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  • SAGE Publications  (383)
  • 1
    Online Resource
    Online Resource
    Novel Decomposition and Ensemble Model with Attention Mechanism for Container Throughput Forecasting at Four Ports in Asia
    SAGE Publications ; 2023
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2677, No. 6 ( 2023-06), p. 530-547
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2677, No. 6 ( 2023-06), p. 530-547
    Abstract: Container shipping has suffered a sharp decline since COVID-19, and risks associated with container transit will persist in the future. The decrease in container transportation has caused a ripple impact on the global supply chain. However, container throughput forecasting is both critical and complicated under the circumstances of economic uncertainty and the outbreak of the COVID-19 pandemic. A novel model propounded in this paper for container throughput forecasting to assist the port management bureau and container shipping industry integrates with the variational mode decomposition (VMD) algorithm, SARIMA technique, convolutional neural network (CNN) method, long short-term memory (LSTM) approach, and attention mechanism, among others. In this model, there are three stages: (i) data decomposition, (ii) component prediction, and (iii) ensemble output. In the first stage, the original data of the container throughput time series is decomposed into several different components using the VMD algorithm. Next, from low frequency to high frequency, each component is modeled by the corresponding prediction approach. Subsequently, the prediction results of each component generated by the previous stage are integrated into the final forecasting results by addition strategy. To enhance the prediction accuracy in the second stage, the attention mechanism is adopted in the CNN-bidirectional LSTM method. Finally, six measurement criteria, the container throughput times series at four ports, and a statistical evaluation approach are applied to comprehensively evaluate the proposed model compared with seven benchmark models. The empirical analysis demonstrates that the proposed model significantly outperforms other comparable models with regard to prediction results, level, and directional prediction accuracy.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.1177/03611981221149434
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2403378-9
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  • 2
    Online Resource
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    Risk Factors Correlated With Risk of Insulin Resistance Using Homeostasis Model Assessment in Adolescents in Taiwan
    SAGE Publications ; 2015
    In:  Asia Pacific Journal of Public Health Vol. 27, No. 2 ( 2015-03), p. NP476-NP484
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 27, No. 2 ( 2015-03), p. NP476-NP484
    Abstract: The study aims to discover risk factors significantly correlated with insulin resistance among adolescents in Taiwan. A total of 339 study subjects were recruited in this cross-sectional study. A self-administered questionnaire and physical examinations including anthropometrics and biochemistry profiles were collected. Insulin resistance was assessed using homeostasis model assessment for insulin resistance (HOMA-IR). Study subjects had a significantly increased risk of IR for those with abnormal level of body mass index (odds ratio [OR] = 3.54; 95% confidence interval [CI] = 1.81-6.91), body fat (OR = 2.71; 95% CI = 1.25-5.88), and waist circumference (OR = 25.04; 95% CI = 2.93-214.14) when compared with those who have normal values. Furthermore, a significantly joint effect of 10.86-fold risk for HOMA-IR abnormality among body fat, body mass index, and systolic blood pressure was observed. The identification of risk factors significantly correlated with IR will be important to prevent metabolic syndrome–related diseases and complications for adolescents in their future life.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539512471075
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2394975-2
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  • 3
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    Design, synthesis, and biological evaluation of quinazoline derivatives containing piperazine moieties as antitumor agents
    SAGE Publications ; 2020
    In:  Journal of Chemical Research Vol. 44, No. 9-10 ( 2020-09), p. 536-542
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 44, No. 9-10 ( 2020-09), p. 536-542
    Abstract: A series of novel quinazoline derivatives containing piperazine analogs are synthesized via substitution reactions with 6,7-disubstituted 4-chloroquinazoline and benzyl piperazine (amido piperazine). Potent antiproliferative activities are observed against A549, HepG2, K562, and PC-3 with N-(3-chlorophenyl)-2-(4-(7-methoxy-6-(3-morpholino-propoxy)quinazoline-4-yl)piperazine-1-yl)acetamidename C9 showing excellent activity. This active derivative was screened for cell migration ability, proliferation effects, and apoptosis against A549 and PC-3 cells, with the result showing biological activity almost equal to that of the control gefitinib.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.1177/1747519820910384
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 3010810-X
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  • 4
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    Comparison of the effect of clarithromycin triple therapy with or without N -acetylcysteine in the eradication of Helicobacter pylori : a randomized controlled trial
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Gastroenterology Vol. 13 ( 2020-01), p. 175628482092730-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 13 ( 2020-01), p. 175628482092730-
    Abstract: Whether adjunctive N-acetylcysteine (NAC) may improve the efficacy of triple therapy in the first-line treatment of Helicobacter pylori infection remains unknown. Our aim was to compare the efficacy of 14-day triple therapy with or without NAC for the first-line treatment of H. pylori. Material and methods: Between 1 January 2014 and 30 June 2018, 680 patients with H. pylori infection naïve to treatment were enrolled in this multicenter, open-label, randomized trial. Patients were randomly assigned to receive triple therapy with NAC [NAC-T14, dexlansoprazole 60 mg four times daily (q.d.); amoxicillin 1 g twice daily (b.i.d.), clarithromycin 500 mg b.i.d., NAC 600 mg b.i.d.] for 14 days, or triple therapy alone (T14, dexlansoprazole 60 mg q.d.; amoxicillin 1 g b.i.d., clarithromycin 500 mg b.i.d.) for 14 days. Our primary outcome was the eradication rates by intention to treat (ITT). Antibiotic resistance and CYP2C19 gene polymorphism were determined. Results: The ITT analysis demonstrated H. pylori eradication rates in NAC-T14 and T14 were 81.7% [276/338, 95% confidence interval (CI): 77.5–85.8%] and 84.3% (285/338, 95% CI 80.4–88.2%), respectively. In 646 participants who adhered to their assigned therapy, the eradication rates were 85.7% and 88.0% with NAC-T14 and T14 therapies, respectively. There were no differences in compliance or adverse effects. The eradication rates in subjects with clarithromycin-resistant, amoxicillin-resistant, or either clarithromycin/amoxicillin resistant strains were 45.2%, 57.9%, and 52.2%, respectively, for NAC-T14, and were 66.7%, 76.9%, and 70.0%, respectively, for T14. The efficacy of NAC-T14 and T14 was not affected by CYP2C19 polymorphism. Conclusion: Add-on NAC to triple therapy was not superior to triple therapy alone for first-line H. pylori eradication [ClinicalTrials.gov identifier: NCT02249546].
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/1756284820927306
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2440710-0
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  • 5
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    Online Resource
    Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 7 ( 2020-07), p. 030006051987140-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 7 ( 2020-07), p. 030006051987140-
    Abstract: To detect the involvement of immune cells in the pathogenesis of endometriosis in patients with stable status or pelvic pain. Methods Blood was collected from patients with endometriosis with and without pelvic pain. Natural killer (NK) and Th17 cells were analyzed by flow cytometry, and secretion of inflammatory cytokines (tumor necrosis factor-α, interleukin (IL)-1β, IL-6, IL-7) was verified by enzyme-linked immunosorbent assay. We isolated immune cells from blood by density-gradient centrifugation to investigate the expression of functional molecules including sterile alpha motif domain-containing protein 9 (SAMD9), Ral guanine nucleotide dissociation stimulator-like 2 (RGL2), early growth response protein 1, and Akirin2. We also searched the BIOGPS database for protein expression profiles. Results SAMD9 and RGL2 expression levels were significantly upregulated in patients with pelvic pain. Furthermore, lysophosphatidic acid receptor 1 expression was higher in endometrial tissues from patients with pelvic pain, and was mainly localized in stromal and glandular epithelial cells in ectopic lesions. Conclusion NK cells play an important role in the pathogenesis of endometriosis in patients with pelvic pain. Suppressing the cytotoxic activity of NK cells may thus help to reduce the progression of pelvic pain in patients with endometriosis.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060519871407
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 6
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    Deciphering the Emerging Roles of Adipocytes and Adipose-Derived Stem Cells in Fat Transplantation
    SAGE Publications ; 2021
    In:  Cell Transplantation Vol. 30 ( 2021-01-01), p. 096368972199779-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 30 ( 2021-01-01), p. 096368972199779-
    Abstract: Autologous fat transplantation is widely regarded as an increasingly popular method for augmentation or reshaping applications in soft tissue defects. Although the fat transplantation is of simple applicability, low donor site morbidity and excellent biocompatibility, the clinical unpredictability and high resorption rates of the fat grafts remain an inevitable problem. In the sites of fat transplantation, the most essential components are the adipocyte and adipose-derived stem cells (ADSCs). The survival of adipocytes is the direct factor determining fat retention. The efficacy of fat transplantation is reduced by fat absorption and fibrosis due to the inadequate blood flow, adipocyte apoptosis and fat necrosis. ADSCs, a heterogeneous mixture of cells in adipose tissue, are closely related to tissue survival. ADSCs exhibit the ability of multilineage differentiation and remarkable paracrine activity, which is crucial for graft survival. This article will review the recent existing research on the mechanisms of adipocytes and ADSCs in fat transplantation, especially including adipocyte apoptosis, mature adipocyte dedifferentiation, adipocyte browning, ADSCs adipogenic differentiation and ADSCs angiogenesis. The in-depth understanding of the survival mechanism will be extremely valuable for achieving the desired filling effects.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689721997799
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2020466-8
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  • 7
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    Exploring the causal pathway from body mass index to coronary heart disease: a network Mendelian randomization study
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Chronic Disease Vol. 11 ( 2020-01), p. 204062232090904-
    Details
    In: Therapeutic Advances in Chronic Disease, SAGE Publications, Vol. 11 ( 2020-01), p. 204062232090904-
    Abstract: We applied a network Mendelian randomization (MR) framework to determine the causal association between body mass index (BMI) and coronary heart disease (CHD) and explored whether glycated hemoglobin (HbA1c) and lipid parameters (total cholesterol, TC; low-density lipoprotein cholesterol, LDL; high-density lipoprotein cholesterol, HDL; triglycerides, TG) serve as causal mediators from BMI to CHD by integrating summary-level genome-wide association study data. Methods: Network MR analysis, an approach using genetic variants as the instrumental variables for both the exposure and mediator to infer causality was performed. Summary statistics from the GIANT consortium were used ( n = 152,893) for BMI, CARDIoGRAMplusC4D consortium data were used ( n = 184,305) for CHD, Global Lipids Genetics Consortium data were used ( n = 108,363) for TC, LDL, HDL and TG, and MAGIC consortia data were used ( n = 108,363) for HbA1c. Results: The inverse-variance-weighted-method estimate indicated that the odds ratio (95% confidence interval) for CHD was 1.562 (1.391–1.753) per 1 standard deviation (kg/m 2 ) increase in BMI. Results were consistent in MR Egger method and weighted-median methods. MR estimate indicated that BMI was positively associated with HbA1c and TG, and negatively associated with HDL, but was not associated with TC or LDL. Moreover, HbA1c, TC, LDL, and TG were positively associated with CHD, yet there was no causal association between HDL and CHD. HbA1c was positively associated with TC, LDL, and HDL, but was not associated with TG. Conclusions: Higher BMI conferred an increased risk of CHD, which was partially mediated by HbA1c and lipid parameters. HbA1c and TG might be the main mediators in the link from BMI to CHD.
    Type of Medium: Online Resource
    ISSN: 2040-6223 , 2040-6231
    URL: Article
    DOI: 10.1177/2040622320909040
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2554816-5
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  • 8
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    T2 mapping in orbital masses: preliminary study on differential diagnostic ability of T2 relaxation time
    SAGE Publications ; 2020
    In:  Acta Radiologica Vol. 61, No. 5 ( 2020-05), p. 668-674
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 61, No. 5 ( 2020-05), p. 668-674
    Abstract: T2 mapping has been proven to be useful in tumor characterization. As to orbital masses, its diagnostic value needs to be investigated. Purpose To evaluate the usefulness of T2 mapping in orbital masses and the ability of T2 relaxation time in differentiating malignant from benign orbital masses. Material and Methods Forty-seven patients with solid orbital masses (33 benign and 14 malignant) who underwent T2 mapping examination for preoperative assessment were enrolled in the current study. T2 mapping was acquired using 16 TE values (range 12–192 ms; delta TE 12 ms). Mean T2 relaxation time was calculated based on the whole mass region of interest and compared between the malignant and benign groups using the unpaired t-test. Receiver operating characteristic curve analysis was adopted to calculate its diagnostic value. Results Malignant orbital masses showed significantly lower T2 relaxation time than benign masses (76.4 ± 13.0 ms vs. 119.1 ± 20.4 ms; P  〈  0.001). If setting a T2 relaxation time of 89.5 ms as the threshold value, optimal differentiating performance could be achieved (area under the curve 0.936; sensitivity 100.0%; specificity 87.9%; accuracy 91.5%; positive predictive value 77.8%; negative predictive value 100%). Conclusion T2 mapping and its derived T2 relaxation time could provide quantitative information and serve as a supplementary imaging marker for differentiating malignant from benign orbital masses.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185119874476
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2024579-8
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  • 9
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    Wound Documentation by Using 3G Mobile as Acquisition Terminal : An Appropriate Proposal for Community Wound Care
    SAGE Publications ; 2015
    In:  The International Journal of Lower Extremity Wounds Vol. 14, No. 2 ( 2015-06), p. 200-203
    Details
    In: The International Journal of Lower Extremity Wounds, SAGE Publications, Vol. 14, No. 2 ( 2015-06), p. 200-203
    Abstract: The increasing numbers of cases of wound disease are now posing a big challenge in China. For more convenience of wound patients, wound management in community health care centers under the supervision of a specialist at general hospitals is an ideal solution. To ensure an accurate diagnosis in community health clinics, it is important that “the same language” for wound description, which may be composed of unified format description, including wound image, must be achieved. We developed a wound information management system that was built up by acquisition terminal, wound description, data bank, and related software. In this system, a 3G mobile phone was applied as acquisition terminal, which could be used to access to the data bank. This documentation system was thought to be an appropriate proposal for community wound care because of its objectivity, uniformity, and facilitation. It also provides possibility for epidemiological study in the future.
    Type of Medium: Online Resource
    ISSN: 1534-7346 , 1552-6941
    URL: Article
    DOI: 10.1177/1534734614549925
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2135166-1
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  • 10
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    Histogram analysis of dynamic contrast-enhanced magnetic resonance imaging for differentiating malignant from benign orbital lymphproliferative disorders
    SAGE Publications ; 2019
    In:  Acta Radiologica Vol. 60, No. 2 ( 2019-02), p. 239-246
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 60, No. 2 ( 2019-02), p. 239-246
    Abstract: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been used for assessing orbital lymphoproliferative disorders (OLPDs). However, only the mean values of quantitative parameters were obtained in previous studies and tumor heterogeneity was ignored. Purpose To assess the value of DCE-MRI derived histogram parameters in differentiating malignant from benign OLPDs. Material and Methods Forty-eight OLPDs patients (25 malignant and 23 benign) who had undergone DCE-MRI for pre-treatment evaluation were retrospectively included. Histogram parameters of K trans , k ep , and v e were calculated and compared between two groups using the independent sample’s t-test. Receiver operating characteristic (ROC) curve analyses were used to determine the diagnostic value of each significant parameter. Multivariate stepwise logistic regression analysis was used to identify the independent predictors of malignant OLPDs. Results Tenth k ep , mean k ep , median k ep , and 90th k ep were significantly higher in the malignant OLPD group than in the benign OLPD group. Tenth v e was significantly lower in the malignant OLPD group than in the benign OLPD group. Ninetieth k ep was the only independent predictor of malignant OLPDs ( P = 0.019), with an area under ROC curve of 0.828, a sensitivity of 92.00%, and a specificity of 78.26% at a cut-off value of 1.057 min −1 . Conclusion Histogram analysis of DCE-MRI derived parameters may help to differentiate malignant from benign OLPDs. The 90th k ep hold the potential as an independent predictor for malignant OLPDs.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185118778873
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024579-8
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