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  • SAGE Publications  (12)
  • 1
    In: Ear, Nose & Throat Journal, SAGE Publications
    Abstract: To observe the efficacy and safety of postoperative long-term low-dose oral administration of clarithromycin in patients with refractory chronic rhinosinusitis (RCRS), to explore the characteristics of postoperative microbiota in the nasal cavity in patients with RCRS, and to compare the differences and changes in microbiota in the nasal cavity before and after medication. Methods: This was a prospective, self-controlled study. Eighteen patients with RCRS who had persistent symptoms after endoscopic sinus surgery and standard therapy with normal immunoglobulin E and eosinophil level were included. Low dose (250 mg, once daily) clarithromycin was orally administrated for 12 weeks. Symptom severity and endoscopic findings were evaluated before, after 4 weeks, and 12 weeks of treatment, and nasal cavity microbiota was analyzed simultaneously. Results: A total of 18 patients with RCRS were enrolled and 17 patients completed the study. Four weeks after oral administration of clarithromycin, significant improvement was observed in subjective symptoms including nasal congestion, rhinorrhea, postnasal drip, and general discomfort, as well as endoscopic findings including general surgical cavity condition, rhinedema, and rhinorrhea ( P 〈 .05). After continuous treatment to the 12th week, symptoms showed significant improvement compared with baseline, and endoscopic score showed significant improvement compared with both baseline and 4 weeks after treatment. Analysis of middle nasal meatus flora revealed a significant decrease of Streptococcus pneumoniae after 12 weeks of clarithromycin treatment ( P 〈 .05), while the richness, composition, and diversity were similar before and after treatment. Patients enrolled experienced no adverse drug reaction or allergic reaction, nor clinical significant liver function impairment observed. Conclusion: Postoperative low-dose long-term oral administration of clarithromycin in patients with RCRS can improve the clinical symptoms and facilitate the mucosal epithelialization, with good tolerance and safety. The efficacy of clarithromycin in patients with RCRS may be related to its regulatory effect on nasal cavity microbiota.
    Type of Medium: Online Resource
    ISSN: 0145-5613 , 1942-7522
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2067528-8
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  The American Journal of Sports Medicine Vol. 51, No. 6 ( 2023-05), p. 1480-1490
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 51, No. 6 ( 2023-05), p. 1480-1490
    Abstract: Although meniscal injury is common after anterior cruciate ligament (ACL) injury, the underlying process in different meniscal regions remains unclear. Purpose: To investigate macroscopic and histological alterations in different meniscal regions in an ACL transection (ACLT) rabbit model. Study Design: Controlled laboratory study. Methods: ACLT was performed on New Zealand White rabbits. Both the medial meniscus (MM) and the lateral meniscus (LM) of the ACLT knees were obtained at 8 (n = 6) and 26 (n = 6) weeks postoperatively. MM and LM collected from nonoperated knees were considered 0 weeks (n = 6) postoperatively. Menisci were then divided into posterior, central, and anterior regions for macroscopic (width) and histological (hematoxylin and eosin, safranin O/fast green, collagen type 2 [COL2]) analysis. Results: The macroscopic widths of MM and LM increased and then decreased over 26 weeks postoperatively, with all 3 MM widths at 8 weeks significantly wider than at 0 weeks (posterior: P 〈 .01; central: P 〈 .05; anterior: P 〈 .05). In the MM, chondrocyte-like cell density increased and then decreased postoperatively, whereas in the LM, it decreased and then remained almost unchanged. Cell density was significantly higher in the central MM region at 8 weeks than at 0 weeks ( P 〈 .05). Glycosaminoglycan (GAG) and COL2 percentages of MM and LM decreased from 0 to 8 weeks and then returned to nearly normal levels at 26 weeks postoperatively. In the MM, the GAG percentage in the posterior ( P 〈 .05) and central ( P 〈 .01) regions and the COL2 percentage in the posterior region ( P 〈 .05) was significantly lower at 8 weeks than at 0 weeks. Conclusion: After ACLT in rabbit meniscus, the extracellular matrix (ECM) initially decreased and then increased to almost normal. Additionally, there were significant differences in the ECM percentage in the posterior and central regions of the MM in comparison with other meniscal regions between 0 and 8 weeks postoperatively. Clinical Relevance: The results indicate that the time for meniscal injury after ACL injury is important, and attention should be paid to the posterior and central regions of the MM after ACLT.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Journal of Applied Biomaterials & Functional Materials Vol. 20 ( 2022-01), p. 228080002211018-
    In: Journal of Applied Biomaterials & Functional Materials, SAGE Publications, Vol. 20 ( 2022-01), p. 228080002211018-
    Abstract: Chitosan and its derivatives show potent biocompatibility, biodegradability, antimicrobial activity, hemostatic effects, and wound healing properties. Their application in wound dressings has garnered substantial research interest. In this work, we prepared a drug-loaded hydrogel by mixing N-glycosylated chitosan with polyvinyl alcohol (PVA), followed by loading of ofloxacin. A 2:1 volume ratio of chitosan to PVA was found to be optimal based on swelling and water evaporation rates. The slow-drug-release performance of the blended hydrogel was best when the ofloxacin loading was 5.0%. The ofloxacin-loaded hydrogel shows excellent antimicrobial properties in vitro and wound healing ability in an in vivo rabbit full-thickness excision wound model. The chitosan/PVA blended hydrogel has great potential for use in wound dressings and sustained drug release.
    Type of Medium: Online Resource
    ISSN: 2280-8000 , 2280-8000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2673624-X
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Orthopaedic Journal of Sports Medicine Vol. 10, No. 2 ( 2022-02-01), p. 232596712110622-
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 10, No. 2 ( 2022-02-01), p. 232596712110622-
    Abstract: The best nonsurgical treatment for frozen shoulder is still unclear. Extracorporeal shockwave therapy (ESWT) is an innovative adjunctive treatment for frozen shoulder, but its effect is still unclear. Purpose: To evaluate the published literature regarding the potential of ESWT as an adjunctive therapy for frozen shoulder. Study Design: Systematic review; Level of evidence, 1. Methods: Searches were conducted in the PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), and VIP Information databases for relevant studies between inception and November 2020. Included were randomized controlled trials (RCTs) for frozen shoulder that compared ESWT with routine treatments to controls. There were no restrictions on the treatment period, type of ESWT, or severity of symptoms. At least 1 of the following outcome indices was assessed: visual analog scale (VAS) for pain, Constant-Murley score (CMS) for shoulder function assessment, or external rotation range of movement (ER ROM). RevMan 5.3 software was used to evaluate the bias and quality of the included studies. For continuous variables, the mean difference (MD) or standardized MD (SMD) with the 95% CI was extracted. For dichotomous data, event ratios and sample sizes were extracted. Results: Overall, 20 studies were included. The ESWT used as an adjunct to other interventions had better outcomes compared with control groups regarding immediate and short-term analgesic effects (immediate: MD, –1.10 [95% CI, –1.27 to –0.92], P 〈 .00001; short-term: MD, –0.72 [95% CI, –0.94 to –0.50], P 〈 .00001) as well as immediate function (SMD, 1.54 [95% CI, 1.19 to 1.89], P 〈 .00001], I 2 = 0%). There was significant heterogeneity between studies for long-term analgesia (MD, –0.90 [95% CI, –1.40 to –0.41], P 〈 .00001, I 2 = 89%) and ER ROM (MD, 10.31 [95% CI, 3.46 to 17.17], P 〈 .003, I 2 = 93%). Conclusion: ESWT seems to be beneficial to patients with frozen shoulder by alleviating pain and improving function. ESWT could be used as an adjunct therapy to routine treatments, although the quality of the included RCTs was hampered by significant heterogeneity regarding long-term analgesia and joint ROM.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2706251-X
    SSG: 31
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  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  ECNU Review of Education Vol. 1, No. 3 ( 2018-09), p. 116-142
    In: ECNU Review of Education, SAGE Publications, Vol. 1, No. 3 ( 2018-09), p. 116-142
    Abstract: The purpose of the paper is to investigate the impact of various types of intergovernmental fiscal transfers on local public education expenditure at the county level in China and to estimate the leakage of categorical subsidies for rural compulsory education. Design/Approach/Methods It is a quantitative study. The paper constructs a quantile regression model and adopt data collected in 2007 for 1,985 counties in China to examine the impact of relevant fiscal transfers. Findings The results reveal that most intergovernmental fiscal transfers exert a substitution effect on the local education expenditure, whereas subsidies for rural compulsory education from the Central Government have a crowding-out effect on education investments from local financial resources. Although the subsidy program generally narrows the education expenditure disparity across counties, there are heterogeneous effects across different regions. Originality/Value The paper estimates and compares the impact of fiscal transfers on both the level and disparity of local public education in different regions, and provides a possible explanation for the crowding-out effect of fiscal transfers in China.
    Type of Medium: Online Resource
    ISSN: 2096-5311 , 2632-1742
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 3010076-8
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2016
    In:  High Performance Polymers Vol. 28, No. 9 ( 2016-11), p. 1096-1101
    In: High Performance Polymers, SAGE Publications, Vol. 28, No. 9 ( 2016-11), p. 1096-1101
    Abstract: A novel ceramizable organic composite was prepared by compression molding using silicone-modified phenolic resin (PR) as the matrix, nano-aluminum oxide powder as the filler, glass powder with low melting point as the forming additive, and vitreous silica fiber as the reinforced material. The ablative characteristics were explored in terms of linear/mass ablation rate and microscopic pattern of ablation via the oxyacetylene torch tests. Thermal stability of the investigated composites was estimated by means of thermogravimetric analysis. The final charring yields after pyrolysis increased from 63% to 69% and 74%, respectively. The silicone-modified PR acted as cross-linking adhesive at low-temperature region and tended to convert to bonding layer at high-temperature region. The formation and growth of the ceramic phase after thermal treatment enhanced the thermal stability and ablation performance of the composites at high-temperature region. The morphology and phase composition of the residual chars were studied by scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction, respectively. The test results revealed that the modified composite possessed excellent thermal stability and ablation property.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1483713-4
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  Technology in Cancer Research & Treatment Vol. 16, No. 6 ( 2017-12), p. 1187-1193
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 16, No. 6 ( 2017-12), p. 1187-1193
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 8
    In: Cancer Control, SAGE Publications, Vol. 29 ( 2022-01), p. 107327482211152-
    Abstract: Many markers of inflammation are increasingly found to have prognostic significance in some cancers. This study investigated the prognostic value of albumin/globulin (AGR), lymphocyte/monocyte ratio (LMR), and other inflammatory markers, including neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR), in patients with papillary thyroid carcinoma (PTC). Methods We retrospectively analyzed the data of 764 patients newly diagnosed with PTC (608 women, 156 men) aged 10-83 years. Univariate and multivariate analyses were used to analyze recurrence rates and assess potential prognostic factors. Furthermore, we used random survival forests to construct a random survival forest score (RSFscore). The correlations between various inflammatory factors and traditional prognostic factors were analyzed. We also compared the areas under the curve (AUCs) of the RSFscore and 4 inflammation-based markers. Results AGR, NLR, PLR, and LMR were strongly associated with invasive clinicopathological features (tumor size, lesions, lymph node metastasis, and lymph node metastasis rate) and postoperative recurrence. In the multivariate analysis, AGR and LMR were independent prognostic markers for recurrent PTC. Higher NLR and PLR values indicated a higher risk of recurrence, while higher LMR and AGR values suggested a lower recurrence risk. The predictive power of the combined indicators was stronger than that of single indicators alone. Conclusion Compared to the analysis of a single indicator, the combination of inflammatory markers was more helpful in determining the risk of PTC recurrence, which has an important impact on predicting patients’ cancer-free survival and quality of life.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1526-2359
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2004182-2
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  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  High Performance Polymers Vol. 29, No. 3 ( 2017-04), p. 279-288
    In: High Performance Polymers, SAGE Publications, Vol. 29, No. 3 ( 2017-04), p. 279-288
    Abstract: To improve the thermal stability of phenolic resin and develop functional sustainable adhesive, a thermal-resistant cardanol-containing boron–phenolic resin (CBPR) was prepared by copolymerizing salicyl alcohol, cardanol, and boric acid. The structure of CBPR was characterized by Fourier transform infrared spectroscopy. Thermal stability of the investigated composites was estimated using thermogravimetric analysis (TGA). The results of TGA indicated that the modified resin exhibited excellent thermal stability. Specifically, the B-0.2 thermoset had a char yield of 69% when the boron content was only 1.27 wt%. The curing kinetic behavior was well described by differential scanning calorimetry and model-free kinetic analysis. Further, CBPRs, nano-aluminum oxide powders, glass powders with low melting point, and vitreous silica fibers were used as resin matrix, filler, forming additive, and reinforced material, respectively, to produce a novel ceramizable phenolic molding composite. The ablative characteristics of the co-cured blends were explored in terms of linear/mass ablation rate and microscopic pattern of ablation via the oxyacetylene torch tests. After thermal treatment, the formation and growth of the ceramic phase enhanced the thermal stability and ablation performance of the composites at high-temperature region. The morphology and phase composition of the residual chars were studied by scanning electron microscopy and energy dispersive spectroscopy, respectively. The linear and mass ablation rates for the modified composites decreased obviously in comparison with those of the unmodified composites, indicating that the modified composites possessed enhanced thermal stability and ablation property.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 1483713-4
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  • 10
    In: High Performance Polymers, SAGE Publications, Vol. 29, No. 4 ( 2017-05), p. 493-498
    Abstract: This work reports a boron- and silicon-containing phenolic-formaldehyde (PF) resin exhibiting an extremely high thermal decomposition temperature and char yield and formed by copolymerizing phenol, formaldehyde, boric acid (BA), and phenyltriethoxysilane (PTES). The structure of BA and PTES-modified PF (BSPF) resin was characterized by Fourier transform infrared spectroscopy. Thermal stability of the investigated composites was estimated by means of thermogravimetric analysis (TGA). The results of TGA indicated that the modified resin exhibited excellent thermal stability. Specifically, the thermoset had a char yield of 77.0% when the boron and silicon contents were only 1.27 wt% and 1.7 wt%, respectively. Compared with the unmodified resin (PF), the temperature at the maximum decomposing rate of the BSPF increased by 84°C and its charring yield was enhanced by 15.0%. The cured products of PF and BSPF were further investigated by X-ray diffraction and Raman spectroscopy, respectively. The incorporation of boron and silicon into the carbon lattice results in a decrease of interlayer spacing, and Raman I D / I G values for PF and BSPF (2.63 and 1.32) show that the rearrangement of crystalline structure leads to an increase in graphite structure and a decrease in disordered structure upon the modification processes.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 1483713-4
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