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  • SAGE Publications  (216)
  • 1
    Online Resource
    Online Resource
    The Expression of Egfl7 in Human Normal Tissues and Epithelial Tumors
    SAGE Publications ; 2013
    In:  The International Journal of Biological Markers Vol. 28, No. 1 ( 2013-01), p. 71-83
    Details
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 28, No. 1 ( 2013-01), p. 71-83
    Abstract: To investigate the expression of Egfl7 in normal adult human tissues and human epithelial tumors. Methods RT-PCR and Western blot were employed to detect Egfl7 expression in normal adult human tissues and 10 human epithelial tumors including hepatocellular carcinoma (HCC), lung cancer, breast cancer, prostate cancer, colorectal cancer, gastric cancer, esophageal cancer, malignant glioma, ovarian cancer and renal cancer. Immunohistochemistry and cytoimmunofluorescence were subsequently used to determine the localization of Egfl7 in human epithelial tumor tissues and cell lines. ELISA was also carried out to examine the serum Egfl7 levels in cancer patients. In addition, correlations between Egfl7 expression and clinicopathological features as well as prognosis of HCC and breast cancer were also analyzed on the basis of immunohistochemistry results. Results Egfl7 was differentially expressed in 19 adult human normal tissues and was overexpressed in all 10 human epithelial tumor tissues. The serum Egfl7 level was also significantly elevated in cancer patients. The increased Egfl7 expression in HCC correlated with vein invasion, absence of capsule formation, multiple tumor nodes and poor prognosis. Similarly, upregulation of Egfl7 in breast cancer correlated strongly with TNM stage, lymphatic metastasis, estrogen receptor positivity, Her2 positivity and poor prognosis. Conclusions Egfl7 is significantly upregulated in human epithelial tumor tissues, suggesting Egfl7 to be a potential biomarker for human epithelial tumors, especially HCC and breast cancer.
    Type of Medium: Online Resource
    ISSN: 1724-6008 , 1724-6008
    URL: Article
    DOI: 10.5301/JBM.2013.10568
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 1475778-3
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  • 2
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    Comparative Analysis of the MRI Characteristics of Meningiomas According to the 2016 WHO Pathological Classification
    SAGE Publications ; 2020
    In:  Technology in Cancer Research & Treatment Vol. 19 ( 2020-01-01), p. 153303382098328-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 19 ( 2020-01-01), p. 153303382098328-
    Abstract: To evaluate the performance of preoperative magnetic resonance imaging (MRI) in evaluating diagnoses, operation methods and recurrence of meningiomas according to the World health organization (WHO) pathological classification. Methods: MRI characteristics of 127 meningioma patients were retrospectively analysed according to pathological results (WHO grade) and their association with Simpson’s grades (resection) and recurrence. Results: The T1-weighted imaging (T1WI) signal intensity of WHO grade I meningiomas was slightly hypointense or isointense gray, while the T2-weighted imaging (T2WI) signal intensity was isointense or slightly hyperintense. The T1WI and T2WI signal intensity in WHO grade II and III meningiomas was isointense gray. The enhancement degree and patterns, lobulation, flowing voids, dural tail, maximum diameter, peritumoural oedema, ADC values and margin were significantly different between any 2 grades (P 〈 0.05). The ADC values were higher for WHO grade I tumors than for WHO grade II and III tumors (P 〈 0.001). Among all the analyzed characteriscs, ADC values, peritumoural oedema, and margin effectively predicted the diagnosis according to the WHO classification. The operation method and surgical resection were different between WHO grade Ⅰ and WHO grade Ⅱ/Ⅲ meningiomas (P 〈 0.05). The recurrence rate increased with tumor grade, but there was no statistical difference among the 3 types(P 〉 0.05). Conclusions: WHO grades and pathological subtypes of meningiomas can generally be determined based on their MRI characteristics. In addition, MRI provides significant guidance for the grading of surgical success and prognosis.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033820983287
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 3
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    Cycle slip detection and repair for BeiDou-3 triple-frequency signals
    SAGE Publications ; 2020
    In:  International Journal of Advanced Robotic Systems Vol. 17, No. 3 ( 2020-05-01), p. 172988142092640-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 17, No. 3 ( 2020-05-01), p. 172988142092640-
    Abstract: When carrier phase observations are applied to high-precision positioning, how to handle the cycle slip is an unavoidable problem. For cycle slip correction, detection combination noise and the ionospheric delay are two crucial factors. Specifically, the drastic changes in the ionosphere and the increased noise of code observations will increase the failure probability of cycle slip detection. To reduce the influence of code observation noise and ionospheric bias, a novel cycle slip detection method for BDS-3 satellites is proposed. Considering that code measurement noise is closely related to the satellite elevation angle, an elevation-based model is built to evaluate the code measurement noise. Firstly, two modified code-phase combinations are selected optimally based on 1% missed detection rate and 99% success detection rate to minimize the effects of code measurement noise. However, the second modified code-phase combination is more affected by ionospheric delay bias, so ionospheric bias of current epoch needs to be corrected. To reduce the influence of ionospheric bias, two moving windows of time-differenced ionospheric delay are introduced to correct the ionospheric bias of the second code-phase combination. Experiments with BeiDou-3 data are implemented in three different scenarios. To verify the effectiveness of the algorithm in the environment of high code observations noise, Gaussian noise is added to the code observations in the first scenario, and the results demonstrate that the success rate of cycle slip detection and repair is still greater than 95% when the standard deviation of Gaussian noise is 0.8 m. The second scenario is carried out under low ionospheric activity, and results indicate that the proposed method significantly reduces the times of failed detection and repair. Moreover, in the third scenario, BeiDou-3 data with cycle slips of different types under high ionospheric activity are tested, and all cycle slips can be correctly detected and corrected.
    Type of Medium: Online Resource
    ISSN: 1729-8814 , 1729-8814
    URL: Article
    DOI: 10.1177/1729881420926404
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2202393-8
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  • 4
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    Treatment for thoracoabdominal aortic aneurysm by fenestrated endovascular aortic repair with physician-modified stent graft
    SAGE Publications ; 2018
    In:  Journal of International Medical Research Vol. 46, No. 5 ( 2018-05), p. 2014-2022
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 46, No. 5 ( 2018-05), p. 2014-2022
    Abstract: Despite being widely used for several years, the endovascular aortic repair (EVAR) of a thoracoabdominal aneurysm (TAAA) remains challenging, particularly the revascularization of the abdominal aortic visceral branches. A 66-year-old male was admitted to hospital with abdominal bloating and pain. Computed tomographic angiography (CTA) confirmed a Crawford type III TAAA from the distal descending aorta to the suprarenal abdominal aorta that involved the celiac axis, accompanied with an occlusion of the left subclavian artery. Fenestrated-EVAR was performed successfully and 1 week later CTA showed a type III endoleak, which had resolved 3 months later, without stent migration or visceral artery occlusion. In this present case, the surgeons preferred to perform the procedure in three surgical stages, postponing the deployment of a covered stent in the CA fenestration to provide additional time for the development of collateral circulation to the spinal cord as a possible means of preventing postoperative paraplegia.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060518761521
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2082422-1
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  • 5
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    Enzymatic modification of jute fabrics for enhancing the reinforcement in jute/PP composites
    SAGE Publications ; 2018
    In:  Journal of Thermoplastic Composite Materials Vol. 31, No. 4 ( 2018-04), p. 483-499
    Details
    In: Journal of Thermoplastic Composite Materials, SAGE Publications, Vol. 31, No. 4 ( 2018-04), p. 483-499
    Abstract: In this work, laccase was employed to improve the properties of lignocellulosic jute fabrics and then the modified jute was used as the fiber reinforcement of polypropylene (PP) matrix composites to improve its reinforcing effect on the polymer resins and obtain composite materials with better performance. The decrease in the –C–O–H component and the increase in the –C–O–C component on the surface of laccase-treated jute fabrics suggested that phenolic hydroxyl groups of lignins on the jute fiber surface were oxidized by laccase and the produced phenoxyl radicals were coupled to form ether structures. The laccase-treated jute fiber surface became smooth with lignins attached tightly. Moreover, the surface hydrophobicity and tensile properties of the jute fabrics were increased via the laccase-mediated reactions of lignins. PP composites reinforced by the laccase-treated jute fabrics showed higher breaking strength, storage modulus, and melting temperature than the control. The fracture surface of the laccase-treated jute fabric/PP composites was neat and jute fibers on the section surface were surrounded by PP resins closely, which indicated better interfacial adhesion between the modified jute reinforcement and PP matrix.
    Type of Medium: Online Resource
    ISSN: 0892-7057 , 1530-7980
    URL: Article
    DOI: 10.1177/0892705717706538
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2098671-3
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  • 6
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    Identification of CEACAM5 as a Biomarker for Prewarning and Prognosis in Gastric Cancer
    SAGE Publications ; 2015
    In:  Journal of Histochemistry & Cytochemistry Vol. 63, No. 12 ( 2015-12), p. 922-930
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 63, No. 12 ( 2015-12), p. 922-930
    Abstract: MGd1, a monoclonal antibody raised against gastric cancer cells, possesses a high degree of specificity for gastric cancer (GC). Here we identified that the antigen of MGd1 is CEACAM5, and used MGd1 to investigate the expression of CEACAM5 in non-GC and GC tissues (N=643), as a biomarker for prewarning and prognosis. The expression of CEACAM5 was detected by immunohistochemistry in numerous tissues; its clinicopathological correlation was statistically analyzed. CEACAM5 expression was increased progressively from normal gastric mucosa to chronic atrophic gastritis, intestinal metaplasia, dysplasia and finally to GC ( p 〈 0.05). In gastric precancerous lesions (intestinal metaplasia and dysplasia), CEACAM5-positive patients had a higher risk of developing GC as compared with CEACAM5-negative patients (OR = 12.68, p 〈 0.001). Besides, CEACAM5 was found positively correlated with invasion depth of gastric adenocarcinoma ( p 〈 0.001). In survival analysis, CEACAM5 was demonstrated to be an independent prognostic predictor for patients with GC of clinical stage IIIA/IV ( p=0.033). Our results demonstrate that CEACAM5 is a promising biomarker for GC prewarning and prognostic evaluation.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1369/0022155415609098
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 1421306-0
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  • 7
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    Experimental studies on rotary valves for single-tube pulse detonation rocket engines
    SAGE Publications ; 2014
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 228, No. 2 ( 2014-02), p. 262-270
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 228, No. 2 ( 2014-02), p. 262-270
    Abstract: Two types of rotary valve were designed and fabricated for single-tube pulse detonation rocket engines. According to their driving components, they were named as gear-driven and cam-driven rotary valve, respectively. Preliminary experimental investigations were carried out to test their feasibility for supply of the single-tube pulse detonation rocket engine. Based on the gear-driven rotary valve, the single-tube pulse detonation rocket engine operated at 10 Hz stably. When operating frequency was increased to 15 Hz, inconsecutive detonations happened which was due to signal output block in the encoder. It was found that optimal ignition timing needed to be adjusted to obtain stable operation in the gear-driven rotary-valved pulse detonation rocket engine. Discussion on this was conducted. Operations of the cam-driven rotary-valved pulse detonation rocket engine were also performed. Fully developed and successive detonations at 40 Hz were successfully obtained although an explosion happened in initial tests. Experimental results showed that these two types of rotary valve were able to realize supply control of single-tube pulse detonation rocket engines effectively.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/0954410012470606
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2032759-6
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  • 8
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    Lasting Effects of a Community-Based Self-Management Intervention for Patients With Type 2 Diabetes in China: Outcomes at 2-Year Follow-up of a Randomized Trial
    SAGE Publications ; 2021
    In:  Asia Pacific Journal of Public Health Vol. 33, No. 1 ( 2021-01), p. 30-38
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 33, No. 1 ( 2021-01), p. 30-38
    Abstract: This research is to evaluate the lasting effects of a community-based self-management intervention for patients with type 2 diabetes at 2-year follow-up in China. Five hundred patients with diabetes were recruited and randomly divided into intervention group and control group. Eight times standardized self-management intervention group activities were conducted. The results of physical examination, biochemical laboratory examination, health behavior, and self-efficacy information were collected before intervention, 3 months after intervention, and 2 years after intervention. The total score for self-efficacy in the intervention group increased from 96.12 ± 17.48 to 112.90 ± 14.58 after intervention and decreased after 2 years (106.98 ± 18.03; F = 6.64, P = .0014). The number of days of self-blood glucose monitoring in the intervention group was increased from 1 day per week to 2 days per week after intervention, and 2 days per week at 2-year follow-up ( F = 8.02, P = .0003). The frequency of average number of aerobic exercises in the intervention group increased from 6 days per week to 7 days per week after intervention and was 7 days per week at 2-year follow-up ( F = 3.63, P = .0269). Community-based self-management group intervention for patients with diabetes has long-term effects.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539520975266
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2394975-2
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  • 9
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    RETRACTED: Hypo-fractionation radiotherapy normalizes tumor vasculature in non-small cell lung cancer xenografts through the p-STAT3/HIF-1 alpha signaling pathway
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592096585-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592096585-
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920965853
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
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  • 10
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    Silencing of Glucose Transporter Protein-1 by RNA Interference Inhibits Human Osteosarcoma Mg63 Cells Growth in vivo
    SAGE Publications ; 2015
    In:  Technology in Cancer Research & Treatment Vol. 14, No. 2 ( 2015-04), p. 243-248
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 14, No. 2 ( 2015-04), p. 243-248
    Abstract: While knock-down of glucose transporter protein 1 (GLUT-1) inhibited various human cancer cell growth in vitro and in vivo, including osteosarcoma cell growth in vitro, there has been no report on whether knock-down of GLUT-1 by siRNA may inhibit osteosarcoma cell growth in vivo. We hypothesized that siRNA may inhibit osteosarcoma cell growth in vivo. We introduced siRNA-GLUT-1 by lentivirus into MG63 osteosarcoma cells which were xenograted into nude mice. Immunohistochemical staining, Western blot and reverse transcriptase quantitative (RT-qPCR) were used to determine GLUT-1 protein and mRNA expression of the tumor cells. The results showed the tumor volume of GLUT-1-siRNA-MG63 cells xenorafted nude mice was significantly less than that of siGFP-MG63 or MG63 cells xenografted nude mice ( P 〈 0.05), suggesting that silencing of GLUT-1 inhibited tumor formation and growth of osteosarcoma cells in vivo. Our findings suggest that the lentiviral-mediated siRNA interference against GLUT-1 may be a valuable tool for gene therapy for osteosarcoma.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.7785/tcrt.2012.500412
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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