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  • 1
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    Online Resource
    Approval status of essential therapeutic drugs for systemic sclerosis versus that of drugs for rheumatoid arthritis
    SAGE Publications ; 2024
    In:  Journal of Scleroderma and Related Disorders
    Details
    In: Journal of Scleroderma and Related Disorders, SAGE Publications
    Abstract: Systemic sclerosis, a rare disease characterized by chronic multisystem fibrosis, requires lifelong management, necessitating enough insurance coverage for the patient. Official drug approval is the first step to ensuring that the drug is covered by insurance. In this study, we investigated the approval status of essential therapeutic drugs for systemic sclerosis across eight countries and compared it with that of drugs for rheumatoid arthritis. Methods: The essential therapeutic drug lists for systemic sclerosis and rheumatoid arthritis were taken from the guidelines of the American College of Rheumatology and the European Alliance of Associations for Rheumatology. Official drug approval status for the selected drugs was confirmed by searching representative Internet databases from eight countries: the United States, the United Kingdom, Germany, France, Italy, Switzerland, Japan, and the Republic of Korea. Results: A total of 21 and 16 drugs were selected for systemic sclerosis and rheumatoid arthritis, respectively. The drug approval rates of the 21 drugs for systemic sclerosis varied among countries. Most drugs used to treat pulmonary arterial hypertension, which were developed recently and are expensive, are approved by most countries; however, most older drugs—which are still essential for management of Raynaud’s phenomenon, digital ulcers, interstitial lung disease, and skin fibrosis—are not approved by most countries. By contrast, almost all of the 16 drugs used to treat rheumatoid arthritis, whether old or new, are approved by most countries. Conclusion: Approval rates for drugs used to treat systemic sclerosis, a rare disease, are much lower than those for drugs used to treat rheumatoid arthritis. Thus, approval rates of essential therapeutic drugs for systemic sclerosis need to improve, which will benefit patients by increasing the number of drugs covered by insurance.
    Type of Medium: Online Resource
    ISSN: 2397-1983 , 2397-1991
    URL: Article
    DOI: 10.1177/23971983231222368
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2964332-6
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  • 2
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    Heart-lung transplantation for refractory diffuse alveolar hemorrhage supported by prolonged extracorporeal membrane oxygenation after cardiogenic shock from ST segment elevation myocardial infarction: a case report
    SAGE Publications ; 2020
    In:  Perfusion Vol. 35, No. 8 ( 2020-11), p. 870-874
    Details
    In: Perfusion, SAGE Publications, Vol. 35, No. 8 ( 2020-11), p. 870-874
    Abstract: Diffuse alveolar hemorrhage after percutaneous coronary intervention is a rare but fatal complication. Although timely application of extracorporeal membrane oxygenator and discontinuation of antiplatelet/anticoagulation is the treatment of choice, bleeding is often irreversible. Herein, we introduce a patient with refractory diffuse alveolar hemorrhage after prolonged extracorporeal membrane oxygenator and percutaneous coronary intervention, who was eventually rescued with heart-lung transplantation.
    Type of Medium: Online Resource
    ISSN: 0267-6591 , 1477-111X
    URL: Article
    DOI: 10.1177/0267659120915396
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2029611-3
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  • 3
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    Mobility Changes of the First Ray after Hallux Valgus Surgery: Clinical Results after Proximal Metatarsal Chevron Osteotomy and Distal Soft Tissue Procedure
    SAGE Publications ; 2008
    In:  Foot & Ankle International Vol. 29, No. 5 ( 2008-05), p. 468-472
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 29, No. 5 ( 2008-05), p. 468-472
    Type of Medium: Online Resource
    ISSN: 1071-1007
    URL: Article
    DOI: 10.3113/FAI.2008.0468
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2129503-7
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  • 4
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    A Simpler Device for Measuring the Mobility of the First Ray of the Foot
    SAGE Publications ; 2008
    In:  Foot & Ankle International Vol. 29, No. 2 ( 2008-02), p. 213-218
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 29, No. 2 ( 2008-02), p. 213-218
    Abstract: Background: Since some devices can be cumbersome to use, we evaluated the validity and reliability of a specially designed device for easily checking the mobility of the first ray of the foot. Materials and Methods: To analyze the validity of the device, the dorsal mobility of the first ray of the foot was measured with the modified Coleman block test developed by Fritz et al., the Klaue device, and the custom device. Two-tailed Student's paired t-test and Pearson correlation were used to compare the values of the two tests. For evaluation of inter- and intra observer reliability of the EMC device, 3 independent observers measured the dorsal mobility of the first ray of the foot twice. The results were analyzed with two-tailed Student's paired t-test and ANOVA to evaluate intraobserver and interobserver reliability, respectively. Results: For both the first and second examinations of reliability, the difference between the two values was significant ( p 〈 0.05) for the Coleman block test but not significant ( p = 0.118) in comparison with the Klaue device. The measurements from both examinations showed good correlation (Pearson correlation coefficient: comparison with the Coleman block test = 0.84 ( p 〈 0.05), with the Klaue device = 0.92 ( p 〈 0.05)). The paired t-test for intraobserver validity showed no statistically significant difference among observers ( p = 0.52, 0.58, 0.96, Pearson correlation coefficient = 0.76, 0.79, 0.80), and ANOVA testing for interobserver reliability showed no significant difference either ( p = 0. 96, Pearson correlation coefficients = 0.83, 0.84, and 0.86, respectively). Conclusion: This study demonstrated that the EMC device is both reliable and valid for measuring the mobility of the first ray of the foot.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.3113/FAI.2008.0213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2129503-7
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  • 5
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    Can Combination of Peripheral Nerve Block and Non-opioidal Patient Controlled Analgesia Be an Effective Postoperative Pain Control Method?
    SAGE Publications ; 2019
    In:  Foot & Ankle Orthopaedics Vol. 4, No. 4 ( 2019-10-01), p. 2473011419S0023-
    Details
    In: Foot & Ankle Orthopaedics, SAGE Publications, Vol. 4, No. 4 ( 2019-10-01), p. 2473011419S0023-
    Abstract: Ankle, Pain medicine Introduction/Purpose: Even though bone surgery is very painful after operation, there is no established method to control postoperative pain due to efficacy and side effects. Ultrasound-guided peripheral nerve block (PNB) and nonsteroidal anti- inflammatory drugs (NSAIDs) patient controlled analgesia (PCA) can effectively control pain and reduce side effects. Methods: We conducted a prospective study of 150 patients over 18 years of age who underwent bone surgery from June 2018 to December 2018. All operations were performed under anesthetic ultrasound-guided PNB and additional PNB was performed to control postoperative pain. Among the 120 patients who participated in the final study, NSAIDs PCA was used in group A (65 patients) and NSAIDs PCA was not used in group B (55 patients) for pain control. Postoperative management except PCA was same in both groups. Pain scores are measured at 6, 12, 18, 24, 36, 48, and 72 hours after the operation and they were compared using visual analogue scale (VAS) pain scores. Survey was done on satisfaction of patients, and their willingness to reconsider same method of pain control when they undergo same surgery next time. Also, we evaluated possible side effects that might happen during process of controlling pain. Results: VAS pain score were significantly different only at 24 h postoperatively (p=0.004). In Group A, three patients were prescribed 3 amples of pethidine intramuscular injection as rescue analgesic. In group B, 35 patients were prescribed 50 amples of pethidine and 12 patients of them were received additional 18 amples of ketorolac intramuscular injection as rescue analgesic(p=0.000). In group A, all patients were satisfied with the pain control method, but 5 of the group B patients were dissatisfied (p=0.001). 3 patients responded to severe pain after operation and 2 of them due to postoperative nausea and vomiting (PONV). In group A, there were no patients complaining of PONV, but in group B, 5 patients complained of symptoms (p=0.018), and 3 of them were prescribed additional antiemetics (p=0.093). Conclusion: Combined use of ultrasound-guided PNB and NSAIDs PCA seems to be an effective postoperative pain control method in foot and ankle surgery. Because, pain can be effectively controlled and PONV can be reduced.
    Type of Medium: Online Resource
    ISSN: 2473-0114 , 2473-0114
    URL: Article
    DOI: 10.1177/2473011419S00239
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2874570-X
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  • 6
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    Identification of a Novel DHCR7 Mutation in a Korean Patient With Smith-Lemli-Opitz Syndrome
    SAGE Publications ; 2007
    In:  Journal of Child Neurology Vol. 22, No. 11 ( 2007-11), p. 1297-1300
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 22, No. 11 ( 2007-11), p. 1297-1300
    Abstract: Smith-Lemli-Opitz syndrome is a unique malformation syndrome characterized by a defect in cholesterol biosynthesis, which is very rare among populations in Middle and East Asia. The authors identified compound heterozygous mutations ([p.Arg352Trp] + [p.Lys376ArgfsX37] ) in a Korean girl with clinical and laboratory features typical of Smith-Lemli-Opitz syndrome. The Lys376ArgfsX37 mutation is a novel mutation, and to the best of the authors' knowledge, this is the first report of a clinically and genetically confirmed case of Smith-Lemli-Opitz syndrome in Korea.
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/0883073807307099
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2068710-2
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  • 7
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    Diagnostic performance and radiation dose of lower extremity CT angiography using a 128-slice dual source CT at 80 kVp and high pitch
    SAGE Publications ; 2016
    In:  Acta Radiologica Vol. 57, No. 7 ( 2016-07), p. 822-828
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 57, No. 7 ( 2016-07), p. 822-828
    Abstract: Multi-detector computed tomography (MDCT) angiography is now used for the diagnosing patients with peripheral arterial disease. The dose of radiation is related to variable factors, such as tube current, tube voltage, and helical pitch. Purpose To assess the diagnostic performance and radiation dose of lower extremity CT angiography (CTA) using a 128-slice dual source CT at 80 kVp and high pitch in patients with critical limb ischemia (CLI). Material and Methods Twenty-eight patients (mean, 64.1 years; range, 39–80 years) with CLI were enrolled in this retrospective study and underwent CTA using a 128-slice dual source CT at 80 kVp and high pitch and subsequent intra-arterial digital subtraction angiography (DSA), which was used as a reference standard for assessing diagnostic performance. Results For arterial segments with significant disease ( 〉 50% stenosis), overall sensitivity, specificity, and accuracy of lower extremity CTA were 94.8% (95% CI, 91.7–98.0%), 91.5% (95% CI, 87.7–95.2%), and 93.1% (95% CI, 90.6–95.6%), respectively, and its positive and negative predictive values were 91.0% (95% CI, 87.1–95.0%), and 95.1% (95% CI, 92.1–98.1%), respectively. Mean radiation dose delivered to lower extremities was 266.6 mGy.cm. Conclusion Lower extremity CTA using a 128-slice dual source CT at 80 kVp and high pitch was found to have good diagnostic performance for the assessment of patients with CLI using an extremely low radiation dose.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185115604512
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2024579-8
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  • 8
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    Long-Term Exercise Improves Memory Deficits via Restoration of Myelin and Microvessel Damage, and Enhancement of Neurogenesis in the Aged Gerbil Hippocampus After Ischemic Stroke
    SAGE Publications ; 2016
    In:  Neurorehabilitation and Neural Repair Vol. 30, No. 9 ( 2016-10), p. 894-905
    Details
    In: Neurorehabilitation and Neural Repair, SAGE Publications, Vol. 30, No. 9 ( 2016-10), p. 894-905
    Abstract: Background. The positive correlation between therapeutic exercise and memory recovery in cases of ischemia has been extensively studied; however, long-term exercise begun after ischemic neuronal death as a chronic neurorestorative strategy has not yet been thoroughly examined. Objective. The purpose of this study is to investigate possible mechanisms by which exercise ameliorates ischemia-induced memory impairment in the aged gerbil hippocampus after transient cerebral ischemia. Methods. Treadmill exercise was begun 5 days after ischemia-reperfusion (I-R) and lasted for 1 or 4 weeks. The animals were sacrificed 31 days after the induction of ischemia. Changes in short-term memory, as well as the hippocampal expression of markers of cell proliferation, neuroblast differentiation, neurogenesis, myelin and microvessel repair, and growth factors were examined by immunohistochemistry and/or western blots. Results. Four weeks of exercise facilitated memory recovery despite neuronal damage in the stratum pyramidale (SP) of the hippocampal CA1 region and in the polymorphic layer (PoL) of the dentate gyrus (DG) after I-R. Long-term exercise enhanced cell proliferation and neuroblast differentiation in a time-dependent manner, and newly generated mature cells were found in the granule cell layer of the DG, but not in the SP of the CA1 region or in the PoL of the DG. In addition, long-term exercise ameliorated ischemia-induced damage of myelin and microvessels, which was correlated with increased BDNF expression in the CA1 region and the DG. Conclusions. These results suggest that long-term treadmill exercise after I-R can restore memory function through replacement of multiple damaged structures in the ischemic aged hippocampus.
    Type of Medium: Online Resource
    ISSN: 1545-9683 , 1552-6844
    URL: Article
    DOI: 10.1177/1545968316638444
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2100545-X
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  • 9
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    Comparison of noise-optimized linearly blended images and noise-optimized virtual monoenergetic images evaluated by dual-source, dual-energy CT in cardiac vein assessment
    SAGE Publications ; 2021
    In:  Acta Radiologica Vol. 62, No. 5 ( 2021-05), p. 594-602
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 62, No. 5 ( 2021-05), p. 594-602
    Abstract: The coronary venous system is frequently used as an entry route to the heart and treatment modalities for many cardiac diseases and many procedures. Consequently, evaluation of the coronary venous system and understanding cardiac vein anatomy is crucial. Purpose To determine the optimal image set in a comparison of noise-optimized linearly blended images (F_0.6) and noise-optimized virtual monoenergetic images (VMI+) evaluated by dual-energy computed tomography (DECT) for cardiac vein assessment. Material and Methods Thirty-four patients (mean age 58.2 ± 14.2 years) who underwent DECT due to chest pain were enrolled. Images were post-processed with the F_0.6, and VMI+ algorithms at energy levels in the range of 40–100 keV in 10-keV increments. Enhancement (HU), noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were objectively measured at two points in the great cardiac vein by consensus of two radiologists. Two blinded observers evaluated the subjective image quality of the great cardiac vein on a 4-point scale. Results HU, noise, and SNR peaked at 40 keV VMI+ ( P  〈  0.05) among 50–100 keV VMI+. CNR peaked at 100 keV VMI+; however, there were no significant differences compared to CNR images processed at 40–90 keV VMI+. HU and noise were significantly higher in 40 keV VMI+ than F_0.6 images; however, both SNR and CNR were significantly higher in F_0.6 images. An assessment of subjective vein delineation revealed that F_0.6 images had the highest scores Conclusion F_0.6 images were superior to VMI+ and provided the optimal image set for cardiac vein assessment.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185120933242
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2024579-8
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  • 10
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    Effects of donor age on human adipose-derived adherent stromal cells under oxidative stress conditions
    SAGE Publications ; 2018
    In:  Journal of International Medical Research Vol. 46, No. 3 ( 2018-03), p. 951-964
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 46, No. 3 ( 2018-03), p. 951-964
    Abstract: Adipose-derived stromal vascular fractions (SVFs) are heterogeneous complex populations of cells with therapeutic efficacy for tissue generation and vascular stabilization. SVFs have cardiomyogenic potential, and many researchers have examined the possibility of SVF transplantation for heart disease. In cell-based therapies, donor age affects the regenerative capability, cell yield, and differentiation potential of adult tissues; however, opposing or controversial results have been found in humans. We examined whether SVF transplantation into impaired heart tissue shows differential effects according to donor age. Methods We investigated differences in protein expression in human umbilical vein endothelial cells (HUVECs) co-cultured with adipose-derived adherent stromal cells (ADASs) from donors of different ages [ 〉 40-year-olds (40s group) and 〉 60-year-olds (60s group)] under oxidative stress conditions. Results Although co-culturing HUVECs with ADASs ameliorated inflammation due to increased oxidative stress conditions, few differences were observed between the ADASs from the 40s and 60s groups. Moreover, the Database for Annotation, Visualization, and Integrated Discovery classification tool revealed differentially expressed genes in the Kyoto Encyclopedia of Genes and Genomes pathway associated with cytokine–cytokine receptor interaction in response to ADASs. Conclusion Protein expression profiles were unchanged in HUVECs induced by isolated ADASs from donors of different ages under oxidative stress conditions.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060517731684
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2082422-1
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