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  • SAGE Publications  (9)
  • 1
    Online-Ressource
    Online-Ressource
    Effect of Sex on the Induction of Anti-DNA Antibodies in Normal Mice Immunized with Bacterial DNA
    SAGE Publications ; 1993
    In:  Lupus Vol. 2, No. 1_suppl ( 1993-02), p. 251-255
    Details
    In: Lupus, SAGE Publications, Vol. 2, No. 1_suppl ( 1993-02), p. 251-255
    Kurzfassung: Immunization of normal mice with bacterial DNA elicits a significant IgG anti-DNA response and has been explored as a model of systemic lupus erythematosus. To determine whether this induced response is influenced by sex, we have measured anti-DNA levels in normal male and female BALB/c mice immunized with single stranded DNA from E. coli as complexes with methylated bovine serum albumin (mBSA) in adjuvant. By ELISA assays, anti-DNA levels of immunized females were approximately 16-fold higher than those of immunized males; levels of antibodies to the mBSA carrier were similar, however. The antibodies from females and males showed a similar degree of cross-reactivity when assayed using other natural and synthetic DNA antigens, including mammalian DNA. These findings suggest the potentiation of anti-DNA production in females by antigen-specific mechanisms and provide further evidence that immunization with bacterial DNA replicates features of autoantibody production in SLE.
    Materialart: Online-Ressource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203393002001121
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1993
    ZDB Id: 2008035-9
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    Effect of Sex on the Induction of Anti-DNA Antibodies in Normal Mice Immunized with Bacterial DNA
    SAGE Publications ; 1993
    In:  Lupus Vol. 2, No. 4 ( 1993-08), p. 251-255
    Details
    In: Lupus, SAGE Publications, Vol. 2, No. 4 ( 1993-08), p. 251-255
    Kurzfassung: Immunization of normal mice with bacterial DNA elicits a significant IgG anti-DNA response and has been explored as a model of systemic lupus erythematosus. To determine whether this induced response is influenced by sex, we have measured anti-DNA levels in normal male and female BALB/c mice immunized with single stranded DNA from E. coli as complexes with methylated bovine serum albumin (mBSA) in adjuvant. By ELISA assays, anti-DNA levels of immunized females were approximately 16-fold higher than those of immunized males; levels of antibodies to the mBSA carrier were similar, however. The antibodies from females and males showed a similar degree of cross-reactivity when assayed using other natural and synthetic DNA antigens, including mammalian DNA. These findings suggest the potentiation of anti-DNA production in females by antigen-specific mechanisms and provide further evidence that immunization with bacterial DNA replicates features of autoantibody production in SLE.
    Materialart: Online-Ressource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/096120339300200408
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1993
    ZDB Id: 2008035-9
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Nitric Oxide Induces Apoptosis in Spleen Lymphocytes from MRL/Ipr Mice
    SAGE Publications ; 2004
    In:  Journal of Investigative Medicine Vol. 52, No. 1 ( 2004-01), p. 62-71
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 52, No. 1 ( 2004-01), p. 62-71
    Materialart: Online-Ressource
    ISSN: 1081-5589
    URL: Article
    DOI: 10.1097/00042871-200401000-00029
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2004
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Allogeneic Mesenchymal Stem Cell Transplantation in Severe and Refractory Systemic Lupus Erythematosus: 4 Years of Experience
    SAGE Publications ; 2013
    In:  Cell Transplantation Vol. 22, No. 12 ( 2013-12), p. 2267-2277
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 22, No. 12 ( 2013-12), p. 2267-2277
    Kurzfassung: Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitors and are capable of differentiating into several tissues of mesenchymal origin. We have shown that bone marrow-derived MSCs from both SLE patients and lupus-prone MRL/lpr mice are defective structurally and functionally. Here we observe the long-term safety and efficacy of allogeneic MSC transplantation (MSCT) in treatment-resistant SLE patients. Eighty-seven patients with persistently active SLE who were refractory to standard treatment or had life-threatening visceral involvement were enrolled. Allogeneic bone marrow or umbilical cord-derived MSCs were harvested and infused intravenously (1 × 10 6 cells/kg of body weight). Primary outcomes were rates of survival, disease remission and relapse, as well as transplantation-related adverse events. Secondary outcomes included SLE disease activity index (SLEDAI) and serologic features. During the 4-year follow-up and with a mean follow-up period of 27 months, the overall rate of survival was 94% (82/87). Complete clinical remission rate was 28% at 1 year (23/83), 31% at 2 years (12/39), 42% at 3 years (5/12), and 50% at 4 years (3/6). Rates of relapse were 12% (10/83) at 1 year, 18% (7/39) at 2 years, 17% (2/12) at 3 years, and 17% (1/6) at 4 years. The overall rate of relapse was 23% (20/87). Disease activity declined as revealed by significant changes in the SLEDAI score, levels of serum autoantibodies, albumin, and complements. A total of five patients (6%) died after MSCT from non-treatment-related events in the 4-year follow-up, and no transplantation-related adverse event was observed. Allogeneic MSCT resulted in the induction of clinical remission and improvement in organ dysfunction in drug-resistant SLE patients.
    Materialart: Online-Ressource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368911X582769c
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2013
    ZDB Id: 2020466-8
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 5
    Online-Ressource
    Online-Ressource
    Nitric Oxide Induces Apoptosis in Spleen Lymphocytes from MRL/lpr Mice
    SAGE Publications ; 2004
    In:  Journal Of Investigative Medicine Vol. 52, No. 01-S1 ( 2004), p. 062-
    Details
    In: Journal Of Investigative Medicine, SAGE Publications, Vol. 52, No. 01-S1 ( 2004), p. 062-
    Materialart: Online-Ressource
    ISSN: 1081-5589
    URL: Article
    DOI: 10.2310/6650.2004.12395
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2004
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    Nitric Oxide Induces Apoptosis in Spleen Lymphocytes from MRL/Ipr Mice
    SAGE Publications ; 2004
    In:  Journal of Investigative Medicine Vol. 52, No. 1 ( 2004-01-01), p. 62-71
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 52, No. 1 ( 2004-01-01), p. 62-71
    Materialart: Online-Ressource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1136/jim-52-01-29
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2004
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 7
    Online-Ressource
    Online-Ressource
    Nitric Oxide Induces Apoptosis in Spleen Lymphocytes from MRL/ lpr Mice
    SAGE Publications ; 2004
    In:  Journal of Investigative Medicine Vol. 52, No. 1 ( 2004-01), p. 62-71
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 52, No. 1 ( 2004-01), p. 62-71
    Kurzfassung: MRL/MpJ -Tnfrsf6 lpr (MRL/ lpr) mice, a murine model of systemic lupus erythematosus (SLE), have defective expression of Fas, substantially reducing signaling for apoptosis via this mechanism. However, it is known that MRL//pr mice have increased spontaneous apoptosis of leukocytes. These conflicting observations have stimulated interest in apoptosis in this SLE model. MRL/ lpr mice overproduce nitric oxide (NO) as autoimmune disease progresses. In vitro administration of NO may induce or decrease apoptosis depending on the cell type. Therefore, we hypothesized that NO induces MRL/ lpr spleen lymphocyte apoptosis independent of Fas receptor engagement. Methods Percentages of apoptotic spleen lymphocytes from MRL/ lpr and BALB/cJ mice were determined ex vivo after in vivo treatment with N G -monomethyl-l-arginine (NMMA), a nitric oxide synthase (NOS) inhibitor. After culture in varying concentrations of a slow-acting NO donor, the following were determined in spleen lymphocytes: (1) levels of apoptosis, (2) the effect of phorbol myristate acid (PMA) on levels of NO-induced apoptosis, and (3) protein kinase C (PKC) activity. Results Spleen lymphocytes from MRL/ lpr mice with active disease had increased levels of ex vivo apoptosis when compared with BALB/cJ controls. This increase was reduced by pharmacologic inhibition of NOS in MRL/ lpr but not in BALB/cJ mice. Exogenous administration of NO in vitro reduced PKC activity and induced apoptosis in MRL/ lpr spleen lymphocytes, an effect that could be reduced via coadministration of PMA in vitro. Conclusion These results suggest that NO plays a role in spleen lymphocyte apoptosis in MRL/ lpr mice, possibly via inhibition of PKC, despite a Fas defect.
    Materialart: Online-Ressource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1177/108155890405200129
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2004
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 8
    Online-Ressource
    Online-Ressource
    Effectiveness of Sublingual Clonidine in Patients Unable to Take Oral Medication
    SAGE Publications ; 1987
    In:  Drug Intelligence & Clinical Pharmacy Vol. 21, No. 3 ( 1987-03), p. 262-263
    Details
    In: Drug Intelligence & Clinical Pharmacy, SAGE Publications, Vol. 21, No. 3 ( 1987-03), p. 262-263
    Kurzfassung: We report evidence that sublingual Clonidine may be effective in the treatment of hypertension in the patient unable to take oral medication. Four cases are presented illustrating the utility of this regimen; few side effects were observed. Sublingual Clonidine may be a useful addition to the treatment of the hypertensive patient because of its apparent effectiveness, simplicity, and safety.
    Materialart: Online-Ressource
    ISSN: 0012-6578
    URL: Article
    DOI: 10.1177/106002808702100305
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1987
    ZDB Id: 2053518-1
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 9
    Online-Ressource
    Online-Ressource
    Inducible Nitric Oxide Synthase Inhibitor SD-3651 Reduces Proteinuria in MRL/lpr Mice Deficient in the NOS2 Gene
    SAGE Publications ; 2008
    In:  Journal of Investigative Medicine Vol. 56, No. 7 ( 2008-10), p. 911-919
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 56, No. 7 ( 2008-10), p. 911-919
    Kurzfassung: Several studies have demonstrated the effectiveness of arginine analog nitric oxide synthase (NOS) inhibitor therapy in preventing and treating murine lupus nephritis. However, MRL/MpJ- FAS lpr (MRL/lpr) mice lacking afunctional NOS2 (inducible NOS [iNOS]) gene (NOS2 −/− ) develop proliferative glomerulonephritis in a fashion similar to their wild-type (wt) littermates. This finding suggests that the effect of arginine analog NOS inhibitors is through a non-iNOS-mediated mechanism. This study was designed to address this hypothesis. NOS2 −/− mice were given either vehicle or a NOS inhibitor (SD-3651) to determine if pharmacological NOS inhibition prevented glomerulonephritis, using wt mice as positive controls. Urine was collected fortnightly to measure albumin. At the time of full disease expression in wt mice, all mice were killed, and renal tissue was examined for light, immunofluorescence, and electron microscopic evidence of disease. Serum was analyzed for anti-double-stranded DNA antibody production. NOS2 −/− mice had higher serum anti-double-stranded DNA antibody antibody levels than those of wt mice. SD-3651 therapy reduced proteinuria, glomerular immunoglobulin G deposition, and electron microscopic evidence of podocytopathy and endothelial cell swelling without affecting proliferative lesions by light microscopy. These studies confirm that genetic iNOS deficiency alone is insufficient to prevent proliferative glomerulonephritis and suggest that iNOS activity may inhibit autoantibody production. These results also suggest that SD-3651 therapy acts via a non-iNOS-mediated mechanism to prevent endothelial cell and podocyte pathology. Studies that elucidate this mechanism could provide a useful drug target for the treatment of nephritis.
    Materialart: Online-Ressource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.2310/JIM.0b013e3181889e13
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2008
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
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