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  • 1
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    Acute Hemodynamic Effects of Recruitment Maneuvers in Patients With Acute Respiratory Distress Syndrome
    SAGE Publications ; 2009
    In:  Journal of Intensive Care Medicine Vol. 24, No. 6 ( 2009-11), p. 376-382
    Details
    In: Journal of Intensive Care Medicine, SAGE Publications, Vol. 24, No. 6 ( 2009-11), p. 376-382
    Abstract: Background: The recruitment maneuver (RM) in acute respiratory distress syndrome (ARDS) can cause hemodynamic derangement. We evaluated circulatory and cardiac changes during RMs. Methods: We performed sustained inflation (SI) with a pressure of 40 cm H 2 O for 30 seconds as an RM on 22 patients with ARDS. Blood pressure (BP) and heart rate were recorded immediately before, every 10 seconds during, and 30 seconds after the RM. Ventricular dimensions were obtained simultaneously using M-mode echocardiography, and tissue Doppler imaging was performed on the left ventricular wall. Results: Mean, systolic, and diastolic BP decreased at 20 and 30 seconds during 30-second RMs (mean BP: 92 ± 12 at baseline to 83 ± 18 mm Hg at the end of the RM, P 〈 .05) and subsequently recovered. Heart rate decreased at 10 and 20 seconds during the RM, and tended to increase afterward. Both ventricular dimensions decreased significantly during the RM. The left ventricular ejection fraction and peak velocity of the left ventricle during systole remained stable. The fractional changes in mean BP and left ventricular end-diastolic dimension during the RMs were correlated significantly with each other (r s = 0.59). Static compliance of the respiratory system (Crs) was lower in patients with mean BP change ≥15% than in patients in whom the change was 〈 15% (P 〈 .05). Conclusions: A transient decrease in mean BP was observed during the RM, and its degree was correlated with the preload decrease, while cardiac contractility was maintained.
    Type of Medium: Online Resource
    ISSN: 0885-0666 , 1525-1489
    URL: Article
    DOI: 10.1177/0885066609344952
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2001472-7
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  • 2
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    Utilizing Strengths in Assessment
    SAGE Publications ; 1998
    In:  Families in Society: The Journal of Contemporary Social Services Vol. 79, No. 1 ( 1998-02), p. 25-32
    Details
    In: Families in Society: The Journal of Contemporary Social Services, SAGE Publications, Vol. 79, No. 1 ( 1998-02), p. 25-32
    Abstract: Little empirical evidence is available to show the extent to which social workers emphasize strengths in their practice, know how to use strengths concepts, and believe strengths are important in practice. Using a case analogue, the authors found that social workers emphasized both strengths and deficits and rated strengths over deficits when evaluating the case of an elderly woman who required services to maintain independent living. Social workers employed in mental health facilities rated deficits higher than did those employed in other settings and were more likely to rate counseling as important in the case plan than were others. In the same manner, those who indicated that their theoretical base was psychodynamic rated the deficits found in the assessment as being more important than did others and gave higher ratings to counseling as a case plan than did others.
    Type of Medium: Online Resource
    ISSN: 1044-3894 , 1945-1350
    URL: Article
    DOI: 10.1606/1044-3894.1797
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1998
    detail.hit.zdb_id: 2069655-3
    SSG: 3,4
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  • 3
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    Association of homozygous deletion of the Humhv3005 and the VH3-30.3 genes with renal involvement in systemic lupus erythematosus
    SAGE Publications ; 2003
    In:  Lupus Vol. 12, No. 5 ( 2003-05), p. 400-405
    Details
    In: Lupus, SAGE Publications, Vol. 12, No. 5 ( 2003-05), p. 400-405
    Abstract: To investigate whether deletion of the Humhv3005 and the homologous VH3-30.3 (both share an identical amino acid sequence) genes is associated with susceptibility and/or certain clinical manifestations of systemic lupus erythematosus(SLE), DNA from 108 Korean SLE patients and 102 healthy subjects were analysed for the status of hv3005 gene by polymerase chain reaction-enzyme-linked immunosorbent assay. This method consists of amplification of selected germline VH3 genes with biotinylated primers, efficient capture of amplicons onto streptavidin-coated wells, and quantitative typing of bound VH3 gene with diagnostic oligonucleotides. We found that deletion of the hv3005 gene (including VH3-30.3) was more frequent in SLE patients than in healthy controls (26.9 versus 11.8%, P 0.006, odds ratio 2.75). When clinical features were examined, patients with hv3005 deletion have a higher frequency of lupus nephritis (LN) (75.9 versus 44.3% for those without, P 0.004), and higher activity index [median (range), 6 (2-14) versus 4 (1-16) for those without, P 0.044] when biopsy-provenLN was studied. Collectively, our data suggest that deletion of the hv3005 and the 3-30.3 genes may predispose individual SLE patients to the development of LN.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1191/0961203303lu385oa
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 2008035-9
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  • 4
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    Evaluation of a human glycated hemoglobin test in canine diabetes mellitus
    SAGE Publications ; 2019
    In:  Journal of Veterinary Diagnostic Investigation Vol. 31, No. 3 ( 2019-05), p. 408-414
    Details
    In: Journal of Veterinary Diagnostic Investigation, SAGE Publications, Vol. 31, No. 3 ( 2019-05), p. 408-414
    Abstract: Glycated hemoglobin A1c (HbA1c) is widely used for monitoring and diagnosing human diabetes mellitus, but is rarely used in veterinary clinics. The goal of our study was to validate the commercial HbA1c testing system SD A1cCare analyzer (Bionote, Gyeoggi-do, South Korea) for use in dogs. Dogs were recruited with owner’s consent. Diabetic status was determined based on clinical signs, fasting hyperglycemia, and glycosuria. Intra-assay precision and linearity were evaluated with EDTA, heparin, or citrate as anticoagulants, and had excellent precision with mean coefficients of variation (CVs) of 2.47%, 2.26%, and 1.92%, respectively. Diluted anticoagulated blood samples showed excellent linear relationships with R 2 of 0.991, 0.996, and 0.994, respectively. Inter-assay precision revealed that the mean CV of the normal control was 2.18% and that of the high control was 2.01% (30 repeats). Observed total error of a normal control was 7.81%, and 6.12% for the high control. HbA1c level measured before and after removal of plasma and replacement by saline showed minimal interference by lipid contents ( p = 0.929). The HbA1c concentrations of diabetic dogs were significantly higher than those of non-diabetic dogs ( p 〈 0.001). HbA1c value 〉 6.2% indicated canine diabetes through a classification and regression tree model. In most cases, fructosamine and HbA1c were highly correlated ( r = 0.674, p 〈 0.001). The HbA1c testing system could be a valuable testing system to evaluate canine diabetes mellitus, providing an alternative in-house option for use by veterinary clinicians.
    Type of Medium: Online Resource
    ISSN: 1040-6387 , 1943-4936
    URL: Article
    DOI: 10.1177/1040638719832071
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2265211-5
    SSG: 22
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  • 5
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    Rosa hybrida Petal Extract Exhibits Antitumor Effects by Abrogating Tumor Progression and Angiogenesis in Bladder Cancer Both In Vivo and In Vitro
    SAGE Publications ; 2022
    In:  Integrative Cancer Therapies Vol. 21 ( 2022-01), p. 153473542211143-
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 21 ( 2022-01), p. 153473542211143-
    Abstract: The edible Rosa hybrida (RH) petal is utilized in functional foods and cosmetics. Although the biological function of RH petal extract is known, mechanism of action studies involving tumor-associated angiogenesis have not yet been reported. Herein, we investigated the regulatory effect of the ethanol extract of RH petal (EERH) on tumor growth and tumor angiogenesis against bladder cancer. EERH treatment inhibited the bladder carcinoma T24 cell and 5637 cell proliferation because of G 1 -phase cell cycle arrest by inducing p21WAF1 expression and reducing cyclins/CDKs level. EERH regulated signaling pathways differently in both cells. EERH-stimulated suppression of T24 and 5637 cell migration and invasion was associated with the decline in transcription factor-mediated MMP-9 expression. EERH oral administration to xenograft mice reduced tumor growth. Furthermore, no obvious toxicity was observed in acute toxicity test. Decreased CD31 levels in EERH-treated tumor tissues led to examine the angiogenic response. EERH alleviated VEGF-stimulated tube formation and proliferation by downregulating the VEGFR2/eNOS/AKT/ERK1/2 cascade in HUVECs. EERH impeded migration and invasion of VEGF-induced HUVECs, which is attributed to the repressed MMP-2 expression. Suppression of neo-microvessel sprouting, induced by VEGF, was verified by treatment with EERH using the ex vivo aortic ring assay. Finally, kaempferol was identified as the main active compound of EERH. The present study demonstrated that EERH may aid the development of antitumor agents against bladder cancer.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/15347354221114337
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2101248-9
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  • 6
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    Nondestructive Identification of Freezing-Induced Cracks in Concrete Sleepers of High-Speed Railways in South Korea
    SAGE Publications ; 2010
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2159, No. 1 ( 2010-01), p. 98-109
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2159, No. 1 ( 2010-01), p. 98-109
    Abstract: The construction of a high-speed railway in South Korea was recently impeded by the unexpected problem of cracks in sleepers. These were presumably induced by the volume expansion of freezing water entrapped in the fastening assemblies during the winter. A total of 306,000 sleepers had to be investigated on an urgent basis for hairline cracks and possible latent cracks. These findings suggested that an appropriate nondestructive testing (NDT) technique for the inspection of concrete sleepers should be designed to meet two requirements: speed and reliability in testing. Research was performed to identify an optimal NDT technique by using sleepers with three different crack conditions: without any cracks, with a surface-opening crack, and with a hairline crack and possible latent cracks. Flexural rigidity rather than material stiffness or depth to multiple reflections was chosen as a key parameter for assessment of the structural integrity of a sleeper. The results allowed the design of a two-stage testing procedure: the flexural rigidity assessment of concrete tracks by antisymmetric Lamb (FRACTAL) waves technique for preliminary scanning and spectral analysis of surface waves (SASW) tests for in-depth investigation. A total of 18,177 sleepers that required testing were examined using FRACTAL tests, and 387 of these sleepers were double-checked using SASW tests. Before the overall examination of sleepers, a series of statistical analyses were performed to establish the criteria for defining the quality of a sleeper. The results of the FRACTAL test agreed with those of the SASW test in identifying sleepers with hairline cracks or possible latent cracks.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/2159-13
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2403378-9
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  • 7
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    Peritoneal Solute Clearances in Diabetics
    SAGE Publications ; 1990
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 10, No. 1 ( 1990-01), p. 85-88
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 10, No. 1 ( 1990-01), p. 85-88
    Abstract: In order to examine solute transport across the peritoneal membrane and responsiveness of the peritoneal microcirculation to a vasodilator in diabetics on continuous ambulatory peritoneal dialysis (CAPD), we obtained peritoneal clearances of urea (Curea) and creatinine (Ccr), protein concentrations in the drained dialysate (D PC), and percentage of peritoneal glucose absorption (% PGA) before and after nitroprusside (NP) addition to the dialysate in 13 diabetics (DM) and 13 nondiabetics (non-DM) matched for age, sex, body weight, and duration of CAPD. Control (before NP) Curea, Ccr, D PC, and %PGA were not different between DM and non-DM. NP significantly enhanced Curea, Ccr, and D PC in both DM and non-DM. Curea, Ccr, D PC, and %PGA after NP were again not different between DM and non-DM. The findings suggest that peritoneal solute clearances and responsiveness of the peritoneal microcirculation to NP in diabetics are not different from nondiabetics at the beginning of CAPD despite evidence for widespread vascular diseases in diabetic ESRD patients.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.1177/089686089001000121
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1990
    detail.hit.zdb_id: 2075957-5
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  • 8
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    Significance of Vertebral Body Sliding Osteotomy as a Surgical Strategy for the Treatment of Cervical Ossification of the Posterior Longitudinal Ligament
    SAGE Publications ; 2022
    In:  Global Spine Journal Vol. 12, No. 6 ( 2022-07), p. 1074-1083
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 12, No. 6 ( 2022-07), p. 1074-1083
    Abstract: Retrospective cohort study. Objectives: Vertebral body sliding osteotomy (VBSO) has previously been reported as a technique to decompress ossification of the posterior longitudinal ligament (OPLL) by translating the vertebral body anteriorly. This study aimed to evaluate the radiological and clinical efficacies of VBSO and clarify the surgical indications of VBSO for treating myelopathy caused by OPLL. Methods: Ninety-seven patients with symptomatic OPLL-induced cervical myelopathy treated with VBSO or laminoplasty who were followed up for more than 2 years were retrospectively reviewed. Cervical alignment, range of motion, fusion, modified K-line (mK-line) status, and minimum interval between ossified mass and mK-line (INT (min) ), and the Japanese Orthopaedic Association (JOA) score were assessed. Patients in the VBSO group were compared with those who underwent laminoplasty. Results: Cervical lordosis and INT (min) significantly increased in the VBSO group. All patients in the VBSO group assessed as mK-line (-) preoperatively were assessed as mK-line (+) postoperatively. However, in the LMP group, the mK-line status changed from (+) preoperatively to (−) postoperatively in 3 patients. Final JOA score (p = 0.02) and JOA score improvement (p = 0.01) were significantly higher in the VBSO group. JOA recovery ratio (p = 0.03) and proportion of patients with a recovery rate ≥50% were significantly higher in the VBSO group (p 〈 0.01). Conclusions: VBSO is an effective surgical option for OPLL-induced myelopathy, demonstrating favorable neurological recovery and lordosis restoration with low complication rates. It is best indicated for kyphotic alignment, OPLL with a high space-occupying ratio, and OPLL involving ≤3 segments.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/2192568220975387
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2648287-3
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  • 9
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    Performance Evaluation of Deformable Image Registration Algorithms Using Computed Tomography of Multiple Lung Metastases
    SAGE Publications ; 2022
    In:  Technology in Cancer Research & Treatment Vol. 21 ( 2022-01), p. 153303382210784-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 21 ( 2022-01), p. 153303382210784-
    Abstract: Purpose: Various deformable image registration (DIR) methods have been used to evaluate organ deformations in 4-dimensional computed tomography (4D CT) images scanned during the respiratory motions of a patient. This study assesses the performance of 10 DIR algorithms using 4D CT images of 5 patients with fiducial markers (FMs) implanted during the postoperative radiosurgery of multiple lung metastases. Methods: To evaluate DIR algorithms, 4D CT images of 5 patients were used, and ground-truths of FMs and tumors were generated by physicians based on their medical expertise. The positions of FMs and tumors in each 4D CT phase image were determined using 10 DIR algorithms, and the deformed results were compared with ground-truth data. Results: The target registration errors (TREs) between the FM positions estimated by optical flow algorithms and the ground-truth ranged from 1.82 ± 1.05 to 1.98 ± 1.17 mm, which is within the uncertainty of the ground-truth position. Two algorithm groups, namely, optical flow and demons, were used to estimate tumor positions with TREs ranging from 1.29 ± 1.21 to 1.78 ± 1.75 mm. With respect to the deformed position for tumors, for the 2 DIR algorithm groups, the maximum differences of the deformed positions for gross tumor volume tracking were approximately 4.55 to 7.55 times higher than the mean differences. Errors caused by the aforementioned difference in the Hounsfield unit values were also observed. Conclusions: We quantitatively evaluated 10 DIR algorithms using 4D CT images of 5 patients and compared the results with ground-truth data. The optical flow algorithms showed reasonable FM-tracking results in patient 4D CT images. The iterative optical flow method delivered the best performance in this study. With respect to the tumor volume, the optical flow and demons algorithms delivered the best performance.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/15330338221078464
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 10
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    Risk Factors of Extensive Subcutaneous Emphysema after Closed-Tube Thoracostomy for Spontaneous Pneumothorax
    SAGE Publications ; 2019
    In:  The American Surgeon Vol. 85, No. 2 ( 2019-02), p. 71-73
    Details
    In: The American Surgeon, SAGE Publications, Vol. 85, No. 2 ( 2019-02), p. 71-73
    Type of Medium: Online Resource
    ISSN: 0003-1348 , 1555-9823
    URL: Article
    DOI: 10.1177/000313481908500202
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
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