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  • SAGE Publications  (128)
  • 1
    Online Resource
    Online Resource
    Circulating tumor cells dynamics during chemotherapy predict survival and response in advanced non-small-cell lung cancer patients
    SAGE Publications ; 2023
    In:  Therapeutic Advances in Medical Oncology Vol. 15 ( 2023-01), p. 175883592311678-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 15 ( 2023-01), p. 175883592311678-
    Abstract: Circulating tumor cells (CTCs) are prognostic biomarker in non-small-cell lung cancer (NSCLC). CTCs could also be used as predictor of efficacy of systemic treatments in advanced NSCLC. Objectives: We described the dynamic changes of CTCs during first-line platinum-based chemotherapy in advanced NSCLC and clarified the correlation between CTC counts and efficacy of chemotherapy. Design: Chemotherapy is administered and blood specimens are collected at four time points from baseline to disease progression for CTC detection. Methods: This multicenter prospective study enrolled patients with previously untreated stage III or IV NSCLC fit for standard platinum-based chemotherapy. Bloods were sampled as per standard operating procedures at baseline, cycle 1 and cycle 4 of chemotherapy, and at disease progression for CTC analysis using the CellSearch system. Results: Among 150 patients enrolled, median overall survival (OS) was 13.8, 8.4, and 7.9 months in patients with CTC − , KIT − CTC, and KIT + CTC at baseline ( p = 0.002). Patients with persistent negative CTC (46.0%) had longer progression-free survival [5.7 months, 95% confidence interval (CI): 5.0–6.5 versus 3.0 months, 0.6–5.4; hazard ratio (HR): 0.34, 95% CI: 0.18–0.67) and OS (13.1 months, 10.9–15.3 versus 5.6 months, 4.1–7.1; HR: 0.17, 0.08–0.36) compared with patients with persistent positive CTC (10.7%), which was not impacted by chemotherapy. Chemotherapy decreased CTC from 36.0% (54/150) to 13.7% (13/95). Conclusions: CTC persistent presence during treatment represents poor prognosis and resistance to chemotherapy in advanced NSCLC. Chemotherapy could effectively eliminate CTCs. Molecular characterization and the functionalization of CTC will be warranted for further intensive investigation. Trial registration: NCT01740804.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359231167818
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2503443-1
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  • 2
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    Application of thromboelastography in comparing coagulation difference of rivaroxaban and enoxaparin for thromboprophylaxis after total hip arthroplasty
    SAGE Publications ; 2021
    In:  Journal of Orthopaedic Surgery Vol. 29, No. 3 ( 2021-09), p. 230949902110426-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 29, No. 3 ( 2021-09), p. 230949902110426-
    Abstract: Purpose: The purpose of this study was to compare the coagulation difference in patients with either rivaroxaban or enoxaparin as thromboprophylaxis after total hip arthroplasty (THA) regarding thromboelastography (TEG) and routine coagulation tests. Patients and methods: Two hundred and twenty-eight patients undergoing primary THA were recruited in this study. They were divided into two groups according to a computer-generated random sequence. Patients in the rivaroxaban group received 10 mg of rivaroxaban orally once daily. Patients in the enoxaparin group received 4000 AxaIU (0.4 mL) of enoxaparin subcutaneously once daily. Rivaroxaban and enoxaparin were started 6–8 h after surgery. The administration of the anticoagulant prophylaxis was lasted for a minimum of 14 days. TEG and routine coagulation tests were performed on the day before the operation and 1 day and 7 days after the operation. Results: No difference was observed in the incidence of deep vein thrombosis (DVT) or pulmonary embolism (PE) between the two groups. There was no significant difference with regard to prothrombin time (PT), activated partial thromboplastin time (PTT), international normalized ratio (INR), and thrombin time (TT) between the two groups. However, while considering TEG, R time of the rivaroxaban group was significantly higher than that of the enoxaparin group ( p = 0.003), whereas the maximum amplitude (MA) ( p = 0.036) value and coagulation index (CI) ( p = 0.002) value were significantly lower than those of the enoxaparin group. Conclusion: With regard to TEG analysis, there was coagulation difference in patients with rivaroxaban and those with enoxaparin as thromboprophylaxis after THA. Under recommended dose of rivaroxaban and enoxaparin, patients undergoing THA were in hypercoagulability on 7days postoperative.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/23094990211042674
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2128854-9
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  • 3
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    Comparison of Accuracy and Clinical Outcomes of Robot-Assisted Versus Fluoroscopy-Guided Pedicle Screw Placement in Posterior Cervical Surgery
    SAGE Publications ; 2022
    In:  Global Spine Journal Vol. 12, No. 4 ( 2022-05), p. 620-626
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 12, No. 4 ( 2022-05), p. 620-626
    Abstract: This was a prospective controlled study. Objective: To compare the accuracy and clinical outcomes of robot-assisted (RA) and fluoroscopy-guided (FG) pedicle screw placement in posterior cervical surgery. Methods: This study included 58 patients. The primary outcome measures were the 1-time success rate and the accuracy of pedicle screw placement according to the Gertzbein-Robbins scales. The secondary outcome measures, including the operative time, intraoperative blood loss, hospital stay, cumulative radiation time, radiation dose, intraoperative advent events, and postoperative complications, were recorded and analyzed. The Japanese Orthopedics Association (JOA) scores and Neck Disability Index (NDI) were used to assess the neurological function of patients before and at 3 and 6 months after surgery. Results: The rate of grade A was significantly higher in the RA group than in the FG group (90.6% and 71.1%; P 〈  .001). The clinically acceptable accuracy was 97.2% in the RA group and 90.7% in the FG group ( P = .009). Moreover, the 1-time success rate was significantly higher in the RA group than in the FG group. The RA group had less radiation time ( P 〈  .001) and less radiation dose ( P = .002) but longer operative time ( P = .001). There were no significant differences in terms of intraoperative blood loss, hospital stay, intraoperative adverse events, postoperative complications, JOA scores, and NDI scores at each follow-up time point between the 2 groups. Conclusions: The RA technique achieved higher accuracy and 1-time success rate of pedicle screw placement in posterior cervical surgery while achieving comparable clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/2192568220960406
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2648287-3
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  • 4
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    Apoptosis and injuries of heavy ion beam and x-ray radiation on malignant melanoma cell
    SAGE Publications ; 2017
    In:  Experimental Biology and Medicine Vol. 242, No. 9 ( 2017-05), p. 953-960
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 242, No. 9 ( 2017-05), p. 953-960
    Abstract: This study aims to investigate the influence of high linear energy transfer (LET) heavy ion ( 12 C 6+ ) and low LET X-ray radiation on apoptosis and related proteins of malignant melanoma on tumor-bearing mice under the same physical dosage. C57BL/6 J mice were burdened by tumors and randomized into three groups. These mice received heavy ion ( 12 C 6+ ) and X-ray radiation under the same physical dosage, respectively; their weight and tumor volumes were measured every three days post-radiation. After 30 days, these mice were sacrificed. Then, median survival time was calculated and tumors on mice were proliferated. In addition, immunohistochemistry was carried out for apoptosis-related proteins to reflect the expression level. After tumor-bearing mice were radiated to heavy ion, median survival time improved and tumor volume significantly decreased in conjunction with the upregulated expression of pro-apoptosis factors, Bax and cytochrome C, and the downregulated expression of apoptosis-profilin (Bcl-2, Survivin) and proliferation-related proteins (proliferating cell nuclear antigen). The results indicated that radiation can promote the apoptosis of malignant melanoma cells and inhibit their proliferation. This case was more suitable for heavy ion ( 12 C 6+ ). High LET heavy ion ( 12 C 6+ ) radiation could significantly improve the killing ability for malignant melanoma cells by inducing apoptosis in tumor cells and inhibiting their proliferation. These results demonstrated that heavy ion ( 12 C 6+ ) presented special advantages in terms of treating malignant melanoma. Impact statement Malignant melanoma is a malignant skin tumor derived from melanin cells, which has a high malignant degree and high fatality rate. In this study, proliferating cell nuclear antigen (PCNA) can induce the apoptosis of malignant melanoma cells and inhibit its proliferation, and its induction effect on apoptosis is significantly higher than low LET X-ray; hence, it is expected to overcome its lower sensitivity to radiation. This study can provide theoretical basis for clinical trials, in which malignant melanoma is treated by heavy ion ( 12 C 6+ ), in order to accurately determine the clinical efficacy of heavy ion therapy. Clinical applications has revealed that local tumor control rate is high when heavy ion is used to treat malignant melanoma, indicating that heavy ion is an important direction in treating melanoma in the future.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370216689827
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2020856-X
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  • 5
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    Development of poly( N -isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment
    SAGE Publications ; 2014
    In:  Journal of Biomaterials Applications Vol. 28, No. 9 ( 2014-05), p. 1376-1385
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 28, No. 9 ( 2014-05), p. 1376-1385
    Abstract: In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the hydrogel-grafted fabrics to achieve sustained drug release. The prepared hydrogel-grafted fabrics embedding of berberine nanosuspension was characterized by FT-IR spectroscopy, scanning electron microscopy, and swelling degree studies. Fourier transform infrared spectroscopy revealed that berberine was embedded into the matrix of hydrogel-grafted fabrics, rather than on the surface. Scanning electron microscopy showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that hydrogel-grafted fabric had water absorbing characteristic with reversible temperature sensitivity. The drug release study demonstrated that hydrogel-grafted fabrics can be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded hydrogel-grafted fabric was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328213509503
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2072559-0
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  • 6
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    Gender Differences do not Influence the Blood Coagulopathy in Patients Undergoing Total Knee Arthroplasty: A Retrospective Thromboelastography Analysis
    SAGE Publications ; 2021
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 27 ( 2021-01), p. 107602962110557-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 27 ( 2021-01), p. 107602962110557-
    Abstract: Deep vein thrombosis (DVT) is one of the severe complications after total knee arthroplasty (TKA). Gender has been considered to influence the incidence of the thrombosis formation in TKA patients. However, it remains controversial which gender would be more prone to form thrombosis. The aim of this study was to assess the effects of gender differences on coagulation status after TKA via the thromboelastography (TEG). Methods A total of 57 male patients who underwent primary TKA from September 2015 to January 2021 were included in this study. According to the matching principle of age, body mass index (BMI), and anticoagulation treatment, 60 female patients were selected. The conventional coagulation tests, routine blood tests, and thromboelastography were conducted before the operation, 1 day and 7 days after the operation. In addition, Doppler ultrasound was also performed 1 day before the operation and at the 7 days after the operation. The parameters of conventional coagulation tests, routine blood tests, and thromboelastography were compared between the two groups. Results There were no significant differences in the blood transfusion rate, the incidence of DVT during the perioperative period, D-dimer (D-D), fibrin degradation products (FDP), hemoglobin (HB), hematocrit (HCT), prothrombin time (PT), activated partial thromboplastin time (APTT), and C-reactive protein (CRP) at any corresponding time point between the male group and the female group ( P  〉  .05). There were no significant differences in neutrophil-to-lymphocyte ratio (NLR) preoperatively; however, there were significant differences in NLR 1 day after the surgery and 7 days after the surgery between the two groups ( P  〈  .05). There were significant differences in reaction time (R) and α angle 1 day after the surgery between the two groups ( P  〈  .05), but there were no significant differences in other TEG indexes at any corresponding time point between the two groups ( P  〉  .05). Binary logistic regression analysis demonstrated that gender, age, BMI, tourniquet application time were not independent predictors ( P  〉  .05). Conclusion Gender differences have no significant influence in TKA patients with regard to conventional coagulation tests and thromboelastography.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/10760296211055716
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2230591-9
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  • 7
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    The projection of the thoracic nerve roots and their connection with intervertebral discs: a cadaver and radiological study
    SAGE Publications ; 2020
    In:  Acta Radiologica Vol. 61, No. 8 ( 2020-08), p. 1050-1056
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 61, No. 8 ( 2020-08), p. 1050-1056
    Abstract: The anatomical features of the thoracic nerve roots in connection with intervertebral discs may prevent surgery-related complications and improve patients’ neurological functional status during thoracic spine surgery. There is limited literature evidence regarding this concept using cadavers. Purpose To elucidate the qualitative anatomical features of the thoracic nerve roots in connection with intervertebral discs. Material and Methods Fifteen formalin-preserved spine specimens were used in this study. Small pieces of stainless-steel wires were placed along the root sleeves from their points of origin, after exposing the dural sac and bilateral nerve roots. The standard anteroposterior and lateral radiographs were taken after the placement of the wires. Measurements were done on radiographs using the picture archiving communication system. Results Take-off angles of the nerve roots at the coronal plane gradually increased from the level of T2 (36.1°±2.72°) to T9 (84.1°±1.84°) and from T9, it decreased to T12 (46.3° ± 2.67°). Similar variation tendency was discovered in take-off angles of the nerve roots at the sagittal plane. No consistent tendency was found both in the distance from the origin of the root sleeve to its superior and inferior vertebral endplate. Distance from the origin of the root sleeve to the posterior midline (DM) exponentially decreased from T1 (8.2 ± 0.87 mm) to T4 (6.0 ± 0.93 mm). It slowly increased from T5 (5.5 ± 0.68 mm) to T12 (10.9 ± 1.79 mm), with T5 having the smallest DM. Distance between the origins of neighboring nerve roots showed an obvious increase from the T1–T2 interval (23.1 ± 2.22 mm) to T7–T8 interval (30.9 ± 2.68 mm). However, it progressively decreased at the T10–T11 interval (26.0 ± 2.40 mm). Conclusion The dimensions of the thoracic nerve roots vary greatly from T1 to T12 intervertebral discs. Sound knowledge of these anatomical features of the thoracic nerve is mandatory for the thoracic spine surgery, especially in the posterolateral approach and transforaminal endoscopic surgery.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185119890089
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2024579-8
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  • 8
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    Microstructure and finite element analysis of 3D five-directional braided composites
    SAGE Publications ; 2012
    In:  Journal of Reinforced Plastics and Composites Vol. 31, No. 2 ( 2012-01), p. 107-115
    Details
    In: Journal of Reinforced Plastics and Composites, SAGE Publications, Vol. 31, No. 2 ( 2012-01), p. 107-115
    Abstract: Microstructure of 3D five-directional braided composites determines its mechanical properties. Microscopic evidence of the microstructure reveals that the cross-sections of the axial yarn are variable along its central axial due to the lateral compression from the adjacent braiding yarns. On the basis of microscopic observations, a dense but non-intersecting geometry internal unit cell model of 3D five-directional braided composites is established. By using the unti-cell model, a 3D mesomechanical FEA is proposed to predict the effective elastic properties of 3D five-directional braided composites. Compared with existing model, present model is more effective to calculate the mechanical properties of 3D five-directional braided composites with more than 50% fiber volume fraction.
    Type of Medium: Online Resource
    ISSN: 0731-6844 , 1530-7964
    URL: Article
    DOI: 10.1177/0731684411429535
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2051886-9
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  • 9
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    A novel integrated modeling approach for filter diagnosis in gas turbine air intake system
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy Vol. 236, No. 3 ( 2022-05), p. 435-449
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy, SAGE Publications, Vol. 236, No. 3 ( 2022-05), p. 435-449
    Abstract: Due to the complex and harsh environmental factors, the useful life of the filter in the gas turbine air intake system is usually less than its design life. When the filter is seriously degraded, the power and thermal efficiency of the gas turbine will decrease obviously due to the increase of inlet pressure loss. For evaluating the health condition of filters in the air intake system, this work forms a filter pressure loss model with the defined health index for the filter and five external environmental and control factors. By integrating the gas path component model, the combined model is applied in a real data set and the results show that (i) the proposed health index is efficient in representing the degradation state of the filter, (ii) the influencing factors on the pressure loss are successfully decoupled and their contributions on the pressure are quantitatively estimated, and (iii) the integrated model of filter pressure loss and gas path component can be used to better estimate the deterioration states of the filter as well as the gas turbine performance.
    Type of Medium: Online Resource
    ISSN: 0957-6509 , 2041-2967
    URL: Article
    DOI: 10.1177/09576509211044392
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2024892-1
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  • 10
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    Experimental investigation of effects of suction side squealer tip on the aeroelastic stability of a linear oscillating compressor cascade
    SAGE Publications ; 2017
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 231, No. 11 ( 2017-09), p. 2120-2131
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 231, No. 11 ( 2017-09), p. 2120-2131
    Abstract: This paper investigates the unsteady tip flow characteristics and their effects on the aeroelastic stability of a linear oscillating compressor cascade experimentally. Two test cases with different tip clearance configurations were tested, including a suction side squealer configuration and a control test. The unsteady pressure on the blade surface was measured at three blade vibration frequencies, and then was utilized to establish the aero-damping of the cascade. The results show that the impact of suction side squealer tip clearance on the tip clearance flow mainly exists at the region where it rolls up, and the unsteady flow induced by the vibration blade has no effect on the time-averaged result. In tip area of the blade, the leakage vortex plays a dominant role in determining the distribution of the first harmonic of unsteady static pressure. Compared with the baseline test case, the suction side squealer tip geometry exhibits better aerodynamic stability at high oscillating frequency. The aerodynamic response (phase angle) of the leakage flow lags behind the vibration of blade, and its streamwise variation implies strongly associated with the development of the tip leakage vortex. The spanwise three-dimensional unsteady characteristic of suction side squealer tip geometry is more obvious than that of the baseline test case.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/0954410016662057
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2032759-6
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