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  • SAGE Publications  (2)
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  • SAGE Publications  (2)
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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 1992
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 12, No. 2 ( 1992-04), p. 252-256
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 12, No. 2 ( 1992-04), p. 252-256
    Abstract: Oxidative cell damage due to the production of free radical species has been implicated in the pathogenesis of cardiovascular disease for which dialysis patients are at increased risk. Plasma lipid peroxides (malon-dialdehyde), the antioxidants plasma albumin thiol, and red cell superoxide dismutase (SOD) were therefore measured in 18 patients undergoing continuous ambulatory peritoneal dialysis (CAPD), 20 hemodialysis patients, and 30 normal controls. Setting Renal dialysis unit. Results Malondialdehyde(MDA)concentrationswere significantly higher in dialysis patients compared to controls (p 〈 0.001 ) and were significantly higher in CAPD patients compared to hemodialysis patients, p 〈 0.001 (CAPD, median and range: 11.25 (8.4–15.5) nmol/mL; hemodialysis: 8.75 (7.0–12.6) nmol/mL; controls: 6.65 (5.2–9.6) nmol/mL). Plasma thiol and red cell SOD were significantly lower in dialysis patients compared to controls, but there was no significant difference between CAPD and hemodialysis patients (CAPD thiol: 333.5 (282480) μmol/L; hemodialysis thiol: 344 (203–468) μmol/L; control thiol: 421.5 (351 -504) μmol/L; CAPD SOD: 78.2 (42.4 -112.8) u//2 mL red cells; hemodialysis SOD: 89.4 (44.6–121.1) u//2 mL red cells; control SOD: 96.8 (66.8153.4) u//2 mL red cells). Red cell SOD was significantly negatively correlated with duration of dialysis in CAPD patients (r=-0.683, p 〈 0.01 ). Conclusion In dialysis patients there is indirect evidence for increased free radical activity, which may be further influenced by the mode of dialysis.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1992
    detail.hit.zdb_id: 2075957-5
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2021
    In:  Journal of Medical Education and Curricular Development Vol. 8 ( 2021-01), p. 238212052199115-
    In: Journal of Medical Education and Curricular Development, SAGE Publications, Vol. 8 ( 2021-01), p. 238212052199115-
    Abstract: The Covid-19 pandemic is a public health emergency with both physical and mental health risks. Medical students have baseline elevated rates of anxiety, depression and burnout. As such, they may be especially susceptible to the psychological stresses of Covid-19. The current study aimed to evaluate the prevalence of anxiety and depression among United States medical students during the Covid-19 pandemic. Methods: A cross-sectional, survey-based study collected demographic data as well as the 7-item Generalized Anxiety Disorder (GAD-7) and the 9-item Patient Health Questionnaire (PHQ-9) to assess anxiety and depression symptoms, respectively. The survey was administered from April 13, 2020 to April 28, 2020 amidst the height of the Covid-19 pandemic. Results: A total of 1,428 students from 40 US medical schools completed the survey. From those surveyed, 30.6% and 24.3% of respondents screened positive for anxiety and depression, respectively. Median GAD-7 scores were higher among females (7.0 vs 5.0, P  〈  .00001), pre-clinical students (7.0 vs 6.0, P  〈  .00004), and those with a friend or relative diagnosed with Covid-19 (7.0 vs 6.0, P=.001). Median PHQ-9 scores were higher among females (6.0 vs 4.0, P  〈  .00001) and pre-clinical students (6.0 vs 4.0, P  〈  .00001). Conclusion: When compared to previous medical student studies, these results are 61% higher for anxiety and 70% higher for depression during the Covid-19 era. The current study suggests that there should be a heightened awareness of and sensitivity to student’s mental health during the Covid-19 pandemic with certain cohorts at greater potential risk.
    Type of Medium: Online Resource
    ISSN: 2382-1205 , 2382-1205
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2798123-X
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