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  • 1
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    Online Resource
    Clonazepam improves dopamine supersensitivity in a schizophrenia patient: a case report
    SAGE Publications ; 2017
    In:  Therapeutic Advances in Psychopharmacology Vol. 7, No. 3 ( 2017-03), p. 113-117
    Details
    In: Therapeutic Advances in Psychopharmacology, SAGE Publications, Vol. 7, No. 3 ( 2017-03), p. 113-117
    Abstract: Dopamine supersensitivity is an important consideration for assessing treatment-resistant schizophrenia. The emergence of dopamine supersensitivity might be related to upregulation of dopamine D2 receptor, which engenders tolerance to antipsychotics, rebound psychosis, and tardive dyskinesia (TD). A 24-year-old man with a history of treatment-resistant schizophrenia was hospitalized for treatment of bone fracture sustained during a suicide attempt. After the operation, his clinical symptoms implied malignant catatonia. The patient discontinued antipsychotics without rebound psychosis under clonazepam treatment. His psychotic symptoms were controlled further with 24 mg/day aripiprazole without relapse or worsening. Clonazepam might be an effective option for the management of dopamine supersensitivity psychosis (DSP).
    Type of Medium: Online Resource
    ISSN: 2045-1253 , 2045-1261
    URL: Article
    DOI: 10.1177/2045125316681750
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2646542-5
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  • 2
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    Online Resource
    Sequential EEG Analysis during Intermittent Photic Stimulation in Never-Medicated Patients with Schizophrenia
    SAGE Publications ; 2003
    In:  Clinical Electroencephalography Vol. 34, No. 4 ( 2003-10), p. 201-206
    Details
    In: Clinical Electroencephalography, SAGE Publications, Vol. 34, No. 4 ( 2003-10), p. 201-206
    Abstract: To investigate sequential changes in electroencephalograms (EEGs) during intermittent photic stimulation (IPS), quantitative EEG analysis for the alpha band (related to stimulus frequency) was performed in 18 drug-naïve schizophrenic patients and 18 sex- and age-matched control subjects. IPS consisted of white flickers at 10 flashes/sec, lasting 10 sec and repeated six times at 10 sec intervals. The differences between the two groups were assessed for two conditions (i.e., during photic stimulation (PS) and inter-PS). During stimulus, the absolute 9–11 Hz band power of the patient group was higher at the posterior than that at the anterior sites throughout the 10 sec periods. However, this difference between sites was not seen during the first 1 sec in the control group. During the nonstimulus period, posterior dominance of 9–11 Hz band power was prominent in the patient group throughout. In the control group, however, this difference was minor, especially during the latter half of the period. These results suggest that schizophrenic patients show fewer changes in posterior alpha activity during both stimulus and nonstimulus, and this continuity of posterior dominance may reflect hyperarousal, which counteracts any decrease in vigilance throughout the IPS.
    Type of Medium: Online Resource
    ISSN: 0009-9155
    URL: Article
    DOI: 10.1177/155005940303400407
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 2647038-X
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  • 3
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    Online Resource
    Effect of Normal Aging upon Interhemispheric EEG Coherence: Analysis during Rest and Photic Stimulation
    SAGE Publications ; 2000
    In:  Clinical Electroencephalography Vol. 31, No. 4 ( 2000-10), p. 170-174
    Details
    In: Clinical Electroencephalography, SAGE Publications, Vol. 31, No. 4 ( 2000-10), p. 170-174
    Type of Medium: Online Resource
    ISSN: 0009-9155
    URL: Article
    DOI: 10.1177/155005940003100404
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2647038-X
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  • 4
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    Periostin Deficiency Causes Severe and Lethal Lung Injury in Mice With Bleomycin Administration
    SAGE Publications ; 2016
    In:  Journal of Histochemistry & Cytochemistry Vol. 64, No. 7 ( 2016-07), p. 441-453
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 64, No. 7 ( 2016-07), p. 441-453
    Abstract: Pulmonary capillary leakage followed by influx of blood fluid into the air space of lung alveoli is a crucial step in the progression of acute lung injury (ALI). This influx is due to increased permeability of the alveolar–capillary barrier. The extracellular matrix (ECM) between the capillary and the epithelium would be expected to be involved in prevention of the influx; however, the role of the ECM remains to be addressed. Here, we show that the ECM architecture organized by periostin, a matricellular protein, plays a pivotal role in the survival of bleomycin-exposed mice. Periostin was localized in the alveolar walls. Although periostin-null mice displayed no significant difference in lung histology and air–blood permeability, they exhibited early lethality in a model of bleomycin-induced lung injury, compared with their wild-type counterparts. This early lethality may have been due to increased pulmonary leakage of blood fluid into the air space in the bleomycin-exposed periostin-null mice. These results suggest that periostin in the ECM architecture prevents pulmonary leakage of blood fluid, thus increasing the survival rate in mice with ALI. Thus, this study provides an evidence for the protective role of the ECM architecture in the lung alveoli.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1369/0022155416652611
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 5
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    Phlegmonous gastritis secondary to superior mesenteric artery syndrome
    SAGE Publications ; 2015
    In:  SAGE Open Medical Case Reports Vol. 3 ( 2015-01-01), p. 2050313X1559665-
    Details
    In: SAGE Open Medical Case Reports, SAGE Publications, Vol. 3 ( 2015-01-01), p. 2050313X1559665-
    Abstract: We herein report a case of phlegmonous gastritis secondary to superior mesenteric artery syndrome. An 80-year-old woman visited the hospital emergency department with the chief complaints of epigastric pain and vomiting. She was hospitalized urgently following the diagnosis of superior mesenteric artery syndrome based on abdominal computed tomography findings. Conservative therapy was not effective, and phlegmonous gastritis was diagnosed based on the findings of upper gastrointestinal endoscopy and biopsy performed on the 12th day of the disease. Undernutrition and reduced physical activity were observed on hospital admission, and proactive nutritional therapy with enteral nutrition was started. An upper gastrointestinal series, performed approximately 1 month later, confirmed the persistence of strictures and impaired gastric emptying. Because conservative therapy was unlikely to improve oral food intake, open total gastrectomy was performed on the 94th day of the disease. Examination of surgically resected specimens revealed marked inflammation and fibrosis, especially in the body of the stomach. Following a good postoperative recovery, the patient was able to commence oral intake and left our hospital on foot approximately 1 month after surgery.
    Type of Medium: Online Resource
    ISSN: 2050-313X , 2050-313X
    URL: Article
    DOI: 10.1177/2050313X15596651
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2736953-5
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  • 6
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    Online Resource
    Assessment of humoral responses in COVID-19 using various quantitative antibody tests
    SAGE Publications ; 2021
    In:  Annals of Clinical Biochemistry: International Journal of Laboratory Medicine Vol. 58, No. 4 ( 2021-07), p. 368-376
    Details
    In: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, SAGE Publications, Vol. 58, No. 4 ( 2021-07), p. 368-376
    Abstract: Quantitative antibody tests are expected to be useful in diagnostics of COVID-19 and investigation of herd immunity against SARS-CoV-2. To make it proper to perform them, understanding of the immunological aspects is critically important. The present study aimed to assess humoral responses in COVID-19 using various quantitative antibody tests. Methods Four quantitative antibody tests that are different in targeted antigens, detectable immunoglobulin classes and avidity were used. Diagnosis was confirmed by RT-PCR for SARS-CoV-2 detection. Antibody titres of 117 samples collected from 24 COVID-19 patients and 23 non-COVID-19 patients were measured to evaluate correlations between different tests. For 24 COVID-19 patients, antibody titres measured at various time points after the onset or the RT-PCR diagnosis were subjected to assessment of humoral responses. Results Correlations between tests were observed to some degree, although there were discrepancies putatively due to differences in measurement principle. Seronegative COVID-19 was diagnosed for some patients, in whom antibody titres were less than the cut-off value in each test throughout the time courses. IgG seroconversion without prior IgM seroconversion most frequently occurred, while predominance of IgM responses over IgG responses was observed in some severe cases. Viral burdens estimated according to threshold cycle values at the RT-PCR seemed to impact antibody responses. Conclusions The results provide insights into the nature of humoral responses to SARS-CoV-2 and diagnostic performance of antibody tests.
    Type of Medium: Online Resource
    ISSN: 0004-5632 , 1758-1001
    URL: Article
    DOI: 10.1177/00045632211006740
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2041298-8
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  • 7
    Online Resource
    Online Resource
    Differences in EEG Harmonic Driving Responses to Photic Stimulation between Normal Aging and Alzheimer's Disease
    SAGE Publications ; 2002
    In:  Clinical Electroencephalography Vol. 33, No. 2 ( 2002-04), p. 86-92
    Details
    In: Clinical Electroencephalography, SAGE Publications, Vol. 33, No. 2 ( 2002-04), p. 86-92
    Abstract: In order to investigate whether Alzheimer's disease (AD) is the end result of aging of the brain or the result of some other mechanism, we analyzed EEGs showing the absolute power of harmonic responses to photic stimulation (PS) in younger subjects, non-demented elderly subjects and AD patients. At rest, the AD patients generally showed less absolute power than the younger and elderly subjects, with significant differences found at 10Hz and 20Hz. Analysis of EEGs recorded during PS indicated that the elderly subjects generally demonstrated more absolute power than the younger subjects and AD patients. These findings suggest a failure of stimulation-related brain activation in AD patients, and provide further evidence that normal aging and AD employ different mechanisms for functional organization during PS.
    Type of Medium: Online Resource
    ISSN: 0009-9155
    URL: Article
    DOI: 10.1177/155005940203300208
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2647038-X
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  • 8
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    Efficacy of continuous follow-up for preventing the involuntary readmission of psychiatric patients in Japan: A retrospective cohort study
    SAGE Publications ; 2013
    In:  International Journal of Social Psychiatry Vol. 59, No. 3 ( 2013-05), p. 288-295
    Details
    In: International Journal of Social Psychiatry, SAGE Publications, Vol. 59, No. 3 ( 2013-05), p. 288-295
    Abstract: Providing aftercare to psychiatric inpatients is important for preventing frequent readmissions; however, the lack of social resources is a problem in Japan. The prefectural Tama-Fuchu Public Health Centre has attempted to establish a new continuous follow-up system for all discharged psychiatric patients in order to reduce the frequency of readmissions. Aims: This study aims to evaluate the efficacy of this system. Methods: The subjects of the present study were 200 psychiatric inpatients from the Tokyo catchment area. The continuous follow-up system was applied to 130 subjects for one year in addition to conventional standard care (the intervention group). Seventy subjects received conventional care alone (the comparison group). The incident rate ratios (IRR) of total and involuntary readmission to hospital were compared by survival analysis. Results: During the observation period, there were 41 readmissions and 29 involuntary readmissions in 49,731 person-days. The patients subjected to continuous follow-up showed a trend towards a lower overall risk of readmission (IRR = 0.56, 95% CI: 0.29–1.10, p = .057) and a significantly reduced risk of involuntary admission (IRR = 0.48, 95% CI: 0.22–0.96, p = .047). Conclusion: This study provides empirical evidence that providing continuous follow-up examinations as aftercare for discharged psychiatric patients significantly reduces the incidence of involuntary readmission.
    Type of Medium: Online Resource
    ISSN: 0020-7640 , 1741-2854
    URL: Article
    DOI: 10.1177/0020764011433631
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2066492-8
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  • 9
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    Online Resource
    Isolated Coronary Ostial Stenosis in Takayasu's Arteritis: Case Report and Review of the Literature
    SAGE Publications ; 1993
    In:  Angiology Vol. 44, No. 10 ( 1993-10), p. 839-844
    Details
    In: Angiology, SAGE Publications, Vol. 44, No. 10 ( 1993-10), p. 839-844
    Abstract: This report describes a rare clinical course of a young Japanese woman with Takayasu's arteritis and a review of the literature. Her first symptom was angina pectoris due to isolated left coronary ostial stenosis, which was relieved by aortocoronary bypass grafting surgery using a saphenous vein graft. At that time, the C-reactive protein was negative and the histopathologic findings of the specimens of the aorta could not confirm aortitis. Although she was free from any cardiovascular symptoms for about fifteen years,. syncopal attacks occurred owing to severe stenosis of the major branches of the aortic arch revealed by intravenous digital subtraction arteriograms. Thus, Takayasu's arteritis could be a cause of coronary ostial stenosis in young women even if the inflammatory findings are negative and the major branches of the aortic arch are not involved at operation. In addition, revascularization using internal thoracic arteries might possess a potential risk of coronary insufficiency due to a later involvement of these proximal arteries.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/000331979304401013
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1993
    detail.hit.zdb_id: 2065911-8
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  • 10
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    Online Resource
    Estimating an Origin-Destination Table Under Repeated Counts of In-Out Volumes at Highway Ramps: Use of Artificial Neural Networks
    SAGE Publications ; 2000
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 1739, No. 1 ( 2000-01), p. 59-66
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 1739, No. 1 ( 2000-01), p. 59-66
    Abstract: A method is proposed that applies an artificial neural network model to estimate an origin-destination (O-D) matrix for a freeway network for which the data on inflow and outflow at the ramps are gathered regularly. This problem is the same as estimating the elements of an O-D table, given that many sets of data about the right-hand column total (trip production) and the bottom row total (trip attraction) are available. A neural network model is developed to emulate the stimulusresponse process on the freeway traffic, in which the stimulus is the inflow at the entrance ramps and the response the outflow at the exit ramps. After the neural network of a particular structure is trained by many sets of data (e.g., sets of daily volumes), the weights of the neural network are found to represent the ramp-to-ramp volume expressed in the proportion of the in-flow at the corresponding ramps. The model is applied to estimate a ramp-to-ramp O-D table for the Tokyo expressway network. The result is compared with the actual O-D table obtained from a survey. The model is found to be useful not only for estimating the O-D volume with much less data than for the traditional method, but also for verifying the existence of a pattern in the traffic flow.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/1739-08
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2403378-9
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