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  • SAGE Publications  (98)
  • 1
    Online Resource
    Online Resource
    Oscillating Pressure Treatment Upregulates Connexin43 Expression in Skeletal Myoblasts and Enhances Therapeutic Efficacy for Myocardial Infarction
    SAGE Publications ; 2009
    In:  Cell Transplantation Vol. 18, No. 10-11 ( 2009-11), p. 1123-1135
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 18, No. 10-11 ( 2009-11), p. 1123-1135
    Abstract: Transplantation of autologous skeletal myoblasts (SMBs) is a potential therapeutic approach for myocardial infarction. However, their clinical efficacy and safety is still controversial. Electrical coupling through gap junction between SMBs and host myocardium is essential for synchronized contraction and electrical stability. Here, we investigated the effect of heart beat-simulating environment, oscillating pressure, on the expression of connexin43 in two types of SMBs from rat and mouse. We found that connexin43 is markedly decreased under ischemia-mimicking conditions such as serum starvation and hypoxia (1% O 2 ) in rat primary cultured SMBs and mouse C2C12 SMB cell line. Interestingly, the decrease of connexin43 expression under serum starvation was attenuated by oscillating pressure. Oscillating pressure treatment increased the expression of connexin43 twofold through AP-1 stimulation, which was blocked by PD98059, ERK inhibitor. In coculture of cardiomyocytes and C2C12, pressure-treated C2C12 and cardiomyocytes were able to form functional gap junction, which was demonstrated by both calcein-AM dye transfer assay and measurement of simultaneous contraction. In rat myocardial infarction model, transplantation of SMBs pretreated with oscillating pressure resulted in lesser ventricular dilatation and better systolic function than transplantation of untreated SMBs and control group. These results suggested that application of oscillating pressure on SMBs before transplantation may be useful to promote therapeutic efficacy for myocardial infarction by enhancing gap junction formation between transplanted and host cells.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368909X12483162196809
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2020466-8
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  • 2
    Online Resource
    Online Resource
    Simplified dynamic analysis of stepped thickness rectangular plate structures by the assumed mode method
    SAGE Publications ; 2017
    In:  Proceedings of the Institution of Mechanical Engineers, Part M: Journal of Engineering for the Maritime Environment Vol. 231, No. 1 ( 2017-02), p. 177-187
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part M: Journal of Engineering for the Maritime Environment, SAGE Publications, Vol. 231, No. 1 ( 2017-02), p. 177-187
    Abstract: In this article, the assumed mode method is applied to simplified dynamic analysis of stepped thickness rectangular Mindlin plates and stiffened panels with arbitrary boundary conditions. The natural and frequency responses of stepped thickness plate structures subjected to harmonic point excitation force and enforced acceleration at boundaries, respectively, are considered. Potential and kinetic energies of the system are formulated and used to derive eigenvalue problem utilizing Lagrange’s equation of motion, and mode superposition method is further used for forced response assessment. Characteristic orthogonal polynomials having the property of Timoshenko beam functions are used for the assumed modes. Numerical examples analysing vibration of stepped thickness plate structures with different topologies and various sets of boundary conditions are provided. Numerical results are compared with the results from the relevant literature and finite element solutions obtained by a general finite element tool, and a very good agreement is achieved. Hence, it is expected that stepped rectangular plate structures satisfying the prescribed criteria regarding natural and frequency responses can be efficiently designed based on the proposed method.
    Type of Medium: Online Resource
    ISSN: 1475-0902 , 2041-3084
    URL: Article
    DOI: 10.1177/1475090216630001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2089895-2
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  • 3
    Online Resource
    Online Resource
    Natural vibration analysis of vertical rectangular plates and stiffened panels in contact with fluid on one side
    SAGE Publications ; 2016
    In:  Proceedings of the Institution of Mechanical Engineers, Part M: Journal of Engineering for the Maritime Environment Vol. 230, No. 1 ( 2016-02), p. 114-125
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part M: Journal of Engineering for the Maritime Environment, SAGE Publications, Vol. 230, No. 1 ( 2016-02), p. 114-125
    Abstract: This article presents a simple and efficient procedure for the natural vibration analysis of rectangular plates and stiffened panels in contact with fluid on one side. The assumed mode method is applied, where the natural frequencies and mode shapes are obtained by solving an eigenvalue problem of a multi-degree-of-freedom system matrix equation derived by using Lagrange’s equation of motion. The Mindlin thick plate theory is applied for a plate, and in the case of stiffened panels, the effect of framing is taken into account by adding its strain and kinetic energies to the corresponding plate energies. Potential flow theory assumptions are adopted for the fluid, and free surface waves are ignored. The fluid velocity potential is derived from the boundary conditions for the fluid and structure and is utilized for the calculation of added mass using the assumed modes. The applicability and accuracy of the developed procedure are illustrated with several numerical examples using a developed in-house code. A comparison of the results with those obtained by general purpose finite element analysis software is provided, where very good agreement is achieved.
    Type of Medium: Online Resource
    ISSN: 1475-0902 , 2041-3084
    URL: Article
    DOI: 10.1177/1475090214533955
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2089895-2
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  • 4
    Online Resource
    Online Resource
    Ticagrelor Does Not Improve Endothelial Dysfunction in Stable Survivors of Acute Coronary Syndrome
    SAGE Publications ; 2019
    In:  Journal of Cardiovascular Pharmacology and Therapeutics Vol. 24, No. 5 ( 2019-09), p. 442-449
    Details
    In: Journal of Cardiovascular Pharmacology and Therapeutics, SAGE Publications, Vol. 24, No. 5 ( 2019-09), p. 442-449
    Abstract: Ticagrelor is an intriguing antiplatelet agent with a potentially beneficial impact on endothelial dysfunction and confers a mortality benefit beyond 1 month after acute coronary syndrome (ACS). However, little data exist on whether ticagrelor improves endothelial dysfunction in stable patients who survive the acute period and receive guideline-directed medical therapy. Methods and Results: This study is a prospective, randomized, parallel, open-labeled study that enrolled 30-day survivors of non-ST-segment elevation ACS (NSTE-ACS). Forty patients with NSTE-ACS were randomly assigned to ticagrelor or clopidogrel groups. The primary end point was the change in the percentage brachial artery flow-mediated dilation (baFMD) from baseline. Baseline characteristics were not different between the 2 groups. The median time from the stent implantation to screening was 269 days. After 30 days of study medication administration, the change in the percentage baFMD value was similar between the ticagrelor and clopidogrel groups (−0.08 [1.42] vs 0.30 [1.69] , P = .66). There was no difference in the change in high-sensitive C-reactive protein (−0.61 [1.48] vs −0.01 [0.57] , P = .28); however, the change in platelet inhibition significantly differed (P2Y 12 reaction units, −140.5 [49.5] vs −3.9 [51.4] , P 〈 .001). Conclusions: This dual time point baFMD study demonstrated that treatment with ticagrelor was not superior to clopidogrel for improving endothelial dysfunction in stabilized patients with NSTE-ACS.
    Type of Medium: Online Resource
    ISSN: 1074-2484 , 1940-4034
    URL: Article
    DOI: 10.1177/1074248419841640
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2230155-0
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  • 5
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    Online Resource
    In vivo MRI detection of intraplaque macrophages with biocompatible silica-coated iron oxide nanoparticles in murine atherosclerosis
    SAGE Publications ; 2021
    In:  Journal of Applied Biomaterials & Functional Materials Vol. 19 ( 2021-01), p. 228080002110147-
    Details
    In: Journal of Applied Biomaterials & Functional Materials, SAGE Publications, Vol. 19 ( 2021-01), p. 228080002110147-
    Abstract: Identification of a vulnerable atherosclerotic plaque before rupture is an unmet clinical need. Integrating nanomedicine with multimodal imaging has the potential to precisely detect biological processes in atherosclerosis. We synthesized silica-coated iron oxide nanoparticles (SIONs) coated with rhodamine B isothiocyanate and polyethylene glycol and investigated their feasibility in the detection of macrophages in inflamed atherosclerotic plaques of apolipoprotein E-deficient (ApoE −/− ) mice via magnetic resonance (MR) and fluorescence reflectance (FR) imaging. In vitro cellular uptake of SIONs was assessed in macrophages using confocal laser scanning microscopy (CLSM). In vivo MR imaging was performed 24 h after SION injection via the tail vein in 26-week-old ApoE −/− mice fed a high-cholesterol diet (HCD). We also performed FR imaging of the extracted aortas from four different mice: two normal-diet-fed C57BL/6 mice injected with saline or 10 mg/kg SIONs and two HCD-fed ApoE −/− mice injected with 5 or 10 mg/kg SIONs. The harvested aortas were cryosectioned and stained with immunohistochemical staining. The CLSM images at 24 h after incubation showed efficient uptake of SIONs by macrophages, with no evidence of cytotoxicity. The in vivo and ex vivo MR and FR images demonstrated SION deposition in the atheroma. Upon immunohistochemical staining of the aorta, CLSM images revealed colocalization of macrophages and SIONs in the atherosclerotic plaque. These results demonstrate that polyethylene glycosylated SIONs could be a highly effective method to identify macrophage activity in atherosclerotic plaques as a multimodal imaging agent.
    Type of Medium: Online Resource
    ISSN: 2280-8000 , 2280-8000
    URL: Article
    DOI: 10.1177/22808000211014751
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2673624-X
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  • 6
    Online Resource
    Online Resource
    Central washout sign in computer-aided evaluation of breast MRI: preliminary results
    SAGE Publications ; 2011
    In:  Acta Radiologica Vol. 52, No. 3 ( 2011-04), p. 256-263
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 52, No. 3 ( 2011-04), p. 256-263
    Abstract: Although computer-aided evaluation (CAE) programs were introduced to help differentiate benign tumors from malignant ones, the set of CAE-measured parameters that best predict malignancy have not yet been established. Purpose To assess the value of the central washout sign on CAE color overlay images of breast MRI. Material and Methods We evaluated the frequency of the central washout sign using CAE. The central washout sign was determined so that thin, rim-like, persistent kinetics were seen in the periphery of the tumor. Then, sequentially, plateau and washout kinetics appeared. Two additional CAE-delayed kinetic variables were compared with the central washout sign for assessment of diagnostic utility: the predominant enhancement type (washout, plateau, or persistent) and the most suspicious enhancement type (any washout 〉 any plateau 〉 any persistent kinetics). Results One hundred and forty-nine pathologically proven breast lesions (130 malignant, 19 benign) were evaluated. A central washout sign was associated with 87% of malignant lesions but only 11% of benign lesions. Significant differences were found when delayed-phase kinetics were categorized by the most suspicious enhancement type ( P 〈 0.001) and the presence of the central washout sign ( P 〈 0.001). Under the criteria of the most suspicious kinetics, 68% of benign lesions were assigned as plateau or washout pattern. Conclusion The central washout sign is a reliable indicator of malignancy on CAE color overlay images of breast MRI.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1258/ar.2010.100187
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2024579-8
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  • 7
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    Active-Margin Transmission Power Control for Wireless Sensor Networks
    SAGE Publications ; 2014
    In:  International Journal of Distributed Sensor Networks Vol. 10, No. 5 ( 2014-05-01), p. 954109-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 10, No. 5 ( 2014-05-01), p. 954109-
    Abstract: An effective transmission power control (TPC) method is proposed and demonstrated, in which an appropriate active margin is directly applied rather than a step-by-step margin as in the conventional TPC method. Active-margin transmission power control (AM-TPC) is based on an algorithm that selects an optimized transmission power by considering the channel conditions in mobile environments. For obtaining the optimal transmission power, effective minimum detectable signal (EMDS) has been introduced which considers the change both in the channel noise and in the path loss (PL) dispersion caused by multipath fading. The transmission power is determined by the EMDS and active margin to improve the efficiency of the communication. The AM-TPC improves the reliability and reduces the power consumption, because it prevents unnecessary retransmission by reducing the number of error packets. By using the AM-TPC in mobile environments, we have experimentally obtained 28.3% reduction in current consumption when compared with using maximum power transmission.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1155/2014/954109
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2192922-1
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  • 8
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    Hospital-Based Surveillance of Infection-Related Mortality in South Korea
    SAGE Publications ; 2009
    In:  Public Health Reports Vol. 124, No. 6 ( 2009-11), p. 883-888
    Details
    In: Public Health Reports, SAGE Publications, Vol. 124, No. 6 ( 2009-11), p. 883-888
    Type of Medium: Online Resource
    ISSN: 0033-3549 , 1468-2877
    URL: Article
    DOI: 10.1177/003335490912400617
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2017700-8
    SSG: 20,1
    SSG: 27
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  • 9
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    Optimal use of antithrombotic agents in ischemic stroke with atrial fibrillation and large artery atherosclerosis
    SAGE Publications ; 2023
    In:  International Journal of Stroke Vol. 18, No. 7 ( 2023-08), p. 812-820
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 18, No. 7 ( 2023-08), p. 812-820
    Abstract: Optimal antithrombotic regimens to prevent recurrent stroke in patients with ischemic stroke due to atrial fibrillation (AF) and atherosclerotic large-vessel stenosis remain unknown. Aims: This study aimed to evaluate the effect of multiple antithrombotic therapies on outcomes at 1 year after ischemic stroke due to two or more causes. Methods: We identified 862 patients with ischemic stroke due to AF and large artery atherosclerosis from the linked data. These patients were categorized into three groups according to antithrombotic therapies at discharge: (1) antiplatelets, (2) oral anticoagulants (OAC), and (3) antiplatelets plus OAC. The study outcomes were recurrent ischemic stroke, composite outcomes for cardiovascular events, and major bleeding after 1 year. Inverse probability of treatment weighting (IPTW) was used to balance the three groups using propensity scores. Results: Among 862 patients, 169 (19.6%) were treated with antiplatelets, 405 (47.0%) were treated with OAC, and 288 (33.4%) were treated with antiplatelets and OAC. After applying IPTW, only OAC had a significant beneficial effect on the 1-year composite outcome (hazard ratio (HR): 0.37, 95% confidence interval (CI): 0.23–0.60, p  〈  0.001) and death (HR: 0.35, 95% CI: (0.19–0.63), p  〈  0.001). The combination of antiplatelet agents and OAC group had an increased risk of major bleeding complications (HR: 5.27, 95% CI: (1.31–21.16), p = 0.019). However, there was no significant difference in 1-year recurrent stroke events among the three groups. Conclusion: This study demonstrated that OAC monotherapy was associated with lower risks of composite outcome and death in patients at 1 year after ischemic stroke due to AF and atherosclerotic stenosis. In addition, the combination of an antiplatelet and OAC had a high risk of major bleeding.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/17474930231158211
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2211666-7
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  • 10
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    Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases
    SAGE Publications ; 2021
    In:  Multiple Sclerosis Journal Vol. 27, No. 6 ( 2021-05), p. 964-967
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 27, No. 6 ( 2021-05), p. 964-967
    Abstract: We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell–based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458520948213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2008225-3
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