheal intubation, and the procedure is difficult to perform. Therefore, we designed and constructed an automatic video instillator (AVI) for the accurate delivery of a dose of a test compound into the trachea of rats. The device has a videocamera probe for image guidance, and a liquid-crystal display for image display. These two items are used to visualize the larynx and trachea for intratracheal insertion of the tubing, and for placing the tip of the instillation tubing beyond the vocal cords for ITI of the test compound. After a 2 h training session on the use of the AVI in an anaesthetized rat, we assessed the utility of the device by ITI of 0.25% (w/v) solution of Evans Blue dye into the lungs of 30 isoflurane-anaesthetized rats. Necropsy examinations were performed on 20 rats immediately after the completion of the procedure, and on 10 rats three days after the procedure. Based on the results of these examinations, we concluded that the device could be used for rapid, reproducible and successful ITI of a test compound into the lungs of a rat by one operator.
    Type of Medium: Online Resource
    ISSN: 0023-6772 , 1758-1117
    URL: Article
    DOI: 10.1258/la.2009.009003
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2036511-1
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  • 9
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    The effects of using spacer grafts on lower-eyelid retraction surgery in patients with facial nerve palsy
    SAGE Publications ; 2022
    In:  European Journal of Ophthalmology Vol. 32, No. 4 ( 2022-07), p. 2072-2077
    Details
    In: European Journal of Ophthalmology, SAGE Publications, Vol. 32, No. 4 ( 2022-07), p. 2072-2077
    Abstract: To evaluate the effects of the concomitant use of spacer grafts in lateral tarsal strip surgery in patients with facial nerve palsy-related lower-eyelid retraction. Methods Patients who underwent lateral tarsal strip surgery to correct facial nerve palsy-related lower-eyelid retraction were retrospectively reviewed. Postoperative decreases in marginal reflex distance-2 values at 1, 2 and 6 months were measured along with the effects of spacer grafts. Results Forty-five patients (28 males) were included (mean age: 59.56 years). Mean preoperative marginal reflex distance-2 was 6.87 ± 1.34 mm. Twenty patients underwent lateral tarsal strip surgery only (lateral tarsal strip-only); 25 patients underwent lateral tarsal strip surgery using spacer grafts (lateral tarsal strip + graft). Median (interquartile range) follow-up duration was 12.0 (6.0–23.0) months. Retraction was significantly improved and maintained at 1, 2 and 6 months postoperatively in all patients (mean marginal reflex distance-2: 3.78 ± 1.06 mm, 4.30 ± 1.23 mm and 4.72 ± 1.11 mm, respectively). Surgical outcomes were significantly better in the lateral tarsal strip + graft than in the lateral tarsal strip-only group (Δmarginal reflex distance-2: 3.92 vs. 2.05 mm at 1 month, p  〈  0.001; 3.38 vs. 1.61 mm at 2 months, p = 0.001; 2.88 vs. 1.69 at 6 months, p = 0.042). Subgroup analyses by spacer graft type revealed no significant differences. Conclusion The concomitant use of spacer material in lateral tarsal strip surgery yielded better surgical outcomes than lateral tarsal strip surgery alone. The use of spacer grafts should be considered for correcting severe facial nerve palsy-related lower-eyelid retraction.
    Type of Medium: Online Resource
    ISSN: 1120-6721 , 1724-6016
    URL: Article
    DOI: 10.1177/11206721211051931
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 1475018-1
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  • 10
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    Latent stem cell-stimulating therapy for regeneration of chronic tympanic membrane perforations using IGFBP2-releasing chitosan patch scaffolds
    SAGE Publications ; 2019
    In:  Journal of Biomaterials Applications Vol. 34, No. 2 ( 2019-08), p. 198-207
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 34, No. 2 ( 2019-08), p. 198-207
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328219845082
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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