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  • 1
    Online Resource
    Online Resource
    Aberrant Driving Behavior Prediction for Urban Bus Drivers in Taiwan Using Heart Rate Variability and Various Machine Learning Approaches: A Pilot Study
    SAGE Publications ; 2023
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2677, No. 3 ( 2023-03), p. 1304-1320
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2677, No. 3 ( 2023-03), p. 1304-1320
    Abstract: Objective: Aberrant driving behavior (ADB) decreases road safety and is particularly relevant for urban bus drivers, who are required to drive daily shifts of considerable duration. Although numerous frameworks based on human physiological features have been applied to predict ADB, the research remains at an early stage. This study used heart rate variability (HRV) parameters to establish ADB occurrence prediction models with various machine learning approaches. Methods: Twelve Taiwanese urban bus drivers were recruited for four consecutive days of naturalistic driving data collection (from their routine routes) between March and April 2020; driving behaviors and physiological signals were obtained from provided devices. Weather and traffic congestion information was determined from public data, while sleep quality and professional driving experience were self-reported. To develop the ADB prediction model, several machine learning models—logistic regression, random forest, naive Bayes, support vector machine, and gated recurrent unit (GRU)—were trained and 10-fold cross-validated by using the testing data. Results: Most drivers with ADB reported deficient sleep quality (≤80%), with significantly higher mean scores on the Karolinska Sleepiness Scale and driver behavior questionnaire subcategory of lapses and errors than drivers without ADB. Next, HRV indices significantly differed between the measurement of a pre-ADB event and a baseline. The accuracy of the GRU models ranged from 78.84% ± 1.49% to 89.57% ± 1.31%. Conclusion: Drivers with ADB tend to have inadequate sleep quality, which may increase their fatigue levels and impair driving performance. The established time-series models can be considered for ADB occurrence prediction among urban bus drivers.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.1177/03611981221123802
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2403378-9
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  • 2
    Online Resource
    Online Resource
    Caloric restriction improves diabetes-induced cognitive deficits by attenuating neurogranin-associated calcium signaling in high-fat diet-fed mice
    SAGE Publications ; 2016
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 36, No. 6 ( 2016-06), p. 1098-1110
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 36, No. 6 ( 2016-06), p. 1098-1110
    Abstract: Diabetes-induced cognitive decline has been recognized in human patients of type 2 diabetes mellitus and mouse model of obesity, but the underlying mechanisms or therapeutic targets are not clearly identified. We investigated the effect of caloric restriction on diabetes-induced memory deficits and searched a molecular mechanism of caloric restriction-mediated neuroprotection. C57BL/6 mice were fed a high-fat diet for 40 weeks and RNA-seq analysis was performed in the hippocampus of high-fat diet-fed mice. To investigate caloric restriction effect on differential expression of genes, mice were fed high-fat diet for 20 weeks and continued on high-fat diet or subjected to caloric restriction (2 g/day) for 12 weeks. High-fat diet-fed mice exhibited insulin resistance, glial activation, blood–brain barrier leakage, and memory deficits, in that we identified neurogranin, a down-regulated gene in high-fat diet-fed mice using RNA-seq analysis; neurogranin regulates Ca 2+ /calmodulin-dependent synaptic function. Caloric restriction increased insulin sensitivity, reduced high-fat diet-induced blood–brain barrier leakage and glial activation, and improved memory deficit. Furthermore, caloric restriction reversed high-fat diet-induced expression of neurogranin and the activation of Ca 2+ /calmodulin-dependent protein kinase II and calpain as well as the downstream effectors. Our results suggest that neurogranin is an important factor of high-fat diet-induced memory deficits on which caloric restriction has a therapeutic effect by regulating neurogranin-associated calcium signaling.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1177/0271678X15606724
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2039456-1
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  • 3
    Online Resource
    Online Resource
    Effects of anxiety on sedation among pediatric patients undergoing esophagogastroduodenoscopy
    SAGE Publications ; 2022
    In:  Clinical Child Psychology and Psychiatry Vol. 27, No. 3 ( 2022-07), p. 793-803
    Details
    In: Clinical Child Psychology and Psychiatry, SAGE Publications, Vol. 27, No. 3 ( 2022-07), p. 793-803
    Abstract: We investigated whether the severity of anxiety among children undergoing endoscopy could affect sedation. We prospectively recruited patients under 18 years of age who were scheduled to undergo esophagogastroduodenoscopy (EGD). Baseline anxiety was evaluated using the Spence Children’s Anxiety Scale (SCAS). Our analysis considered the type and dose of sedative drugs, degree of sedation, and complications associated with sedation according to the scale score. The mean total SCAS T-scores and each subscale score were significantly higher in the 6–12-year age group. The mean T-score among patients who exhibited irritability during EGD was higher than that among other patients, with significant differences in the Total, Obsessive Disorder, Panic Agoraphobia and General Anxiety subscales. The midazolam doses of children exhibiting irritability were more likely to need higher ( p = 0.006). Other sedation-related complications were not associated with the T-scores in each subscale. Total sleep time was not associated with any T-score subscales. Anxiety levels were significantly higher among 6–12-year-olds and children exhibiting irritability. Anxiety was often associated with irritability, difficulties achieving adequate sedation during EGD, and additional sedative drug administration. We recommend higher doses or more potent drugs to facilitate endoscopy for children with high anxiety levels.
    Type of Medium: Online Resource
    ISSN: 1359-1045 , 1461-7021
    URL: Article
    DOI: 10.1177/13591045221096308
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2004602-9
    SSG: 5,2
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  • 4
    Online Resource
    Online Resource
    Predicting Fatigue-Associated Aberrant Driving Behaviors Using a Dynamic Weighted Moving Average Model With a Long Short-Term Memory Network Based on Heart Rate Variability
    SAGE Publications ; 2023
    In:  Human Factors: The Journal of the Human Factors and Ergonomics Society
    Details
    In: Human Factors: The Journal of the Human Factors and Ergonomics Society, SAGE Publications
    Abstract: This study proposed a moving average (MA) approach to dynamically process heart rate variability (HRV) and developed aberrant driving behavior (ADB) prediction models by using long short-term memory (LSTM) networks. Background Fatigue-associated ADBs have traffic safety implications. Numerous models to predict such acts based on physiological responses have been developed but are still in embryonic stages. Method This study recorded the data of 20 commercial bus drivers during their routine tasks on four consecutive days and subsequently asked them to complete questionnaires, including subjective sleep quality, driver behavior questionnaire and the Karolinska Sleepiness Scale. Driving behaviors and corresponding HRV were determined using a navigational mobile application and a wristwatch. The dynamic-weighted MA (DWMA) and exponential-weighted MA were used to process HRV in 5-min intervals. The data were independently separated for training and testing. Models were trained with 10-fold cross-validation strategy, their accuracies were evaluated, and Shapley additive explanation (SHAP) values were used to determine feature importance. Results Significant increases in the standard deviation of NN intervals (SDNN), root mean square of successive heartbeat interval differences (RMSSD), and normalized spectrum of high frequency (nHF) were observed in the pre-event stage. The DWMA-based model exhibited the highest accuracy for both driver types (urban: 84.41%; highway: 80.56%). The SDNN, RMSSD, and nHF demonstrated relatively high SHAP values. Conclusion HRV metrics can serve as indicators of mental fatigue. DWMA-based LSTM could predict the occurrence of the level of fatigue associated with ADBs. Application The established models can be used in realistic driving scenarios.
    Type of Medium: Online Resource
    ISSN: 0018-7208 , 1547-8181
    URL: Article
    DOI: 10.1177/00187208231183874
    RVK:
    CL 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2066426-6
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  • 5
    Online Resource
    Online Resource
    Antimicrobial Resistance of Streptococci Isolated from Mastitic Bovine Milk Samples in Korea
    SAGE Publications ; 2009
    In:  Journal of Veterinary Diagnostic Investigation Vol. 21, No. 5 ( 2009-09), p. 698-701
    Details
    In: Journal of Veterinary Diagnostic Investigation, SAGE Publications, Vol. 21, No. 5 ( 2009-09), p. 698-701
    Abstract: The aim of the current study was to determine the antimicrobial resistance of streptococci isolated from mastitic bovine milk samples. A total of 178 isolates belonging to 6 different Streptococcus species were examined: S. uberis (n = 99), S. bovis ( n = 30), S. oralis ( n = 24), S. salivarius ( n = 13), S. intermedius ( n = 7), and S. agalactiae ( n = 5). Only 8.9% (16/178) of the isolates were susceptible to all antimicrobial agents tested in this study, and S. agalactiae and S. intermedius isolates were all resistant to at least 1 antimicrobial agent tested. Overall, the most frequently observed resistance was to tetracycline (61.2%), followed by lincomycin (43.2%), gentamycin (35.3%), oxacillin (34.3%), and erythromycin (28.6%). Cephalothin and penicillin were the only antimicrobial agents to which most of the streptococci (92%) were susceptible. Wide differences in the prevalence of resistance are apparent among the individual species: S. salivarius displayed exceptionally high resistance to cephalothin (23.0%) and oxacillin (76.9%) and S. agalactiae (20%) and S. intermedius (14.2%) to penicillin. Streptococcus salivarius and S. agalactiae were all susceptible to erythromycin, but others showed various rates of resistance ranging from 12.5% to 42.8%. Resistance to 3 or more of 7 antimicrobial agents was observed in all species (37.6%, 67/178).
    Type of Medium: Online Resource
    ISSN: 1040-6387 , 1943-4936
    URL: Article
    DOI: 10.1177/104063870902100517
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2265211-5
    SSG: 22
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  • 6
    Online Resource
    Online Resource
    Perceived Health Status and its Correlates among Middle-Aged Laotians
    SAGE Publications ; 2021
    In:  Clinical Nursing Research Vol. 30, No. 8 ( 2021-11), p. 1202-1210
    Details
    In: Clinical Nursing Research, SAGE Publications, Vol. 30, No. 8 ( 2021-11), p. 1202-1210
    Abstract: The purpose of this study is to identify the determinants of perceived health status among Laotian aged 40 to 59. A total of 922 men or women in their 40’s or 50’s living in Vientiane Capital and Province, Lao People’s Democratic Republic were included in the study. Hierarchical multiple regression was used to analyze the data. Perceived health status was negatively correlated with chance health locus of control and physical symptom frequency and positively correlated with doctors health locus of control. Age, drinking, difficulty in health utilization, physical activity, physical symptom frequency, and doctors health locus of control explained 23.5% of the variance in perceived health. To prevent the non-communicable disease, action should be taken not only at the individual level but also at the healthcare system level. In the health care fields, the targeted intervention based on the findings of this study should be devised.
    Type of Medium: Online Resource
    ISSN: 1054-7738 , 1552-3799
    URL: Article
    DOI: 10.1177/10547738211005029
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2034682-7
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  • 7
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    Online Resource
    Research on optimization of the suction parameters of an automotive wind tunnel
    SAGE Publications ; 2015
    In:  Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering Vol. 229, No. 13 ( 2015-11), p. 1788-1800
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, SAGE Publications, Vol. 229, No. 13 ( 2015-11), p. 1788-1800
    Abstract: The suction system of an automotive wind tunnel is important in guaranteeing the precision of experimental data. Optimization methodology employing computational fluid dynamics and experimental data for the parameter design of a suction system was presented. The optimization process consists of three stages: design of experiments, response surface modelling and optimization algorithm execution. The Latin hypercube sampling method was adopted in the design of experiments to generate test sample points; the response values were obtained from experimental data measures in the wind tunnel and from computational fluid dynamics. An approximate model of the suction system was created by using the Kriging model. A non-dominated sorting genetic algorithm was used in the multi-objective optimization of the parameters of the pump system. The effects of the suction system on the wind tunnel test results of the MIRA ladder model, with and without optimization, were compared and analysed. Then, the physical mechanisms of the variation in the flow field with different suction parameters were investigated. Experimental and simulation results showed that, after parameter optimization, the flow field quality in the wind tunnel was improved and the test data were more reliable.
    Type of Medium: Online Resource
    ISSN: 0954-4070 , 2041-2991
    URL: Article
    DOI: 10.1177/0954407015571157
    RVK:
    ZO 4200
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2032754-7
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  • 8
    Online Resource
    Online Resource
    Downregulation of ABCD1 in human renal cell carcinoma
    SAGE Publications ; 2009
    In:  The International Journal of Biological Markers Vol. 24, No. 3 ( 2009), p. 171-178
    Details
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 24, No. 3 ( 2009), p. 171-178
    Type of Medium: Online Resource
    ISSN: 0393-6155
    URL: Article
    DOI: 10.5301/JBM.2009.3280
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 1475778-3
    SSG: 12
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  • 9
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    Controlling Hypertension After Severe Cerebrovascular Event (CHASE): A randomized, multicenter, controlled study
    SAGE Publications ; 2021
    In:  International Journal of Stroke Vol. 16, No. 4 ( 2021-06), p. 456-465
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 16, No. 4 ( 2021-06), p. 456-465
    Abstract: The optimal blood pressure lowering target in the acute phase of severe stroke is uncertain. Our aim was to compare the efficacy and safety of individualized blood pressure lowering with standard blood pressure lowering in severe stroke. Methods Five-hundred consecutive patients with acute severe stroke and elevated BP were recruited from 26 Chinese hospitals. Eligible patients were randomized into an individualized blood pressure lowering group (with 10–15% reduction in systolic blood pressure from admission level or standard blood pressure lowering group (with a target SBP of 〈 200 mm Hg in acute ischemic stroke and 〈 180 mm Hg in intracerebral hemorrhage). The primary outcome was the proportion of patients with a poor functional outcome at day 90 of enrolment. Results Of 483 participants included in the analysis, 242 received individualized blood pressure lowering treatment and 241 received standard treatment. The primary outcome event was observed in 71.1% of the participants in the individualized treatment group and in 73.4% of the standard treatment group (odds ratio with individualized treatment for primary outcome, 0.75; 95% confidence interval, 0.47 to 1.19; p = 0.222). The rates of serious adverse events in the two groups were similar (27.7% vs. 28.2%). Conclusions In patients with acute severe stoke, individualized blood pressure lowering treatment did not significantly reduce the rate of three-month death or dependence. Trial registration Clinicaltrials.gov, NCT02982655. Registered in 5 December 2016, https://clinicaltrials.gov/ct2/show/NCT02982655
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493020932784
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2211666-7
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  • 10
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    Improving the effectiveness of a paediatric handbook for new house officers
    SAGE Publications ; 2022
    In:  Proceedings of Singapore Healthcare Vol. 31 ( 2022-06), p. 201010582110084-
    Details
    In: Proceedings of Singapore Healthcare, SAGE Publications, Vol. 31 ( 2022-06), p. 201010582110084-
    Abstract: To help house officers adjust quickly to their new responsibilities, a departmental handbook is provided. As this had not been updated recently and was underutilised, a quality improvement project was undertaken to improve this resource. Methods: The handbook was updated and new material added based on feedback from house officers and senior medical staff. Subsequently, house officers were surveyed on their utilization rate of the new handbook and its usefulness in various clinical scenarios. An open-book clinical quiz was administered to gauge their clinical competency. Results: There was a 26.8% increase in the proportion of house officers who used the handbook more than once every 2–3 days compared to pre-intervention. There was a significant improvement in quiz scores from 26.7/40 to 31.1/40 between the pre-intervention ( n=19) and post-intervention ( n=37) groups ( p 〈 0.001), as well as perceived usefulness of the handbook in various clinical scenarios as measured on a 10-point Likert scale. Conclusions: We find that improvement in the quality of a handbook for paediatric house officers is associated with increase in its utilization and benefits to their clinical competency and confidence level, especially on call. To increase the utilization rate of the handbook, both the user interface and content need to be improved.
    Type of Medium: Online Resource
    ISSN: 2010-1058 , 2059-2329
    URL: Article
    DOI: 10.1177/20101058211008476
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2831421-9
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