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  • SAGE Publications  (26)
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  • SAGE Publications  (26)
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  • 1
    Online Resource
    Online Resource
    Global analysis of gene expression signature and diagnostic/prognostic biomarker identification of hepatocellular carcinoma
    SAGE Publications ; 2021
    In:  Science Progress Vol. 104, No. 3 ( 2021-07), p. 003685042110294-
    Details
    In: Science Progress, SAGE Publications, Vol. 104, No. 3 ( 2021-07), p. 003685042110294-
    Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. The landscape of HCC’s molecular alteration signature has been explored over the last few decades. Even so, more comprehensive research is still needed to improve understanding of tumorigenesis and progression of HCC, as well as to identify potential biomarkers for the malignancy. In this research, a comprehensive bioinformatics analysis was conducted based on the publicly available databases from both the Cancer Genome Atlas (TCGA) program and the gene expression omnibus (GEO) database. R/Bioconductor was used to analyze differentially expressed genes (DEGs) between HCC tumor and normal control (NC) samples, and then a protein-protein interaction (PPI) network of DEGs was established through the STRING platform. Finally, the application of specific candidate genes as diagnostic or prognostic biomarkers of HCC was explored and evaluated by ROC and survival analysis. A total of 310 DEGs were detected in the HCC tumor samples. Thirty-six hub DEGs in the PPI network and 10 candidates of the 36 genes showed significant alterations in tumor expression, including CDKN3, TOP2A, UBE2C, CDC20, PBK, ASPM, KIF20A, NCAPG, CCNB2, CYP3A4. The 10-gene signature had relatively significant effects when distinguishing tumors from normal samples (sensitivity 〉 70%, specificity 〉 70%, AUC 〉 0.8, p  〈  0.001). Eight candidate genes were negatively correlated with the overall survival rate of the patients ( p  〈  0.05) and were all up-regulated in HCC tumor samples. The age and gender factors had no significant impact on the overall survival rate of HCC patients ( p  〉  0.05), and the TNM stage status factor had a significant negative prognosis correlation ( p  〈  0.05). This research provides evidence for a better understanding of tumorigenesis and progression of HCC and helps to explore candidate targets for disease diagnosis and treatment.
    Type of Medium: Online Resource
    ISSN: 0036-8504 , 2047-7163
    URL: Article
    DOI: 10.1177/00368504211029429
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2483680-1
    detail.hit.zdb_id: 2199376-2
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Research on dynamic characteristic of compressor RIP under thermal oxygen aging and variable preload conditions
    SAGE Publications ; 2023
    In:  Advances in Mechanical Engineering Vol. 15, No. 7 ( 2023-07)
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 15, No. 7 ( 2023-07)
    Abstract: The dynamic characteristics of rubber isolation pad (abbreviated as RIP) after service under the high temperature thermal oxygen aging and the variable preloads have preload dependence and thermal oxygen aging dependence, which is a crucial problem for matching the vibration isolation system of air conditioner compressor to reveal the dynamic characteristic mechanism of the RIP with different preloads and thermal oxygen aging conditions. The Peck model is first introduced to characterize the thermal oxygen aging factor, the fractional derivative Kelvin-Voigt thermal oxygen aging-perturbation model (FDKVTPM) and the Coulomb frictional thermal oxygen aging-perturbation model (CFTPM) are established to describe the frequency dependence and the amplitude dependence, respectively. The thermal oxygen aging-dynamic characteristic model of the RIP is built by considering the influence of variable preloads, the model parameters under different preloads are further identified, the validity of the model was examined by the experimental data. The concepts of the stiffness transition point (STP) and the stiffness transition frequency (STF) are innovatively proposed to better describe softening effect of the RIP under variable preload and variable amplitude working conditions. The results show that the static stiffness of RIP increases by 20.7%, the dynamic stiffness increases by 9.3%, and the loss factor decreases by 35% after thermal oxygen aging under different preload conditions, which can lay a theoretical foundation for in-depth study of the stiffness matching and optimization of air conditioner compressor with the RIP.
    Type of Medium: Online Resource
    ISSN: 1687-8132 , 1687-8140
    URL: Article
    DOI: 10.1177/16878132231186734
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2501620-9
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Design and Development of the Humanoid Robot BHR-5
    SAGE Publications ; 2014
    In:  Advances in Mechanical Engineering Vol. 6 ( 2014-01-01), p. 852937-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 6 ( 2014-01-01), p. 852937-
    Abstract: This paper presents the mechanical and control system design of the latest humanoid robot platform, BHR-5, from Beijing Institute of Technology. The robot was developed as a comprehensive platform to investigate the planning and control for the fast responsive motion under unforeseen circumstances, for example, playing table-tennis. It has improvement on mechanical structure, stiffness, and reliability. An open control architecture based on concurrent multichannel communication mode of CAN bus is proposed to upgrade the real-time communication performance and the expansibility of the control system. Experiments on walking and playing table-tennis validate the effectiveness of the design.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1155/2014/852937
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2501620-9
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  • 4
    Online Resource
    Online Resource
    Abdominal fetus-in-fetu in a two-year-old boy
    SAGE Publications ; 2012
    In:  JRSM Short Reports Vol. 3, No. 7 ( 2012-07), p. 1-2
    Details
    In: JRSM Short Reports, SAGE Publications, Vol. 3, No. 7 ( 2012-07), p. 1-2
    Type of Medium: Online Resource
    ISSN: 2042-5333
    URL: Article
    DOI: 10.1258/shorts.2012.011174
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2762955-7
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  • 5
    Online Resource
    Online Resource
    Giant retroperitoneal liposarcoma
    SAGE Publications ; 2012
    In:  JRSM Short Reports Vol. 3, No. 2 ( 2012-02), p. 1-3
    Details
    In: JRSM Short Reports, SAGE Publications, Vol. 3, No. 2 ( 2012-02), p. 1-3
    Type of Medium: Online Resource
    ISSN: 2042-5333
    URL: Article
    DOI: 10.1258/shorts.2011.011110
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2762955-7
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  • 6
    Online Resource
    Online Resource
    An Effective Surgical Method for Terminal Syringomyelia: Terminal Ventriculostomy-Associated “V”-Type Ostomy
    SAGE Publications ; 2023
    In:  Global Spine Journal Vol. 13, No. 3 ( 2023-04), p. 796-803
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 13, No. 3 ( 2023-04), p. 796-803
    Abstract: Retrospective cohort study. Objectives: We aimed to evaluate the effectiveness of terminal ventriculostomy in treating tethered cord syndrome (TCS) combined with terminal syringomyelia (TS) and describe “V”-type ostomy as an effective surgical method to avoid relapsing syringomyelia based on terminal ventriculostomy. Methods: We retrospectively analyzed the clinical and radiological data of 28 patients admitted to the Department of Neurosurgery, PLA General Hospital who had been diagnosed with TCS combined with TS and underwent terminal ventriculostomy-associated “V”-type ostomy between January 2011 and January 2016. We classified patients’ clinical outcomes into 4 levels according to the Spinal Bifida Neurological Scale: markedly improved, improved, stable, and deteriorated. The size of the syrinx cavity was quantified using the syrinx index, and there was a difference in syrinx cavity size between pre-operation and post-operation. Results: Twenty-eight patients were followed up for 36 months. We found that each syrinx cavity shrunk by at least 50%. More than 90% of patients had achieved “markedly improved” and “improved” outcomes during the follow-up visit. Moreover, no patient relapsed for up to 36 months post-surgery. Conclusion: Terminal ventriculostomy has a beneficial effect on TS, particularly on the syrinx cavity extending to the filum terminale. For this special cavity, we advocate the use of terminal ventriculostomy-associated “V”-type ostomy to avoid potential relapse. As a safe, convenient, and persistently effective approach, terminal ventriculostomy-associated “V”-type ostomy can be considered a promising alternative method for treating TCS combined with TS in clinical practice.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/21925682211009175
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2648287-3
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  • 7
    Online Resource
    Online Resource
    Two Nitrogen-containing Compounds from Pseudostellaria heterophylla
    SAGE Publications ; 2018
    In:  Natural Product Communications Vol. 13, No. 3 ( 2018-03), p. 1934578X1801300-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 13, No. 3 ( 2018-03), p. 1934578X1801300-
    Abstract: Two new nitrogen-containing compounds, pseudosteheterins A (1) and B (2), were isolated from the glycosides-enriched cardioprotective fraction of the 70% EtOH extract of the roots of Pseudostellaria heterophylla. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 was established by quantum chemical TDDFT calculation of the ECD spectrum of its model compound. Pseudosteheterin B showed significant protective effects in H9c2 myocardial cells against CoCl 2 -induced injury.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1801300318
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 8
    Online Resource
    Online Resource
    ABC triblock copolymers with pH-responsive LCST for controlled drug delivery
    SAGE Publications ; 2011
    In:  Journal of Bioactive and Compatible Polymers Vol. 26, No. 2 ( 2011-03), p. 173-190
    Details
    In: Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 26, No. 2 ( 2011-03), p. 173-190
    Abstract: The thermo- and amphiphilic ABC triblock copolymers, single-methoxypoly(ethylene glycol)-b-poly(N-isopropylacrylamide-co-acrylic acid)-b-poly(methyl methacrylate), were synthesized by reversible addition fragmentation chain transfer radical polymerization. The triblock copolymers were characterized by Fourier transform infrared spectroscopy, 1 H-NMR, and gel permeation chromatography. The copolymers self-assemble into thermo-responsive nano-sized micelles in aqueous media. Transmission electron microscopy and dynamic light scattering showed that the micelles were regularly spherical in shape with an average diameter ~120 nm. Fluorescence analysis indicated that the triblock copolymer had a low critical micelle concentration of 2.5 mg/L in aqueous media at pH 7.4 and room temperature. The lower critical solution temperature (LCST) of the micelles could be altered by simply changing the pH. The LCST of the triblock copolymer at pH 5.5 was altered to 37.5 ° C (close to physiological temperature) by copolymerizing N-isopropylacrylamide with acrylic acid. When the pH was increased to 7.4, the LCST increased to 55 ° C and it decreased to 33 ° C when the pH was 2.0. The micelles exhibited good biocompatibility with human embryonic kidney cells, when the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay was performed. The controlled release of folic acid (FA) from FA-loaded micelles under different conditions was evaluated. The rate and amount of the drug released were greater above the LCST than below it.
    Type of Medium: Online Resource
    ISSN: 0883-9115 , 1530-8030
    URL: Article
    DOI: 10.1177/0883911511399415
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2073790-7
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  • 9
    Online Resource
    Online Resource
    Steroid-loaded reconstituted high-density lipoprotein nanocarrier: A new treatment for systemic lupus erythematosus
    SAGE Publications ; 2023
    In:  Journal of Biomaterials Applications Vol. 37, No. 9 ( 2023-04), p. 1542-1554
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 37, No. 9 ( 2023-04), p. 1542-1554
    Abstract: Glucocorticoids (GCs) are the most effective and commonly used drugs for the treatment of systemic lupus erythematosus (SLE). However, a large number of side effects occur after long-term or high-dose glucocorticoid treatment, which severely restricts the use of glucocorticoids. Reconstituted high-density lipoprotein (rHDL), an emerging nanocarrier, is promising for targeted delivery to sites of inflammation and macrophages. Here, we prepared a steroid-loaded recombinant high-density lipoprotein and evaluated its therapeutic efficacy in a murine macrophage cell line (RAW264.7) and a lupus (MRL/lpr mice) mouse model. The obtained corticosteroid-loaded nanomedicine, named PLP-CaP-rHDL, exhibited desirable characteristics. Pharmacodynamics studies revealed that the nanoparticles could significantly reduce the levels of inflammatory cytokines in the macrophages in vitro and also effectively alleviate lupus nephritis in MRL/lpr mice without causing obvious side effects at a dose of 0.25 mg/kg. Thus, our newly developed steroid-loaded rHDL nanocarriers hold a great potential for anti-inflammatory therapy with reduced side effects and may provide a precise targeted therapy for SLE.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/08853282231154342
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Energy characteristics and mechanical properties of tensile fracture of magnetite with consideration of bedding
    SAGE Publications ; 2019
    In:  International Journal of Electrical Engineering & Education ( 2019-06-09), p. 002072091983786-
    Details
    In: International Journal of Electrical Engineering & Education, SAGE Publications, ( 2019-06-09), p. 002072091983786-
    Type of Medium: Online Resource
    ISSN: 0020-7209 , 2050-4578
    URL: Article
    DOI: 10.1177/0020720919837868
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2026370-3
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