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  • SAGE Publications  (2)
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  • SAGE Publications  (2)
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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2020
    In:  Advances in Structural Engineering Vol. 23, No. 11 ( 2020-08), p. 2333-2342
    In: Advances in Structural Engineering, SAGE Publications, Vol. 23, No. 11 ( 2020-08), p. 2333-2342
    Abstract: A long-span stadium roof has always been a wind load sensitive system, given its usual complex curved surface. However, there is no definite method for calculating the wind load shape factor of the complex building in the code. Based on this, the standard [Formula: see text] model was applied to the computational fluid dynamics numerical simulation of a long-span stadium roof at the wind attack angles of 0°–180°. The pressure distribution on the top and bottom surfaces of the stadium roof and the wind load shape factor were obtained by numerical simulation. The results show that the negative pressure was dominant on the top surface of the roof and the positive pressure was dominant on the bottom surface of the stadium at the wind attack angle of 0°. The ring-shaped curtain wall made the wind field environment more complicated, mainly under the wind attack angles of 45° and 180°. Because of the dip angles at both ends of the roof, the wind pressure distribution at both ends of the roof was opposite to the main region. The maximum wind load shape factors of each region were negative. In addition, the maximum wind load shape factor was at 45°, which was −1.1. The maximum wind load shape factors in regions of R13–R19 were larger, which should be paid attention in design stage. In general, the wind load shape factors were large in the central region and small at both ends. The wind load shape factors of the roof were bounded by 90°, showing an anti-symmetric trend.
    Type of Medium: Online Resource
    ISSN: 1369-4332 , 2048-4011
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2026561-X
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  • 2
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 23 ( 2024-01)
    Abstract: Cadonilimab (AK104) is a bispecific IgG-single-chain Fv fragment (ScFv) antibody that binds to PD-1 and CTLA-4. Cadonilimab has shown encouraging anti-tumour activity and a favourable safety profile in several tumour types. In second-line treatment, there is no defined standard of care for patients with extensive-stage small-cell lung cancer (ES-SCLC). Cadonilimab is expected to show substantial clinical efficacy. Objective To assess the antitumor activity and safety of cadonilimab monotherapy or combination with conventional therapy in ES-SCLC patients who failed first-line treatment. Methods In this multicenter, open-label, phase II study, ES-SCLC patients who had failed first-line treatment, also aged 18 years to 70 years with histologically or cytologically confirmed ES-SCLC, and an Eastern Cooperative Oncology Group performance status (ECOG-PS) of 0–2 were eligible. Patients will receive cadonilimab 10 mg/kg every three weeks (Q3 W) among 24 months until progressive disease (PD) or adverse events (AE) discovery. The primary endpoint is progression-free survival (PFS). Trial registration NCT05901584.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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