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  • 1
    Online Resource
    Online Resource
    Tryptophan immunoadsorption during pregnancy and breastfeeding in patients with acute relapse of multiple sclerosis and neuromyelitis optica
    SAGE Publications ; 2018
    In:  Therapeutic Advances in Neurological Disorders Vol. 11 ( 2018-01), p. 175628641877497-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 11 ( 2018-01), p. 175628641877497-
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/1756286418774973
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2442245-9
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  • 2
    Online Resource
    Online Resource
    Uveitis manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study
    SAGE Publications ; 2019
    In:  Therapeutic Advances in Gastroenterology Vol. 12 ( 2019-01), p. 175628481986514-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 12 ( 2019-01), p. 175628481986514-
    Abstract: The knowledge about risk factors for the onset of uveitis manifestations in patients with inflammatory bowel disease (IBD) is still limited. Here, we aimed to provide an overview of the clinical factors associated with the onset of uveitis in the Swiss IBD Cohort Study (SIBDCS). Methods: We included epidemiological and clinical data from 1840 patients with Crohn’s disease (CD) and 1426 patients with ulcerative colitis (UC) followed up in the SIBDCS between 2006 and 2018. Associations between disease characteristics and uveitis were assessed in univariate and multivariate analyses. Results: Overall, we identified 285 patients with uveitis. Uveitis was more frequent in patients with CD (11.1%; 205 of 1635) than UC (5.6%; 80 of 1346; odds ratio 2.11, p  〈  0.001). The occurrence of uveitis manifestations in patients with UC and CD was significantly associated with the onset of other extraintestinal manifestations, also in multivariate analyses. The onset of uveitis was associated with the hallmark features of severe disease in both CD and UC, including a higher clinical disease activity index and the use of immunomodulators or calcineurin inhibitors. In CD, uveitis was more frequent in females and showed a positive correlation with a positive family history of IBD. Conclusions: Our data demonstrate that uveitis in IBD occurs more often in CD as well as in women and is associated with a more severe disease course. This might guide physicians’ awareness in at-risk patients to the presence of uveitis extraintestinal manifestations and help to improve patient care.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/1756284819865142
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440710-0
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  • 3
    Online Resource
    Online Resource
    Effects of anti-TNF therapy and immunomodulators on anxiety and depressive symptoms in patients with inflammatory bowel disease: a 5-year analysis
    SAGE Publications ; 2021
    In:  Therapeutic Advances in Gastroenterology Vol. 14 ( 2021-01), p. 175628482110337-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 14 ( 2021-01), p. 175628482110337-
    Abstract: Anxiety and depression are prevalent in patients with inflammatory bowel diseases (IBD), especially during IBD flares. IBD therapies can profoundly affect the mood of patients with IBD. We aimed to determine the long-term impact of anti-tumor necrosis factor (anti-TNF) and immunomodulators (IM) on anxiety and depressive symptoms in IBD patients. Methods: We compared three treatment groups with IM only (group A), anti-TNF ± IM (group B) and no such therapy (group C). Patients completed the hospital anxiety and depression scale (HADS) at 1 year, 3 years, and 5 years after start of treatment. Results: In total, 581 patients with IBD (42.9% Crohn’s disease, 57.1% ulcerative colitis/IBD unclassified) participated in this study. Effects of treatment were analyzed in a mixed effects model, with and without correction for confounders. Compared with group C, group B showed a significant treatment-related improvement in both anxiety and depressive symptoms within the first 2.5 years and also thereafter. Group A showed a significant long-term improvement of anxiety and both short-term and long-term improvement in depressive symptoms. The significance of these results was maintained after correction for confounders, including corticosteroid treatment. Additionally, both groups A and B showed a significant decrease in disease activity in the first 2.5 years after start of treatment and also thereafter. Anti-TNF and IM treatment were associated with a similarly significant decrease in anxiety and depressive symptoms over an observation period of up to 5 years. Conclusion: Besides a clear benefit for disease activity, anti-TNF and IM apparently improve the mood of patients with IBD.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/17562848211033763
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2440710-0
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  • 4
    Online Resource
    Online Resource
    Industrial relations in European hypermarkets: Home and host country influences
    SAGE Publications ; 2014
    In:  European Journal of Industrial Relations Vol. 20, No. 3 ( 2014-09), p. 255-271
    Details
    In: European Journal of Industrial Relations, SAGE Publications, Vol. 20, No. 3 ( 2014-09), p. 255-271
    Abstract: In this article we examine the industrial relations practices of three large European food retailers when they transfer the hypermarket format to other countries. We ask, first, how industrial relations in hypermarkets differ from those in other food retailing outlets. Second, we examine how far the approach characteristic of each company’s country-of-origin (Germany, France and the UK) shapes the practices adopted elsewhere. Third, we ask how they respond to the specific industrial relations systems of each host country (Turkey, Poland, Ireland and Spain).
    Type of Medium: Online Resource
    ISSN: 0959-6801 , 1461-7129
    URL: Article
    DOI: 10.1177/0959680113519186
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 1475244-X
    SSG: 3,4
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  • 5
    Online Resource
    Online Resource
    CT pulmonary angiography: dose reduction via a next generation iterative reconstruction algorithm
    SAGE Publications ; 2019
    In:  Acta Radiologica Vol. 60, No. 4 ( 2019-04), p. 478-487
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 60, No. 4 ( 2019-04), p. 478-487
    Abstract: Computed tomography pulmonary angiography (CTPA) is the standard imaging modality for detection or rule out of pulmonary embolism (PE); however, radiation exposure is a serious concern. With iterative reconstruction algorithms a distinct dose reduction could be achievable. Purpose To evaluate a next generation iterative reconstruction algorithm for detection or rule-out of PE in simulated low-dose CTPA. Material and Methods Low-dose CT datasets with 50%, 25%, and 12.5% of the original tube current were simulated based on CTPA examinations of 92 patients with suspected PE. All datasets were reconstructed with two reconstruction algorithms: standard filtered back-projection (FBP) and iterative model reconstruction (IMR). In total, 736 CTPA datasets were evaluated by three blinded radiologists regarding image quality, diagnostic confidence, and detectability of PE. Furthermore, contrast-to-noise ratio (CNR) was calculated. Results Images reconstructed with IMR showed better detectability of PE than images reconstructed with FBP, especially at lower dose levels. With IMR, sensitivity was over 95% for central and segmental PE down to a dose level of 25%. Significantly higher subjective image quality was shown at lower dose levels (25% and 12.5%) for IMR images whereas it was higher for FBP images at higher dose levels. FBP was rated as showing less artificial image appearance. CNR was significantly higher with IMR at all dose levels. Conclusion By using IMR, a dose reduction of up to 50% while maintaining satisfactory image quality seems feasible in standard clinical situations, resulting in a mean effective dose of 1.38 mSv for CTPA.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185118784976
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024579-8
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  • 6
    Online Resource
    Online Resource
    Nordic children with myelomeningocele : The utilization of and satisfaction with health care and medical services
    SAGE Publications ; 1995
    In:  Scandinavian Journal of Social Medicine Vol. 23, No. 4 ( 1995-12), p. 258-264
    Details
    In: Scandinavian Journal of Social Medicine, SAGE Publications, Vol. 23, No. 4 ( 1995-12), p. 258-264
    Abstract: A study was conducted on utilization of and satisfaction with the health care and medical services among 527 Scandinavian children (aged 4-18) with myelomeningocele (MMC). Data were collected from two sources: a questionnaire distributed to parents in 1984, and patients' medical records. Comparisons were made with a control group comprised of 7,792 children. Over a period of one year, 52% of the MMC group and 6% of the controls were hospitalized. Over 3 months, children with MMC had more contact with specialist care services than had the controls, while contact with primary health care was the same for both groups. Continuity of care and satisfaction with time spent with the physician were both greater among children with MMC than in the control group. Dissatisfaction with medical services was expressed by approximately 10% of the parents of both categories. Such dissatisfaction was found significantly more frequently among Danish parents and well educated mothers. Dissatisfaction with care was not related to either the child's age or the severity of its disability. Danish children with MMC received treatment relatively more frequently from primary care physicians than from specialists. In Sweden, where satisfaction was the greatest, families with children with MMC were supported by local habilitation teams.
    Type of Medium: Online Resource
    ISSN: 0300-8037
    URL: Article
    DOI: 10.1177/140349489502300407
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1995
    detail.hit.zdb_id: 2027122-0
    detail.hit.zdb_id: 2253902-5
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  • 7
    Online Resource
    Online Resource
    Conditional effects of development aid on political perceptions: mixed-methods evidence from North-East Afghanistan
    SAGE Publications ; 2020
    In:  European Journal of International Relations Vol. 26, No. 3 ( 2020-09), p. 793-819
    Details
    In: European Journal of International Relations, SAGE Publications, Vol. 26, No. 3 ( 2020-09), p. 793-819
    Abstract: Can aid create political trust in conflict-affected states? International aid organizations often argue that supporting states in providing basic services can contribute to strengthening state–society relations. Previous studies in international development have indicated that the provision of basic services can indeed improve people’s attitudes towards state institutions. We take this research a step further: in addition to analysing the impact of aid on political trust, we assess how violence influences this effect. We argue that aid can create opportunities for constructive state–society interactions. As violence increases, however, development-related interactions are crowded out by security-related ones. Violence also fosters corrupt aid governance, which undermines the positive effects of aid on public perceptions. We analyse this hypothesis with a mixed-methods research design that combines original opinion survey data with qualitative interview material systematically collected in 252 villages of northeast Afghanistan. Based on a combination of (a) quantitative analyses, (b) a comparison of most-similar villages, (c) a systematic comparison of qualitative survey response patterns across levels of insecurity, and (d) an in-depth analysis of interview material on aid and trust in highly insecure areas, we show that violence negatively impacts the relative relevance as well as the quality of aid-related state–society interactions. These findings indicate that international aid agencies should refocus from mainly output-oriented project appraisal, design, and monitoring to a stronger process orientation that maximizes state–society interaction and prevents elite capture in areas exposed to high levels of violence.
    Type of Medium: Online Resource
    ISSN: 1354-0661 , 1460-3713
    URL: Article
    DOI: 10.1177/1354066119883686
    RVK:
    MA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 1482719-0
    detail.hit.zdb_id: 1235052-7
    SSG: 8
    SSG: 3,6
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