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  • 1
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    Recurrence after percutaneous ethanol ablation of simple hepatic, renal, and splenic cysts: is it true recurrence requiring an additional treatment?
    SAGE Publications ; 2008
    In:  Acta Radiologica Vol. 49, No. 9 ( 2008-11), p. 982-986
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 49, No. 9 ( 2008-11), p. 982-986
    Abstract: Background: Recurrence after percutaneous ethanol ablation (PEA) of benign hepatic and renal cysts has been common, resulting in re-treatment or additional surgery. However, in recent years, a few cases of spontaneous regression of recurrent cysts following PEA have been experienced, which led to the design of this study to evaluate cyst recurrence after PEA and the necessity of additional treatment. Purpose: To evaluate whether the initial recurrence after PEA of benign hepatic, renal, and splenic cysts is true recurrence, and to decide whether additional treatment is needed. Material and Methods: Thirty-nine benign cysts (21 hepatic, 17 renal, and one splenic) were treated with PEA. PEA was performed with injection of 13–900 ml (40–50% of the volume of aspirated fluid) of absolute ethanol into the cysts. For cysts larger than 100 ml, two or more PEAs were given in one session. Ultrasonography was then performed during a period of 12 months with 1–2-month intervals. Results: Two months after PEA, eight cysts (20.5%) regressed completely; another 31 cysts recurred with decreased size. After 6 months, 10 of the recurrent cysts had regressed spontaneously. Another four recurrent cysts regressed after 8 months, and three regressed after 12 months. Hence, 25 out of 39 (64.1%) cysts regressed within 12 months after PEA. The mean regression time of the 25 recurrent cysts was 6.3 months. All recurrent cysts, including the 14 that were lost to complete follow-up, showed gradual decrease overtime. There were no major complications associated with PEA. Conclusion: Initial relapse of a cyst following PEA does not signify true recurrence, but transient, reactive, or inflammatory fluid collections which eventually disappear within several months, and thus does not necessitate additional treatment.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1080/02841850802325974
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2024579-8
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  • 2
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    Recommended Guidelines for the Conduct and Evaluation of Prognostic Studies in Veterinary Oncology
    SAGE Publications ; 2011
    In:  Veterinary Pathology Vol. 48, No. 1 ( 2011-01), p. 7-18
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 48, No. 1 ( 2011-01), p. 7-18
    Abstract: There is an increasing need for more accurate prognostic and predictive markers in veterinary oncology because of an increasing number of treatment options, the increased financial costs associated with treatment, and the emotional stress experienced by owners in association with the disease and its treatment. Numerous studies have evaluated potential prognostic and predictive markers for veterinary neoplastic diseases, but there are no established guidelines or standards for the conduct and reporting of prognostic studies in veterinary medicine. This lack of standardization has made the evaluation and comparison of studies difficult. Most important, translating these results to clinical applications is problematic. To address this issue, the American College of Veterinary Pathologists' Oncology Committee organized an initiative to establish guidelines for the conduct and reporting of prognostic studies in veterinary oncology. The goal of this initiative is to increase the quality and standardization of veterinary prognostic studies to facilitate independent evaluation, validation, comparison, and implementation of study results. This article represents a consensus statement on the conduct and reporting of prognostic studies in veterinary oncology from veterinary pathologists and oncologists from around the world. These guidelines should be considered a recommendation based on the current state of knowledge in the field, and they will need to be continually reevaluated and revised as the field of veterinary oncology continues to progress. As mentioned, these guidelines were developed through an initiative of the American College of Veterinary Pathologists' Oncology Committee, and they have been reviewed and endorsed by the World Small Animal Veterinary Association.
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1177/0300985810377187
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2106608-5
    SSG: 22
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  • 3
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    D2 receptor occupancy under recommended and high doses of olanzapine: an iodine-123-iodobenzamide SPECT study
    SAGE Publications ; 2000
    In:  Journal of Psychopharmacology Vol. 14, No. 4 ( 2000-07), p. 364-370
    Details
    In: Journal of Psychopharmacology, SAGE Publications, Vol. 14, No. 4 ( 2000-07), p. 364-370
    Abstract: The aim of this study was to compare the degree of striatal dopamine D 2 receptor availability in patients treated with recommended (5–20 mg, mean dose 11.9 ± 6.3 mg daily) and higher doses (25–40 mg, mean 32.1 ± 5.6 mg daily) of the novel antipsychotic drug olanzapine by means of [ 123 I] IBZM Single photon emission computed tomography (SPECT). The results were compared to those of a group of 10 untreated, healthy, age- and sex-matched controls. The degree of dopamine D 2 receptor occupancy in the patient group was correlated with the presence of extrapyramidal symptoms (EPS). A total of 20 patients who met the DSM III R criteria for schizophrenia or schizoaffective disorder received a clinically effective antipsychotic monotherapy with olanzapine. The mean daily dose of olanzapine ranged from 0.05–0.6 mg/kg body weight. The dopamine D 2 receptor binding was reduced in all patients treated with olanzapine. Specific IBZM binding expressed as the [STR-BKG]/BKG ratio ranged from 0.13–0.61 (healthy controls 0.95). The D 2 receptor availability revealed an exponential dose–response relationship (r=–0.85, p 〈 0.001). The frequency of EPS induced by olanzapine was considerably lower. Only one patient, treated with 40 mg olanzapine, suffered from severe EPS symptoms and had to be given biperiden. There were no significant differences in the presence of EPS symptoms between patients with recommended doses and those with higher doses of olanzapine.
    Type of Medium: Online Resource
    ISSN: 0269-8811 , 1461-7285
    URL: Article
    DOI: 10.1177/026988110001400405
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2028926-1
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  • 4
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    Monoamine Oxidase Inhibition by a New Carcinostatic Agent, N-Isopropyl- -(2-Methylhydrazino)-p-Toluamide (MIH)
    SAGE Publications ; 1965
    In:  Experimental Biology and Medicine Vol. 120, No. 2 ( 1965-11-01), p. 561-565
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 120, No. 2 ( 1965-11-01), p. 561-565
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.3181/00379727-120-30590
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1965
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 5
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    Hypotension During Vasopressor Infusion Occurs in Predictable Clusters: A Multicenter Analysis
    SAGE Publications ; 2024
    In:  Journal of Intensive Care Medicine
    Details
    In: Journal of Intensive Care Medicine, SAGE Publications
    Abstract: Background: Published evidence indicates that mean arterial pressure (MAP) below a goal range (hypotension) is associated with worse outcomes, though MAP management failures are common. We sought to characterize hypotension occurrences in ICUs and consider the implications for MAP management. Methods: Retrospective analysis of 3 hospitals’ cohorts of adult ICU patients during continuous vasopressor infusion. Two cohorts were general, mixed ICU patients and one was exclusively acute spinal cord injury patients. “Hypotension-clusters” were defined where there were ≥10 min of cumulative hypotension over a 60-min period and “constant hypotension” was ≥10 continuous minutes. Trend analysis was performed (predicting future MAP using 14 min of preceding MAP data) to understand which hypotension-clusters could likely have been predicted by clinician awareness of MAP trends. Results: In cohorts of 155, 66, and 16 ICU stays, respectively, the majority of hypotension occurred within the hypotension-clusters. Failures to keep MAP above the hypotension threshold were notable in the bottom quartiles of each cohort, with hypotension durations of 436, 167, and 468 min, respectively, occurring within hypotension-clusters per day. Mean arterial pressure trend analysis identified most hypotension-clusters before any constant hypotension occurred (81.2%-93.6% sensitivity, range). The positive predictive value of hypotension predictions ranged from 51.4% to 72.9%. Conclusions: Across 3 cohorts, most hypotension occurred in temporal clusters of hypotension that were usually predictable from extrapolation of MAP trends.
    Type of Medium: Online Resource
    ISSN: 0885-0666 , 1525-1489
    URL: Article
    DOI: 10.1177/08850666241226893
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2001472-7
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  • 6
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    The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: evaluation by the new SPECT-ligand[99mTc]TRODAT-1
    SAGE Publications ; 2005
    In:  Journal of Psychopharmacology Vol. 19, No. 5 ( 2005-09), p. 488-493
    Details
    In: Journal of Psychopharmacology, SAGE Publications, Vol. 19, No. 5 ( 2005-09), p. 488-493
    Abstract: Following the current hypothesis that acute schizophrenic psychotic illness is associated with a striatal ‘hyperdopaminergic state’, presynaptic integrity and dopamine transporter (DAT) density in first-episode, neuroleptic-naive schizophrenic patients was measured by single-photon-emission-tomography (SPECT) and compared with that in healthy control subjects. A new SPECT-ligand for assessment of the striatal DAT, the Technetium- 99 m-labelled tropane TRODAT-1 ([ 99m Tc]TRODAT-1), was used. Ten inpatients suffering from a first acute schizophrenic episode and 10 age- and sex-matched healthy control subjects underwent SPECT with [ 99m Tc]TRODAT-1. On the day of SPECT, psychopathological ratings were performed with the Brief Psychiatric Rating Scale (BPRS), the Positive and Negative Syndrome Scale (PANSS) and Schedule for Assessment of Negative Symptoms (SANS). Patients had not previously received any neuroleptic or antidepressant medication. Mean specific TRODAT-1 binding in the striatum did not differ significantly between the patient and the age- and sex-matched control group (1.25 vs. 1.28). Variance was significantly higher in the patient group. The data obtained with the new ligand in first-episode, drug-naive schizophrenic patients are in line with the PET results from the group of Laakso et al. in a comparable patient sample. [ 99m Tc]TRODAT-1 seems to be a valuable new SPECT-ligand in the evaluation of the presynaptic site of the striatal dopaminergic synapse in schizophrenia.
    Type of Medium: Online Resource
    ISSN: 0269-8811 , 1461-7285
    URL: Article
    DOI: 10.1177/0269881105056530
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2028926-1
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  • 7
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    The Psychometric Properties of the Minnesota Tobacco Withdrawal Scale Among Patients With Mental Illness
    SAGE Publications ; 2020
    In:  Biological Research For Nursing Vol. 22, No. 2 ( 2020-04), p. 247-255
    Details
    In: Biological Research For Nursing, SAGE Publications, Vol. 22, No. 2 ( 2020-04), p. 247-255
    Abstract: Approximately 65% of psychiatric inpatients experience moderate-to-severe nicotine withdrawal (NW), a set of symptoms appearing within 24 hr after an abrupt cessation or reduction of use of tobacco-containing products in those using nicotine daily for at least a couple of weeks. The Minnesota Tobacco Withdrawal Scale (MTWS) is a widely used instrument for detecting NW. However, the psychometric properties of the MTWS have not previously been examined among patients with serious mental illness (SMI) undergoing tobacco-free hospitalization. The objective of this study was to examine the validity and reliability of the MTWS among patients with SMI during tobacco-free psychiatric hospitalization. Methods: Reliability was tested by examining Cronbach’s α and item analysis. Validity was examined through hypothesis testing and exploratory factor analysis ( N = 255). Results: The reliability analysis yielded a Cronbach’s α coefficient of .763, an inter-item correlations coefficient of .393, and item-total correlations between .291 and .691. Hypothesis testing confirmed the construct validity of the MTWS, and an exploratory factor analysis yielded a unidimensional scale. Conclusion: The MTWS demonstrated adequate reliable and valid psychometric properties for measuring NW among patients with SMI. Nurses and other health-care professionals may use this instrument in clinical practice to identify patients with SMI experiencing NW. The MTWS is psychometrically sound for capturing NW during tobacco-free psychiatric hospitalization. Future research should examine the efficacy of the MTWS in measuring NW in this population over an extended period of hospitalization.
    Type of Medium: Online Resource
    ISSN: 1099-8004 , 1552-4175
    URL: Article
    DOI: 10.1177/1099800419895573
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2070503-7
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  • 8
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    Prevalence of Hepatic Parasites in Korean Wild Rats ( Rattus norvegicus ) and Their Association With Pulmonary Arteriolar Medial Hypertrophy
    SAGE Publications ; 2010
    In:  Veterinary Pathology Vol. 47, No. 2 ( 2010-03), p. 292-297
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 47, No. 2 ( 2010-03), p. 292-297
    Abstract: C hepatica, an important zoonotic parasite, and C fasciolaris are common parasites in rodents. In rodent livers, C hepatica causes sequential morphologic changes that are designated as early, intermediate, or late phase, and C fasciolaris forms cysts surrounded by fibroplasia and granulomatous inflammation. The present study describes the prevalence of these parasites and associated liver and lung lesions in wild rats ( Rattus norvegicus) living around pig farms in South Korea. Selected parenchymal organs, including liver and lung, of 89 wild rats were examined. Of 89 rats, 28 (31.5%) were infected with either C hepatica or C fasciolaris or with both parasites. Severe medial hypertrophy of small arterioles was observed in the lungs of 11 of the 28 parasite-infected rats ( P 〈 .01). The pulmonary arteriolar hypertrophy in the rats infected with C hepatica was strongly associated with early and/or intermediate phases (88.8%) of morphologic change in the livers ( P 〈 .01). As such, this report is the first to suggest a significant association between parasite-induced hepatitis and pulmonary arteriolar hypertrophy in rodents. Further studies are warranted for the use of C hepatica–infected rats as an animal model to explore the underlying mechanisms of portopulmonary hypertension in humans.
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1177/0300985809359306
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2106608-5
    SSG: 22
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  • 9
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    A Randomized Trial to Test Personalized Environmental Report Back to Reduce Lung Cancer Risk
    SAGE Publications ; 2019
    In:  Health Education & Behavior Vol. 46, No. 1 ( 2019-02), p. 165-175
    Details
    In: Health Education & Behavior, SAGE Publications, Vol. 46, No. 1 ( 2019-02), p. 165-175
    Abstract: Background. More radon-related lung cancers occur among those exposed to tobacco smoke. Objectives. To test the effects of a personalized environmental report back intervention on change in stage of action for air nicotine testing and adopting a smoke-free home and radon testing and mitigation from baseline to 3 months postintervention. Methods. The study design used a two-arm parallel groups randomized controlled trial with stratified quota sampling. The treatment group received free air nicotine and radon home test kits and a brief problem-solving phone intervention; the control group received a coupon for free test kits. A sample of 515 homeowners were enrolled; 319 completed the 3-month follow-up. Stage of action to test and remediate the home was measured consistent with the precaution adoption process model. Linear mixed modeling assessed whether the main and interaction effects of treatment and time were associated with the testing and remediation outcomes; multiple covariates were included in the models. Results. The models for the four stages of action outcomes (testing and remediating for radon and secondhand smoke) each had a significant treatment-by-time effect. The general pattern was an increase in stage of action from baseline to 3 months. The degree of change was generally larger among the treatment group participants relative to the controls, indicating that those in the treatment group were more ready to take action. For all the models, participants with higher self-efficacy for radon/air nicotine testing and radon/secondhand smoke remediation were more ready to take action to test and remediate. Synergistic risk perception was associated with stage of action for radon mitigation. Conclusions. Homeowners who were provided free radon and air nicotine test kits, given their results, and engaged in a brief telephonic problem-solving consultation tended to show a greater increase in readiness to take action to test and remediate by 3 months compared with those who received standard public health practice. Both groups showed an increase in stage of action for all four outcomes over time.
    Type of Medium: Online Resource
    ISSN: 1090-1981 , 1552-6127
    URL: Article
    DOI: 10.1177/1090198118788602
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2082564-X
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  • 10
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    On-Line Sorting of Wood Treated with Chromated Copper Arsenate Using Laser-Induced Breakdown Spectroscopy
    SAGE Publications ; 2002
    In:  Applied Spectroscopy Vol. 56, No. 10 ( 2002-10), p. 1337-1344
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 56, No. 10 ( 2002-10), p. 1337-1344
    Abstract: This paper details the design, implementation, and field evaluation of an online detector system using laser-induced breakdown spectroscopy (LIBS) for the analysis of copper chromated arsenate (CCA) treated wood products. The LIBS-based instrument functioned by creating the laser-induced plasma directly on the sample surface while wood was translated under the detector system, and was successful in discriminating between CCA treated wood and untreated wood products based on the atomic emission signal of chromium. The system was optimized for plasma emission collection both in and out of the laser focal plane and temporally optimized for chromium analysis using a compact, non-intensified charge-coupled device (CCD)/spectrometer unit. Using either single laser pulse spectra or 5-shot and 10-shot spectral averages, the accuracy of LIBS-based analysis ranged from 92 to 100% for identifying both CCA treated and untreated wood samples from the waste stream at a construction and demolition debris recycling center. Additional implementation issues are discussed in the context of LIBS-based on-line sorting of construction and demolition wood debris.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1366/000370202760355316
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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