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  • 1
    Online Resource
    Online Resource
    Exercise Capacity and Association with Quality of Life in Peritoneal Dialysis Patients
    SAGE Publications ; 2019
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 39, No. 1 ( 2019-01), p. 66-73
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 39, No. 1 ( 2019-01), p. 66-73
    Abstract: Muscle wasting, common and progressive in uremic patients, is associated with a high probability for morbidity, lower health-related quality of life (HRQOL), and mortality. However, exercise tolerance in peritoneal dialysis (PD) patients has not been fully elucidated. The aim of this study was to evaluate exercise capacity, its determinants, and its association with HRQOL in PD patients. Methods Outpatients treated with PD at Keio University Hospital from December 2016 to March 2018 were included in this single-center cross-sectional observational study. Exercise capacity was assessed by incremental shuttle walking test (ISWT) and handgrip and quadriceps strength. In addition to evaluation of PD-related parameters, HRQOL was assessed by the Kidney Disease Quality of Life-Short Form questionnaire. Results Among the 50 recruited PD outpatients, age and PD vintage were 63.8 ± 9.6 and 3.8 ± 2.8 years, respectively. Physical examination revealed ISWT of 312.0 ± 138.2 m, handgrip strength of 27.5 ± 6.9 kg, and quadriceps strength of 23.3 ± 10.0 kg. Multivariate analysis showed that younger age and male sex were significantly associated with higher ISWT and handgrip and quadriceps strength. Skeletal mass index (SMI) remained a significant predictor of handgrip and quadriceps strength. Moreover, only ISWT was strongly correlated with higher HRQOL scores, including physical, mental, and kidney-specific domains, even after adjustment for age and sex. Conclusions Exercise tolerance in PD patients was partially determined by age, sex, and SMI. Moreover, this is the first study to demonstrate the strong relationship between aerobic capacity and HRQOL in PD patients.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.3747/pdi.2018.00075
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 645010-6
    detail.hit.zdb_id: 2075957-5
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  • 2
    Online Resource
    Online Resource
    Non-Tuberculous Mycobacterial Infections Related to Peritoneal Dialysis
    SAGE Publications ; 2018
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 38, No. 2 ( 2018-03), p. 147-149
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 38, No. 2 ( 2018-03), p. 147-149
    Abstract: Most infections related to peritoneal dialysis (PD) are caused by common bacteria, and non-tuberculous mycobacteria are rare. The clinical characteristics and prognosis of PD patients with non-tuberculous mycobacterial infections were investigated at our hospital. Non-tuberculous mycobacteria were detected in 11 patients (exit-site infection, tunnel infection, and peritonitis in 3, 5, and 3 patients, respectively). Mycobacterium fortuitum, Mycobacterium chelonae, and Mycobacterium abscessus were identified in 4, 2, and 2 patients, respectively. Most patients with peritonitis or tunnel infection required catheter removal. During the study period (2007 – 2017), peritonitis occurred in 44 patients, including 3 patients (6.8%) with non-tuberculous mycobacterial peritonitis. When non-tuberculous mycobacterial infection occurs, multi-agent antibiotic therapy, unroofing surgery, and/or catheter replacement should be performed to prevent peritonitis.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.3747/pdi.2017.00172
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 645010-6
    detail.hit.zdb_id: 2075957-5
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  • 3
    Online Resource
    Online Resource
    Vaginal Wall Endometriosis Treated by Low-Dose Estrogen-Progestin: A Case Report
    SAGE Publications ; 2014
    In:  Journal of Endometriosis and Pelvic Pain Disorders Vol. 6, No. 4 ( 2014-10), p. 225-227
    Details
    In: Journal of Endometriosis and Pelvic Pain Disorders, SAGE Publications, Vol. 6, No. 4 ( 2014-10), p. 225-227
    Abstract: As vaginal wall endometriosis is rare, standard therapy has not yet been established. We report here a case of vaginal wall endometriosis that was reduced through administration of low-dose estrogen-progestin (LEP). The patient was a 37-year-old woman who presented with atypical genital bleeding (AGB) and dysmenorrhea. We recognized small hematomatous lesions on the posterior fornix of the vagina and a 3-cm mass in the pouch of Douglas, and we diagnosed the patient with vaginal wall endometriosis. We administered drug therapy with LEP. AGB stopped, and both the hematomatous vaginal wall lesion and the mass in the pouch of Douglas were reduced in size. The vaginal and pouch of Douglas lesions did not grow, and both AGB and dysmenorrhea did not appear for 42 months. LEP reduces vaginal wall endometriosis and rectovaginal endometriosis. In this case, we confirmed the direct effect of LEP on a vaginal wall endometriosis lesion. LEP therapy may be effective as postoperative therapy for vaginal wall endometriosis.
    Type of Medium: Online Resource
    ISSN: 2284-0265 , 2284-0273
    URL: Article
    DOI: 10.5301/je.5000197
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2808441-X
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  • 4
    Online Resource
    Online Resource
    Programmed Death-ligand 1 Expression With Clone 22C3 in Non-small Cell Lung Cancer: A Single Institution Experience
    SAGE Publications ; 2019
    In:  Clinical Medicine Insights: Oncology Vol. 13 ( 2019-01), p. 117955491882131-
    Details
    In: Clinical Medicine Insights: Oncology, SAGE Publications, Vol. 13 ( 2019-01), p. 117955491882131-
    Abstract: In recent years, the anti-programmed cell death 1 (PD-1) drug pembrolizumab (Keytruda) was approved for treatment of unresectable advanced non-small cell lung cancer (NSCLC) as first- or second-line therapy depending on the clone 22C3-programmed death-ligand 1 (PD-L1) immunohistochemical expression score by the companion diagnostic assay. We herein evaluated 22C3-PD-L1 expression of NSCLC in a single institution experience and compared it with clinicopathologic features. Materials and methods: We assessed 22C3-PD-L1 expressions of 411 patients with NSCLC from our institution, including in past specimens. Programmed death-ligand 1 immunohistochemistry (IHC) testing was performed using the PD-L1 clone 22C3 pharmDx kit (Agilent Technologies/Dako, Carpinteria, CA, USA). Patients were separated into 3 groups with 〈 1% (no expression), 1% to 49% (low expression), or ⩾50% (high expression) positive tumor cells. Results: In all, 137 patients (33%) did not express PD-L1, 155 (38%) showed low expression, and 119 (29%) demonstrated high expression. Archival samples showed lower PD-L1 expression than that of recent samples, and the ratios of no expression case significantly increased by using paraffin blocks embedded particularly in more than 4 years ago. Programmed death-ligand 1 positivity was significantly associated with male sex, smoking, higher tumor grade, squamous cell carcinoma in histologic type, wild-type EGFR, and ALK rearrangement positive. Conclusions: The rate of 22C3-PD-L1 expression of NSCLC detected in this study was similar to the frequencies of the previous reports, although the ratio of expression case decreased when using old paraffin blocks.
    Type of Medium: Online Resource
    ISSN: 1179-5549 , 1179-5549
    URL: Article
    DOI: 10.1177/1179554918821314
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2577877-8
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