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  • 1
    Online Resource
    Online Resource
    Primary neonatal and pediatric ECMO transport: First experience in Spain
    SAGE Publications ; 2024
    In:  Perfusion Vol. 39, No. 4 ( 2024-05), p. 797-806
    Details
    In: Perfusion, SAGE Publications, Vol. 39, No. 4 ( 2024-05), p. 797-806
    Abstract: The organization of primary Extracorporeal membrane oxygenation (ECMO) transport is highly variable. Methods To present the experience of the first mobile pediatric ECMO program in Spain, we designed a prospective descriptive study of all primary neonatal and pediatric (0–16 years) ECMO transports carried out over 10 years. The main variables recorded include demographic information, patient background, clinical data, ECMO indications, adverse events, and main outcomes. Results 39 primary ECMO transports were carried out with a 66.7% survival to hospital discharge. The median age was 1.24 months[IQR: 0.09–96]. Cannulation was mostly peripheral venoarterial (33/39). The mean response time from the call from the sending center to the departure of the ECMO team was 4 h[2.2–8] . The median inotropic score at the time of cannulation was 70[17.2–206.5], with a median oxygenation index of 40.5[29–65] . In 10% of the cases, ECMO-CPR was performed. Adverse events occurred in 56.4%, mostly related to the means of transport (40% overall). On arrival at the ECMO center, 44% of the patients underwent interventions. The median PICU stay was 20.5 days[11–32]. 5 patients developed neurological sequels. Statistically significant differences between survivors and deceased patients were not found. Conclusions A good survival rate, with a low prevalence of serious adverse events, suggests a clear benefit of primary ECMO transport when conventional therapeutic measures are exhausted and the patient is too unstable to undergo conventional transport. A nationwide primary ECMO-transport program must therefore be offered to all patients regardless of their location.
    Type of Medium: Online Resource
    ISSN: 0267-6591 , 1477-111X
    URL: Article
    DOI: 10.1177/02676591231161268
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2029611-3
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  • 2
    Online Resource
    Online Resource
    Three-Dimensional Kinematics during the Take-Off Phase in Competitive Long Jumping
    SAGE Publications ; 2013
    In:  International Journal of Sports Science & Coaching Vol. 8, No. 2 ( 2013-06), p. 395-406
    Details
    In: International Journal of Sports Science & Coaching, SAGE Publications, Vol. 8, No. 2 ( 2013-06), p. 395-406
    Abstract: The purpose of the present study was to identify the relationships among selected kinematic variables that affect the take-off phase and performance in elite jumpers. The jump distance was found to be related to: I) the athlete's approach speed before the instant of touch down; and ii) the exchange in spatial velocity components at take-off, which results in a gain in maximum vertical velocity of the centre of mass (CM), favoured by the use of an optimum touch-down angle of the take-off leg, an active landing of the foot at touch-down, and a motion of the take-off leg during the compression phase that helps to manage the loss of horizontal velocity. Nonetheless, the results show that an adequate velocity transformation requires an adaptive technical model to help jumpers to build an efficient individual technical pattern.
    Type of Medium: Online Resource
    ISSN: 1747-9541 , 2048-397X
    URL: Article
    DOI: 10.1260/1747-9541.8.2.395
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2237333-0
    SSG: 31
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  • 3
    Online Resource
    Online Resource
    Long-term survival analysis of masitinib in amyotrophic lateral sclerosis
    SAGE Publications ; 2021
    In:  Therapeutic Advances in Neurological Disorders Vol. 14 ( 2021-01), p. 175628642110303-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 14 ( 2021-01), p. 175628642110303-
    Abstract: A randomized, placebo-controlled phase III study (AB10015) previously demonstrated that orally administered masitinib (4.5 mg/kg/day) slowed rate of functional decline, with acceptable safety, in amyotrophic lateral sclerosis (ALS) patients having an ALS Functional Rating Scale-revised (ALSFRS-R) progression rate from disease onset to baseline of 〈 1.1 points/month. Here we assess long-term overall survival (OS) data of all participants from study AB10015 and test whether a signal in OS is evident in an enriched patient population similar to that prospectively defined for confirmatory study AB19001. Methods: Survival status of all patients originally randomized in AB10015 was collected from participating investigational sites. Survival analysis (using the multivariate log-rank test and Cox proportional hazards model, with stratification factors as covariates) was performed on the intention-to-treat population and enriched subgroups, which were defined according to initial randomization, baseline ALSFRS-R progression rate and baseline disease severity. Results: A significant survival benefit of 25 months ( p = 0.037) and 47% reduced risk of death ( p = 0.025) was observed for patients receiving 4.5 mg/kg/day masitinib ( n = 45) versus placebo ( n = 62) in an enriched cohort with ⩾2 on each baseline ALSFRS-R individual component score (i.e. prior to any complete loss or severe impairment of functionality) and post-onset ALSFRS-R progression rate 〈 1.1 (i.e. exclusion of very fast progressors) [median OS of 69 versus 44 months, respectively; hazard ratio, 0.53 [95% CI (0.31–0.92)]]. This corresponds to the population enrolled in confirmatory phase III study, AB19001. Conclusions: Analysis of long-term OS (75 months average follow-up from diagnosis) indicates that oral masitinib (4.5 mg/kg/day) could prolong survival by over 2 years as compared with placebo, provided that treatment starts prior to severe impairment of functionality. This trial was registered at www.ClinicalTrials.gov under identifier NCT02588677 (28 October 2015).
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/17562864211030365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2442245-9
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  • 4
    Online Resource
    Online Resource
    Low-Dose PET/CT and Full-Dose Contrast-Enhanced CT at the Initial Staging of Localized Diffuse Large B-Cell Lymphomas
    SAGE Publications ; 2016
    In:  Clinical Medicine Insights: Blood Disorders Vol. 9 ( 2016-01), p. CMBD.S38468-
    Details
    In: Clinical Medicine Insights: Blood Disorders, SAGE Publications, Vol. 9 ( 2016-01), p. CMBD.S38468-
    Type of Medium: Online Resource
    ISSN: 1179-545X , 1179-545X
    URL: Article
    DOI: 10.4137/CMBD.S38468
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2593085-0
    detail.hit.zdb_id: 3091795-5
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  • 5
    Online Resource
    Online Resource
    Effectively integrating research argumentation in syllabus learning: A case study of reading journal articles in four fourth-year engineering fluid mechanics courses
    SAGE Publications ; 2023
    In:  International Journal of Mechanical Engineering Education
    Details
    In: International Journal of Mechanical Engineering Education, SAGE Publications
    Abstract: In an emerging trend in engineering education students are engaged in the scientific discovery process through reading about research published in articles rather than textbooks. A research-based and curriculum-oriented intervention in an undergraduate course was designed to elucidate whether students can progressively gain reading skills when provided with selected articles explicitly related to fluid mechanics research. The aim was also to monitor student awareness of their own progress. A questionnaire was designed to evaluate how fourth-year fluid technology students perceived their reading skills during the teaching intervention. A progressive strategy was applied, including warm-up readings, in- and out-of-class assignments, and best practice lectures. Two parallel test exams and test readings were associated and quantitatively analyzed. Each cohort was randomly divided into two groups, and each group was assigned a different test reading before the lectures; the readings were then switched for the post-lecture assignment. The results demonstrate that the students acquired selective reading skills and awareness of accomplishment. The analyses indicated that learners gained an understanding of the core concepts and gave positive feedback on the teaching materials and schedule. These findings may serve as a guide for engineering educators to improve the preparation of undergraduate students.
    Type of Medium: Online Resource
    ISSN: 0306-4190 , 2050-4586
    URL: Article
    DOI: 10.1177/03064190231194343
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2026373-9
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  • 6
    Online Resource
    Online Resource
    Correlation between percentage of fat mass and level of disease activity in rheumatoid arthritis
    SAGE Publications ; 2022
    In:  SAGE Open Medicine Vol. 10 ( 2022-01), p. 205031212210858-
    Details
    In: SAGE Open Medicine, SAGE Publications, Vol. 10 ( 2022-01), p. 205031212210858-
    Abstract: Controversies exist regarding the relationship between body fat and disease activity in patients with rheumatoid arthritis. The evaluation of the disease is critical for establishing treatment and prognosis. Fat mass could be a predictive factor for poor prognosis in rheumatoid arthritis because of its association with low- and high-grade inflammation. Objective: To evaluate the correlation between fat mass values and disease activity in patients with rheumatoid arthritis. Materials and methods: This was a cross-sectional study. Eighty female patients diagnosed with rheumatoid arthritis (American College of Rheumatology of 1987) were evaluated. For each one, the evaluation determined fat mass using bioelectrical impedance analysis and disease activity using the Disease Activity Score on 28 joints (DAS28). Results: The mean age was 59.11 ± 9.92 years, with an average disease duration of 14.13 ± 10.13 years; 85% of patients showed a high body fat percentage. Pearson’s correlation between DAS28 values and fat mass was r = 0.035 ( p = 0.76). Conclusion: The levels of DAS28 showed no correlation with fat mass percentage. Further studies are required to clarify the factors that can modify these levels.
    Type of Medium: Online Resource
    ISSN: 2050-3121 , 2050-3121
    URL: Article
    DOI: 10.1177/20503121221085821
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2735399-0
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  • 7
    Online Resource
    Online Resource
    Intravenous immunoglobulin to prevent myasthenic crisis after thymectomy and other procedures can be omitted in patients with well-controlled myasthenia gravis
    SAGE Publications ; 2019
    In:  Therapeutic Advances in Neurological Disorders Vol. 12 ( 2019-01), p. 175628641986449-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 12 ( 2019-01), p. 175628641986449-
    Abstract: Myasthenic crisis (MC) is a potentially life-threatening complication of myasthenia gravis. Its precipitating factors include surgical procedures, particularly thymectomy. The role of preoperative intravenous immunoglobulin (IVIg) in preventing MC in patients scheduled for thymectomy and other surgery with general anaesthesia is unknown. Our objective was to test the hypothesis that preoperative IVIg is effective in preventing myasthenic crisis in patients with myasthenia gravis scheduled for surgery under general anaesthesia, including thymectomy. Methods: A prospective, randomized, double-blind, single-centre study was conducted over a 4-year period. The treatment group received IVIg, 0.4 g/kg/day preoperatively for 5 consecutive days, and the placebo group received saline solution under the same conditions. The two groups were age-matched, with similar functional status, and Myasthenia Gravis Foundation of America class. All patients had well-controlled myasthenia gravis with minimal manifestations before surgery. The primary outcome measured was MC. Intubation times, time in the recovery room, number of postoperative complications, and days of hospitalization were the secondary outcomes measured. Results: A total of 47 patients were randomized, 25 to the IVIg group and 22 to placebo. There were 19 men and 28 women, with a mean age of 58.6 years, mean body mass index of 27.8 kg/m 2 , and mean acetylcholine receptor antibodies of 12.9 nmol/l. The mean forced vital capacity was 84.4%. The mean quantitative myasthenia gravis sum score was 6.3. Ten patients (five in each arm) had a history of MC. Thymectomy was performed in 16 patients. Only one patient in the placebo group presented with MC requiring non-invasive ventilation (but no reintubation) for 6 days. Neither differences between groups in the univariate analysis nor risk factors for MC in the multivariate analysis were found. Conclusions: Preoperative IVIg to prevent MC does not appear to be justified in well-controlled myasthenia gravis patients. This study provides class I evidence that preparation with IVIg to prevent MC is not necessary in well-controlled myasthenia gravis patients scheduled for surgery with general anaesthesia.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/1756286419864497
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2442245-9
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  • 8
    Online Resource
    Online Resource
    Influence of the interteeth clearances on the flow ripple in a gerotor pump for engine lubrication
    SAGE Publications ; 2012
    In:  Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering Vol. 226, No. 7 ( 2012-07), p. 930-942
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, SAGE Publications, Vol. 226, No. 7 ( 2012-07), p. 930-942
    Abstract: A gerotor pump, which is widely used in the automotive industry for engine oil lubrication, produces an instantaneous flow fluctuation and the estimation of this is fundamental in order to evaluate the pump quality for silent and smooth operation. The intricate aspects of the pumping process of a gerotor pump make computational fluid dynamics the appropriate tool for modelling and simulation to provide insights into its flow characteristics. Because the instantaneous flow is rather dependent on the teeth contact, a new boundary condition of a virtual wall was developed, which allows simulation of the teeth contact in the interteeth radial clearances. This new boundary condition is utilized in a three-dimensional model of the gerotor pump with mesh deformation and remeshing at every time step by means of a home-made ad-hoc code programmed by the present authors and named viscous wall cell. The code has been integrated into the computational fluid dynamics solver. The interteeth clearances are studied under the following different operating conditions (working pressures and rotational velocities): first, no contact points (no teeth contact is studied in order to prove that, even if the interteeth radial clearance is sufficiently small, the leakage cannot be negligible); second, all contact points (the ideal approach is considered with zero interteeth radial clearances used to model zero manufacturing tolerances); third, one contact point at different locations (the existence of manufacturing tolerances and the teeth contact approach make the pump’s operation and its pumping mechanism more realistic in the simulation). The numerical instantaneous flow is compared with the analytical instantaneous flow, with the instantaneous flow modelled by using the bond graph technique, and with the experimental determination of the flow ripple for a specific unit. The results obtained show the importance of simulating the teeth contact and prove to be an excellent estimation of the instantaneous flow behaviour to obtain the dynamic properties of a gerotor pump under more realistic conditions than its design.
    Type of Medium: Online Resource
    ISSN: 0954-4070 , 2041-2991
    URL: Article
    DOI: 10.1177/0954407011431545
    RVK:
    ZO 4200
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2032754-7
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