GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Mesenteric endothelial dysfunction in a cardiopulmonary bypass rat model: The effect of diabetes
    SAGE Publications ; 2012
    In:  Diabetes and Vascular Disease Research Vol. 9, No. 4 ( 2012-10), p. 270-279
    Details
    In: Diabetes and Vascular Disease Research, SAGE Publications, Vol. 9, No. 4 ( 2012-10), p. 270-279
    Abstract: Diabetes is a risk factor for perioperative complications after cardiac surgery. We studied its effects on mesenteric endothelial function in a cardiopulmonary bypass (CPB) model. Methods: Forty Wistar rats were divided into four groups: sham (D-CPB-), cardiopulmonary bypass (D-CPB+), diabetic (D+CPB-) and diabetic that have undergone CPB (D+CPB+). Two samples of mesenteric artery were used for nitric oxide synthase (NOS) Western blot analysis, and two others for assessing contractile response and endothelium relaxations. Nitrite products and tumour necrosis factor-alpha (TNF-α) were assessed as markers of inflammatory response. Results: We observed an enhanced contractile response to the α-adrenergic agonist associated with impairment of mesenteric vasorelaxation in D+CPB+ rats. Western immunoblot analysis of D+CPB+ highlighted an additive effect of hyper-expression of inducible NOS. A significantly increased inflammatory response was observed after CPB in diabetic animals. Conclusions: This work confirms the potential deleterious impact of diabetes on the mesenteric endothelium during CPB in cardiac surgery.
    Type of Medium: Online Resource
    ISSN: 1479-1641 , 1752-8984
    URL: Article
    DOI: 10.1177/1479164111434432
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2250797-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Effect of Fatigue on Medial Elbow Torque in Baseball Pitchers: A Simulated Game Analysis
    SAGE Publications ; 2018
    In:  The American Journal of Sports Medicine Vol. 46, No. 10 ( 2018-08), p. 2509-2513
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 46, No. 10 ( 2018-08), p. 2509-2513
    Abstract: The incidence of overuse injury to the elbow among baseball pitchers continues to rise, despite extensive efforts at pitch count regulations and emphasis on proper throwing mechanics. Purpose: To determine if the medial elbow experiences increased torque levels as a baseball pitcher fatigues through the course of a simulated game. Study Design: Descriptive laboratory study. Methods: High school and collegiate baseball pitchers were recruited for this simulated game study. Each pitcher completed a simulated game consisting of 6 innings and a standardized pitching scheme of fastballs, curveballs, and changeups. In total, each pitcher threw 90 pitches. Fatigue was reported per inning with a visual analog scale, and pitch velocity was captured per pitch with a radar gun. Outcome measures were assessed with a validated mobile sensor and included medial elbow torque, arm speed, arm rotation, and arm slot. Linear and quadratic regression modeling was used to evaluate the relationship between pitcher fatigue and pitching kinematics. Results: A total of 11 pitchers (mean age, 17.6 years; range, 15-20 years) completed the study. Visual analog scale fatigue scores increased 0.72 points per inning pitched ( P 〈 .01, effect size = 0.64). Medial elbow torque also increased beyond inning 3, with an increase of 0.84 N·m each inning ( P 〈 .01, effect size = 0.08), while pitch velocity decreased (0.28 mph per inning, P 〈 .01, effect size = 0.27). Fastballs generated the greatest amount of medial elbow torque (49.3 ± 1.4 N·m, P 〈 .01, effect size = 0.24). There were no differences in arm rotation ( P = .42) or arm speed ( P = .80) as the game progressed. However, arm slot decreased with each successive inning (0.73° on average per inning, P = .03, effect size = 0.12). No adverse outcomes were noted with use of the mobile sensor. Conclusion: In this simulated game analysis, pitchers experienced increased fatigue after each successive inning. While the average pitch velocity declined with each successive inning, the torque on the medial elbow increased after inning 3. These findings signify a possible relationship between fatigue and injury risk.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546518782451
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2063945-4
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Predictors of Elbow Torque Among Youth and Adolescent Baseball Pitchers
    SAGE Publications ; 2018
    In:  The American Journal of Sports Medicine Vol. 46, No. 9 ( 2018-07), p. 2148-2153
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 46, No. 9 ( 2018-07), p. 2148-2153
    Abstract: There has been an increasing incidence of overuse elbow injuries among youth and adolescent pitchers. Pitch type has been implicated as a risk factor for excess torque at the medial elbow; however, this has not been definitively demonstrated. Purpose: To assess predictors of torque across the medial elbow in youth and adolescent pitchers with a mobile sensor. In addition, the authors aimed to determine the differences in elbow torque produced according to pitch type (fastball, curveball, changeup) and pitcher demographics. Study Design: Descriptive laboratory study. Methods: Twenty youth and adolescent pitchers were instructed to throw 8 fastballs, 8 curveballs, and 8 changeups in a standardized but randomized sequence over a 25-minute period. Five pitchers were evaluated each day. A sensor placed at the medial elbow reported elbow torque, arm speed, arm slot, and shoulder rotation for each pitch, while a radar gun measured peak ball velocity. The primary outcome was a determination of thrower and pitch characteristics associated with elevated torque across the medial elbow. Secondary outcomes included the evaluation of differences in throwing biomechanics among different pitch types. Outcomes were assessed via a multivariable model, which controlled for possible covariates. Results: In total, 20 youth baseball pitchers with a mean age of 14.1 years (range, 12-17 years) were included in the study. On average, fastballs caused the greatest torque across the medial elbow (least squares mean ± SE, 47.3 ± 0.5 N·m) as compared with changeups (44.2 ± 0.5 N·m; P 〈 .001) and curveballs (45.0 ± 0.5 N·m; P = .002). However, curveballs produced the greatest arm speed (917.8 rpm). Pitchers who started throwing curveballs at an older age experienced less elbow torque ( P 〈 .001). A multivariable model demonstrated that increased ball velocity and body mass index and decreased arm slot were independent predictors of increased elbow torque. Conversely, increasing age, longer arm length, and greater elbow circumference were independent protectors against elbow torque. Conclusion: This study found that among youth and adolescent pitchers, fastballs generate the highest elbow torque while curveballs generated the greatest arm speed. Increased ball velocity and body mass index and decreased arm slot were predictors of elbow torque; however, increasing age and size of a pitcher’s arm were protectors against elbow torque. These findings are important to better understand risk factors for overuse injury in this at-risk athletic population. Clinical Relevance: These findings may inform future pitching recommendations with intentions of curtailing medial elbow injuries experienced by young pitchers, such as ulnar collateral ligament injuries.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546518770619
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2063945-4
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Cross-Cultural Investigation of Compliance Without Pressure : The “You Are Free to. . .” Technique in France, Ivory Coast, Romania, Russia, and China
    SAGE Publications ; 2012
    In:  Cross-Cultural Research Vol. 46, No. 4 ( 2012-11), p. 394-416
    Details
    In: Cross-Cultural Research, SAGE Publications, Vol. 46, No. 4 ( 2012-11), p. 394-416
    Abstract: Compliance-without-pressure techniques have been widely studied in North America and West Europe. Among these techniques, the “but you are free” (BYAF) is a verbal compliance procedure that solicits someone to comply with a request by simply telling a person that he or she is free to accept or refuse the request. This technique is interpreted with the commitment theory and the psychological reactance theory which are more relevant in individualistic cultures than in collectivist cultures. So, four studies compared the efficiency of the BYAF technique in collectivist cultures (Ivory Coast, Russia, and China) and in individualist cultures (France and Romania). As suggested in the hypothesis, our analysis indicated that the BYAF technique will be much less successful in more collectivist cultures. Such results underline the importance of considering specific cultural contexts in social influence studies.
    Type of Medium: Online Resource
    ISSN: 1069-3971 , 1552-3578
    URL: Article
    DOI: 10.1177/1069397112450859
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2004124-X
    SSG: 3,4
    SSG: 5,2
    SSG: 10
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Baseline and Post-Treatment Hepatitis C NS5A Resistance in Relapsed Patients from a Multicentric Real-Life Cohort
    SAGE Publications ; 2018
    In:  Antiviral Therapy Vol. 23, No. 4 ( 2018-05), p. 307-314
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 23, No. 4 ( 2018-05), p. 307-314
    Abstract: Recent data have suggested that failure to achieve sustained virological response with direct-acting antiviral therapy is usually due to relapse and is primarily associated with the emergence of resistance-associated substitutions. The aim of this study was to investigate the prevalence and characterization of non-structural-5A resistance-associated substitutions in patients infected with HCV genotypes 1, 3 and 4 treated by direct-acting antiviral therapy, including anti-non-structural-5A, and to characterize the pre-existing resistance-associated substitutions in subjects treated with anti-non-structural-5A inhibitors. Methods From January 2014 to March 2016, 2,995 patients infected with HCV genotypes 1, 3 and 4 were exposed to non-structural-5A inhibitors. Sequencing results at the time of virological failure were available for 61 patients; sequencing at baseline was available for 35 of these patients. Results Among the 35 patients with sequencing results available at baseline, 15 had no resistance-associated substitution, 16 had only one resistance-associated substitution, and 4 had more than one resistance-associated substitution. Resistance-associated substitutions were harbored in 57% of the sequences in the non-structural-5A region. Among the 61 patients sequenced at virological failure, 50 (82%) patients presented at least one resistance-associated substitutions inducing a high level of resistance to non-structural-5A inhibitors ( 〉 10-fold resistance). Conclusions This pooled analysis suggests that non-structural-5A resistance-associated substitutions screening should be recommended when considering retreatment with a non-structural-5A inhibitor regimen in patients who have previously experienced failed non-structural-5A treatment.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP3184
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Relationship Between Pitcher Fatigue and Medial Elbow Torque in Baseball Pitchers: A Simulated Game Analysis
    SAGE Publications ; 2018
    In:  Orthopaedic Journal of Sports Medicine Vol. 6, No. 7_suppl4 ( 2018-07-01), p. 2325967118S0007-
    Details
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 6, No. 7_suppl4 ( 2018-07-01), p. 2325967118S0007-
    Abstract: The incidence of overuse injury to the elbow in baseball pitchers continues to rise, despite exhaustive efforts at pitch count regulations and emphasis on proper throwing mechanics. The goal of this study was to determine if the medial elbow experiences increased torque levels as the pitcher fatigues through the course of a simulated game. Methods: Competitive baseball pitchers were recruited for this simulated game study. Medial elbow torque was assessed using a validated mobile sensor that recorded medial elbow torque during the throwing motion. A radar gun was used to capture pitch velocity for each recorded pitch. Each pitcher completed a simulated game consisting of 6 innings and a standardized pitching scheme of fastballs, curveballs, and change-ups. Visual analog scores (VAS) measuring fatigue were recorded in between each inning. In total, each pitcher threw 90 pitches. Data was recorded every pitch to include ball velocity, medial elbow torque, arm speed, arm rotation, and arm slot. Results: A total of 11 pitchers (average age 17.6 years; range 15-20 years) completed the study. No adverse outcomes were noted with use of the mobile sensor. VAS scores increased 0.716 points per inning pitched (p 〈 0.001). Medial elbow torque also was found to increase with successive innings, with an increase of 0.836 Nm each inning (p 〈 0.001), while average pitch velocity was found to decrease as the game progressed (0.28 mile per hour decrease per inning; p 〈 0.001). Fastballs generated the highest amount of medial elbow torque. There were no differences found in arm rotation or arm speed as the game progressed. However, the arm slot was found to decrease with each successive inning (0.731 degree decrease per inning; p 〈 0.001). Conclusion: In this simulated game analysis, pitchers were noted to experience increase fatigue after each successive inning. While the average fastball velocity decreased from inning-to-inning, the medial elbow torque was found to increase, signifying a possible risk factor for overuse injury to the medial elbow.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    URL: Article
    DOI: 10.1177/2325967118S00073
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2706251-X
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Is the Marker the Message? The Role of Some Scalar Adverbs in the Processing of a Public Health Appeal and Its Effectiveness
    SAGE Publications ; 2016
    In:  Journal of Language and Social Psychology Vol. 35, No. 5 ( 2016-10), p. 529-547
    Details
    In: Journal of Language and Social Psychology, SAGE Publications, Vol. 35, No. 5 ( 2016-10), p. 529-547
    Abstract: In this study, we argue that studies in persuasive communication have been undertaken until now without considering enough the main ideas of pragmatics as regards the communication process and the use of language. In particular, we suggest that in this area of research, it could be relevant to ponder the processes involved in the message processing by taking into account the “inferential” and “intentionalist” paradigm of communication. To support our claim, we propose an experimental study designed in the area of health communication which consists in investigating the impact of some linguistic items defined as scalar adverbs on some attitudinal outcomes and the message elaboration. It shows that the introduction of such adverbs in an epidemiological information message increases the self-risk perception, the perceived relevance of the prevention programs, and as regards the message processing, reduces the cognitive elaboration of its content for the benefit of its communicative intention. The persuasiveness of such linguistic items in a preventive message as well as the conditions under which they are likely to act as peripheral cues are addressed in the conclusion of the study.
    Type of Medium: Online Resource
    ISSN: 0261-927X , 1552-6526
    URL: Article
    DOI: 10.1177/0261927X15614343
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1500232-9
    SSG: 5,2
    SSG: 7,11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Autologous dermis graft versus conchal cartilage graft for managing lower eyelid retraction: A comparative study
    SAGE Publications ; 2021
    In:  European Journal of Ophthalmology Vol. 31, No. 4 ( 2021-07), p. 1733-1740
    Details
    In: European Journal of Ophthalmology, SAGE Publications, Vol. 31, No. 4 ( 2021-07), p. 1733-1740
    Abstract: Lower eyelid management is challenging. The conchal cartilage is often considered a spacer of choice for treating lower eyelid retraction. However, dermis graft has also recently been shown to be a viable spacer. The aim of this study was to compare the efficacy of dermis graft to that of conchal cartilage graft in this indication. Methods: A retrospective comparative study was conducted in patients who underwent lower eyelid lengthening with autologous dermis graft (group 1) or autologous conchal cartilage graft (group 2). The main outcome measure was the reduction in inferior scleral show (ISS) assessed by three independent masked surgeons. Secondary outcome measures was the assessment of lagophthalmos and corneal keratitis. Complications were also recorded. Results: Twenty-five eyelids of 23 patients were included: 11 and 14 eyelids, respectively in group 1 (dermis graft) and group 2 (conchal cartilage graft). Patient mean follow-up was 12.3 (±12.5) and 7.1 (±7.7) months, respectively. No statistical differences in postoperative ISS reduction, lagophthalmos and exposure keratitis was observed ( p = 0.540, p = 0.946, p = 0.934, respectively). Three patients experienced a grade I Clavien–Dindo complication in group 1 and one patient experienced a grade II complication in group 2 ( p = 0.540). Conclusion: Autologous dermis grafts and conchal cartilage grafts provide favorable outcomes without major complications.
    Type of Medium: Online Resource
    ISSN: 1120-6721 , 1724-6016
    URL: Article
    DOI: 10.1177/1120672120934408
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 1475018-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Computing Molecular Signatures as Optima of a Bi-Objective Function: Method and Application to Prediction in Oncogenomics
    SAGE Publications ; 2015
    In:  Cancer Informatics Vol. 14 ( 2015-01), p. CIN.S21111-
    Details
    In: Cancer Informatics, SAGE Publications, Vol. 14 ( 2015-01), p. CIN.S21111-
    Abstract: Filter feature selection methods compute molecular signatures by selecting subsets of genes in the ranking of a valuation function. The motivations of the valuation functions choice are almost always clearly stated, but those for selecting the genes according to their ranking are hardly ever explicit. Method We addressed the computation of molecular signatures by searching the optima of a bi-objective function whose solution space was the set of all possible molecular signatures, ie, the set of subsets of genes. The two objectives were the size of the signature-to be minimized–and the interclass distance induced by the signature-to be maximized–. Results We showed that: 1) the convex combination of the two objectives had exactly n optimal non empty signatures where n was the number of genes, 2) the n optimal signatures were nested, and 3) the optimal signature of size k was the subset of k top ranked genes that contributed the most to the interclass distance. We applied our feature selection method on five public datasets in oncology, and assessed the prediction performances of the optimal signatures as input to the diagonal linear discriminant analysis (DLDA) classifier. They were at the same level or better than the best-reported ones. The predictions were robust, and the signatures were almost always significantly smaller. We studied in more details the performances of our predictive modeling on two breast cancer datasets to predict the response to a preoperative chemotherapy: the performances were higher than the previously reported ones, the signatures were three times smaller (11 versus 30 gene signatures), and the genes member of the signature were known to be involved in the response to chemotherapy. Conclusions Defining molecular signatures as the optima of a bi-objective function that combined the signature size and the interclass distance was well founded and efficient for prediction in oncogenomics. The complexity of the computation was very low because the optimal signatures were the sets of genes in the ranking of their valuation. Software can be freely downloaded from http://gardeux-vincent.eu/DeltaRanking.php
    Type of Medium: Online Resource
    ISSN: 1176-9351 , 1176-9351
    URL: Article
    DOI: 10.4137/CIN.S21111
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2202739-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Large Problems of Dynamic Network Assignment and Traffic Equilibrium : Computational Principles and Application to Paris Road Network
    SAGE Publications ; 2009
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2132, No. 1 ( 2009-01), p. 122-132
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2132, No. 1 ( 2009-01), p. 122-132
    Abstract: The paper reports on the algorithmic treatment and computer implementation of a macroscopic dynamic traffic assignment model called LADTA. The modeling assumptions and the mathematical analysis founding the model are first explained. Detailed descriptions of the main algorithms are given, together with the principles of the computer implementation. How the design of the software architecture allows for distributed computation of a traffic assignment is shown. The practical ability of this implementation to tackle large networks is illustrated by an application to the Paris road network, which comprises about 1,300 zones and 39,000 links.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/2132-14
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2403378-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...