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  • SAGE Publications  (16)
  • 1
    Online Resource
    Online Resource
    Application of telehealth intervention in Parkinson’s disease: A systematic review and meta-analysis
    SAGE Publications ; 2020
    In:  Journal of Telemedicine and Telecare Vol. 26, No. 1-2 ( 2020-01), p. 3-13
    Details
    In: Journal of Telemedicine and Telecare, SAGE Publications, Vol. 26, No. 1-2 ( 2020-01), p. 3-13
    Abstract: Telehealth intervention has been proposed as a sustainable and innovative intervention approach to Parkinson’s disease (PD) patients, but there are still conflicting results in the literature about its effect. This study aimed to evaluate the efficacy of telehealth intervention for PD patients. Methods PubMed, EMBASE, CENTRAL and China National Knowledge Infrastructure (CNKI) were searched from the inception to June 2018 for randomized controlled trials (RCTs) and cohort studies, without language restrictions. When feasible, data were statistically pooled for meta-analysis using Review Manager 5.3. Otherwise, narrative summaries were used. Results Twenty-one studies were included. With respect to PD severity, compared with usual care, telehealth intervention was beneficial in lowering motor impairment of PD patients significantly (mean difference (MD) = –2.27, 95% confidence interval (95% CI) −4.25 to −0.29, p = 0.02), rather than mental status (MD = –0.98, 95% CI −2.61 to 0.65, p = 0.24), activities of daily living (MD = –1.51, 95% CI −4.91 to 1.89, p = 0.38) and motor complications (MD = –0.36, 95% CI −1.31 to 0.59, p = 0.46). Telehealth intervention did not lead to significant reduction in quality of life (standardized mean difference (SMD) = 0.04, 95% CI −0.20 to 0.28, p = 0.76), depression (SMD = –0.12, 95% CI −0.37 to 0.13, p = 0.34), cognition (MD = 0.37, 95% CI −0.34 to 1.09, p = 0.31) and balance (MD = 0.09, 95% CI −2.49 to 2.66, p = 0.95). Discussion Telehealth intervention is an effective option for individuals with PD to improve their motor impairment. Further well-designed studies are warranted to confirm our findings.
    Type of Medium: Online Resource
    ISSN: 1357-633X , 1758-1109
    URL: Article
    DOI: 10.1177/1357633X18792805
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2007700-2
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  • 2
    Online Resource
    Online Resource
    Model reduction of aerothermodynamic for hypersonic aerothermoelasticity based on POD and Chebyshev method
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 233, No. 10 ( 2019-08), p. 3734-3748
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 233, No. 10 ( 2019-08), p. 3734-3748
    Abstract: Accurate modeling of aerothermodynamics with low computational cost takes on a crucial role for the optimization and control of hypersonic vehicles. This study examines three reduced-order models (ROMs) to provide a reliable and efficient alternative approach for obtaining the aerothermodynamics of a hypersonic control surface. Coupled computational fluid dynamics (CFD) and computational thermostructural dynamics (CTSD) approaches are used to generate the snapshots for ROMs considering the interactions between aerothermodynamics, structural dynamics and heat transfer. One ROM adopts a surrogate approach named Kriging. The second ROM is constructed by the combination of Proper Orthogonal Decomposition (POD) and Kriging, namely, POD-Kriging. The accuracy of Kriging-based ROM is higher than that of POD-Kriging-based ROM, but the efficiency is lower. Therefore, to address the shortcomings of the above two approaches, a new ROM is developed that is composed of POD and modified Chebyshev polynomials, namely, POD-Chebyshev. The ROM based on POD-Chebyshev has the best precision and efficiency among the three ROMs and generally has less than 2% average maximum error for the studied problem.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/0954410018808634
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2032759-6
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  • 3
    Online Resource
    Online Resource
    MONARCH plus: abemaciclib plus endocrine therapy in women with HR+/HER2– advanced breast cancer: the multinational randomized phase III study
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592096392-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592096392-
    Abstract: To compare the efficacy, safety, and tolerability of abemaciclib plus endocrine therapy (ET) versus ET alone in postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC) from China, Brazil, India, and South Africa. Methods: This randomized, double-blind, phase III study was conducted between 9 December 2016 and 29 March 2019. Postmenopausal women with HR-positive, HER2-negative ABC with no prior systemic therapy in an advanced setting (cohort A) or progression on prior ET (cohort B) received abemaciclib (150 mg twice daily) or placebo plus: anastrozole (1 mg/day) or letrozole (2.5 mg/day) (cohort A) or fulvestrant (500 mg per label) (cohort B). The primary endpoint was progression-free survival (PFS) in cohort A, analyzed using the stratified log-rank test. Secondary endpoints were PFS in cohort B (key secondary endpoint), objective response rate (ORR), and safety. This interim analysis was planned after 119 PFS events in cohort A. Results: In cohort A, 207 patients were randomly assigned to the abemaciclib arm and 99 to the placebo arm. Abemaciclib significantly improved PFS versus placebo (median: not reached versus 14.7 months; hazard ratio 0.499; 95% confidence intervals (CI) 0.346–0.719; p = 0.0001). ORR was 65.9% in the abemaciclib arm and 36.1% in the placebo arm ( p  〈  0.0001, measurable disease population). In cohort B, 104 patients were randomly assigned to the abemaciclib arm and 53 to the placebo arm. Abemaciclib significantly improved PFS versus placebo (median: 11.5 versus 5.6 months; hazard ratio 0.376; 95% CI 0.240–0.588; p  〈  0.0001). ORR was 50.0% in the abemaciclib arm and 10.5% in the placebo arm ( p  〈  0.0001, measurable disease population). The most frequent grade ⩾3 adverse events in the abemaciclib arms were neutropenia, leukopenia, and anemia (both cohorts), and lymphocytopenia (cohort B). Conclusion: The addition of abemaciclib to ET demonstrated significant and clinically meaningful improvement in PFS and ORR, without new safety signals observed in this population. Trial Registration: ClinicalTrials.gov identifier: NCT02763566.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920963925
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
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  • 4
    Online Resource
    Online Resource
    Design, Synthesis and Antiproliferative Evaluation of 3-Aminopropyloxy Derivatives of Chalcone
    SAGE Publications ; 2016
    In:  Journal of Chemical Research Vol. 40, No. 10 ( 2016-10), p. 624-627
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 40, No. 10 ( 2016-10), p. 624-627
    Abstract: A series of 3-aminopropyloxy derivatives of chalcone were synthesised and evaluated for their antiproliferative activity against liver, gastric and neuroendocrine cancer cell lines. Most of the synthesised compounds exhibited moderate to good activity against all three cancer cell lines, but in particular, a 3-(pyrrolidin-1-yl)propyloxy chalcone containing a 3,4,5-trimethoxyphenyl group showed the highest antiproliferative activity with an IC 50 value of 2.74 μM against liver cancer cells.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751916X14740434083371
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 3010810-X
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  • 5
    Online Resource
    Online Resource
    RSS Localization Algorithm Based on Nonline of Sight Identification for Wireless Sensor Network
    SAGE Publications ; 2014
    In:  International Journal of Distributed Sensor Networks Vol. 10, No. 7 ( 2014-07-01), p. 213198-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 10, No. 7 ( 2014-07-01), p. 213198-
    Abstract: Localization is a key issue for wireless sensor network. The traditional localization methods achieve high location accuracy using received signal strength (RSS) in line of sight (LOS) environment. But the localization accuracy degrades significantly in nonline of sight (NLOS) environment. So the localization in NLOS environment is one of the most challenging for wireless sensor network. In this paper, we propose an RSS based localization algorithm in NLOS environment. A NLOS identification algorithm is firstly proposed. This algorithm does not need the parameters of the NLOS in prior. Then we correct the NLOS measurements by subtracting the mean of NLOS errors. Finally, the Kalman filter is employed to mitigate the process noise. In simulations, we demonstrate that the proposed algorithm achieves higher localization accuracy compared with other methods.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1155/2014/213198
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2192922-1
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  • 6
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    Design and Antiproliferative Activity of N-Heterocycle-Chalcone Derivatives
    SAGE Publications ; 2016
    In:  Journal of Chemical Research Vol. 40, No. 10 ( 2016-10), p. 620-623
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 40, No. 10 ( 2016-10), p. 620-623
    Abstract: Nine chalcone derivatives containing an N-heterocyclic compound attached by its nitrogen atom to one of the benzene rings were prepared and evaluated for their antiproliferative activity against liver, gastric and neuroendocrine cancer cell lines. Most of the synthesised compounds exhibited moderate to good activity against all three cancer cell lines, but in particular, a chalcone containing a 4-(imidazol-1-yl)phenyl group and a 3,4,5-trimethoxyphenyl group showed the highest antiproliferative activity with an IC 50 value of 5.39 μM against liver cancer cells.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751916X14740355883191
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 3010810-X
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  • 7
    Online Resource
    Online Resource
    Synthesis of Novel Antiproliferative 1,2,3-triazole Hybrids Using the Molecular Hybridisation Approach
    SAGE Publications ; 2016
    In:  Journal of Chemical Research Vol. 40, No. 11 ( 2016-11), p. 674-677
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 40, No. 11 ( 2016-11), p. 674-677
    Abstract: A series of nine novel 1,2,3-triazole-chalcone derivatives were designed using the molecular hybridisation approach and synthesised by click chemistry. Most of the synthesised compounds exhibited moderate to good antiproliferative activity against oesophagus, gastric and neuroendocrine cancer cell lines, but a compound containing a p-bromo group in the A ring and a [(4,5-dihydrothiazol-2-yl)thio]methyl group attached at the 4-position of a p-[3-(1,2,3-triazol-1-yl)propyloxy] group in the B ring showed the highest activity with an IC50 value of 8.16 μM against neuroendocrine cancer cells. The structure activity relationships of all nine compounds were discussed.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751916X14761050193688
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 3010810-X
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  • 8
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    Online Resource
    Optimization Research on Screening Parameters of Elliptical Vibrating Screen Based on DEM Theory
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering Vol. 236, No. 5 ( 2022-10), p. 1992-2000
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, SAGE Publications, Vol. 236, No. 5 ( 2022-10), p. 1992-2000
    Abstract: Most of the vibrating screens pay too much attention to the screening efficiency and neglect the material transportation speed in the research process, so this paper introduces W to comprehensively consider the influence of screening efficiency and material transportation speed, and optimizes the vibration parameters of the vibrating screen based on the GRNN-PSO model. This optimization method is more accurate and effective than the previous method used to optimize the parameters of the vibrating screen. First, numerical simulation of the screening process based on EDEM software was carried out, and the influence of vibration frequency, amplitude and direction angle of vibration on the screening efficiency and material transportation speed was studied. The orthogonal experiment was further constructed, and the GRNN model between each vibration parameter and W was established based on the orthogonal experiment data and the single factor experiment data. Then, using the established GRNN model as the fitness function, the vibration parameters were optimized by the PSO algorithm, and the obtained optimized parameters were substituted into the simulation model, which further proved the accuracy and effectiveness of the GRNN-PSO model. This research helps understand the combined effect of various vibration parameters and provides a reference for the vibrating screen's efficient operation and parameter design.
    Type of Medium: Online Resource
    ISSN: 0954-4089 , 2041-3009
    URL: Article
    DOI: 10.1177/09544089221078388
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2024897-0
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  • 9
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    Effect of fatigue on kinematics, kinetics and muscle activities of lower limbs during gait
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine Vol. 236, No. 9 ( 2022-09), p. 1365-1374
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, SAGE Publications, Vol. 236, No. 9 ( 2022-09), p. 1365-1374
    Abstract: Muscle fatigue, as a serious social problem, affects the performance of daily living activities, especially for workers. Decrease of movement control ability caused by muscle fatigue is one of the risk and intrinsic factors for occupational accidents, such as slips, trips, falls, etc. In order to reduce the accident rate and optimize the existing prevention measures, it is necessary to investigate the effect of fatigue on kinematics, kinetics, and muscle activities of human body. In this paper, 26 healthy participants were recruited. The kinematics and kinetics analysis of lower limb joints, and surface electromyograms (sEMG) time-domain and frequency-domain analysis of lower limb periarticular muscles were utilized to investigate the effects of muscle fatigue. The results showed that the fatigue reduced the range-of-motion (RoM) of the lower limb joints. Smaller plantarflexion, knee flexion and hip flexion angles, and greater dorsiflexion angles were observed after fatigue. For the joint moment, the fatigue did not alter the joint moments except for the smaller knee flexion moment. For the joint power, the fatigue decreased the generation power of ankle, knee and hip joint and the absorption power of ankle and knee joints, whereas increased the absorption power of hip joint. Besides, the fatigue increased the normalized integrated sEMG (iEMG) and root-mean-square (RMS) of sEMG, and shifted the median frequency (MF) and mean power frequency (MPF) of sEMG toward lower frequencies. The results from the present study concluded that the muscle fatigue changed the kinematics, kinetics and muscle activities of lower limbs during gait, and then could increase the risk rate of occupational accidents.
    Type of Medium: Online Resource
    ISSN: 0954-4119 , 2041-3033
    URL: Article
    DOI: 10.1177/09544119221112516
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2032763-8
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  • 10
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    Methylome Variation Predicts Exemestane Resistance in Advanced ER + Breast Cancer
    SAGE Publications ; 2020
    In:  Technology in Cancer Research & Treatment Vol. 19 ( 2020-01-01), p. 153303381989633-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 19 ( 2020-01-01), p. 153303381989633-
    Abstract: More than 30% of estrogen receptor-positive breast cancers are resistant to primary hormone therapy, and about 40% that initially respond to hormone therapy eventually acquire resistance. Although the mechanisms of hormone therapy resistance remain unclear, aberrant DNA methylation has been implicated in oncogenesis and drug resistance. Purpose: We investigated the relationship between methylome variations in circulating tumor DNA and exemestane resistance, to track hormone therapy efficacy. Methods: We prospectively recruited 16 patients who were receiving first-line therapy in our center. All patients received exemestane-based hormone therapy after enrollment. We collected blood samples at baseline, first follow-up (after 2 therapeutic cycles) and at detection of disease progression. Disease that progressed within 6 months under exemestane treatment was considered exemestane resistance but was considered relatively exemestane-sensitive otherwise. We obtained circulating tumor DNA-derived methylomes using the whole-genome bisulfide sequencing method. Methylation calling was done by BISMARK software; differentially methylated regions for exemestane resistance were calculated afterward. Results: Median follow-up for the 16 patients was 19.0 months. We found 7 exemestane resistance-related differentially methylated regions, located in different chromosomes, with both significantly different methylation density and methylation ratio. Baseline methylation density and methylation ratio of chromosome 6 [32400000-32599999] were both high in exemestane resistance. High baseline methylation ratios of chromosome 3 [67800000-67999999] ( P = .013), chromosome 3 [140200000-140399999] ( P = .037), and chromosome 12 [101200000-101399999] ( P = .026) could also predict exemestane resistance. During exemestane treatment, synchronized changes in methylation density and methylation ratio in chromosome 6 [32400000-32599999] could accurately stratify patients in terms of progression-free survival ( P = .000033). Cutoff values of methylation density and methylation ratio for chromosome 6 [149600000-149799999] were 0.066 and 0.076, respectively. Conclusion: Methylation change in chromosome 6 [149600000-149799999] is an ideal predictor of exemestane resistance with great clinical potential.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033819896331
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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