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  • 1
    Online Resource
    Online Resource
    Radiation Therapy without Surgery for Spinal Metastases: Clinical Outcome and Prognostic Factors Analysis for Pain Control
    SAGE Publications ; 2012
    In:  Global Spine Journal Vol. 2, No. 3 ( 2012-09), p. 137-141
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 2, No. 3 ( 2012-09), p. 137-141
    Abstract: The purpose of radiation therapy (RT) for patients with spinal metastases is pain relief and control of paralysis. The aim of the present study was to assess pain relief using RT and to evaluate prognostic factors for pain control. We evaluated 97 consecutive patients, of mean age 62.7 years (range 28 to 86), with spinal metastases that had been treated by RT. We evaluated the effects of RT using pain level assessed using a drug grading scale based on the World Health Organization standards. The following potential prognostic factors for pain control of RT were evaluated using multivariate logistic regression analysis: age, gender, tumor type, performance status (PS), number of spinal metastases, and a history of chemotherapy. Among the 97 patients who underwent RT for pain relief, 68 patients (70.1%) presented with pain reduction. PS (odds ratio: 1.931; 95% confidence interval: 1.244 to 2.980) was revealed by multivariate logistic regression analysis to be the most important prognostic factor for pain control using RT. In conclusion, we found that RT was more effective for patients with spinal metastases while they maintained their PS.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1055/s-0032-1326948
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2648287-3
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  • 2
    Online Resource
    Online Resource
    High tartrate-resistant acid phosphatase (TRACP 5b) level in cystic fluid is a significant prognostic marker for postoperative recurrence in solitary bone cysts
    SAGE Publications ; 2022
    In:  Journal of Children's Orthopaedics Vol. 16, No. 6 ( 2022-12), p. 519-527
    Details
    In: Journal of Children's Orthopaedics, SAGE Publications, Vol. 16, No. 6 ( 2022-12), p. 519-527
    Abstract: The pathogenesis of cystic fluid storage in solitary bone cysts remains unclear. We aimed to compare the results of the biochemical analysis of cystic fluid with clinical findings. We identified a significant marker of postoperative recurrence. Methods: Twenty-seven male and eight female patients were studied; the median age at diagnosis was 11 (5–23) years. The mean follow-up period was 60 months (range: 14–146 months). Clinical information including sex, age, affected site, radiological findings of phase (active or latent), surgical procedure, outcome, and biochemical analysis of serum and cystic fluid was obtained. Results: The 5-year healing rate was 64.0%. Biochemical analysis revealed that total protein and albumin values in the cystic fluid were significantly lower, compared to those in the serum. Levels of bone turnover markers, such as alkaline phosphatase, bone-specific alkaline phosphatase, and tartrate-resistant acid phosphatase 5b were remarkably elevated in the cystic fluid than in the serum. R values were 0.127, 0.076, and 0.095 for alkaline phosphatase, bone-specific alkaline phosphatase, and tartrate-resistant acid phosphatase 5b, respectively. Areas under the receiver operating characteristic curves, calculated to assess the association of alkaline phosphatase, bone-specific alkaline phosphatase, and tartrate-resistant acid phosphatase 5b levels in the cystic fluid with postoperative recurrence, were 0.57, 0.51, and 0.70, respectively. Conclusions: No clear correlation of bone turnover marker levels between the serum and cystic fluid was observed. The high tartrate-resistant acid phosphatase 5b level in the cystic fluid was associated with postoperative recurrence. The bone resorption caused by osteoclasts is considered to affect postoperative recurrence. Level of evidence: Level IV.
    Type of Medium: Online Resource
    ISSN: 1863-2521 , 1863-2548
    URL: Article
    DOI: 10.1177/18632521221129368
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2268264-8
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  • 3
    Online Resource
    Online Resource
    A Case Report of Surgical Debulking for a Huge Mass of Elephantiasis Neuromatosa
    SAGE Publications ; 2009
    In:  Rare Tumors Vol. 1, No. 1 ( 2009-07-14), p. 7-8
    Details
    In: Rare Tumors, SAGE Publications, Vol. 1, No. 1 ( 2009-07-14), p. 7-8
    Abstract: Achievement of a safe outcome for an extensive mass with hypervascularity in the extremities requires a surgical team skilled in musculoskeletal oncology. We report debulking surgery for a huge mass of elephantiasis neuromatosa in the right leg of a 56-year old man using the novel Ligasure ® vessel sealing system.
    Type of Medium: Online Resource
    ISSN: 2036-3613 , 2036-3613
    URL: Article
    DOI: 10.4081/rt.2009.e11
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2514363-3
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  • 4
    Online Resource
    Online Resource
    A Case of Dedifferentiated Liposarcoma Showing a Biphasic Pattern on 2-Deoxy-2-F 18 -Fluoro-D-Glucose Positron Emission Tomography/Computed Tomography
    SAGE Publications ; 2013
    In:  Rare Tumors Vol. 5, No. 2 ( 2013-06-07), p. 95-97
    Details
    In: Rare Tumors, SAGE Publications, Vol. 5, No. 2 ( 2013-06-07), p. 95-97
    Abstract: Integrated 2-deoxy-2-F 18 -fluoro-D-glucose positron emission tomography combined with computed tomography (FDG-PET/CT) has been used in the field of soft tissue sarcoma. We report an 81-year-old man with dedifferentiated liposarcoma in the left thigh, which was composed of well-differentiated liposarcoma and pleomorphic malignant fibrous histiocytoma. As well as other radiological modalities, FDG-PET was able to demonstrate a biphasic signal pattern composed of well-differentiated liposarcoma and dedifferentiated area, being consistent with the histological grade of malignancy.
    Type of Medium: Online Resource
    ISSN: 2036-3613 , 2036-3613
    URL: Article
    DOI: 10.4081/rt.2013.e26
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2514363-3
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  • 5
    Online Resource
    Online Resource
    A Comparative Study of Clinicopathological Features Between Simple Bone Cysts of the Calcaneus and the Long Bone
    SAGE Publications ; 2014
    In:  Foot & Ankle International Vol. 35, No. 4 ( 2014-04), p. 374-382
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 35, No. 4 ( 2014-04), p. 374-382
    Abstract: The potential unrevealed clinicopathological differences between simple bone cysts situated in the calcaneus (calcaneal bone cysts) and those situated in long bones (long bone cysts) were investigated in the present study. Methods: A total of 41 cysts from 41 patients who underwent operative treatment were evaluated: 16 cysts in the calcaneus, 17 in the humerus, 7 in the femur, and 1 in the tibia. The clinical course, radiological findings, and histological features were retrospectively reviewed. Results: The mean patient age was 11.5 years (range, 3 to 25 years), and the mean follow-up was 33.0 months (range, 12 to 77 months). The mean patient age was significantly higher in patients with calcaneal bone cysts (13.5 years; long bone cysts, 10.2 years, P 〈 .05). No treatment failure was seen for patients with calcaneal bone cysts, while 7 long bone cysts required reoperation. In H & E-stained specimens of the cyst wall, cholesterol clefts were identified in 10 of the 16 calcaneal bone cysts (62.5%), whereas none were identified in long bone cysts (0%; P 〈 .0001). Conclusion: Our study elucidates the different clinicopathological features existing between calcaneal bone cysts and long bone cysts. Cholesterol clefting is most likely due to hemorrhaging and the subsequent breakdown of blood in the cyst. The significance of these differences between long bone and calcaneal cysts is still open to conjecture. Level of Evidence: Level III, retrospective comparative series.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.1177/1071100713519600
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2129503-7
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