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  • 1
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 12 ( 2019-01), p. 175628481984703-
    Abstract: Inflammatory bowel disease (IBD) is associated with a considerable burden to the patient and society. However, current data on IBD incidence and burden are limited because of the paucity of nationwide epidemiological studies, heterogeneous designs, and a low number of participating centers and sample size. The EpidemIBD study is a large-scale investigation to provide an accurate assessment of the incidence of IBD in Spain, as well as treatment patterns and outcomes. Methods: This multicenter, population-based incidence cohort study included patients aged 〉 18 years with IBD (Crohn’s disease, ulcerative colitis, or unclassified IBD) diagnosed during 2017 in 108 hospitals in Spain, covering 50% of the Spanish population. Each participating patient will attend 10 clinic visits during 5 years of follow up. Demographic data, IBD characteristics and family history, complications, treatments, surgeries, and hospital admissions will be recorded. Results: The EpidemIBD study is the first large-scale nationwide study to investigate the incidence of IBD in Spain. Enrollment is now completed and 3627 patients are currently being followed up. Conclusions: The study has been designed to overcome many of the limitations of previous European studies into IBD incidence by prospectively recruiting a large number of patients from all regions of Spain. In addition to epidemiological information about the burden of IBD, the 5-year follow-up period will also provide information on treatment patterns, and the natural history and financial burden of IBD.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440710-0
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  • 2
    In: Nursing Ethics, SAGE Publications, Vol. 25, No. 3 ( 2018-05), p. 346-358
    Abstract: The acquisition of experience is a major concern for nurses in intensive care units. Although the emotional component of the clinical practice of these nurses has been widely studied, greater examination is required to determine how this component influences their learning and practical experience. Objective: To discover the relationships between emotion, memory and learning and the impacts on nursing clinical practice. Research design: This is a qualitative phenomenological study. The data were collected from open, in-depth interviews. A total of 22 intensive care unit nurses participated in this research between January 2012 and December 2014. Ethical considerations: The School of Nursing Ethics Committee approved the study, which complied with ethical principles and required informed consent. Findings: We found a clear relationship between emotion, memory and the acquisition of experience. This relationship grouped three dimensions: (1) satisfaction, to relieve the patient’s pain or discomfort, give confidence and a sense of security to the patient, enable the presence of family members into the intensive care unit and provide family members with a realistic view of the patient’s situation; (2) error experience, which nurses feel when a patient dies, when they fail to accompany a patient in his or her decision to abandon the struggle to live or when they fail to lend support to the patient’s family; and (3) the feel bad–feel good paradox, which occurs when a mistake in the patient’s care or handling of his or her family is repaired. Conclusion: Emotion is a capacity that impacts on nurses’ experience and influences improvements in clinical practice. Recalling stories of satisfaction helps to reinforce good practice, while recalling stories of errors helps to identify difficulties in the profession and recognise new forms of action. The articulation of emotional competencies may support the development of nursing ethics in the intensive care unit to protect and defend their patients and improve their relationships with families in order to maximise the potential for patient care.
    Type of Medium: Online Resource
    ISSN: 0969-7330 , 1477-0989
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2031461-9
    SSG: 0
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  • 3
    In: Vascular Surgery, SAGE Publications, Vol. 27, No. 7 ( 1993-09), p. 543-548
    Abstract: A sixty-seven-year-old woman suffering from combined mitral and aortic rheumatic valve disease was shown by coronary angiography to have two congenital coronary artery fistulas, one originating from the proximal left anterior descending artery, the other from the right coronary artery, and both draining into the pulmonary trunk. Surgical correction of the fistulas and implantation of two mechanical prosthetic valves were successfully performed. As far as the authors know, this is the first reported case of a surgical correction of double congenital coronary artery fistulas and rheumatic mitral and aortic valve disease.
    Type of Medium: Online Resource
    ISSN: 0042-2835
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1993
    detail.hit.zdb_id: 2095223-5
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  • 4
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 12 ( 2019-01), p. 175628481986784-
    Abstract: The effect of low-frequency functional variation on anti-tumor necrosis factor alpha (TNF) response in Crohn’s disease (CD) patients remains unexplored. The objective of this study was to investigate the impact of functional rare variants in clinical response to anti-TNF therapy in CD. Methods: CD anti-TNF naïve patients starting anti-TNF treatment due to active disease [Crohn’s Disease Activity Index (CDAI 〉 150)] were included. The whole genome was sequenced using the Illumina Hiseq4000 platform. Clinical response was defined as a CDAI score 〈 150 at week 14 of anti-TNF treatment. Low-frequency variants were annotated and classified according to their damaging potential. The whole genome of CD patients was screened to identify homozygous loss-of-function (LoF) variants. The TNF signaling pathway was tested for overabundance of damaging variants using the SKAT-O method. Functional implication of the associated rare variation was evaluated using cell-type epigenetic enrichment analyses. Results: A total of 41 consecutive CD patients were included; 3250 functional rare variants were identified (2682 damaging and 568 LoF variants). Two homozygous LoF mutations were found in HLA-B and HLA-DRB1 genes associated with lack of response and remission, respectively. Genome-wide LoF variants were enriched in epigenetic marks specific for the gastrointestinal tissue (colon, p = 4.11e–4; duodenum, p = 0.011). The burden of damaging variation in the TNF signaling pathway was associated with response to anti-TNF therapy ( p = 0.016); damaging variants were enriched in epigenetic marks from CD8 + ( p = 6.01e–4) and CD4+ ( p = 0.032) T cells. Conclusions: Functional rare variants are involved in the response to anti-TNF therapy in CD. Cell-type enrichment analysis suggests that the gut mucosa and CD8 + T cells are the main mediators of this response.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440710-0
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  • 5
    In: Therapeutic Advances in Psychopharmacology, SAGE Publications, Vol. 7, No. 4 ( 2017-04), p. 137-140
    Abstract: The rapidly-acting antidepressant properties of ketamine are a trend topic in psychiatry. Despite its robust effects, these are ephemeral and can lead to certain adverse events. For this reason, there is still a general concern around the off-label use of ketamine in clinical practice settings. Nonetheless, for refractory depression, it should be an indication to consider. We report the case of a female patient admitted for several months due to a treatment-resistant depressive bipolar episode with chronic suicidal behaviour. After repeated intravenous ketamine infusions without remarkable side effects, the patient experienced a complete clinical recovery during the 4 weeks following hospital discharge. Unfortunately, depressive symptoms reappeared in the 5th week, and the patient was finally readmitted to hospital as a result of a suicide attempt.
    Type of Medium: Online Resource
    ISSN: 2045-1253 , 2045-1261
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2646542-5
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  • 6
    In: Clinical medicine. Cardiology, SAGE Publications, Vol. 2 ( 2008-01), p. CMC.S654-
    Type of Medium: Online Resource
    ISSN: 1178-1165
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2575256-X
    detail.hit.zdb_id: 2423816-8
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2006
    In:  Journal of Transcultural Nursing Vol. 17, No. 2 ( 2006-04), p. 164-170
    In: Journal of Transcultural Nursing, SAGE Publications, Vol. 17, No. 2 ( 2006-04), p. 164-170
    Abstract: A collaborative study between faculty from the United States and Spain was undertaken to investigate levels of cultural self-efficacy among a sample of Spanish nursing students and nurses. Bandura’s self-efficacy theory provided the conceptual framework for this descriptive study. The Spanish version of the Cultural Self-Efficacy Scale (CSES-S) was translated from the original developed by Bernal and Froman using the back-translation technique recommended by Brislin. The CSES-S was administered to 113 Spanish nurses and students. Alpha coefficient results for the CSES-S ranged from .90 to .95. Low to neutral levels of confidence in caring for four ethnic groups were found. Regression analyses showed significant relationships between cultural exposure and cultural self-efficacy for the practicing nurses. Results will assist this collaborative transcultural nursing research effort between the United States and Spain to develop and implement programs and experiences to increase cultural self-efficacy among Spanish nurses and improve care provided to Spain’s diverse population.
    Type of Medium: Online Resource
    ISSN: 1043-6596 , 1552-7832
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2069642-5
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  • 8
    In: HAND, SAGE Publications, Vol. 12, No. 1 ( 2017-01), p. 85-90
    Abstract: Background: Management and indications for surgery in the tetraplegic patient are highly complex because of the substantial functional deficits that they present and their effect on their daily activity. Our purpose was to evaluate the functional outcome in tetraplegic patients who underwent biceps-to-triceps transfer surgery according to Zancolli’s modified technique. Methods: This is a retrospective study of 6 biceps-to-triceps transfers using Zancolli’s modified technique in 4 patients. Mean follow-up was 45 months. We evaluated each patient’s DASH (Disabilities of the Arm, Shoulder and Hand) score before surgery and 12 months later. Results: In the 6 arms that underwent surgery, full and active elbow extension against gravity at 12 months after surgery was achieved. The mean DASH score was 73.2 preoperatively and 20.8 twelve months postoperatively. One complication occurred. One patient reported loss of elbow flexion preventing thigh lift for transfers. This was resolved with a program of rehabilitation and specific muscle strengthening Conclusions: Zancolli’s modified technique is simple and effective, with few complications, whereby we can provide more autonomy for the tetraplegic patient.
    Type of Medium: Online Resource
    ISSN: 1558-9447 , 1558-9455
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2316440-2
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  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 2021
    In:  Environment and Planning B: Urban Analytics and City Science Vol. 48, No. 2 ( 2021-02), p. 280-297
    In: Environment and Planning B: Urban Analytics and City Science, SAGE Publications, Vol. 48, No. 2 ( 2021-02), p. 280-297
    Abstract: In Europe, especially in the Valencian Community, Spain, the growth of cities in the last few decades has brought with it a major paradigm change, shifting from a compact to a sprawling urban model. Although it is known about its important environmental, social, and economic effects, there is no clear and unequivocal measurement of the impact of urban sprawl on municipal spending. The impact of the sprawling city on public finances and on the cost of local public services is clearly one of the conditioning factors that should be assessed when making urban development decisions. Based on a measurement of the sprawling city, our aim is to calculate the effect of urban sprawl on the local administration’s expenditure and particularly on the cost of basic public municipal services. These are obtained through a statistical model with cost functions that can assess the increase in spending prompted by urban sprawl for municipal current expenditure. The proposed model is novel in the field of urban planning and is based on a Bayesian hierarchical model with the ability to include modeling constraints among the expenditures variables and handle missing values accurately. With this paper, we show that urban sprawl has a significant and positive effect on the unit cost of local public services, which results in an inefficient urban growth model from the economic point of view. The effect is not transferred homogeneously to the budget. There are spending items that are more sensitive to urban sprawl like expenditure on security and public transportation and community wellbeing, which primarily covers waste collection, elimination, and treatment; sanitation, and water supply and distribution; road cleaning; and public lighting.
    Type of Medium: Online Resource
    ISSN: 2399-8083 , 2399-8091
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2879402-3
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  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Journal of Hospitality & Tourism Research Vol. 46, No. 7 ( 2022-09), p. 1241-1256
    In: Journal of Hospitality & Tourism Research, SAGE Publications, Vol. 46, No. 7 ( 2022-09), p. 1241-1256
    Abstract: Rural tourism is currently one of the most dynamic segments of tourism demand, and rural accommodation is one of the accommodation choices most in demand. Based on various documentary sources, the goal of this article was to analyse aspects related to the qualitative evolution of this activity that have led to the rapid growth of this type of accommodation. Using a purpose-built database generated from the information obtained from our own survey, which was developed following other studies on this topic, we applied a partial least squares model to analyse the impacts on the environment in terms of the offer and their relationship with environmental management. The results show that the attitude of rural establishment managers has a decisive influence on the behaviour of their clients regarding ecological respect and a positive impact on water and energy consumption.
    Type of Medium: Online Resource
    ISSN: 1096-3480 , 1557-7554
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2202405-0
    SSG: 3,2
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