GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • SAGE Publications  (76)
Material
Publisher
  • SAGE Publications  (76)
Person/Organisation
Language
Years
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Plasma fluoroacetic acid concentrations: Symptoms, hematological, and biochemical characteristics in patients with fluoroacetic acid poisoning in the emergency department
    SAGE Publications ; 2020
    In:  Human & Experimental Toxicology Vol. 39, No. 5 ( 2020-05), p. 634-641
    Details
    In: Human & Experimental Toxicology, SAGE Publications, Vol. 39, No. 5 ( 2020-05), p. 634-641
    Abstract: Fluoroacetic acid (FAcOH) was once a highly toxic rodenticide widely used in the world. In the past, studies on the toxicity of FAcOH have focused on animal experiments. The toxicity of FAcOH to humans and the changes of FAcOH in plasma have not been studied. Therefore, the present study aimed to describe the changes of plasma FAcOH concentrations, hematological, and biochemical characteristics in patients with FAcOH intoxication. According to clinical symptoms, 68 patients from the emergency department were divided into different groups: convulsion group, unconsciousness group, death group, and control groups. Plasma FAcOH concentrations, hematological, and biochemical parameters were investigated. Results demonstrated that patients in the convulsion group and the unconsciousness group had a significant increase ( p 〈 0.01) in the level of neuron-specific enolase (NSE), creatine kinase MB (CKMB), glucose (GLU), and white blood cell count (WBC) and a significant decrease ( p 〈 0.01) in serum potassium compared with the control group, respectively. Moreover, patients in the death group had a significant increase ( p 〈 0.01) in the level of NSE, CKMB, N-terminal pro-brain natriuretic peptide, GLU, and WBC and a significant decrease ( p 〈 0.01) in serum potassium and total calcium compared with the survival group. The concentrations of FAcOH in plasma in the convulsion group, the unconsciousness group, and the death group were 72.31 ± 42.29, 118.33 ± 55.41, and 163.78 ± 43.32 μg/mL, respectively. These changes and the plasma FAcOH concentrations may increase our understanding of the toxicity of FAcOH to humans and may help doctors to judge the clinical prognosis of patients with FAcOH intoxication.
    Type of Medium: Online Resource
    ISSN: 0960-3271 , 1477-0903
    URL: Article
    DOI: 10.1177/0960327119897743
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 1483723-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Combined Blockade and Akt/Mtor Pathway Inhibits Growth of Human Hemangioma via Downregulation of Proliferating Cell Nuclear Antigen
    SAGE Publications ; 2012
    In:  International Journal of Immunopathology and Pharmacology Vol. 25, No. 4 ( 2012-10), p. 945-953
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 25, No. 4 ( 2012-10), p. 945-953
    Abstract: Protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in the tumorigenesis and progression of multiple tumors, and has been shown to be important therapeutic targets for cancer. The present study aimed to explore the role and molecular mechanisms of AKT/mTOR pathway in human hemangioma (HA). Twenty-five cases of human HA tissues were collected. The expression of AKT, mTOR and proliferating cell nuclear antigen (PCNA) proteins was evaluated using semi-quantitative immunohistochemistry in biopsy samples in different phases of HA. AKT/mTOR pathway was blocked by recombinant small hairpin RNA adenovirus vector rAd5-AKT+mTOR (rAd5-Am), used for infecting proliferating phase HA-derived endothelial cells (HDEC). The expression of AKT, mTOR and PCNA was detected by Real-time PCR and Western blot assays. Cell proliferative activities were determined by MTT assay, and cell cycle distribution and apoptosis were analyzed by flow cytometry. As a consequence, the expression of AKT, mTOR and PCNA was significantly increased in proliferative phase HA, while that was decreased in involutive phase. Combined blockade of AKT/mTOR pathway by rAd5-Am diminished cell proliferative activities, and induced cell apoptosis and cycle arrest with the decreased expression of AKT, mTOR and PCNA in proliferative phase HDEC. In conclusion, the activity of AKT/mTOR pathway was increased in proliferative phase HA, while it was decreased in involutive phase. Combined blockade of AKT/mTOR pathway might suppress cell proliferation via down-regulation of PCNA expression, and induce apoptosis and cycle arrest in proliferative phase HDEC, suggesting that AKT/mTOR pathway might represent the important therapeutic targets for human HA.
    Type of Medium: Online Resource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/039463201202500412
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2505963-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    A 12-week subchronic intramuscular toxicity study of risperidone-loaded microspheres in rats
    SAGE Publications ; 2015
    In:  Human & Experimental Toxicology Vol. 34, No. 2 ( 2015-02), p. 205-223
    Details
    In: Human & Experimental Toxicology, SAGE Publications, Vol. 34, No. 2 ( 2015-02), p. 205-223
    Abstract: Long-acting injectable formulations of antipsychotics have been an important treatment option to increase the compliance of the patient with schizophrenia by monitoring drug administration and identifying medication noncompliance and to improve the long-term management of schizophrenia. Risperidone, a serotoninergic 5-HT 2 and dopaminergic D 2 receptor antagonist, was developed to be a long-acting sustained-release formulation for the treatment of schizophrenia. In this study, 12-week subchronic toxicity study of risperidone-loaded microspheres (RMs) in rats by intramuscular injection with an 8-week recovery phase was carried out to investigate the potential subchronic toxicity of a novel long-acting sustained-release formulation. The results indicated that the dosage of 10–90 mg/kg of RM for 2 weeks did not cause treatment-related mortality. The main drug-related findings were contributed to the dopamine D 2 receptor and α 1 -adrenoceptor antagonism of risperidone such as elevation of serum and pituitary prolactin levels and ptosis and changes in reproductive system (uterus, ovary, vagina, mammary gland, testis, seminal vesicle, epididymis, and prostate). In addition, foreign body granuloma in muscle at injection sites caused by poly-lactide-co-glycolide was observed. At the end of the recovery phase, these changes mostly returned to normal. The results indicated that RM had a good safety profile in rats.
    Type of Medium: Online Resource
    ISSN: 0960-3271 , 1477-0903
    URL: Article
    DOI: 10.1177/0960327114532380
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 1483723-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Sdccag3 Promotes Implant Osseointegration during Experimental Hyperlipidemia
    SAGE Publications ; 2020
    In:  Journal of Dental Research Vol. 99, No. 8 ( 2020-07), p. 938-948
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 99, No. 8 ( 2020-07), p. 938-948
    Abstract: Hyperlipidemia adversely affects bone metabolism, often resulting in compromised osseointegration and implant loss. In addition, genetic networks associated with osseointegration have been proposed. Serologically defined colon cancer antigen 3 (Sdccag3) is a novel endosomal protein that functions in actin cytoskeleton remodeling, protein trafficking and secretion, cytokinesis, and apoptosis, but its roles in the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and in implant osseointegration under hyperlipidemic conditions have not been uncovered. Here, we performed microarray and RNA sequencing analysis to determine the differential expression of the Sdccag3 gene and related noncoding RNAs (ncRNAs) and to assess the long noncoding RNA (lncRNA) MSTRG.97162.4-miR-193a-3p-Sdccag3 coexpression network in bone tissues within the region 0.5 mm around implants in hyperlipidemic rats. In this experiment, we found that Sdccag3 and the previously uncharacterized lncRNA-MSTRG.97162.4 were downregulated during hyperlipidemia, while miR-193a-3p was upregulated. Sdccag3 overexpression increased new trabecular formation, the bone volume/total volume (BV/TV) (1.24-fold), and bone-implant combination ratio (BIC%) (1.26-fold). An RNA pulldown experiment revealed that Sdccag3 protein targeted lncRNA-MSTRG.97162.4 nucleotides 361 to 389. In addition, lncRNA-MSTRG.97162.4 overexpression significantly enhanced Sdccag3 (2.78-fold) expression and increased BV/TV (1.45-fold) and BIC% (1.07-fold) at the bone-implant interface. Taken together, these findings indicate that Sdccag3 overexpression enhances implant osseointegration under hyperlipidemic conditions by binding to lncRNA-MSTRG.97162.4. Furthermore, miR-193a-3p overexpression inhibited lncRNA-MSTRG.97162.4 (0.63-fold) and Sdccag3 (0.88-fold) expression and induced poor implant osseointegration (BV/TV, 0.86-fold; BIC%, 0.82-fold), while miR-193a-3p downregulation produced the opposite results (lncRNA-MSTRG.97162.4, 10.69-fold; Sdccag3, 6.96-fold; BV/TV, 1.20-fold; BIC%, 1.26-fold). Therefore, our findings show that Sdccag3 promotes implant osseointegration, and its related lncRNA-MSTRG.97162.4 and miR-193a-3p play an important role in osseointegration during hyperlipidemia, which might be a promising therapeutic target for improving dental implantation success rates.
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/0022034520916400
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2057074-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Combined detection of uMCP-1 and uTWEAK for rapid discrimination of severe lupus nephritis
    SAGE Publications ; 2018
    In:  Lupus Vol. 27, No. 6 ( 2018-05), p. 971-981
    Details
    In: Lupus, SAGE Publications, Vol. 27, No. 6 ( 2018-05), p. 971-981
    Abstract: Reliable markers for the rapid discrimination of severe renal damage remain a vital concern for lupus nephritis (LN). To determine a better tool for kidney damage detection, the present study compared the evaluation ability of novel urinary cytokines and chemokines (namely urinary monocyte chemoattractant protein 1 (uMCP-1), tumor necrosis factor-like weak inducer of apoptosis (uTWEAK)) with traditional serum or urinary markers (namely urinary alpha 1-microgrobulin (uα1-MG), beta 2-microglobulin (uβ2-MG) and serum complement C3 (C3), complement C4 (C4), creatinine (Cr), blood urea nitrogen (BUN) and cystatin C (Cys C)) in discriminating LN renal damage. Correlations between markers with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) renal SLEDAI scores, biopsy activity index (BAI) and biopsy chronicity index (BCI) scores were evaluated. Receiver operating characteristic (ROC) curves were generated to evaluate a single or combined model in discriminating active renal involvement (rSLEDAI scores  〉  0) and patients with poor pathological outcome (BAI scores ≥ 7). uMCP-1 and uTWEAK possess higher correlation coefficients with renal damage and larger areas under ROC curves (AUCs) than other markers. A combined model of uMCP-1 and uTWEAK showed an AUC of 0.887, sensitivity of 86.67% and specificity of 80.00% to discriminate active LN, and an AUC of 0.778, sensitivity of 75.00% and specificity of 81.82% to discriminate LN with poor outcome, which are better than the utility of any markers individually.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203318758507
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2008035-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Product line selection and pricing under modular composition choices and inventory pooling strategy
    SAGE Publications ; 2011
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture Vol. 225, No. 4 ( 2011-04), p. 587-598
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications, Vol. 225, No. 4 ( 2011-04), p. 587-598
    Abstract: Modularity is widely adopted in manufacturing industry as an effective method to balance market pressure for low prices and customer demand pressure for high product variety. Modular design can help to achieve high product variety easily and cheaply by altering different options for one component of the product. An effective inventory strategy is also important for reducing total cost. Under the inventory cost constraint, when the product variety is high, the inventory level of each kind of product will be relatively low and stock-out probability is likely to be high. On the other hand, the manufacturer who offers a product line with low product variety may face the problem of losing customers. In this paper, the problem of product line selection and pricing is studied. The impact of inventory pooling strategy and set-up cost on the product line selection and pricing is considered by proposing a mixed integer programme optimization model. The experimental results show that the proposed model and algorithm are effective.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    URL: Article
    DOI: 10.1177/2041297510394082
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2032745-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Phospholipid coating on a polydimethylsiloxane microchannel wall to minimize aqueous evaporation in microdroplet maintenance
    SAGE Publications ; 2008
    In:  Proceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanoengineering and Nanosystems Vol. 222, No. 2 ( 2008-06-01), p. 39-42
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanoengineering and Nanosystems, SAGE Publications, Vol. 222, No. 2 ( 2008-06-01), p. 39-42
    Abstract: In this paper, some factors governing the evaporation rate of aqueous microdroplets generated in a newly developed PDMS (polydimethylsiloxane) microchannel device were examined. Microdroplets of about 0.25nL, composed of any one of the conventional solvents (including water, ethanol, and hexane) were found to be disappearing in about 1 h in a PDMS microchannel (diameter 80μm) when exposed to heating under light microscopy, although this slightly slowed down when placed in an ambient environment. Furthermore, when the inner wall of the PDMS microchannel was microfluidic coated by phospholipid solution, aqueous microdroplets could be maintained with no volume-loss up to at least 1 h.
    Type of Medium: Online Resource
    ISSN: 1740-3499 , 2041-3092
    URL: Article
    DOI: 10.1243/17403499JNN141
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2197969-8
    detail.hit.zdb_id: 2961164-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Polypyrrole/oligonucleotide nanocomposite: Its initial growth
    SAGE Publications ; 2008
    In:  Proceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanoengineering and Nanosystems Vol. 222, No. 2 ( 2008-06-01), p. 57-63
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanoengineering and Nanosystems, SAGE Publications, Vol. 222, No. 2 ( 2008-06-01), p. 57-63
    Abstract: In this work, the initial growth process of a polypyrrole/oligonucleotide (PPy/ODN) nanocomposite electrochemically synthesized on an indium tin oxide (ITO)-coated glass surface was investigated by means of chronoamperometric measurements combined with optical microscopy and atomic force microscopy (AFM). It was found that the growth of PPy/ODN onto ITO was a three-stage process including incubation, rapid nucleation and growth, and constant nucleation and growth. The presence of ODN molecules significantly shortened the first stage. Further analysis showed that the nucleation and growth mechanism of PPy/ODN was progressive nucleation and 3D growth, which then changed to instantaneous nucleation and 3D growth before nucleus overlapping. In the third stage, the nucleation and growth mechanism of PPy/ODN was a combination of progressive nucleation and 3D growth and instantaneous nucleation and 3D growth.
    Type of Medium: Online Resource
    ISSN: 1740-3499 , 2041-3092
    URL: Article
    DOI: 10.1243/17403499JNN143
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2197969-8
    detail.hit.zdb_id: 2961164-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Preparation and tribology of ultrafine and amorphous strontium borate
    SAGE Publications ; 2001
    In:  Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications Vol. 215, No. 3 ( 2001-07-01), p. 133-140
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications, SAGE Publications, Vol. 215, No. 3 ( 2001-07-01), p. 133-140
    Abstract: Ultrafine amorphous strontium borate was prepared using an ethanol supercritical fluid drying (ESFD) technique and characterized using transmission electron microscopy (TEM), X-ray diffractometry (XRD), small angle X-ray scattering (SAXS) and nitrogen physical adsorption. Its tribological properties, as an antiwear additive of lubricating oil, were evaluated with four-ball and block-on-ring tribotester. The wear scar was characterized using scanning electron microscopy (SEM). Results indicated that strontium borate prepared in this way possessed a porous structure with a pore size below 20 nm. The wear resistance and load-carrying capacity of lubricating oil were improved by the strontium borate and the friction coefficient was also slightly decreased. The improvement of lubricating oil tribological properties resulted from the deposition of strontium borate and its tribo-chemical reaction product containing boron.
    Type of Medium: Online Resource
    ISSN: 1464-4207 , 2041-3076
    URL: Article
    DOI: 10.1243/1464420011544978
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2032772-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Real-Time Imaging and Detection of Intracranial Haemorrhage by Electrical Impedance Tomography in a Piglet Model
    SAGE Publications ; 2010
    In:  Journal of International Medical Research Vol. 38, No. 5 ( 2010-10), p. 1596-1604
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 38, No. 5 ( 2010-10), p. 1596-1604
    Abstract: The aim of this study was to use electrical impedance tomography (EIT) to detect and image acute intracranial haemorrhage (ICH) in an animal model. Blood was infused into the frontal lobe of the brains of anaesthetized piglets and impedance was measured using 16 electrodes placed in a circle on the scalp. The EIT images were constructed using a filtered back-projection algorithm. The mean of all the pixel intensities within a region of interest – the mean resistivity value (MRV) – was used to evaluate the relative impedance changes in the target region. A symmetrical index (SI), reflecting the relative impedance on both sides of the brain, was also calculated. Changes in MRV and SI were associated with the injection of blood, demonstrating that EIT can successfully detect ICH in this animal model. The unique features of EIT may be beneficial for diagnosing ICH early in patients after cranial surgery, thereby reducing the risk of complications and mortality.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/147323001003800504
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2082422-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...