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  • 1
    Online Resource
    Online Resource
    Association between Coarse Particulate Matter (PM 10-2.5 ) and Nasopharyngeal Carcinoma among Taiwanese Men
    SAGE Publications ; 2020
    In:  Journal of Investigative Medicine Vol. 68, No. 2 ( 2020-02), p. 419-424
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 68, No. 2 ( 2020-02), p. 419-424
    Abstract: The nasopharyngeal tract traps mainly coarse particles in inhaled air. Soluble carcinogenic compounds, endotoxins, and trace metals contained in these particles are potential causes of inflammation and oxidative stress which could enhance carcinogenesis. The aim of this study was to determine the association between coarse particulate matter (PM 10-2.5 ) and nasopharyngeal cancer (NPC). A total of 521,098 men (355 cases and 520,743 non-cases), aged ≥40 years were included in this study. Data were retrieved from the Taiwan Cancer Registry, the Adult Preventive Medical Services Database, and the Air Quality Monitoring Database. PM 10-2.5 was significantly associated with a higher risk of NPC after adjusting for SO 2 , NOx, O 3 , age, body mass index, smoking, alcohol drinking, betel nut chewing, exercise, hypertension, diabetes, and hyperlipidemia. With PM 10-2.5 〈 20.44 μg/m 3 as the reference, the ORs and 95% CIs were 1.47; 1.03–2.11, 1.34; 0.94–1.91, and 1.68; 1.16–2.44 for 20.44≤PM 10-2.5 〈 24.08, 24.08≤PM 10-2.5 〈 29.27, and PM 10-2.5 ≥29.27 μg/m 3 , respectively. PM 10-2.5 remained significantly associated with a higher risk of NPC after further adjustments were made for the aforementioned covariates and PM 2.5 . The ORs; 95% CIs were 1.42; 0.96 to 2.12, 1.41; 0.94 to 2.10, and 1.71; 1.10 to 2.66 for 20.44≤PM 10-2.5 〈 24.08, 24.08≤PM 10-2.5 〈 29.27, and PM 10-2.5 ≥29.27 μg/m 3 , respectively. In conclusion, PM 10-2.5 was significantly associated with a higher risk of NPC in Taiwanese men.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1136/jim-2019-001119
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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  • 2
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    Graph theoretical analysis of functional networks and its relationship to cognitive decline in patients with carotid stenosis
    SAGE Publications ; 2016
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 36, No. 4 ( 2016-04), p. 808-818
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 36, No. 4 ( 2016-04), p. 808-818
    Abstract: Significant carotid stenosis compromises hemodynamics and impairs cognitive functions. The interplay between these changes and brain connectivity has rarely been investigated. We aimed to discover the changes of functional connectivity and its relation to cognitive decline in carotid stenosis patients. Twenty-seven patients with unilateral carotid stenosis (≥60%) and 20 age- and sex-matched controls underwent neuropsychological tests and resting-state functional magnetic resonance imaging. The patients also received perfusion magnetic resonance imaging. The relationships between cognitive function and functional networks among the patients and controls were evaluated. Graph theory was applied on resting-state functional magnetic resonance imaging network analysis, which revealed that the hemispheres ipsilateral to the stenosis were significantly impaired in “degree” and “global efficiency.” The neuropsychological performances were positively correlated with degree, clustering coefficient, local efficiency, and global efficiency, and negatively correlated with characteristic path length, modularity, and small-worldness in the patients, whereas these relationships were not observed in the controls. In this study, we identified the networks that were impaired in the affected hemispheres in patients with carotid stenosis. Specific indices (global efficiency, characteristic path length, and modularity) were highly correlated with neuropsychological performance in our patients. Analysis of brain connectivity may help to elucidate the relationship between hemodynamic impairment and cognitive decline.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1177/0271678X15608390
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2039456-1
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  • 3
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    Shared decision-making and patient decision aids in choosing first-line targeted therapy for metastatic colorectal cancer in Taiwan
    SAGE Publications ; 2022
    In:  Journal of Oncology Pharmacy Practice Vol. 28, No. 6 ( 2022-09), p. 1293-1302
    Details
    In: Journal of Oncology Pharmacy Practice, SAGE Publications, Vol. 28, No. 6 ( 2022-09), p. 1293-1302
    Abstract: In Taiwan, given the discrepancy between current treatment guidelines and reimbursement options, patients might require a tool to support their decision-making process when selecting a regimen for metastatic colorectal cancer, especially therapeutic strategies, and subsequent costs, along with efficacy and safety outcomes. Therefore, we developed a patient decision aid (PDA) to support patients in choosing between treatment options recommended based on the current evidence and those reimbursed by the Taiwanese National Health Insurance. Methods By carefully reviewing the updated data and then interpreting the clinical tool, we conducted a needs assessment using a serial questionnaire to test for a step-by-step adjustment of the PDA. Results Patients, their relatives, and medical team members were most concerned about outcomes, such as overall survival, progression-free survival, objective response rate, tumor shrinkage to resectable status, total medical cost, severe gastrointestinal perforation, and severe skin reaction. After a serial alpha test for quality, we performed quantitative evaluation and beta tests, revealing average scores of more than 4 points (on a scale of 1–5) for both perceptibility and utility. Conclusions The present findings suggest that PDAs are useful and supplement the shared decision-making practice, helping patients make decisions about preferences and consider the pros and cons of treatment regimens, along with insurance reimbursement options.
    Type of Medium: Online Resource
    ISSN: 1078-1552 , 1477-092X
    URL: Article
    DOI: 10.1177/10781552211020806
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2026590-6
    SSG: 15,3
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  • 4
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    Association of dipeptidyl peptidase-4 inhibitor use and the risk of asthma development among type 2 diabetes patients
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Respiratory Disease Vol. 16 ( 2022-01), p. 175346662211353-
    Details
    In: Therapeutic Advances in Respiratory Disease, SAGE Publications, Vol. 16 ( 2022-01), p. 175346662211353-
    Abstract: Numerous studies have shown that dipeptidyl peptidase-4 inhibitors (DPP-4i) may regulate immunological pathways implicated in asthma. The association between DPP-4i use and risk of asthma development is limited, however. Aim: We aimed to evaluate if DPP-4i treatment in individuals with type 2 diabetes mellitus (T2DM) is associated with a lower risk and severity of asthma. Methods: We performed a population-based retrospective cohort study using the Longitudinal National Health Insurance Research database between 2008 and 2015. After one-to-four propensity score matching from 1,914,201 patients with defined criteria, we enrolled 3001 patients who were on DPP-4i (DPP-4i group) for a diagnosis of T2DM but without a diagnosis of asthma for further analysis. Cox proportional hazards regression analysis was performed to estimate and compare the risk of developing and severity of asthma, including no acute exacerbations event (No-AE), acute exacerbations (AEs), status asthmaticus (Status), and required endotracheal intubation (ET-tube intubated), between the two groups. Results: The participants had a mean age of 66.05 ± 17.23 years and the mean follow-up time was 4.96 ± 4.39 years. The risk of asthma development was significantly lower in the DPP-4i group than in the non-DPP-4i group [adjusted hazard ratio (HR) = 0.65; 95% confidence interval (CI) = 0.29–0.83; p  〈  0.001], with a class effect. This trend was observed for severity of asthma as No-AE (HR = 0.55; 95% CI = 0.24–0.70; p  〈  0.001), AE (HR = 0.57; 95% CI = 0.26–0.73; p  〈  0.001), and Status (HR = 0.78; 95% CI = 0.35–0.99; p = 0.047), but not in ET-tube intubated cases (HR = 0.96; 95% CI = 0.43–1.22; p = 0.258). Conclusion: The use of DPP-4i decreased the risk and severity of asthma with a class effect among No-AE, AE, status of asthma events, but not in ET-tube intubated events. Our report suggests that DPP-4i may play a role in attenuating the impact of asthma on incidence in the future and on more severe forms of disease exacerbation in T2DM patients.
    Type of Medium: Online Resource
    ISSN: 1753-4666 , 1753-4666
    URL: Article
    DOI: 10.1177/17534666221135320
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2387506-9
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  • 5
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    Self-Organized Cognitive Sensor Networks: Distributed Channel Assignment for Pervasive Sensing
    SAGE Publications ; 2014
    In:  International Journal of Distributed Sensor Networks Vol. 10, No. 3 ( 2014-03-01), p. 183090-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 10, No. 3 ( 2014-03-01), p. 183090-
    Abstract: We study the channel assignment strategy in multichannel wireless sensor networks (WSNs) where macrocells and sensor nodes are overlaid. The WSNs dynamically access the licensed spectrum owned by the macrocells to provide pervasive sensing services. We formulate the channel assignment problem as a potential game which has at least one pure strategy Nash equilibrium (NE). To achieve the NE, we propose a stochastic learning-based algorithm which does not require the information of other players’ actions and the time-varying channel. Cluster heads as players in the game act as self-organized learning automata and adjust assignment strategies based on their own action-reward history. The convergence property of the proposed algorithm toward pure strategy NE points is shown theoretically and verified numerically. Simulation results demonstrate that the learning algorithm yields a 26% sensor node capacity improvement as compared to the random selection, and incurs less than 10% capacity loss compared to the exhaustive search.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1155/2014/183090
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2192922-1
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  • 6
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    Composition and Antifungal Activities of the Leaf Essential oil of Litsea Coreana from Taiwan
    SAGE Publications ; 2010
    In:  Natural Product Communications Vol. 5, No. 10 ( 2010-10), p. 1934578X1000501-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 5, No. 10 ( 2010-10), p. 1934578X1000501-
    Abstract: The hydrodistilled leaf essential oil of Litsea coreana was analyzed by GC/FID and GC/MS. Fifty-two compounds were identified, the main components being n-decanal (27.5%), 2 E,6 E-farnesol (25.8%), β-eudesmol (10.3%), ethyl n-dodecanoate (8.0%) and τ-cadinol (6.6%). Oxygenated sesquiterpenes (56.8%) and non-terpenoids (37.0%) were the predominant groups of compounds. The leaf oil exhibited excellent antifungal and anti-wood-decay fungal activities.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1000501033
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 7
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    Quality of Life in Patients With Pulmonary Hypertension
    SAGE Publications ; 2023
    In:  Clinical Nursing Research Vol. 32, No. 3 ( 2023-03), p. 539-548
    Details
    In: Clinical Nursing Research, SAGE Publications, Vol. 32, No. 3 ( 2023-03), p. 539-548
    Abstract: We explored positive and negative affect, quality of life (QOL), and associated factors in patients with pulmonary hypertension. We conducted this cross-sectional study using convenience sampling at a medical center in Taiwan. We used the Social Support Scale, positive and negative affect scale, and Short Form 36-item Health Survey to collect data. In these patients, greater social support was associated with less negative affect and better QOL (mental components). Lower Borg dyspnea scores or greater distances in the six-minute walk test were associated with more positive affect, less negative affect, and better QOL (both physical and mental components). Patients with less negative affect and more positive affect had better QOL (mental components). Therefore, nursing staff should routinely monitor the emotional status and QOL of patients with pulmonary hypertension, especially those with less social support and poorer cardiopulmonary function. Strengthening these aspects may improve patients’ emotional status and QOL.
    Type of Medium: Online Resource
    ISSN: 1054-7738 , 1552-3799
    URL: Article
    DOI: 10.1177/10547738221096558
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2034682-7
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  • 8
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    Online Resource
    Predictive Factors and Audiometric Outcome Comparison Between Titanium Prosthesis and Autologous Incus in Traumatic Ossicular Injury
    SAGE Publications ; 2023
    In:  Annals of Otology, Rhinology & Laryngology
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications
    Abstract: To investigate the etiology and ossicular pathology of traumatic ossicular injury in Taiwan and examine the hearing outcomes and predictive factors between the titanium prosthesis and autologous incus groups. Methods: We retrospectively analyzed patients with traumatic ossicular injury from 2011 to 2020 in Taiwan. Patients were divided into the titanium or autologous group according to the surgical materials used. The audiometric outcomes and predictive factors of ossiculoplasty were analyzed between groups. Results: Twenty patients with ossicular chain discontinuity were enrolled (8 in the titanium group and 12 in the autologous group). The postoperative hearing threshold (26.6 ± 8.9 dB) and air-bone gap (10.3 ± 5.6 dB) improved significantly compared with the preoperative hearing threshold (50.7 ± 13.3 dB) and air-bone gap (29.9 ± 11.0 dB). The improvements in the hearing threshold and air-bone gap were not significantly different between the titanium and autologous groups. Our patients presented an improvement in hearing restoration with 65% closure of the air-bone gap in 0 to 10 dB range and 30% in 11 to 20 dB range, without sensorineural hearing loss during surgery. Univariate regression analysis revealed that vertigo, benign paroxysmal positional vertigo, and temporal bone fracture may serve as negative factors influencing the air-bone gap gain. Conclusions: Ossiculoplasty with both titanium prosthesis and autologous materials demonstrated favorable hearing recovery in traumatic ossicular injury. Vertigo, benign paroxysmal positional vertigo, and temporal bone fracture may serve as negative predictive factors of the hearing benefit after surgery.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/00034894231181746
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2033055-8
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  • 9
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    Downregulation of Calreticulin and Annexin A2 Expression in Acquired Middle Ear Cholesteatoma by 2-DE Analysis
    SAGE Publications ; 2023
    In:  Annals of Otology, Rhinology & Laryngology Vol. 132, No. 6 ( 2023-06), p. 684-691
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 132, No. 6 ( 2023-06), p. 684-691
    Abstract: Many factors are thought to be associated with the development of cholesteatoma, while the mechanisms of its formation remain unclear. This study aimed to identify the potential mechanisms of the proliferation and growth of cholesteatoma by analysis of the differential expressions of proteins in cholesteatoma and retroauricular skin tissue collected from the same patients. Methods: The present study is a retrospective study performed in an academic medical center. Comparative proteomics analyses using two-dimensional gel electrophoresis (2-DE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), in addition to immunohistochemical analysis, were conducted to identify differentially-expressed proteins in cholesteatoma tissue as compared with retroauricular skin tissue. Western blotting was also employed to verify the expression patterns of the specific proteins identified by 2-DE and to measure the changes in potential modulators related to cholesteatoma proliferation and growth. Results: Calreticulin (CRT) and annexin A2 (AnxA2) were identified as being differentially-expressed in cholesteatoma by 2-DE and LC-MS/MS, the results of which were in agreement with the results of immunohistochemical analysis and western blotting. Downregulation of CRT and AnxA2 were observed in cholesteatoma. Conclusion: Our data suggests that CRT and AnxA2 downregulation are seen in cholesteatoma compared to retroauricular skin. We speculate that the reduced expression of CRT and the persistent inflammatory response play important roles in the epithelial proliferation of cholesteatoma.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/00034894221111255
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
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  • 10
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    Cerebral Microvascular Damage Occurs Early after Hypoxia–Ischemia via nNOS Activation in the Neonatal Brain
    SAGE Publications ; 2014
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 34, No. 4 ( 2014-04), p. 668-676
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 34, No. 4 ( 2014-04), p. 668-676
    Abstract: Microvascular injury early after hypoxic ischemia (HI) may contribute to neonatal brain damage. N-methyl-D-aspartate receptor overstimulation activates neuronal nitric oxide synthases (nNOS). We hypothesized that microvascular damage occurs early post-HI via nNOS activation and contributes to brain injury. Postpartum day-7 rat pups were treated with 7-nitroindazole (7-NI) or aminoguanidine (AG) before or after HI. Electron microscopy was performed to measure neuronal and endothelial cell damage. There were vascular lumen narrowing at 1 hour, pyknotic neurons at 3 hours, and extensive neuronal damage and loss of vessels at 24 hours post HI. Early after reoxygenation, there were neurons with heterochromatic chromatin and endothelial cells with enlarged nuclei occluding the lumen. There was also increased 3-nitrotyrosin in the microvessels and decreased cerebral blood perfusion. 7-NI and AG treatment before hypoxia provided complete and partial neuroprotection, respectively. Early post-reoxygenation, the AG group showed significantly increased microvascular nitrosative stress, microvascular interruptions, swollen nuclei that narrowed the vascular lumen, and decreased cerebral perfusion. The 7-NI group showed significantly decreased microvascular nitrosative stress, patent vascular lumen, and increased cerebral perfusion. Our results indicate that microvascular damage occurs early and progressively post HI. Neuronal nitric oxide synthases activation contributes to microvascular damage and decreased cerebral perfusion early after reoxygenation and worsens brain damage.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1038/jcbfm.2013.244
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2039456-1
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