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  • 1
    Online Resource
    Online Resource
    CD4 + T-Cell Count Increase in HIV-1-Infected Patients with Suppressed Viral Load Within 1 year after start of antiretroviral therapy
    SAGE Publications ; 2007
    In:  Antiviral Therapy Vol. 12, No. 6 ( 2007-08), p. 889-898
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 12, No. 6 ( 2007-08), p. 889-898
    Abstract: CD4 + T-cell recovery in patients with continuous suppression of plasma HIV-1 viral load (VL) is highly variable. This study aimed to identify predictive factors for long-term CD4 + T-cell increase in treatment-naive patients starting combination antiretroviral therapy (cART). Methods Treatment-naive patients in the Swiss HIV Cohort Study reaching two VL measurements 〈 50 copies/ml 〉 3 months apart during the 1st year of cART were included ( n=1,816 patients). We studied CD4 + T-cell dynamics until the end of suppression or up to 5 years, subdivided into three periods: 1st year, years 2–3 and years 4–5 of suppression. Multiple median regression adjusted for repeated CD4 + T-cell measurements was used to study the dependence of CD4 + T-cell slopes on clinical covariates and drug classes. Results Median CD4 + T-cell increases following VL suppression were 87, 52 and 19 cells/μl per year in the three periods. In the multiple regression model, median CD4 + T-cell increases over all three periods were significantly higher for female gender, lower age, higher VL at cART start, CD4 + T-cell 〈 650 cells/μ l at start of the period and low CD4 + T-cell increase in the previous period. Patients on tenofovir showed significantly lower CD4 + T-cell increases compared with stavudine. Conclusions In our observational study, long-term CD4 + T-cell increase in drug-naive patients with suppressed VL was higher in regimens without tenofovir. The clinical relevance of these findings must be confirmed in, ideally, clinical trials or large, collaborative cohort projects but could influence treatment of older patients and those starting cART at low CD4 + T-cell levels.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350701200602
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2118396-X
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  • 2
    Online Resource
    Online Resource
    Simultaneous immunoelectron microscopic visualization of protein B23 and C23 distribution in the HeLa cell nucleolus.
    SAGE Publications ; 1989
    In:  Journal of Histochemistry & Cytochemistry Vol. 37, No. 9 ( 1989-09), p. 1371-1374
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 37, No. 9 ( 1989-09), p. 1371-1374
    Abstract: The intranucleolar distribution of phosphoproteins B23 and C23 was visualized simultaneously by post-embedding immunoelectron microscopy in HeLa cell nucleoli, using specific antibodies. The data show that proteins B23 and C23 co-localize to the same nucleolar compartments, i.e., the dense fibrillar component and the granular component. Neither of the two antibodies is significantly associated with the fibrillar centers in these cells, although the fibrillar centers appear positive after silver staining. These findings suggest that other unidentified components must be responsible for the silver staining observed in the fibrillar centers of interphase nucleoli. The results are discussed in the light of previously reported data obtained by preembedding immunolabeling techniques and by silver staining, which both suggested a localization of protein C23 inside the fibrillar centers.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1177/37.9.2768807
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1989
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Neuromuscular Warm-Up is Associated with Fewer Overuse Injuries in Ballet Dancers Compared to Traditional Ballet-Specific Warm-Up
    SAGE Publications ; 2022
    In:  Journal of Dance Medicine & Science Vol. 26, No. 4 ( 2022-12-15), p. 244-254
    Details
    In: Journal of Dance Medicine & Science, SAGE Publications, Vol. 26, No. 4 ( 2022-12-15), p. 244-254
    Abstract: Neuromuscular warm-up exercises (NMWU) have been shown to prevent injuries. In dance, research on warming-up is scarce. We investigated warm-up habits among ballet dancers and the effects of NMWU and traditional ballet-specific warm-up (TBSWU) on injuries. Using a cross-sectional survey among ballet dancers over the age of 18 years, we recorded acute and overuse injuries sustained in the previous 2 years. Warm-up behavior was assessed through 28 items. Dancers were grouped into NMWU or TBSWU: NMWU was based on neuromuscular warm-up programs in sports science and included exercises improving strength, power, proprioception, sensorimotor control, or cardiovascular stimulus; and TBSWU consisted of stretching, dance-technical exercises, marking steps and running-through-choreographies, or stretching with tools. Separate linear regression analyses adjusted for confounding factors were performed for acute and overuse injuries. A total of 192 dancers (26.7 ± 7.82 years, 159 females, 132 professionals) reported 203 acute and 469 overuse injuries. In total, 47.4% of dancers always warmed up (mean duration 20.7 ± 13.2 minutes) based on stretching (63%), technical-exercises (58.9%), strength-training (54.7%), and the barre (53.6%); and 9.4% never warmed up. A total of 31 dancers (16.15%) were classified as TBSWU, 16 dancers (8.3%) for NMWU, and 145 dancers did combined exercises. Those in the NMWU group were associated with fewer overuse injuries compared to those in the TBSWU group (β = -2.34; 95%CI -3.54 to -1.14). No association was found with acute injuries. As in other athletes, NMWU might be protective against overuse injuries in dancers. Large-scale prospective cohort studies are needed to gain more insight into NMWU as a possible component of injury prevention in ballet.
    Type of Medium: Online Resource
    ISSN: 1089-313X
    URL: Article
    DOI: 10.12678/1089-313X.121522e
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 4
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    Online Resource
    sec -Butylpropylacetamide (SPD) has antimigraine properties
    SAGE Publications ; 2016
    In:  Cephalalgia Vol. 36, No. 10 ( 2016-09), p. 924-935
    Details
    In: Cephalalgia, SAGE Publications, Vol. 36, No. 10 ( 2016-09), p. 924-935
    Abstract: Though migraine is disabling and affects 12%–15% of the population, there are few drugs that have been developed specifically for migraine prevention. Valproic acid (VPA) is a broad-spectrum antiepileptic drug (AED) that is also used for migraine prophylaxis, but its clinical use is limited by its side effect profile. sec-Butylpropylacetamide (SPD) is a novel VPA derivative, designed to be more potent and tolerable than VPA, that has shown efficacy in animal seizure and pain models. Methods We evaluated SPD’s antimigraine potential in the cortical spreading depression (CSD) and nitroglycerin (NTG) models of migraine. To evaluate SPD’s mechanism of action, we performed whole-cell recordings on cultured cortical neurons and neuroblastoma cells. Results In the CSD model, the SPD-treated group showed a significantly lower median number of CSDs compared to controls. In the NTG-induced mechanical allodynia model, SPD dose-dependently reduced mechanical sensitivity compared to controls. SPD showed both a significant potentiation of GABA-mediated currents and a smaller but significant decrease in NMDA currents in cultured cortical neurons. Kainic acid-evoked currents and voltage-dependent sodium channel currents were not changed by SPD. Conclusions These results demonstrate SPD’s potential as a promising novel antimigraine compound, and suggest a GABAergic mechanism of action.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1177/0333102415612773
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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  • 5
    Online Resource
    Online Resource
    Characterizing Adversity of Lysosomal Accumulation in Nonclinical Toxicity Studies: Results from the 5th ESTP International Expert Workshop
    SAGE Publications ; 2018
    In:  Toxicologic Pathology Vol. 46, No. 2 ( 2018-02), p. 224-246
    Details
    In: Toxicologic Pathology, SAGE Publications, Vol. 46, No. 2 ( 2018-02), p. 224-246
    Abstract: Lysosomes have a central role in cellular catabolism, trafficking, and processing of foreign particles. Accumulation of endogenous and exogenous materials in lysosomes represents a common finding in nonclinical toxicity studies. Histologically, these accumulations often lack distinctive features indicative of lysosomal or cellular dysfunction, making it difficult to consistently interpret and assign adverse dose levels. To help address this issue, the European Society of Toxicologic Pathology organized a workshop where representative types of lysosomal accumulation induced by pharmaceuticals and environmental chemicals were presented and discussed. The expert working group agreed that the diversity of lysosomal accumulations requires a case-by-case weight-of-evidence approach and outlined several factors to consider in the adversity assessment, including location and type of cell affected, lysosomal contents, severity of the accumulation, and related pathological effects as evidence of cellular or organ dysfunction. Lysosomal accumulations associated with cytotoxicity, inflammation, or fibrosis were generally considered to be adverse, while those found in isolation (without morphologic or functional consequences) were not. Workshop examples highlighted the importance of thoroughly characterizing the biological context of lysosomal effects, including mechanistic data and functional in vitro readouts if available. The information provided here should facilitate greater consistency and transparency in the interpretation of lysosomal effects.
    Type of Medium: Online Resource
    ISSN: 0192-6233 , 1533-1601
    URL: Article
    DOI: 10.1177/0192623317749452
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2056753-4
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  • 6
    Online Resource
    Online Resource
    Long-Term Virological Response to Multiple Sequential Regimens of Highly Active Antiretroviral Therapy for HIV Infection
    SAGE Publications ; 2004
    In:  Antiviral Therapy Vol. 9, No. 2 ( 2004-02), p. 263-274
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 9, No. 2 ( 2004-02), p. 263-274
    Abstract: Information about the virological response to sequential highly active antiretroviral therapy (HAART) for HIV infection is limited. The virological response to four consecutive therapies was evaluated in the Swiss HIV Cohort. Design Retrospective analysis in an observational cohort. Methods 1140 individuals receiving uninterrupted HAART for 4.8 ±0.6 years were included. The virological response was classified as success ( 〈 400 copies/ml), low-level (LF: 400–5000 copies/ml) or high-level failure (HF: 〉 5000 copies/ml). Potential determinants of the virological response, including patient demographics, treatment history and virological response to previous HAART regimens were analysed using survival and logistic regression analyses. Results 40.1% failed virologically on the first (22.0% LF; 18.1% HF), 35.1% on the second (14.2% LF; 20.9% HF), 34.2% on the third (9.9% LF; 24.3% HF) and 32.7% on the fourth HAART regimen (9% LF; 23.7% HF). Nucleoside pre-treatment (OR: 2.34; 95% CI: 1.67–3.29) and low baseline CD4 T-cell count (OR: 0.79/100 cells rise; 95% CI: 0.72–0.88) increased the risk of HF on the first HAART. Virological failure on HAART with HIV-1 RNA levels exceeding 1000 copies/ml predicted a poor virological response to subsequent HAART regimens. A switch from a protease inhibitor- to a non-nucleoside reverse transcriptase inhibitor-containing regimen significantly reduced the risk of HF. Multiple switches of HAART did not affect the recovery of CD4 T lymphocytes. Conclusion Multiple sequential HAART regimens do not per se reduce the likelihood of long-term virological suppression and immunological recovery. However, early virological failure increases significantly the risk of subsequent unfavourable virological responses. The choice of a potent initial antiretroviral drug regimen is therefore critical. This study has been presented in part at the 10th Conference on Retroviruses & Opportunistic Infections. Boston, Mass., USA, 2003. Abstract #571.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350400900212
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
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  • 7
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    Online Resource
    Cannabis use for Sleep Disturbance Among Older Patients in a Geriatrics Clinic
    SAGE Publications ; 2023
    In:  The International Journal of Aging and Human Development Vol. 97, No. 1 ( 2023-07), p. 3-17
    Details
    In: The International Journal of Aging and Human Development, SAGE Publications, Vol. 97, No. 1 ( 2023-07), p. 3-17
    Abstract: Cannabis use is growing among older adults to manage medical concerns including poor sleep. In this study, we characterized how patients seen at a geriatrics clinic use cannabis to address sleep disturbance. Specifically, we conducted an anonymous survey of 568 adults, including 83 who reported cannabis use within the past 3 years, to inquire about such use. We compared cannabis use characteristics between those using it for sleep disturbance versus all other conditions. We considered a p-value 〈 .10 to be statistically significant. Among the cannabis users in our sample, 29% reported using cannabis for sleep disturbance (N = 24). They were more likely than other users to be female ( p = .07), consume cannabis more frequently ( p = .01), use products containing tetrahydrocannabinol (THC) (vs. cannabidiol [CBD]-only; p  〈  .01), and use cannabis to target more symptoms ( p  〈  .01). As cannabis use continues to grow in older populations, it is essential to delineate better how cannabis may be used safely and effectively to improve older adults’ sleep health.
    Type of Medium: Online Resource
    ISSN: 0091-4150 , 1541-3535
    URL: Article
    DOI: 10.1177/00914150221128971
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2067347-4
    SSG: 5,2
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  • 8
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    Online Resource
    Significance of Alterations in Main Renal Artery Calibre and Configuration
    SAGE Publications ; 1972
    In:  Acta Radiologica. Diagnosis Vol. 12, No. 6 ( 1972-11), p. 803-832
    Details
    In: Acta Radiologica. Diagnosis, SAGE Publications, Vol. 12, No. 6 ( 1972-11), p. 803-832
    Type of Medium: Online Resource
    ISSN: 0567-8056
    URL: Article
    DOI: 10.1177/028418517201200614
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1972
    detail.hit.zdb_id: 1492623-4
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  • 9
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    Online Resource
    Specificity of Cerebellar Vermian Abnormalities in Autism: A Quantitative Magnetic Resonance Imaging Study
    SAGE Publications ; 2003
    In:  Journal of Child Neurology Vol. 18, No. 7 ( 2003-07), p. 463-470
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 18, No. 7 ( 2003-07), p. 463-470
    Abstract: To gain insight into the specificity of cerebellar vermian abnormalities reported in autism, we conducted a magnetic resonance imaging (MRI) study of boys with either of two conditions associated with autism, Down syndrome and fragile X syndrome, compared with boys with idiopathic autism and controls. The subjects, ranging in age from 3 to 9 years, included 16 boys with Down syndrome + autism and 11 boys with Down syndrome only; 13 boys with fragile X syndrome + autism and 9 boys with fragile X syndrome only; 10 boys with idiopathic autism; and 22 controls. Diagnosis of autism was based on DSM-IV criteria, confirmed primarily by the Autism Diagnostic Interview. T 1 -weighted midsagittal MRIs were used to measure midline structures. Intracranial area, reflecting brain size, was significantly smaller in subjects with Down syndrome. Therefore, all vermian measures were expressed as ratios to intracranial area. Analysis of covariance (covarying for age and IQ) demonstrated that posterior vermi (lobules VI—VII and VIII—X) were markedly smaller in both Down syndrome groups and those with fragile X syndrome only, whereas only lobules VI—VII were reduced in idiopathic autism. Factorial analyses of variance tested interactions between autism factor and the diagnosis of Down syndrome or fragile X syndrome. The size of lobules VI—VII/intracranial area was dependent on autism status only in fragile X syndrome, with ratios significantly larger in fragile X syndrome with autism with respect to fragile X syndrome only. We conclude that selective posterior vermis hypoplasia is seen not only in idiopathic autism but also in Down syndrome and some individuals with fragile X syndrome. However, reductions in vermian lobules VI and VII appear to be specific to idiopathic autism, whereas increased size of lobules VI and VII is associated with autism in fragile X syndrome. The latter results are consistent with MRI studies showing lobules VI—VII hyperplasia in a subset of subjects with idiopathic autism and cerebral and hippocampal enlargements in fragile X syndrome. ( J Child Neurol 2003;18:463—470).
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/08830738030180070501
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 2068710-2
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  • 10
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    Online Resource
    Locus of Control and Entrepreneurship in the Russian Republic
    SAGE Publications ; 1995
    In:  Entrepreneurship Theory and Practice Vol. 20, No. 1 ( 1995-10), p. 43-56
    Details
    In: Entrepreneurship Theory and Practice, SAGE Publications, Vol. 20, No. 1 ( 1995-10), p. 43-56
    Abstract: An internal locus of control has been linked empirically to entrepreneurial activity. In changing to a market economy, therefore, the Russian Republic may face hidden psychological barriers if 70 years of a closely managed economy has Induced a perception of control located In powerful others rather than oneself. Levenson's (three-dimensional) locus of control scale Is administered In the former Soviet Union and the results compared to baseline data across various countries and cultures. The findings Indicate that when compared to most countries, the Russian respondents did possess lower Internal locus of control scores and In some Instances higher powerful other scores.
    Type of Medium: Online Resource
    ISSN: 1042-2587 , 1540-6520
    URL: Article
    DOI: 10.1177/104225879502000103
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1995
    detail.hit.zdb_id: 2069619-X
    SSG: 3,2
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