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  • SAGE Publications  (5)
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  • SAGE Publications  (5)
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  • 1
    Online-Ressource
    Online-Ressource
    A Monoclonal Antibody Selection for Immunohistochemical Examination of Lymphoid Tissues From Non-human Primates
    SAGE Publications ; 2009
    In:  Journal of Histochemistry & Cytochemistry Vol. 57, No. 12 ( 2009-12), p. 1159-1167
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 57, No. 12 ( 2009-12), p. 1159-1167
    Kurzfassung: Non-human primates (NHPs) offer valuable animal models for basic research into human diseases and for the preclinical validation of new therapeutics. Detailed in situ examination of the involved cell types using immunohistochemistry is often hampered by the lack of cross-reactive antibodies (Abs). In the current study, we have tested a large panel of monoclonal antibodies raised against human leukocyte differentiation and activation markers for cross-reactivity on cryosections of lymphoid tissue from six NHP species. In total, we have tested 130 Abs against 69 antigens expressed in tissues from one great ape species (chimpanzee/ Pan troglodytes), two Old World species (rhesus macaque/ Macaca mulatta and cynomolgus macaque/ Macaca fascicularis), and three New World species (common marmoset/ Callithrix jacchus, cotton-top tamarin/ Saguinus oedipus, and owl monkey/ Aotus triviogatus). We have found a large panel of cross-reactive Abs: 93 of 102 (91%) in chimpanzee, 97 of 125 (78%) in rhesus macaque, 70 of 109 (64%) in cynomolgus macaque, 69 of 116 (60%) in common marmoset, 40 of 81 (49%) in cotton-top tamarin, and 35 of 80 (44%) in owl monkey. The availability of a reliable panel of cross-reactive markers is important to gaining further insight into immunological processes in disease-affected tissues from NHP species.
    Materialart: Online-Ressource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1369/jhc.2009.954123
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2009
    ZDB Id: 1421306-0
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    Why does multiple sclerosis only affect human primates?
    SAGE Publications ; 2016
    In:  Multiple Sclerosis Journal Vol. 22, No. 4 ( 2016-04), p. 559-563
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 22, No. 4 ( 2016-04), p. 559-563
    Kurzfassung: Multiple sclerosis (MS) develops exclusively in humans. Non-human primates are resistant against MS, although they are highly susceptible to the MS animal model, experimental autoimmune encephalomyelitis (EAE). Unravelling of the cause(s) underlying this discrepancy is highly relevant as insights might be gained into the elusive event(s) that trigger(s) MS. A well-established difference between the human primate ( Homo sapiens) and non-human primates is that humans are unable to synthesize the sialic acid N-glycolylneuraminic acid (Neu5Gc). Viewpoint: We propose the concept that long-term ingestion by human primates of the foreign Neu5Gc, via red meat consumption, is an ignored environmental risk factor for MS. Conceptually, incorporation of dietary Neu5Gc into vital regions of the central nervous system, such as the blood–brain barrier (BBB) and the axon–myelin unit, creates targets for binding of de novo synthesized heterophilic anti-NeuGc antibodies. Binding of the antibodies can cause BBB leakage and destabilization of the axon–myelin coupling. The ensuing cytodegeneration and release of self-antigens could be a start of the characteristic pathological features of MS.
    Materialart: Online-Ressource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458515591862
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2016
    ZDB Id: 2008225-3
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Myelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin
    SAGE Publications ; 2016
    In:  Multiple Sclerosis Journal - Experimental, Translational and Clinical Vol. 2 ( 2016-01-01), p. 205521731663099-
    Details
    In: Multiple Sclerosis Journal - Experimental, Translational and Clinical, SAGE Publications, Vol. 2 ( 2016-01-01), p. 205521731663099-
    Kurzfassung: Myelin oligodendrocyte glycoprotein (MOG) is a candidate primary target of the autoimmune attack on the central nervous system (CNS) in multiple sclerosis (MS). However, the physiological function of MOG has been unclear for a long time. Objective We propose that MOG has a central role in the regulation of tolerance and autoimmunity. Conclusion The interaction of MOG with DC-SIGN, an innate antigen receptor of myeloid antigen-presenting cells (m-APCs), present inside the CNS (microglia) or in draining lymph nodes (dendritic cells; DCs), keeps these cells in an immature/tolerogenic state. We postulate that this tolerogenic mechanism may be disturbed in MS by unknown factors.
    Materialart: Online-Ressource
    ISSN: 2055-2173 , 2055-2173
    URL: Article
    DOI: 10.1177/2055217316630999
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2016
    ZDB Id: 2841884-0
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    An essential role of virus-infected B cells in the marmoset experimental autoimmune encephalomyelitis model
    SAGE Publications ; 2017
    In:  Multiple Sclerosis Journal - Experimental, Translational and Clinical Vol. 3, No. 1 ( 2017-03), p. 205521731769018-
    Details
    In: Multiple Sclerosis Journal - Experimental, Translational and Clinical, SAGE Publications, Vol. 3, No. 1 ( 2017-03), p. 205521731769018-
    Kurzfassung: Infection with Epstein–Barr virus (EBV) has been associated with an enhanced risk of genetically susceptible individuals to develop multiple sclerosis (MS). However, an explanation for the contrast between the high EBV infection prevalence (60–90%) and the low MS prevalence (0.1%) eludes us. Here we propose a new concept for the EBV–MS association developed in the experimental autoimmune encephalomyelitis model in marmoset monkeys, which are naturally infected with the EBV-related γ1-herpesvirus CalHV3. The data indicate that the infection of B cells with a γ1-herpesvirus endows them with the capacity to activate auto-aggressive CD8+ T cells specific for myelin oligodendrocyte glycoprotein.
    Materialart: Online-Ressource
    ISSN: 2055-2173 , 2055-2173
    URL: Article
    DOI: 10.1177/2055217317690184
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2017
    ZDB Id: 2841884-0
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 5
    Online-Ressource
    Online-Ressource
    We should focus more on finding therapeutic targets for the non-inflammatory damage in MS – No
    SAGE Publications ; 2018
    In:  Multiple Sclerosis Journal Vol. 24, No. 10 ( 2018-09), p. 1274-1276
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 24, No. 10 ( 2018-09), p. 1274-1276
    Materialart: Online-Ressource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458518761571
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2018
    ZDB Id: 2008225-3
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
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