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  • SAGE Publications  (69)
  • 1
    In: Journal of Health Psychology, SAGE Publications, Vol. 22, No. 5 ( 2017-04), p. 627-636
    Type of Medium: Online Resource
    ISSN: 1359-1053 , 1461-7277
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2021897-7
    SSG: 5,2
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  Journal of Reinforced Plastics and Composites Vol. 42, No. 13-14 ( 2023-07), p. 648-655
    In: Journal of Reinforced Plastics and Composites, SAGE Publications, Vol. 42, No. 13-14 ( 2023-07), p. 648-655
    Abstract: In this paper, the strain energy density (SED) is used to study the over-examination to tire in flywheel test induced by pressure correction process. Flywheel test is the main method for evaluating tire durability, which cannot be measured on flat ground due to the variable road conditions. “Pressure Correction” is a necessary step in flywheel tests, but this process can lead to an over-examination of tire durability, which means the tire durability will be underestimated. However, it is impossible to obtain the tire durability from ideal flat ground test, so this paper utilizes the finite element method (FEM) to simulate the tire rolling condition on flat ground and differently sized flywheels, and the SED is used to evaluate the over-examination of tire durability in flywheel test. According to the results, a flywheel with too small diameter has a large amount of over-examination, and the amount caused by a large flywheel is acceptable. This methodology can be a guideline to assess the over-examination on different sized flywheel tests relative to the flat ground, and for the certain tire in this study, flywheels with 3–5 times the tire diameter appear to have an acceptable over-examination.
    Type of Medium: Online Resource
    ISSN: 0731-6844 , 1530-7964
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2051886-9
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Journal of International Medical Research Vol. 46, No. 6 ( 2018-06), p. 2410-2422
    In: Journal of International Medical Research, SAGE Publications, Vol. 46, No. 6 ( 2018-06), p. 2410-2422
    Abstract: Clinical sepsis-associated biomarkers were utilized in a cecal ligation and puncture (CLP) septic mouse model to provide a reference for investigating pathophysiological mechanisms and evaluating novel therapeutic interventions for sepsis. Methods Sepsis in mice was induced by CLP, and clinical biomarkers were evaluated (survival rate, blood physiological and biochemical indices, cytokines, hepatorenal function parameters, and blood coagulation). Results The mortality rate was 〉 70%. The body temperature, blood pressure, and heart rate decreased within 48 h. Low lactic acid was found at 8 h. The CLP mice showed typical inflammatory symptoms with decreased white blood cells and procalcitonin and increased levels of soluble triggering receptor expressed on myeloid cells-1, interleukin (IL)-6, IL-10, tumor necrosis factor-α, macrophage inflammatory protein (MIP)-1α, MIP-1β, and MIP-2. The platelet count and activated partial thromboplastin time significantly decreased, and the prothrombin time and prothrombin time–international normalized ratio markedly increased. Phenotypes of multiple organ dysfunction were found in the CLP model, including increased liver alanine aminotransferase and aspartate transaminase; significantly reduced total protein, globulin, and serum albumin; increased blood urea nitrogen and creatinine; and decreased blood glucose. Conclusion The clinical features of the CLP mouse model were similar to those of human patients with sepsis.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2082422-1
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Diabetes and Vascular Disease Research Vol. 19, No. 6 ( 2022-11), p. 147916412211377-
    In: Diabetes and Vascular Disease Research, SAGE Publications, Vol. 19, No. 6 ( 2022-11), p. 147916412211377-
    Abstract: The relationship between different glycaemic variability (GV) indexes and adverse cardiovascular outcomes is not well understood. This study aims to determine whether GV is related to the occurrence of adverse cardiovascular events in patients with acute coronary syndrome (ACS). Methods PubMed, EMBASE, and Web of Science were comprehensively searched from the establishment of databases to 29 June 2022. The relationship between two important GV indexes, including the mean amplitude of glycemic excursion (MAGE) and standard deviation (SD), and the adverse cardiovascular events in ACS patients were evaluated, respectively. Results A total of 11 studies with 3709 ACS patients were included. Pooled results showed that patients with higher GV had significantly increased risk of adverse cardiovascular events, including MAGE (relative risk [RR] = 1.76, 95% CI: 1.40 to 2.22, p 〈 0.001, I 2 = 25%) and SD (RR = 2.14, 95% CI: 1.73 to 2.66, p 〈 0.001, I 2 = 0%). Conclusions Increased GV is related to the poor prognosis in patients with ACS. Additionally, more well-designed studies comparing different indicators of GV with adverse cardiovascular events in ACS patients are still warranted.
    Type of Medium: Online Resource
    ISSN: 1479-1641 , 1752-8984
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2250797-8
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  • 5
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 240, No. 4 ( 2015-04), p. 498-507
    Abstract: A feature of allergic airway disease is the observed increase of nitric oxide (NO) in exhaled breath. Gram-negative bacterial infections have also been linked with asthma exacerbations. However, the role of NO in asthma exacerbations with gram-negative bacterial infections is still unclear. In this study, we examined the role of NO in lipopolysaccharide (LPS)-induced inflammation in an ovalbumin (OVA)-challenged mouse asthma model. To determine whether NO affected the LPS-induced response, a NO donor ( S-nitroso- N-acetylpenicillamine, SNAP) or a selective inhibitor of NO synthase (1400W) was injected intraperitoneally into the mice before the LPS stimulation. Decreased levels of proinflammatory cytokines were demonstrated in the bronchoalveolar lavage fluid from mice treated with SNAP, whereas increased levels of cytokines were found in the 1400W-treated mice. To further explore the molecular mechanism of NO-mediated inhibition of proinflammatory responses in macrophages, RAW 264.7 cells were treated with 1400W or SNAP before LPS stimulation. LPS-induced inflammation in the cells was attenuated by the presence of NO. The LPS-induced IκB kinase (IKK) activation and the expression of IKK were reduced by NO through attenuation of the interaction between Hsp90 and IKK in the cells. The IKK decrease in the lung immunohistopathology was verified in SNAP-treated asthma mice, whereas IKK increased in the 1400W-treated group. We report for the first time that NO attenuates the interaction between Hsp90 and IKK, decreasing the stability of IKK and causing the down-regulation of the proinflammatory response. Furthermore, the results suggest that NO may repress LPS-stimulated innate immunity to promote pulmonary bacterial infection in asthma patients.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2024
    In:  Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit Vol. 238, No. 4 ( 2024-04), p. 437-448
    In: Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit, SAGE Publications, Vol. 238, No. 4 ( 2024-04), p. 437-448
    Abstract: During the operation of the Chinese 250 km/h-level EMU, hunting occurs when the EMU crosses from Line B to Line A. Numerous tests and simulations have been conducted to investigate the mechanism of this phenomenon. Comparisons of the measured rail profiles of the two lines indicate that the left rail in Line A is higher than that in Line B at the inner rail shoulder. In addition, the top position of the right rail in Line A is approximately 2–3 mm closer to the inside than that of the right rail in Line B, with the right rail in Line A being higher than that in Line B at the inner rail shoulder. These differences cause a significant increase in the wheel–rail equivalent conicity when the EMU crosses from Line B to Line A and further cause the hunting phenomenon. Moreover, simulations and experiments are conducted to investigate the countermeasures for EMU cross-line hunting. Field test results show that both increasing the damping of the yaw damper and wheel reprofiling can improve the stability during EMU cross-line operation; however, the effect of increasing the damping of the yaw damper is limited under particularly poor wheel–rail relationship. Simulation results reveal that rail grinding of Line A referring to the Chinese 60N rail profile can also improve the stability of the EMU during cross-line operation.
    Type of Medium: Online Resource
    ISSN: 0954-4097 , 2041-3017
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2024901-9
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  • 7
    In: Cell Transplantation, SAGE Publications, Vol. 29 ( 2020-01-01), p. 096368972095021-
    Abstract: This study aimed to investigate the protective effects of erythrocyte-mediated endoplasmic reticulum (ER) stress in macrophages in hemorrhagic shock. An hemorrhagic shock model was established in male BALB/c mice. Animals were randomly divided into three groups ( n = 8): control group (A), erythrocyte reinfusion group (B), and TLR9 inhibition group (C). Eight healthy BALB/c mice were also included as group N ( n = 8). Mice in group A were not treated, while mice in groups B and C were transfused with red blood cells separated from the blood of mice in group N. Flow cytometry was used to detect the expression of erythrocyte surface protein TLR9 in each group. Immunofluorescence assay was used to analyze the distribution and relative expression of protein STING in macrophages. Flow cytometry was used to analyze the expression of STING, ATF6, and IRE1 in macrophages. Enzyme-linked immunosorbent assay was used to analyze the levels of inflammatory signal molecules, including IFN-α, IFN-β, IL-6, CCL4, CCL5, and IL-6. FITC-Annexin V was used to analyze the apoptosis of immune cells (macrophages) in mouse blood samples and to detect the concentration of calcium ions in erythrocyte cytoplasm. The results showed that the expression of erythrocyte surface protein TLR9; the distribution of STING-positive cells in macrophages; the expressions of STING, ATF6, and IRE1 in macrophages; the levels of inflammatory signal molecules; the apoptosis rate of macrophages; and the intracellular calcium concentration in erythrocytes in group B were higher than those in group A, followed by group C. These results suggest that TLR9 regulates ER stress in macrophages of mice with hemorrhagic shock through the TLR9-cGAS-STING-IFN signaling pathway. Increased expression of TLR9 enhanced macrophage activity, reduced apoptosis, enhanced inflammatory response and immune response, and restored electrolyte level, which might be a therapeutic option for the treatment of hemorrhagic shock.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2020466-8
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  • 8
    In: INQUIRY: The Journal of Health Care Organization, Provision, and Financing, SAGE Publications, Vol. 60 ( 2023-01)
    Abstract: The composition of influenza vaccines is updated annually. To ensure vaccine safety, the coverage and adverse events following immunization (AEFI) of 6 manufacturers of trivalent inactivated influenza vaccine (TIV3) need to be evaluated. In January 2022, we analyzed data from more than 1.59 million children in the Childhood Vaccination Information Management System and the AEFI Surveillance Information Management System and evaluated influenza vaccines for children aged 6 to 35 months in Guangzhou from 2016/17 to 2019/20 Vaccination rates and AEFI reporting rates. From 2016/17 to 2019/20, the 1-dose influenza vaccination rate was 25.0% (range: 20.7%-30.2%), and the 2-dose (full course) influenza vaccination rate was 21.6% (range: 17.7%-26.4%). The full vaccination coverage rate has trended down since 2017/2018 (2017/18: 26.0%; 2018/19: 8.3; 2019/20: 17.7%). Fifty-two cases (13.1/100 000) and 24 cases (6.9/100 000) received AEFI reports for 1 dose and 2 doses, respectively, mainly due to fever ≥38.6°C (39 cases for 1 dose, 9.8/100 000; 15 cases for 2 dose, 4.3/100 000) and allergic rash (9 cases with 1 dose, 2.3/100 000; 5 cases with 2 doses, 1.4/100 000). Patients who received A and F manufacturers were more likely to report side effects. The safety of influenza vaccines from 6 manufacturers is good, and it is necessary to improve the recommended information on influenza vaccines to dispel people’s concerns and increase the vaccination rate.
    Type of Medium: Online Resource
    ISSN: 0046-9580 , 1945-7243
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2147137-X
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  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Journal of Biomaterials Applications Vol. 37, No. 5 ( 2022-11), p. 891-902
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 37, No. 5 ( 2022-11), p. 891-902
    Abstract: In this study, Zn-xCu (-0.1 Mg) wires with a diameter of 0.3 mm were obtained by hot extrusion and cold drawing. The microstructures, mechanical properties, and degradation behaviour were investigated to evaluate their feasibility as biodegradable metals. During the drawing process of the Zn-xCu alloys, many granular CuZn 5 phases were dynamically precipitated, and the grains were significantly refined, along with a significant work softening with the tensile strength decreasing and the elongation increasing (from 161 MPa to 92 MPa and 22%–103% for Zn-0.2Cu). With the increase of Cu additions, the phenomenon of work softening was more intense and there was an opposite trend in the strength changes between the as-extruded rods (increase) and as-drawn wires (decrease). With 0.1 wt.% Mg added, the stable rod-like Mg 2 Zn 11 phase was formed in as-extruded Zn-xCu-0.1 Mg rods, which obviously improved the strength, and inhibited the dynamic precipitation of granular CuZn 5 phase and work softening phenomenon in the drawing process (from 332 MPa to 313 MPa and 11%–46% for Zn-0.2Cu-0.1 Mg). In addition, due to the micro-galvanic effect induced by the precipitates, alloying accelerated the degradation of Zn alloy wires, especially Zn-1Cu-0.1 Mg, which was related to the shape, distribution, and potential of the phases.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  Journal of Investigative Medicine Vol. 65, No. 5 ( 2017-06), p. 899-911
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 65, No. 5 ( 2017-06), p. 899-911
    Abstract: Telemedicine interventions may be associated with reductions in hospital admission rate and mortality in patients with heart failure (HF). The present study is an updated analysis (as of June 30, 2016) of randomized controlled trials, where patients with HF underwent telemedicine care or the usual standard care. Data were extracted from 39 eligible studies for all-cause and HF-related hospital admission rate, length of stay, and mortality. The overall all-cause mortality (pooled OR=0.80, 95% CI 0.71 to 0.91, p 〈 0.001), HF-related admission rate (pooled OR=0.63, 95% CI 0.53 to 0.76, p 〈 0.001), and HF-related length of stay (pooled standardized difference in means=−0.37, 95% CI −0.72 to −0.02, p=0.041) were significantly lower in the telemedicine group (teletransmission and telephone-supported care), as compared with the control group. In subgroup analysis, all-cause mortality (pooled OR=0.69, 95% CI 0.56 to 0.86, p=0.001), HF-related admission rate (OR=0.61, 95% CI 0.42 to 0.88, p=0.008), HF-related length of stay (pooled standardized difference in means=−0.96, 95% CI −1.88 to −0.05, p=0.039) and HF-related mortality (OR=0.68, 95% CI 0.54 to 0.85, p=0.001) were significantly lower in the teletransmission group, as opposed to the standard care group, whereas only HF-related admission rate (OR=0.64, 95% CI 0.52 to 0.79, p 〈 0.001) was lower in the telephone-supported care group. Overall, telemedicine was shown to be beneficial, with home-based teletransmission effectively reducing all-cause mortality and HF-related hospital admission, length of stay and mortality in patients with HF.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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