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  • SAGE Publications  (6)
  • 1
    Online Resource
    Online Resource
    β-Phenylselenoethanol, an Efficient Reagent for the One-Pot Synthesis of Aryl Vinyl Ethers
    SAGE Publications ; 2008
    In:  Journal of Chemical Research Vol. 2008, No. 10 ( 2008-10), p. 595-597
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 2008, No. 10 ( 2008-10), p. 595-597
    Abstract: β-Phenylselenoethanol was treated with phenols under Mitsunobu conditions and subsequent oxidation-elimination with 30% hydrogen peroxide furnished aryl vinyl ethers with good yields (85–90%) in a one-pot, two-step transformation.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/030823408X360355
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 3010810-X
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  • 2
    Online Resource
    Online Resource
    Study on the effect of Periplaneta americana on ulcerative colitis in rats induced by 2,4,6-trinitrobenzene sulfonic acid
    SAGE Publications ; 2020
    In:  European Journal of Inflammation Vol. 18 ( 2020-01), p. 205873922094262-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 18 ( 2020-01), p. 205873922094262-
    Abstract: Ulcerative colitis (UC) is a chronic inflammatory disease of intestinal tract, and Periplaneta americana has been found to be effective in the treatment for UC. The purpose of the study was to investigate the therapeutic effect of Periplaneta americana extract Ento-A on UC in rats induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) and to explore its mechanism. The Sprague-Dawley (SD) rats were randomly divided into normal control group; TNBS-treated group; sulfasalazine (SASP) treated group; Ento-A low- (50 mg/kg), medium- (100 mg/kg), and high-dose (200 mg/kg) groups, respectively. The UC model of rats was induced via TNBS. Disease activity index (DAI) was used to evaluate the severity of UC in rats. The macroscopic and microscopic damages of colon were accessed by colon mucosa damage index (CMDI) and histopathological score (HS), respectively. The levels of interleukin-4 (IL-4), interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in serum and the contents of myeloperoxidase (MPO), transforming growth factor-β1 (TGF-β1), and epidermal growth factor (EGF) in colonic mucosa were measured by enzyme-linked immunosorbent assay (ELISA). Compared with the normal control group, the TNBS-treated group showed increase in DAI, CMDI, HS, IL-17, TNF-α, IFN-γ as well as MPO and decrease in the levels of IL-4, EGF, and TGF-β1. However, Ento-A-administrated groups reversed the changes in the DAI, CMDI, HS, and the cytokines caused by TNBS. The study indicates that Periplaneta americana extract Ento-A can effectively alleviate the inflammation in TNBS-induced UC of rats, and the mechanism of that may be related to restoring the balance of T helper 1 (Th1)/Th2/Th17/T regulatory (Treg) cytokines.
    Type of Medium: Online Resource
    ISSN: 2058-7392 , 2058-7392
    URL: Article
    DOI: 10.1177/2058739220942629
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2584683-8
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  • 3
    Online Resource
    Online Resource
    Organo-Soluble Fluorinated Polyimides Derived from 4,4′-Bis (3-amino-5-tri uoromethylphenoxy)-3,3′,5,5′-tetramethyl biphenyl (TFMDA) and Aromatic Dianhydrides
    SAGE Publications ; 2006
    In:  High Performance Polymers Vol. 18, No. 2 ( 2006-04), p. 145-161
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 18, No. 2 ( 2006-04), p. 145-161
    Abstract: A series of organo-soluble polyimides based on a new fluorinated diamine, 4,4′-bis(3-amino-5-trifluoromethylphenoxy)-3,3′,5,5′-tetramethyl biphenyl (3,5-TFMDA) and various aromatic dianhydrides, were synthesized and characterized. The structures of the obtained polyimides were affirmed by Fourier transform infrared measurement and the properties were evaluated by wide-angle X-ray diffraction measurement, ultraviolet-visible analysis, thermogravimetry (TG), differential scanning calorimetry (DSC), tensile and electrical tests, and solubility tests. It was shown that the polyimides have good solubility not only in polar aprotic solvents, but in many common solvents, such as cyclopentanone, chloroform, and even in toluene for PI-4, derived from TFMDA and 2,2′-bis(3,4-dicarboxyphenyl) hexafluoropropane dianhydride (6FDA). The polyimide solutions could be cast into flexible and tough films, which exhibited good thermal stability up to 500° C and showed glass transition temperatures in the range of 250–280° C. The films also showed acceptable tensile properties and good electrical insulating properties. Furthermore, the polyimide films exhibited good transparency in the visible light region with transmittance higher than 80% at 450 nm and a cut-off wavelength lower than 360 nm.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008306056751
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 1483713-4
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  • 4
    Online Resource
    Online Resource
    Three Gorges Project: Efforts and challenges for the environment
    SAGE Publications ; 2010
    In:  Progress in Physical Geography: Earth and Environment Vol. 34, No. 6 ( 2010-12), p. 741-754
    Details
    In: Progress in Physical Geography: Earth and Environment, SAGE Publications, Vol. 34, No. 6 ( 2010-12), p. 741-754
    Abstract: The Three Gorges Project has been subject to intense debates regarding its benefits and costs. The environmental impacts of this huge project have been an important focus of these debates since the project planning stage. After the operation of the Three Gorges Dam at full capacity at the end of 2008, new environmental and ecological issues are emerging. This paper gives a brief description of the Three Gorges Project and its environmental impact assessment process, as well as major efforts to control environmental problems brought about by the project. From the long and complicated evaluation process, it is clear that there are large uncertainties and competing opinions regarding the benefits and costs, especially the ecological and environmental ones, of the project even after great research effort. Emphasis here is given to the environmental challenges including: (1) water quality control; (2) water and sediment regulation; (3) biodiversity conservation in the riparian and aquatic ecosystems; (4) environmentally friendly dam operation and regional sustainable development. Opportunities often grow out of the challenges. The Three Gorges Project provides opportunities for grand-scale experiments on the environmental, ecological, and socio-economic impacts of large dams. Local, national, and international concerted efforts and concrete actions should be directed to the mitigation and control of the negative impacts as well as securing the positive contributions of the project across scales.
    Type of Medium: Online Resource
    ISSN: 0309-1333 , 1477-0296
    URL: Article
    DOI: 10.1177/0309133310370286
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2006623-5
    SSG: 14
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  • 5
    Online Resource
    Online Resource
    Elevated Human Endothelial Cell-Specific Molecule-1 Level and Its Association with Coronary Artery Disease in Patients with Hypertension
    SAGE Publications ; 2015
    In:  Journal of Investigative Medicine Vol. 63, No. 7 ( 2015-10), p. 867-870
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 63, No. 7 ( 2015-10), p. 867-870
    Abstract: Endothelial dysfunction plays an important role in the pathophysiology of coronary artery disease (CAD). Previous studies suggested that human endothelial cell-specific molecule-1 (endocan) may be a novel endothelial dysfunction marker. This study aims to investigate the relationship between serum endocan level and the presence and severity of CAD in patients with hypertension. Methods A total of 190 eligible hypertension patients were enrolled in this study. Serum endocan level was measured by enzyme-linked immunosorbent assay. The presence and severity of CAD were evaluated by coronary angiography. Results Hypertensive patients with CAD had significantly higher serum endocan level than those without CAD (1.63 ± 0.51 ng/mL vs 1.31 ± 0.65 ng/mL, P 〈 0.05). Multivariate logistic regression revealed that serum endocan level was independently associated with the presence of CAD (odds ratio, 2.662; 95% confidence interval, 1.560–4.544; P 〈 0.001). Spearman rank correlation analysis demonstrated that serum endocan level was associated with SYNergy between PCI with TAXUS and Cardiac Surgery score (r = 0.349, P = 0.001). Conclusions Serum endocan level is independently correlated with the presence and severity of CAD in hypertension patients, and those with high endocan level may have an increased risk of developing atherosclerosis.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1097/JIM.0000000000000219
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
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  • 6
    Online Resource
    Online Resource
    Effects of the Traditional Chinese Medicine Formula Ento-PB in Experimental Models of Ulcerative Colitis
    SAGE Publications ; 2022
    In:  Natural Product Communications Vol. 17, No. 3 ( 2022-03), p. 1934578X2210784-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 17, No. 3 ( 2022-03), p. 1934578X2210784-
    Abstract: The traditional Chinese medicine (TCM) formula Ento-PB containing Periplaneta americana (Linnaeus) (Blattidae) and Taraxacum mongolicum Hand.-Mazz. (Compositae) has great potential for treating inflammation. This study explored the effects of Ento-PB on ulcerative colitis (UC). The UC model was induced with 2,4,6-trinitrobenzene sulfonic acid (TNBS) by enema. Male Sprague–Dawley rats (n = 32) were divided into four groups: (1) control group that received 2.5 mL/kg normal saline, (2) TNBS group that received 2.5 mL/kg normal saline, (3) Ento-PB low-dose group that received 100 mg/kg Ento-PB, and (4) Ento-PB high-dose group that received 200 mg/kg Ento-PB. Rats were administered drugs via enema for 14 days after modeling. The disease activity index (DAI), colon mucosa damage index (CMDI), histopathological score (HS), levels of interleukin-8 (IL-8), IL-10, IL-17, tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) in serum, contents of IL-2, myeloperoxidase (MPO), transforming growth factor-β1 (TGF-β1), and epidermal growth factor (EGF) in the colon, and abundance of Bifidobacterium, Lactobacillus, Enterococcus, Bacteroides, and Escherichia coli were assessed. Ento-PB administration showed a significant reduction in DAI, CMDI, and HS, contents of IL-2, IL-8, IL-17, TNF-α, CRP, and MPO, and a significant increase in the levels of IL-10, TGF-β1, and EGF. Compared with the TNBS-administered group, the abundance of Bifidobacterium, Lactobacillus, Enterococcus, and E. coli decreased, while an obvious increase in the proportion of Bacteroides was found in the Ento-PB-administered groups. Ento-PB alleviated inflammation in UC by regulating the equilibrium of Th1/Th17/Treg cytokines and recovering the imbalance between the gut microbiota. Applying Ento-PB in treating UC could be suggested.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X221078453
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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