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  • 1
    Online Resource
    Online Resource
    Rare Autosomal Dominant POLG1 Mutation in a Family With Metabolic Strokes, Posterior Column Spinal Degeneration, and Multi-Endocrine Disease
    SAGE Publications ; 2010
    In:  Journal of Child Neurology Vol. 25, No. 6 ( 2010-06), p. 752-756
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 25, No. 6 ( 2010-06), p. 752-756
    Abstract: DNA POLG is the only mitochondrial DNA polymerase and is encoded by nuclear DNA. Depending on the location and inheritance, mutations in POLG1, the catalytic subunit, can cause symptoms including severe infantile epilepsy, metabolic strokes, chronic ataxia, neuropathy, and ophthalmoplegia. We reviewed medical records and conducted extensive interviews with the family of identical twin probands with a mutation in the linker region of DNA polymerase gamma 1 (POLG1) (G517V) and discuss postmortem findings from their grandmother. Both twins developed type I diabetes, adrenal insufficiency, hypothyroidism, and psychiatric problems in addition to neurological difficulties including bilateral basal ganglia infarcts, headaches, and seizures. The maternal grandmother, now deceased, had psychosis and balance problems, and postmortem findings include lacunar infarcts in the basal ganglia (caudate nucleus, putamen, and globus pallidus) and posterior spinal column degeneration. We discuss novel aspects of their presentation and implications for practice.
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/0883073809343313
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 639288-X
    detail.hit.zdb_id: 2068710-2
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  • 2
    Online Resource
    Online Resource
    A Chimpanzee ( Pan troglodytes ) Model of Triarchic Psychopathy Constructs : Development and Initial Validation
    SAGE Publications ; 2016
    In:  Clinical Psychological Science Vol. 4, No. 1 ( 2016-01), p. 50-66
    Details
    In: Clinical Psychological Science, SAGE Publications, Vol. 4, No. 1 ( 2016-01), p. 50-66
    Abstract: The current work sought to operationalize constructs of the triarchic model of psychopathy in chimpanzees ( Pan troglodytes), a species well suited for investigations of basic biobehavioral dispositions relevant to psychopathology. Across three studies, we generated validity evidence for scale measures of the triarchic model constructs in a large sample ( N = 238) of socially housed chimpanzees. Using a consensus-based rating approach, we first identified candidate items for the chimpanzee triarchic (CHMP-Tri) scales from an existing primate personality instrument and refined these into scales. In Study 2, we collected data for these scales from human informants ( N = 301) and examined their convergent and divergent relations with scales from another triarchic inventory developed for human use. In Study 3, we undertook validation work examining associations between CHMP-Tri scales and task measures of approach-avoidance behavior ( N = 73) and ability to delay gratification ( N = 55). Current findings provide support for a chimpanzee model of core dispositions relevant to psychopathy and other forms of psychopathology.
    Type of Medium: Online Resource
    ISSN: 2167-7026 , 2167-7034
    URL: Article
    DOI: 10.1177/2167702615568989
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2723286-4
    detail.hit.zdb_id: 2682220-9
    SSG: 5,2
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  • 3
    Online Resource
    Online Resource
    Mindfulness-Based Interventions Targeting Modifiable Lifestyle Behaviors Associated With Brain Health: A Systematic Review and Meta-Analysis
    SAGE Publications ; 2024
    In:  American Journal of Lifestyle Medicine
    Details
    In: American Journal of Lifestyle Medicine, SAGE Publications
    Abstract: A systematic review and meta-analysis investigated randomized clinical trials (RCTs) of mindfulness-based interventions (MBIs) targeting lifestyle behaviors commonly associated with brain health in adults. Data sources included Ovid Medline, Ovid PsycINFO, CINAHL [EBSCO], Embase, Cochrane Library [Ovid] , Web of Science, and https://ClinicalTrials.gov . Studies were screened using Covidence 2.0. A total of 79 published RCTs of MBIs for adults (18+, patient and non-patient populations) targeting one or more lifestyle behavior (physical activity, sleep, diet, alcohol use, tobacco cessation, and social and mental activities) met eligibility criteria. MBIs were associated with reduced sleep disturbance (40/54 RCTs; 3537 participants; SMD = −.53; 95% CI = −.74 to −.32; I 2 = 78%), increased physical activity (9/17 RCTs analyzed; 685 participants; SMD = .72; 95% CI = .04 to 1.40; I 2 = 89%), improved tobacco cessation (8/12 RCTs; 1234 participants; OR = 2.11; 95% CI = 1.12 to 3.97; I 2 = 55%), and lowered alcohol use (4/6 RCTs; 261 participants; SMD = −.39; 95% CI = −.45 to −.32; I 2 = 0%). This review found moderate to high-quality evidence for MBIs targeting sleep, physical activity, alcohol use, and tobacco cessation. Heterogeneity for these outcomes and insufficient data to analyze diet, mental activities, and cognitive functioning limit our ability to draw definitive conclusions about the effects of MBIs on brain health.
    Type of Medium: Online Resource
    ISSN: 1559-8276 , 1559-8284
    URL: Article
    DOI: 10.1177/15598276241230467
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2265653-4
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  • 4
    Online Resource
    Online Resource
    Randomized controlled trial of an e-learning designed behavioral intervention for increasing physical activity behavior in multiple sclerosis
    SAGE Publications ; 2017
    In:  Multiple Sclerosis Journal - Experimental, Translational and Clinical Vol. 3, No. 4 ( 2017-12), p. 205521731773488-
    Details
    In: Multiple Sclerosis Journal - Experimental, Translational and Clinical, SAGE Publications, Vol. 3, No. 4 ( 2017-12), p. 205521731773488-
    Abstract: Internet-delivered, behavioral interventions represent a cost-effective, broadly disseminable approach for teaching persons with multiple sclerosis (MS) the theory-based skills, techniques, and strategies for changing physical activity. Objectives This pilot, randomized controlled trial examined the efficacy of a newly developed Internet website based on e-learning approaches that delivered a theory-based behavior intervention for increasing physical activity and improving symptoms, walking impairment, and neurological disability. Methods Participants with MS ( N = 47) were randomly assigned into behavioral intervention ( n = 23) or waitlist control ( n = 24) conditions delivered over a six-month period. Outcomes were administered before and after the six-month period using blinded assessors, and data were analyzed using analysis of covariance in SPSS. Results There was a significant, positive intervention effect on self-reported physical activity ( P = 0.05, [Formula: see text]   = 0.10), and non-significant improvement in objectively measured physical activity ( P = 0.24, [Formula: see text]   = 0.04). There were significant, positive effects of the intervention on overall ( P = 0.018, [Formula: see text]   = 0.13) and physical impact of fatigue ( P = 0.003, [Formula: see text]   = 0.20), self-reported walking impairment ( P = 0.047, [Formula: see text]   = 0.10), and disability status ( P = 0.033, [Formula: see text]   = 0.11). There were non-significant improvements in fatigue severity ( P = 0.10, [Formula: see text]   = 0.06), depression ( P = 0.10, [Formula: see text]   = 0.07) and anxiety ( P = 0.06, [Formula: see text]   = 0.09) symptoms, and self-reported disability ( P = 0.10, [Formula: see text]   = 0.07). Conclusions We provide evidence for the efficacy of an Internet-based behavioral intervention with content delivered through interactive video courses grounded in e-learning principles for increasing physical activity and possibly improving secondary outcomes of fatigue, depression, anxiety, and walking impairment/disability in persons with MS.
    Type of Medium: Online Resource
    ISSN: 2055-2173 , 2055-2173
    URL: Article
    DOI: 10.1177/2055217317734886
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2841884-0
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