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  • SAGE Publications  (2)
  • 1
    Online Resource
    Online Resource
    Clinical Evaluation of a New High-Flux Cellulose Acetate Membrane
    SAGE Publications ; 1989
    In:  The International Journal of Artificial Organs Vol. 12, No. 2 ( 1989-02), p. 85-90
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 12, No. 2 ( 1989-02), p. 85-90
    Abstract: One major goal of dialysis therapy has become the removal of ß2-microglobulin (ß2-m). The interdialytic elimination of ß2-m was studied using a newly developed high-flux cellulose acetate (CA) membrane. The results show that high-flux CA dialyzers offer better biocompatibility than classical Cuprophan or high-flux Cuprophan devices, with regard to leukopenia, C3a desarg generation, and elastase release from polymorphonuclear (PMN) leukocytes. Compared to high-flux CA membranes, high-flux PMMA membranes induce less C3a desarg formation but comparable leukopenia. High-flux PMMA membranes, however cause greater leukocyte stimulation than CA as demonstrated by more PMN elastase release during hemodialysis. Using high-flux CA or high-flux PMMA membranes, serum ß2-m levels decreased 32% during dialysis. Serum ß2-m dropped 10% with high-flux Cuprophan membranes, but remained unchanged with conventional Cuprophan dialyzers. Sieving coefficients for ß2-microglobulin (ß2-m) were virtually zero with classical Cuprophan and 0.66 with high-flux cellulose acetate membranes. High-flux membranes made of Cuprophan and PMMA gave coefficients of 0.25 and 0.45, respectively. This indicates the high removal capacity of the new CA-membrane for substances with high molecular weight. This high-flux CA membrane thus appears to combine a good degree of biocompatibility with a high capacity for ß2-m removal.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/039139888901200204
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1989
    detail.hit.zdb_id: 1474999-3
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Effectiveness and Safety of Recombinant Human Erythropoietin (r-HuEPO) in the Treatment of Anemia of Chronic Renal Failure in Non Dialysis Patients
    SAGE Publications ; 1994
    In:  The International Journal of Artificial Organs Vol. 17, No. 4 ( 1994-04), p. 195-202
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 17, No. 4 ( 1994-04), p. 195-202
    Abstract: Seventy-five non-dialized patients with chronic renal failure (CRF) and severe renal anemia were enrolled in a study, receiving r-HuEPO subcutaneously thrice weekly for 6 months. In 64 patients (85%) 7 weeks of treatment with a weekly dose of 158 U/kg were required to achieve Hb concentrations within the target range of 10 to 12 g/dl. Of the 11 patients (15%) who failed to achieve the target Hb range, none were considered to be non-responders as they were excluded for unrelated reasons prior to week 16 (8 cases), or were iron deficient (2 cases), or had bleeding complications (1 patient). Maintaining the Hb concentration at a level of 10.5 g/dl required a mean r-HuEPO dose of 92 U/kg per week. Adverse events were generally mild or moderate. The most commonly reported were hypertension (8%), viral infection/including flu-like syndrome (7%), nausea (7%), and dizziness (5%). Statistically significant increases in mean creatinine concentrations observed after 12 and 24 weeks were most likely due to the progression of renal disease. These results confirm that 50 U/kg of r-HuEPO given 3 times per week subcutaneously provide a safe and effective therapy for anemic predialysis patients.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/039139889401700402
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1994
    detail.hit.zdb_id: 1474999-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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