In:
Cephalalgia, SAGE Publications, Vol. 10, No. 5 ( 1990-10), p. 213-219
Abstract:
In spite of recent theories about the aetiopathogenesis of migraine, serotonin continues to play a central role, explaining the efficacy of almost all migraine prophylactic drugs. In migraineurs with and without aura we measured (by HPLC-EC) the serum serotonin (5–HT) and 5–hydroxyindoleacetic acid (5–HIAA) levels between as well as during headache attacks. Between attacks of migraine with aura and at the beginning of attacks of both types of migraine the serum 5–HT and 5–HIAA concentration was significantly increased. These results were corroborated by 3 H-spiperone binding to platelet membranes: in migraineurs with aura in the attack-free interval, there was a significant decrease in its B max , which suggests down-regulation of 5–HT 2 receptors. In conclusion, we have verified that migraine with aura differs biochemically from migraine without aura.
Type of Medium:
Online Resource
ISSN:
0333-1024
,
1468-2982
DOI:
10.1046/j.1468-2982.1990.1005213.x
Language:
English
Publisher:
SAGE Publications
Publication Date:
1990
detail.hit.zdb_id:
2019999-5
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