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  • SAGE Publications  (91)
  • 1
    In: Molecular Pain, SAGE Publications, Vol. 7 ( 2011-01-01), p. 1744-8069-7-19-
    Abstract: Functional acupoint specificity is crucial to the clinical efficacy of acupuncture treatment, such as pain relief. Whether acupuncture needling at a peripheral acupoint produces distinct patterns of brain responses remains controversial. Results: This fMRI study employed the complex network analysis (CNA) to test the hypothesis that acupuncture stimulation at an acupoint correspondingly induced activity changes in one or more intrinsic or resting-state brain networks. Built upon the sustained effect of acupuncture and its time-varying characteristics, we constructed a dynamic encoding system with the hub anchored at the posterior cingulate cortex and precuneus (PCC/pC). We found that needling at two visual acupoints (GB37 and BL60) and a non-visual acupoint (KI8) induced a spatially converging brain response, which overlapped at the PCC/pC. We also found distinct neural modulations during and after acupoint stimulation. During this period, the PCC/pC interacted with a visual resting-state network in different patterns. Furthermore, there was a delayed functional correspondence between the intrinsic visual network and manipulation over the visual acupoints (i.e., GB37 or BL60), but not the non-visual acupoint (KI8) via the PCC/pC, implicating a specific temporal-spatial encoding/decoding mechanism underlying the post-effect of acupuncture. Conclusions: This study provided an integrated view exploring the functional specificity of acupuncture in which both the needling sensation and the following neural cascades may contribute to the overall effect of acupuncture through dynamic reconfiguration of complex neural networks.
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2174252-2
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  • 2
    In: Gene Regulation and Systems Biology, SAGE Publications, Vol. 4 ( 2010-01), p. GRSB.S6065-
    Abstract: The protein phosphatase-2A (PP-2A), one of the major phosphatases in eukaryotes, is a heterotrimer, consisting of a scaffold A subunit, a catalytic C subunit and a regulatory B subunit. Previous studies have shown that besides regulating specific PP-2A activity, various B subunits encoded by more than 16 different genes, may have other functions. To explore the possible roles of the regulatory subunits of PP-2A in vertebrate development, we have cloned the PR55/B family regulatory subunits: β and δ, analyzed their tissue specific and developmental expression patterns in Goldfish ( Carassius auratus). Our results revealed that the full-length cDNA for PR55/Bβ consists of 1940 bp with an open reading frame of 1332 nucleotides coding for a deduced protein of 443 amino acids. The full length PR55/Bδ cDNA is 2163 bp containing an open reading frame of 1347 nucleotides encoding a deduced protein of 448 amino acids. The two isoforms of PR55/B display high levels of sequence identity with their counterparts in other species. The PR55/Bβ mRNA and protein are detected in brain and heart. In contrast, the PR55/Bδ is expressed in all 9 tissues examined at both mRNA and protein levels. During development of goldfish, the mRNAs for PR55/Bβ and PR55/Bδ show distinct patterns. At the protein level, PR55/Bδ is expressed at all developmental stages examined, suggesting its important role in regulating goldfish development. Expression of the PR55/Bδ anti-sense RNA leads to significant downregulation of PR55/Bδ proteins and caused severe abnormality in goldfish trunk and eye development. Together, our results suggested that PR55/Bδ plays an important role in governing normal trunk and eye formation during goldfish development.
    Type of Medium: Online Resource
    ISSN: 1177-6250 , 1177-6250
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2383407-9
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 233, No. 1 ( 2019-01), p. 180-196
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 233, No. 1 ( 2019-01), p. 180-196
    Abstract: This paper deals with the controllers design using a novel siding mode control and proportional–derivative control for the trajectory tracking problem of a new multi-rotor aircraft, which experiences angular velocity sensor faults and external disturbances. The control system is divided into two parts: the inner loop for attitude subsystem and outer loop for position subsystem. For the inner loop, the angular velocity sensor faults, including bias, drift, loss of accuracy, and loss of effectiveness are considered as equivalent mismatched disturbances, while the system internal coupling, nonlinearity, and external disturbances are considered as equivalent matched disturbances. A novel sliding mode control approach is proposed for inner loop controller design, which includes a nonlinear disturbance observer to estimate both mismatched and matched disturbances, a novel switching surface based on the estimation of the mismatched disturbance to counteract its impact, a double power reaching law to attenuate the chattering problem, and a compensation for the matched disturbance to reduce the controller gains. The sensor faults are handled without fault detection and controller reconfiguration, making the method require less computation and easy implementation. The proposed method enhances the robustness without sacrificing the nominal properties. For outer loop, the proportional–derivative approach is used to design the virtual controller. The closed-loop system stability is proved by the Lyapunov theory. Finally, various simulation experiments are shown to validate the effectiveness, robustness, and the superiority of the proposed flight control scheme.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2032759-6
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  • 4
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 28 ( 2022-01), p. 107602962211333-
    Abstract: Left atrial thrombus (LAT) often complicates with atrial fibrillation (AF). The evidence whether fibrin D-dimer levels could be used as a predictive biomarker for LAT is contradictory. This study firstly investigated the relationship between ‘normal range’ D-dimer and prevalent LAT. Second, we explored factors contributing to normal D-dimer levels in the presence of LAT. Methods We studied 244 AF patients with LAT (mean age: 59.9 years, SD:11.7; 53.3% female): of these, 103 (42.2%) had normal D-dimer, 25 (10.2%) had atrial thrombus exclusion score (ATE score) of 0 19 (16.7%) males had CHA 2 DS 2 -VASc score of 0, 21(16.2%) females had CHA 2 DS 2 -VASc score of 1 and 16 had overlapped ATE score of 0 and CHA 2 DS 2 -VASc score of 0 (N = 8 if male) or CHA 2 DS 2 -VASc score of 1(N = 8 if female). Using multivariate binary analysis, larger left atrial diameter (LAD; adjusted OR: 1.06, 1.03−1.10, p = 0.001) were associated with increased D-dimer. Patients with high body mass index (BMI), hypertension history and previous anticoagulation were more likely to show normal range D-dimer levels in the presence of LAT. Conclusions A high prevalence (42.2%) of ‘normal range’ D-dimer levels was found in AF patients with LAT, especially in those with hypertension, high BMI and prior anticoagulation. D-dimer levels of those patients with larger LAD were more likely to be increased.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2230591-9
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  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2007
    In:  Journal of Chemical Research Vol. 2007, No. 6 ( 2007-06), p. 350-352
    In: Journal of Chemical Research, SAGE Publications, Vol. 2007, No. 6 ( 2007-06), p. 350-352
    Abstract: The monoprotonated bipyridinium cation can complex with dibenzo-24-crown-8 by means of ion-dipole and charge-transfer interactions. They both thread to form a [2]pseudorotaxane-like complex for further intercomplex association to produce pseudopolyrotaxane arrays through N + –H···N hydrogen bonding in the solid state.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 3010810-X
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2020
    In:  Science Progress Vol. 103, No. 1 ( 2020-01), p. 003685041988445-
    In: Science Progress, SAGE Publications, Vol. 103, No. 1 ( 2020-01), p. 003685041988445-
    Abstract: Long-distance gas pipelines generally have complex, undulating sections. Trapped air pockets are often present at the high points or ends of pipelines. This article carries out an experimental research to figure out the transient changes. First of all, under the condition of using the pig with 231 g and the injection pressure of 0.3 MPa, the hydraulic pulse increases from 0.31 to 0.54 MPa as the liquid level rises from 1 to 8 m. And at the liquid level of 8 m, the injection pressure grows from 0.3 to 0.75 MPa and the hydraulic pulse from 0.54 to 0.95 MPa. When the interception air mass is located at the blind side of the pipeline’s end, the injection pressure is 0.75 MPa, and the hydraulic pulse decreases from 4.9 to 3.21 MPa with the increase in the void fraction. The maximum hydraulic pressure generates when the air pocket is located at the rear end of the drainage system (4.9 MPa) is far higher than that when the air pocket is located in front of the pig (1.0 MPa). Therefore, it is necessary to minimize the generation of trapped air pockets at the rear end of the pipeline system to ensure safety.
    Type of Medium: Online Resource
    ISSN: 0036-8504 , 2047-7163
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2483680-1
    detail.hit.zdb_id: 2199376-2
    SSG: 11
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2016
    In:  Advances in Mechanical Engineering Vol. 8, No. 12 ( 2016-12), p. 168781401667991-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 8, No. 12 ( 2016-12), p. 168781401667991-
    Abstract: The friction and wear behavior exists in ultra-deep coal mine between multi-layer winding hoisting ropes, and it decreases the rope’s service life directly, which threatens the safety coal mine hoist. In order to obtain the tribological properties of winding hoisting rope, the effects of sliding velocity, displacement amplitude, and their combination on the tribological behavior of winding hoisting rope in ultra-deep coal mine were investigated on a self-made test rig. The results show that the effect of velocity on the coefficient of friction and temperature rise is more obvious than the stroke. Additionally, the mean value of the coefficient of friction in steady stage decreases from 0.721 to 0.524 with an increase in velocity and stroke at the same time. Furthermore, the temperature rise increases from about 3.43°C to 13.73°C with the velocity at stable stage, and the stroke has little influence on the temperature rise. Moreover, with the increase in velocity and stroke simultaneously, the damage in the wear region does not become more severe. In addition, the wear mechanisms include abrasive wear and adhesive wear, and its wear characteristics in the wear region are plastic deformation, pits, furrows, broken wires, cracking, and spalling.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2501620-9
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2020
    In:  Advances in Mechanical Engineering Vol. 12, No. 3 ( 2020-03), p. 168781402091298-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 12, No. 3 ( 2020-03), p. 168781402091298-
    Abstract: The Thomson coil actuator has an important application prospect in direct current high-speed switch due to its short respond time and fast operation speed. However, the large electromagnetic impact force during the opening process may bring the stress deformation of movable components and thus cause damage to the mechanism. Therefore, the dynamic stress and strain evaluation of the moving parts is very important for the design and optimization of direct current high-speed switch. In this article, a novel method of structure strength analysis based on the flexible body theory is established for direct current high-speed switch. The electromagnetic and buffer forces in the rapid opening process are calculated, and then the stress and strain distribution of the key components are obtained. Finally, the strain test circuit of the key components is built. By comparing the simulation and experimental results of dynamic strain, the validity of the established simulation model is verified.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2501620-9
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  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Advances in Mechanical Engineering Vol. 14, No. 1 ( 2022-01), p. 168781402110729-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 14, No. 1 ( 2022-01), p. 168781402110729-
    Abstract: Multiphase pumps play an important role in the exploitation of natural gas hydrate. Compared with ordinary pumps, they can handle fluids with higher gas volume fraction (GVF). Therefore, it is important to improve the performance of the pump under high GVF. A model pump is designed based on the design theory of axial flow pump and centrifugal pump inducer. The hydraulic performance of the model pump is verified by numerical simulation and experiment. The Sparse Grid method is applied to the design of experiment (DOE), and three different adaptive refined response surface methods (RSM) are applied to the build the approximate model. Refinement points and verification points are used to improve and verify the precision of the response surface, respectively. The model with high precision and high computational efficiency is obtained through comparison and analysis. The multi-objective optimization of the optimal response surface model is carried out by MOGA (Multi-Objective Genetic Algorithm) method. The pressure increment of the optimized model is increased by 38 kPa. The efficiency is significantly improved under large mass flow conditions. The hydraulic performance of the optimized model is compared with that of the basic model. And the reasons that affect the performance of the multiphase pump are analyzed.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2501620-9
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  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Advances in Mechanical Engineering Vol. 11, No. 7 ( 2019-07), p. 168781401985138-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 11, No. 7 ( 2019-07), p. 168781401985138-
    Abstract: First, the lifting mechanism of neutron spectrometer sample table was designed. Then, every single part flexible multibody models and all parts flexible multibody model were built using ANSYS and ADAMS. Finally, the single part flexible multibody models and all parts flexible multibody model were analyzed when lifting mechanism reached the highest position and sliding table was moving along the X- or Y-axis with 1 ton load. The results indicate that the average deformation along Z direction is maximum among all directions of sliding table center, which is 30.1 μm. Outer cylinder takes up the largest proportion of the deformation in X direction, which is 75.8%, middle cylinder takes up the largest proportion of the deformation in Y direction, which is 91.32%, and inner cylinder takes up the largest proportion of the deformation in Z direction, which is 89.36%. Among the eight guide rails of lifting mechanism, four guide rails between the inner and middle cylinders are under uniform load, and the other four guide rails between middle and outer cylinder are under non-uniform load. The findings of the research could guide the optimal design of the neutron spectrometer sample table.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2501620-9
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