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  • SAGE Publications  (36)
  • 1
    Online Resource
    Online Resource
    A study on tool condition monitoring and diagnosis of micro-grinding process based on feature extraction from force data
    SAGE Publications ; 2015
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture Vol. 229, No. 8 ( 2015-08), p. 1472-1478
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications, Vol. 229, No. 8 ( 2015-08), p. 1472-1478
    Abstract: In this article, a new algorithm for diagnosing tool conditions in micro-scale grinding process is proposed using features extracted from measured tangential grinding force data with the aid of wavelet packet decomposition and back-propagation neural network methods. The tangential grinding forces are measured in a series of micro-grinding experiments by varying depth of cut and feed rate, and those measured profiles are analyzed to define the tool conditions—sharp, middle and dull. From each tangential grinding force signal, 32 node energies are extracted by applying a wavelet packet decomposition method, and a total of 34 features including 32 node energies, depth of cut and feed rate are used to build the micro-grinding tool condition diagnosis model based on a back-propagation neural network approach. In this model, the grinding tool condition can be represented as a numerical confidence value. The experimental verification is conducted and it is demonstrated that the developed model is applicable for effectively diagnosing the micro-grinding tool conditions.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    URL: Article
    DOI: 10.1177/0954405414539497
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2032745-6
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  • 2
    Online Resource
    Online Resource
    A Framework for Monitoring the Malaria Eradication Programme in Korea
    SAGE Publications ; 2003
    In:  Asia Pacific Journal of Public Health Vol. 15, No. 1 ( 2003-01), p. 44-49
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 15, No. 1 ( 2003-01), p. 44-49
    Abstract: The World Health Organisation established the Roll Back Malaria (RBM) strategy to reduce the global burden of malaria in 1998. A set of RBM indicators will not be suitable to the Republic of Korea due to the differences of the epidemiological and socio-cultural situation. Therefore, we have developed a framework and indicators for monitoring the outcomes and impact of the national malaria eradication programme that are appropriate for the situation in Korea. We reviewed the existing data in the national malaria eradication programme. We adopted general principles in developing a monitoring framework and indicators for monitoring RBM. Monitoring areas were recombined components and content that included the project plan, training health personnel, health education and public information, supply for manpower, equipment and materials, disease control, information system, supervision, community participation, intersectoral collaboration within practical guidelines for the national malaria eradication programme along with malaria control and RBM strategy of WHO. Twenty one monitoring areas were selected that identified critical areas for the national malaria eradication programme. Fifteen indicators of ten categories are proposed for use by the national malaria eradication programme in Korea. Asia Pac J Public Health 2003; 15(1): 44-49.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/101053950301500108
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 2394975-2
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  • 3
    Online Resource
    Online Resource
    Expression of RON in colorectal cancer and its relationships with tumor cell behavior and prognosis
    SAGE Publications ; 2012
    In:  Tumori Journal Vol. 98, No. 5 ( 2012-09), p. 652-662
    Details
    In: Tumori Journal, SAGE Publications, Vol. 98, No. 5 ( 2012-09), p. 652-662
    Abstract: The aims of the current study were to evaluate whether recepteur d'origine nantais (RON) affects tumor cell behavior and oncogenic signaling pathways in colorectal cancer, and to examine the relationship of its expression with various clinicopathological parameters and patient survival. Methods Immunohistochemistry, Western blot and RT-PCR were used to detect the expression of the RON gene in human colorectal cancer tissue. To study the biological role of RON in tumor cell behavior and cellular signaling pathways, we used small interfering RNA (siRNA) to knock down RON gene expression in human colorectal cancer cell lines. Results Knockdown of RON inhibited the induction of the invasive growth phenotype and the activation of oncogenic signaling pathways including Akt, MAPK and β-catenin. RON overexpression was associated with tumor size, lymphovascular invasion, depth of invasion, lymph node metastasis, distant metastasis, tumor stage and poor survival. Conclusions These results suggest that RON overexpression may help in predicting poor clinical outcomes in colorectal cancer.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/030089161209800517
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 4
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    Preclinical Evaluation of interferon-gamma primed human Wharton’s jelly-derived mesenchymal stem cells
    SAGE Publications ; 2023
    In:  Human & Experimental Toxicology Vol. 42 ( 2023-12), p. 096032712311716-
    Details
    In: Human & Experimental Toxicology, SAGE Publications, Vol. 42 ( 2023-12), p. 096032712311716-
    Abstract: The potential of human mesenchymal stem cells (MSCs) for cell therapy has been investigated in numerous immune-mediated conditions; MSCs are considered one of the most promising cellular therapeutics to treat intractable diseases. Recently, approaches to prime MSCs have been investigated, thereby generating cellular products with enhanced potential for a variety of clinical applications. Interferon-gamma (IFN-γ) priming is a current approach used to increase the therapeutic efficacy of MSCs. In this study, we determined the systemic toxicity, tumorigenicity and biodistribution of IFN-γ-primed Wharton’s jelly-derived (WJ)-MSCs in male and female BALB/c-nu/nu mice. There were no deaths or pathologic lesions in the mice treated with 5 × 10 6 cells/kg IFN-γ-primed MSCs in the repeated dose study. In the tumorigenicity study, one of the subcutaneously treated mice showed bronchioloalveolar adenoma in the lung but tested negative for human-specific anti-mitochondrial antibody, suggesting the spontaneous murine origin of the adenoma. A biodistribution study using real-time quantitative polymerase chain reaction demonstrated the systemic IFN-γ-primed MSC clearance by day 28. Based on the toxicity, biodistribution, and tumorigenicity studies, we concluded that IFN-γ-primed MSCs at 5 × 10 6 cells/kg do not induce tumor formation and adverse changes.
    Type of Medium: Online Resource
    ISSN: 0960-3271 , 1477-0903
    URL: Article
    DOI: 10.1177/09603271231171650
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 1483723-7
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  • 5
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    Online Resource
    Post-Stroke Depressive Symptoms: Varying Responses to Escitalopram by Individual Symptoms and Lesion Location
    SAGE Publications ; 2021
    In:  Journal of Geriatric Psychiatry and Neurology Vol. 34, No. 6 ( 2021-11), p. 565-573
    Details
    In: Journal of Geriatric Psychiatry and Neurology, SAGE Publications, Vol. 34, No. 6 ( 2021-11), p. 565-573
    Abstract: The efficacy of antidepressants in post-stroke depressive symptoms (PSD) varies. We aimed to examine whether the effect of escitalopram on PSD differs according to individual depressive symptoms and stroke lesion location. Methods: This is a post hoc analysis of EMOTION ( ClinicalTrials.gov , NCT01278498), a randomized, placebo-controlled, double-blind trial that examined the efficacy of escitalopram on depression in acute stroke patients (237 with placebo, 241 with escitalopram). Depressive symptoms were evaluated with the 10-item Montgomery-Åsberg Depression Rating Scale (MADRS). Changes in MADRS and individual item scores at 12 weeks were compared between the treatment groups and among the stroke lesion location groups. Stroke lesion locations were grouped according to the anatomical distribution of serotonin fibers that originate from the midbrain/pons and spread to the forebrain via subcortical structures: “Midbrain-Pons,” “Frontal-Subcortical,” and “Others.” Least-squares means were calculated to demonstrate the independent effect of lesion location. Results: Total MADRS scores decreased more significantly in the escitalopram than in the placebo group, while a significant effect of escitalopram was observed in only 3 items: apparent sadness, reported sadness, pessimistic thoughts. In the lesion location analyses, escitalopram users in the Frontal-Subcortical group showed significant improvement in total MADRS scores (placebo [n = 130] vs. escitalopram [n = 148] , least-square mean [95% CI]: -2.3 [-3.5 to -0.2] vs. -4.5 [-5.5 to -3.4], p = .005), while those in the Midbrain-Pons and Others groups did not. Conclusions: The effect of escitalopram on PSD may be more prominent in patients with particular depressive symptoms and stroke lesion locations, suggesting the need for tailored treatment strategies.
    Type of Medium: Online Resource
    ISSN: 0891-9887 , 1552-5708
    URL: Article
    DOI: 10.1177/0891988720957108
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2094096-8
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  • 6
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    Anisotropic Thermal Characteristics of Graphene-Embedded Polyimide Composite Sheets
    SAGE Publications ; 2016
    In:  Polymers and Polymer Composites Vol. 24, No. 5 ( 2016-06), p. 315-321
    Details
    In: Polymers and Polymer Composites, SAGE Publications, Vol. 24, No. 5 ( 2016-06), p. 315-321
    Abstract: Polyimide-graphene (PIG) composites were prepared, and their thermal properties were characterized as films or sheets. Graphene loadings were controlled up to 8 wt.% or 12 wt.% in their composites. The graphenes used in this work were prepared by the chemical treatment of graphite. The as-prepared polyimide-graphene composites were thermally characterized in films or sheets. The thermal conductivities of the PIG sheets were separately analyzed in both in-plane and out-of-plane directions. The thermal expansion coefficients (TECs) of the PIG composites slightly changed with the amount of graphene added to the composites. The in-plane thermal conductivities were higher than the out-of-plane thermal conductivities, and the thermal conductivities of both directions proportionally increased with the graphene loadings in the PIG composites. The temperature-dependent stresses of the composite films monotonically decreased with the graphene loadings. The experimentally obtained thermal characteristics of the polyimide-graphene composites were compared and discussed on the basis of the composite morphologies.
    Type of Medium: Online Resource
    ISSN: 0967-3911 , 1478-2391
    URL: Article
    DOI: 10.1177/096739111602400502
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2099644-5
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  • 7
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    Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial
    SAGE Publications ; 2022
    In:  International Journal of Stroke Vol. 17, No. 8 ( 2022-10), p. 931-937
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 17, No. 8 ( 2022-10), p. 931-937
    Abstract: Very early stage blood pressure (BP) levels may affect outcome in stroke patients who have successfully undergone recanalization following intra-arterial treatment, but the optimal target of BP management remains uncertain. Aim We hypothesized that the clinical outcome after intensive BP-lowering is superior to conventional BP control after successful recanalization by intra-arterial treatment. Sample-size estimates We aim to randomize 668 patients (334 per arm), 1:1. Methods and design We initiated a multicenter, prospective, randomized, open-label trial with a blinded end-point assessment (PROBE) design. After successful recanalization (thrombolysis in cerebral infarction score ≥ 2 b), patients with elevated systolic BP level, defined as the mean of two readings ≥ 140 mmHg, will be randomly assigned to the intensive BP-lowering (systolic BP  〈  140 mm Hg) group or the conventional BP-lowering (systolic BP, 140−180 mm Hg) group. Study outcomes The primary efficacy outcomes are from dichotomized analysis of modified Rankin Scale (mRS) scores at three months (mRS scores: 0–2 vs. 3–6). The primary safety outcomes are symptomatic intracerebral hemorrhage and death within three months. Discussion The OPTIMAL-BP trial will provide evidence for the effectiveness of active BP control to achieve systolic BP  〈  140 mmHg during 24 h in patients with successful recanalization after intra-arterial treatment. Clinical trial registration ClinicalTrials.gov Identifier: NCT04205305.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/17474930211041213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2211666-7
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  • 8
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    Neuromuscular retraining therapy for early stage severe Bell's palsy patients minimizes facial synkinesis
    SAGE Publications ; 2023
    In:  Clinical Rehabilitation Vol. 37, No. 11 ( 2023-11), p. 1510-1520
    Details
    In: Clinical Rehabilitation, SAGE Publications, Vol. 37, No. 11 ( 2023-11), p. 1510-1520
    Abstract: To explore whether early physical interventions, including neuromuscular retraining therapy, can minimize excessive movement or any unwanted co-contraction after a severe Bell's palsy. Data sources From March 2021 to August 2022, the therapist treated Bell's palsy patients for the acute ( 〈 3 months, Group A), subacute (3–6 months, Group B) and chronic ( 〉 6 months, Group C) stages of the condition. Methods We explored whether early physical interventions, including neuromuscular retraining therapy, can minimize facial synkinesis after a severe episode of Bell's palsy. Each patient was informed about the potential for synkinesis and the therapist explained that the main purpose of neuromuscular retraining therapy is to learn new patterns to minimize synkinesis. The facial function of Group A was compared to that of Groups B and C using the ‘Synkinesis’ scale of the Sunnybrook Facial Grading System. Results The final facial function score after neuromuscular retraining therapy was significantly associated with both the initial electroneuronographic degeneration rate and initial facial function. Early therapy did not prevent synkinetic movement in 84.7% of the patients. But, there was a significant difference between patients who started early neuromuscular retraining therapy and other groups in final facial function. Conclusion Synkinesis in Bell's palsy patients can be minimized if physiotherapy commences before synkinesis develops; appropriate neuromuscular retraining therapy timing is essential. A patient with sudden severe Bell's palsy should receive oral steroids as soon as possible, along with physical therapy (including neuromuscular retraining therapy) within 3 months, to minimize synkinesis just before synkinesis onset.
    Type of Medium: Online Resource
    ISSN: 0269-2155 , 1477-0873
    URL: Article
    DOI: 10.1177/02692155231166216
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2028323-4
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  • 9
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    Therapeutic Effects of Intranasal Cyclosporine for Eosinophilic Rhinosinusitis with Nasal Polyps in a Mouse Model
    SAGE Publications ; 2015
    In:  American Journal of Rhinology & Allergy Vol. 29, No. 1 ( 2015-01), p. e29-e32
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 29, No. 1 ( 2015-01), p. e29-e32
    Abstract: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a principally type 2 T helper cell (Th2)-mediated inflammatory disease. Systemic corticosteroids currently represent the most effective treatment for CRSwNP, but their long-term use is constrained due to their detrimental side effects. Long-term use oftopical steroids is safe, but their efficacy is often limited. Topical cyclosporine has proven to be safe and effective for Th2-mediated diseases such as allergic conjunctivitis. Objective It was hypothesized that topical cyclosporine would be an effective novel drug for the treatment of CRSwNP; its therapeutic efficacy was assessed using a previously established mouse model. Methods After induction of eosinophilic CRSwNP in four-week-old BALB/c mice according to previous protocols, the therapeutic effects of intranasal cyclosporine were evaluated and compared with those of triamcinolone acetonide (TAC). Histopathologic changes were evaluated using hematoxylin and eosin for polyp formation and Sirius red staining for eosinophilic infiltration. The production of cytokines in sinonasal tissues, including tumor necrosis factor (TNF), interleukin (IL)-2, interferon (IFN)-y, IL-4, IL-5, IL-13, and IL-17A, was measured using a cytometric bead array. Results The number of polyp-like lesions was reduced significantly only by systemic TAC, but the degree of eosinophilic infiltration was decreased significantly by topical cyclosporine, the potency of which was similar to that of topical or systemic TAC. Except for IFN-γ, the majority of measured cytokines were reduced significantly by topical cyclosporine, although their effects on IL-2 and IL-13 were less potent than those of systemic TAC. Conclusion Topical cyclosporine might be an effective drug for the management of CRSwNP.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.2500/ajra.2015.29.4152
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2554548-6
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  • 10
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    Effects of irradiation using a radioisotope-filled balloon on tissue hyperplasia caused by stent placement in a canine urethral model
    SAGE Publications ; 2006
    In:  Acta Radiologica Vol. 47, No. 4 ( 2006-05), p. 436-443
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 47, No. 4 ( 2006-05), p. 436-443
    Abstract: Purpose: To evaluate 20 Gy and 40 Gy of intraluminal beta-irradiation using a 188 Re-7mercaptoacetyltriglycine (MAG 3 )-filled balloon catheter to reduce tissue hyperplasia caused by covered stent placement for 12 weeks of follow-up in a canine urethral model. Material and Methods: Ten dogs underwent 188 Re-MAG 3 -filled balloon dilatation immediately after stent placement; 20 Gy at 1-mm tissue depth in group I ( n = 5) and 40 Gy in group II ( n = 5), whereas 5 dogs (group III) underwent conventional balloon dilatation only. Results: There were no significant differences among the three groups for percentage diameter of stenosis, although this was highest in group III. There was a tendency toward lower mean thickness of the epithelial layer and the papillary projection for out-stent area, and thickness of the papillary projection and degree of inflammatory cells for in-stent area in groups I and II compared with group III. Thickness of the papillary projection in out-stent area was significantly different among the three groups ( P = 0.031). It was significantly less thick in group I than in group III ( P 〈 0.05), whereas group II was not significantly different from group III. Conclusion: 188 Re-MAG 3 -filled balloon dilatation has the potential to reduce tissue hyperplasia after 12 weeks of follow-up in a canine urethral model. The use of 20 Gy compared to 40 Gy did not show significant differences.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1080/02841850600557125
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2024579-8
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