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  • SAGE Publications  (117)
  • 1
    Online Resource
    Online Resource
    Cardiolipin and Its Different Properties in Mitophagy and Apoptosis
    SAGE Publications ; 2015
    In:  Journal of Histochemistry & Cytochemistry Vol. 63, No. 5 ( 2015-05), p. 301-311
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 63, No. 5 ( 2015-05), p. 301-311
    Abstract: Cardiolipin (CL) is a unique dimeric phospholipid that exists almost exclusively in the inner mitochondrial membrane (IMM) in eukaryotic cells. Two chiral carbons and four fatty acyl chains in CL result in a flexible body allowing interactions with respiratory chain complexes and mitochondrial substrate carriers. Due to its high content of unsaturated fatty acids, CL is particularly prone to reactive oxygen species (ROS)-induced oxidative attacks. Under mild mitochondrial damage, CL is redistributed to the outer mitochondrial membrane (OMM) and serves as a recognition signal for dysfunctional mitochondria, which are rapidly sequestered by autophagosomes. However, peroxidation of CL is far greater in response to severe stress than under normal or mild-damage conditions. The accumulation of oxidized CL on the OMM results in recruitment of Bax and formation of the mitochondrial permeability transition pore (MPTP), which releases Cytochrome c (Cyt c) from mitochondria. Over the past decade, the significance of CL in the function of mitochondrial bioenergy has been explored. Moreover, approaches to analyzing CL have become more effective and accurate. In this review, we discuss the unique structural features of CL as well as the current understanding of CL-based molecular mechanisms of mitophagy and apoptosis.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1369/0022155415574818
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 1421306-0
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  • 2
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    CCNB1 promotes the development of hepatocellular carcinoma by mediating DNA replication in the cell cycle
    SAGE Publications ; 2022
    In:  Experimental Biology and Medicine Vol. 247, No. 5 ( 2022-03), p. 395-408
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 247, No. 5 ( 2022-03), p. 395-408
    Abstract: In our studies, cyclin B1 ( CCNB1) mRNA and protein were overexpressed in hepatocellular carcinoma (HCC) tissues compared with non-HCC tissues. Moreover, CCNB1 was overexpressed in the serum of HCC patients. The expression of CCNB1 was associated with several crucial clinicopathologic characteristics, and the HCC patients with overexpressed CCNB1 had worse overall survival outcomes. In the screening of interactional genes, a total of 266 upregulated co-expression genes, which were positively associated with CCNB1, were selected from the datasets, and 67 downregulated co-expression genes, which were negatively associated with CCNB1, were identified. The key genes might be functionally enriched in DNA replication and the cell cycle pathways. CDC20, CCNA2, PLK1, and FTCD were selected for further research because they were highly connected in the protein-protein interaction networks. Upregulated CDC20, CCNA2, and PLK1 and downregulated FTCD might result in undesirable overall survival outcomes for HCC patients. The univariate Cox analysis results showed that CDC20 and PLK1 might be two independent risk factors, while FTCD might be protective in HCC. Therefore, CCNB1 may participate in the cell cycle of HCC by regulating DNA replication, and CCNB1 may provide a direction for the diagnosis of early-stage HCC and targeted HCC therapy.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/15353702211049149
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2020856-X
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  • 3
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    Immune regulation effect of lienal polypeptides extract in Lewis lung carcinoma-bearing mice treated with cyclophosphamide
    SAGE Publications ; 2018
    In:  Experimental Biology and Medicine Vol. 243, No. 1 ( 2018-01), p. 66-77
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 243, No. 1 ( 2018-01), p. 66-77
    Abstract: Polypeptides extracted from animal immune organs have been proved to exert immunomodulatory activities in previous reports. However, relative experimental data regarding the influence of a polypeptide mixture extracted from healthy calf spleen (lienal polypeptide [LP]) on the immune function in tumor therapy are limited, and the components in LP remain unclear. In the present study, the immune regulatory effect of LP was investigated in normal mice and Lewis lung carcinoma (LLC)-bearing mice treated with cyclophosphamide (CTX). The components of LP were identified by liquid chromatography–electrospray ionization-coupled with tandem mass spectrometry (LC–MS/MS) analysis and bioinformatic analysis. In LLC-bearing mice, LP showed a synergic antitumor effect with CTX, whereas LP alone did not present direct antitumor activity. Further, LP was found to enhance immune organ indexes, splenocyte number, and T lymphocyte subsets in normal mice and LLC-bearing mice treated with CTX. The decline of white blood cell and platelet counts, splenocyte proliferation activity, and peritoneal macrophage phagocytic function caused by CTX were also significantly suppressed by LP treatment in LLC-bearing mice. Notably, LP treatment significantly decreased the expression of phagocytosis-related proteins including CD47/signal regulatory protein α/Src homology phosphatase-1 in the tumor tissue of LLC-bearing mice treated with CTX. LC-MS/MS-based peptidomics unraveled the main polypeptides in LP with a length from 8 to 25 amino acids. Bioinformatics analysis further confirmed the possibility of LP to regulate immunity, especially in phagocytosis-related pathway. Our above findings indicated that LP can relieve the immunosuppression induced by chemotherapy and is a beneficial supplement in cancer therapy. Impact statement The immunomodulatory activities of polypeptides extracted from animal immune organs have incurred people’s interests since a long time ago. In this study, we investigated the immune regulation effects of a polypeptide mixture extracted from health calf spleen (lienal polypeptide [LP]) in Lewis lung carcinoma-bearing mice treated with cyclophosphamide (CTX). Liquid chromatography–electrospray ionization-coupled with tandem mass spectrometry-based peptidomics and bioinformatics analysis unraveled the main polypeptides in LP and further confirmed that LP is mainly associated with immune regulating pathway, especially in tumor cell phagocytosis-related pathway. Our study for the first time revealed that polypeptides from spleen can relieve the immunosuppression induced by CTX and is a beneficial supplement in cancer therapy.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370217737982
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2020856-X
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  • 4
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    Burden of kidney disease among patients with peritoneal dialysis versus conventional in-centre haemodialysis: A randomised, non-inferiority trial
    SAGE Publications ; 2022
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 42, No. 3 ( 2022-05), p. 246-258
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 42, No. 3 ( 2022-05), p. 246-258
    Abstract: Little is known about the impact of haemodialysis (HD) and peritoneal dialysis (PD) on health-related quality of life (HRQoL). We compared HRQoL between conventional in-centre HD and home-based PD in 1082 newly diagnosed kidney failure patients. Methods: This was an open-label, randomised, non-inferiority trial of adult patients with a diagnosis of end-stage kidney disease (estimated glomerular filtration rate ≤ 15 mL/min/1.73 m 2 ) requiring maintenance dialysis from 36 sites in China randomised 1:1 to receive PD or conventional in-centre HD. The primary outcome was the ‘Burden of Kidney Disease’ assessed using the Kidney Disease Quality of Life-Short Form (KDQoL-SF) survey over 48 weeks and the main secondary outcomes were the remaining scales of KDQoL-SF and all-cause mortality. The effect of PD versus HD on the primary outcome was compared by their geometric mean (GM) ratio, and non-inferiority was defined by the lower bound of a one-sided 95% confidence interval (CI) 〉 0.9. Results: A total of 725 subjects completed the trial per protocol (395 PD and 330 HD, mean age 49.8 (standard deviation (SD) 14.4) years, 41.4% women). For the primary outcome, the mean (SD) change in ‘Burden of Kidney Disease’ over 48 weeks was 2.61 (1.27) in PD group and 2.58 (1.35) in HD group, and the GM ratio (95% CI) was 1.059 (0.908–1.234), exceeding the limit for non-inferiority. For the secondary outcomes, the PD and HD groups were similar in all scales. There were 17 and 31 deaths in PD and HD groups, respectively. Patients receiving PD had more adverse events, adverse event leading to hospitalisation and serious adverse events compared to those allocated to HD, but adverse events leading to death and discontinuation of the trial were not different between PD and HD. Conclusions: In this trial, PD may be non-inferior to HD on the ‘Burden of Kidney Disease’ among Chinese kidney failure patients who are of younger age and have lower comorbidity after 48 weeks’ follow-up.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.1177/08968608221088638
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2075957-5
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  • 5
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    Haematocrit differences modify the association of cardiopulmonary bypass reoxygenation with acute kidney injury after paediatric Tetralogy of Fallot repair
    SAGE Publications ; 2019
    In:  Perfusion ( 2019-09-04), p. 026765911987177-
    Details
    In: Perfusion, SAGE Publications, ( 2019-09-04), p. 026765911987177-
    Abstract: Little is known regarding the potential impact of haematocrit differences in the association between cardiopulmonary bypass reoxygenation and acute kidney injury following Tetralogy of Fallot repair. Methods: We investigated the association of perfusate oxygenation during aortic occlusion associated with acute kidney injury between 204 normal and 248 higher haematocrit children with Tetralogy of Fallot, aged 1 month-18 years, who were surgically repaired in 2012-2018. Normal and higher haematocrit children were defined as having a preoperative haematocrit within and above age- and sex-specific reference intervals, respectively. Acute kidney injury was determined as a binary variable according to the Kidney Disease Improving Global Outcomes criteria. Results: After adjusting for baseline and clinical covariates, a significant interaction between the haematocrit and continuous perfusate oxygenation on acute kidney injury was found (p interaction  = 0.049): a higher perfusate oxygenation was associated with a greater acute kidney injury risk among higher haematocrit children (adjusted odds ratio = 1.50, 95% confidence interval = [1.02, 2.22] per SD, p = 0.038) but not among normal haematocrit children (adjusted odds ratio = 0.91, 95% confidence interval = [0.51, 1.63] per SD, p = 0.73). After a similar adjustment, there was a marginal interaction between tertiles of perfusate oxygenation and haematocrit on acute kidney injury (p interaction  = 0.09): the middle and top tertiles of perfusate oxygenation were associated with a trend towards increased acute kidney injury risks among higher haematocrit children (adjusted odds ratio = 1.69, 95% confidence interval = [0.61, 4.66]; adjusted odds ratio = 2.25, 95% confidence interval = [0.84, 5.99] , respectively) but not among normal haematocrit children (adjusted odds ratio = 1.16, 95% confidence interval = [0.46, 2.94]; adjusted odds ratio = 0.45, 95% confidence interval = [0.15, 1.36] , respectively) compared with the bottom tertile. Conclusion: Preoperative haematocrit differences significantly modify the association of perfusate oxygenation with acute kidney injury, highlighting differential control of reoxygenation for different haematocrit children with Tetralogy of Fallot in the management of cardiopulmonary bypass.
    Type of Medium: Online Resource
    ISSN: 0267-6591 , 1477-111X
    URL: Article
    DOI: 10.1177/0267659119871777
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2029611-3
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  • 6
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    Mathematical and geometrical modeling of braided ropes bent over a sheave
    SAGE Publications ; 2020
    In:  Journal of Engineered Fibers and Fabrics Vol. 15 ( 2020-01), p. 155892502093972-
    Details
    In: Journal of Engineered Fibers and Fabrics, SAGE Publications, Vol. 15 ( 2020-01), p. 155892502093972-
    Abstract: As soft elements for force transmission, braided fiber ropes play important roles in many fields where the fiber ropes are used bent over sheaves, while the relevant experiments are time-consuming and expensive. Computational simulation is a promising choice for evaluating the performance of fiber ropes when bent over a sheave. This article presents two methods that could be employed to build a model of braided rope bent over a sheave. One is the mathematical method which deduces the exact mathematical equations of braiding curves based on the Frenet–Serret frame. The spatial equations, considering the phase difference of strands in the same direction and the difference of strands’ projection in different directions, are discussed carefully. The final equation of braided strands is confirmed by modeling the braided rope in Maple ® 17. The other method, which is inspired by the analysis of braiding movements, is based on the intersection of surfaces of braiding surface and helical surface which are introduced and defined based on the motion analysis of bobbins and take-up roller. The SolidWorks ® 2018 is successfully employed to realize the modeling process.
    Type of Medium: Online Resource
    ISSN: 1558-9250 , 1558-9250
    URL: Article
    DOI: 10.1177/1558925020939726
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2393988-6
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  • 7
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    Similar simulation test study on the influence of mining on shaft deflection of deep soil based on hydraulic permeability model
    SAGE Publications ; 2023
    In:  Energy Exploration & Exploitation Vol. 41, No. 1 ( 2023-01), p. 19-43
    Details
    In: Energy Exploration & Exploitation, SAGE Publications, Vol. 41, No. 1 ( 2023-01), p. 19-43
    Abstract: Ensuring shaft safety is critical in the process of coal mining. During coal mining in the Guotun coal mine, Shandong Province, China, issues, such as shaft deflection, tank channel and shaft deformation, and tank jamming, which did not appear in the shaft before, brought huge hidden dangers to safety. In this study, a set of three-dimensional analog simulation systems for assessing the influence of mining on shaft deflection was designed by using penetration force simulations of gravity fields. In this system, electromagnetic displacement meter is used to collect surface settlement data, which verifies the feasibility of using hydraulic pillow to simulate formation disturbance caused by coal mining. the strain of the shaft is measured by optical fibers and strain gauges, and the amount that mining influenced the deflection of the shaft is obtained. The results show that there is an approximately positive linear correlation between the horizontal displacement of the shaft caused by mining and the mining thickness of the coal. The horizontal displacement of shaft caused by coal mining is inversely proportional to the moving Angle within a reasonable range. The horizontal displacement of shaft is affected by mining mode, and symmetrical mining can significantly reduce the horizontal displacement of shaft. The horizontal displacement of the shaft at different depths caused by mining decreases with increasing shaft depth, which is the main cause of shaft deflection.
    Type of Medium: Online Resource
    ISSN: 0144-5987 , 2048-4054
    URL: Article
    DOI: 10.1177/01445987221111470
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2026571-2
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  • 8
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    Screening the Chemical Composition and Bioactivity of Cerasus serrulata Flower Extracts Using Two Extraction Methods
    SAGE Publications ; 2023
    In:  Pharmacognosy Magazine Vol. 19, No. 3 ( 2023-09), p. 551-563
    Details
    In: Pharmacognosy Magazine, SAGE Publications, Vol. 19, No. 3 ( 2023-09), p. 551-563
    Abstract: Cerasus serrulata has an excellent antioxidative, antibacterial, and anti-alopecia effect, but its active ingredients and the underlying mechanism are currently unclear, in addition to the fact that the active products vary with the extraction methods. Aim Therefore, this study aims to clarify the active components and antioxidative property of C. serrulata extracted by two different methods (low-temperature vacuum extraction and ethanol extraction) and explore its potential biofunction. Materials and Methods First, the compositions in extracts were characterized by gas chromatographic mass spectrometry (GC-MS) and liquid chromatography-mass spectrography (LC-MS). Then, the antioxidative activity of both extracts was evaluated using free radical scavenging assay (ABTS) and ORAC. Next, the antibacterial activity of both extracts was measured via a bacteriostatic circle experiment. The anti-alopecia effects of both extracts were studied using a mouse model of alopecia. The hematoxylin and eosin (H & E) staining was used to evaluate hair follicles; vascular endothelial-derived growth factor (VEGF) and interleukin-6 (IL-6) expression in mouse skin were evaluated by immunohistochemistry, while β-catenin expression in tissues was used by immunofluorescence. The expression of FGFR and insulin-like growth factor 1 (IGF-1) in the skin was determined to evaluate using real-time quantitative polymerase chain reaction (RT-qPCR). The levels of DHT and 5α-reductase in the experimental mice were determined by ELISA. Results The GC-MS analysis results showed that the extracts were rich in alkanes and aromatic compounds, specifically benzaldehyde, which was the highest component in the cold vacuum extraction, while pipecolic acid was the main component in the ethanol extract. This indicates that C. serrulata has components that exhibit strong inhibitory ability against the growth of five common bacterial strains, expressing excellent free radical scavenging ability. In addition, the active ingredients in C. serrulata were found to significantly deregulate the protein levels in the skin of androgenetic alopecia (AGA) mice, with the levels of IL-6. They were also able to significantly inhibit VEGF reduction. The β-catenin was being significantly upregulated in skin tissue. In addition, FGFR and IGF-1 gene expression also increased. The 5α-reductase and dihydrotestosterone (DHT) can be reduced in the C. serrulata treatment. Conclusion Our data indicate that C. serrulata extract could be beneficial supplements of natural antioxidative, antibacterial, and anti-alopecia agents.
    Type of Medium: Online Resource
    ISSN: 0973-1296 , 0976-4062
    URL: Article
    DOI: 10.1177/09731296231173558
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2274976-7
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  • 9
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    Lack of Effect of Ginkgo biloba on Voriconazole Pharmacokinetics in Chinese Volunteers Identified as CYP2C19 Poor and Extensive Metabolizers
    SAGE Publications ; 2009
    In:  Annals of Pharmacotherapy Vol. 43, No. 4 ( 2009-04), p. 726-731
    Details
    In: Annals of Pharmacotherapy, SAGE Publications, Vol. 43, No. 4 ( 2009-04), p. 726-731
    Abstract: Ginkgo biloba is one of the most popular herbal supplements in the world. The supplement has been shown to induce the enzymatic activity of CYP2C19, the main cytochrome P450 isozyme involved in voriconazole metabolism. Because this enzyme exhibits genetic polymorphism, the inductive effect was expected to be modulated by the CYP2C19 metabolizer status. Objective: To examine the possible effects of Ginkgo biloba as an inducer of CYP2C19 on single-dose pharmacokinetics of voriconazole in Chinese volunteers genotyped as either CVP2C19 extensive or poor metabolizers. Methods: Fourteen healthy, nonsmoking volunteers–7 CYP2C19 extensive metabolizers (2C19*1/2C19*1) and 7 poor metabolizers (2C19*2/2C19*2)–were selected to participate in this study. Pharmacokinetics of oral voriconazole 200 mg after administration of Ginkgo biloba 120 mg twice daily for 12 days were determined for up to 24 hours by liquid chromatography–electrospray tandem mass spectrometry in a 2-phase randomized crossover study with 4-week washout between phases. Results: For extensive metabolizers, the median value for voriconazole area under the plasma concentration–time curve from zero to infinity (AUC 0-00 ) was 5.17 μg•h/mL after administration of voriconazole alone and 4.28 μg•/mL after voriconazole with Ginkgo biloba (p 〉 0.05). The other pharmacokinetic parameters of voriconazole such as AUC 0-24 , time to reach maximum concentration, half-life, and apparent clearance also did not change significantly for extensive metabolizers in the presence of Ginkgo biloba. Pharmacokinetic parameters followed a similar pattern for poor metabolizers. Conclusions: The results suggest that 12 days of treatment with Ginkgo biloba did not significantly alter the single-dose pharmacokinetics of voriconazole in either CYP2C19 extensive or poor metabolizers. Therefore, the pharmacokinetic interactions between voriconazole and Ginkgo biloba may have limited clinical significance.
    Type of Medium: Online Resource
    ISSN: 1060-0280 , 1542-6270
    URL: Article
    DOI: 10.1345/aph.1L537
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2053518-1
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  • 10
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    Action Mechanism of Extracts from Cerasus serrulata Flower for Hair-Blacking in C57BL/6 Mice
    SAGE Publications ; 2023
    In:  Pharmacognosy Magazine Vol. 19, No. 2 ( 2023-06), p. 303-315
    Details
    In: Pharmacognosy Magazine, SAGE Publications, Vol. 19, No. 2 ( 2023-06), p. 303-315
    Abstract: Hair color retention and rejuvenation have recently emerged as a new research hot spot, with many studies focused on developing treatments to prevent premature greying. Aim This study is aimed to explore the hair-blacking effects and possible mechanisms of Cerasus serrulata flower extracts (CSE) using a C57BL/6 premature greying mouse model. Materials and Methods The variations in hair follicle number, hair follicle depth and cortical thickness were evaluated by hematoxylin and eosin staining. The quantity changes of melanocytes were also evaluated using Masson-Fontana Melanin staining. The relative abundance of vascular endothelial growth factor (VEGF), β-catenin and tyrosinase transcripts following transformed growth were further quantified using RT-qPCR and immunofluorescence. The changes in protein level expression of β-catenin, VEGF and tyrosinase were also evaluated by western blot. Results The β-catenin and VEGF expression were significantly up-regulated in skin tissues treated with C. serrulata extracts, promoting hair growth and blackening. Conclusion CSE can promote the efficient hair-blacking likely via the VEGF pathway, making it a potential therapeutic candidate for treating premature greying.
    Type of Medium: Online Resource
    ISSN: 0973-1296 , 0976-4062
    URL: Article
    DOI: 10.1177/09731296231157182
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2274976-7
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