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  • SAGE Publications  (12)
  • 1
    Online Resource
    Online Resource
    A comparison and review of three sets of classification criteria for systemic lupus erythematosus for distinguishing systemic lupus erythematosus from pure mucocutaneous manifestations in the lupus disease spectrum
    SAGE Publications ; 2020
    In:  Lupus Vol. 29, No. 14 ( 2020-12), p. 1854-1865
    Details
    In: Lupus, SAGE Publications, Vol. 29, No. 14 ( 2020-12), p. 1854-1865
    Abstract: Although the original purpose of the systemic lupus erythematosus (SLE) classification criteria was to distinguish SLE from other mimic diseases, and to facilitate sample selection in scientific research, they have become widely used as diagnostic criteria in clinical situations. It is not known yet if regarding classification criteria as diagnostic criteria, what problems might be encountered? This is the first study comparing the three sets of classification criteria for SLE, the 1997 American College of Rheumatology (ACR’97), 2012 Systemic Lupus International Collaborating Clinics (SLICC’12) and 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR’19), for their ability to distinguish patients with SLE from patients with pure mucocutaneous manifestations (isolated cutaneous lupus erythematosus without internal disease, i-CLE) in the lupus disease spectrum. 1,865 patients with SLE and 232 patients with i-CLE were recruited from a multicenter study. We found that, due to low specificity, none of the three criteria are adept at distinguishing patients with SLE from patients with i-CLE. SLICC’12 performed best among the original three criteria, but if a positive ANA was removed as an entry criterion, EULAR/ACR’19 would performed better. A review of previous studies that compared the three sets of criteria was presented in this work.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203320959716
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2008035-9
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  • 2
    Online Resource
    Online Resource
    Synthesis and Characterisation of a New Pyridinium Salt/Crown Ether Complex and its Self-Assembly
    SAGE Publications ; 2007
    In:  Journal of Chemical Research Vol. 2007, No. 6 ( 2007-06), p. 350-352
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 2007, No. 6 ( 2007-06), p. 350-352
    Abstract: The monoprotonated bipyridinium cation can complex with dibenzo-24-crown-8 by means of ion-dipole and charge-transfer interactions. They both thread to form a [2]pseudorotaxane-like complex for further intercomplex association to produce pseudopolyrotaxane arrays through N + –H···N hydrogen bonding in the solid state.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/030823407X225482
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 3010810-X
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  • 3
    Online Resource
    Online Resource
    Experimental study on pressure pulses in long-distance gas pipeline during the pigging process
    SAGE Publications ; 2020
    In:  Science Progress Vol. 103, No. 1 ( 2020-01), p. 003685041988445-
    Details
    In: Science Progress, SAGE Publications, Vol. 103, No. 1 ( 2020-01), p. 003685041988445-
    Abstract: Long-distance gas pipelines generally have complex, undulating sections. Trapped air pockets are often present at the high points or ends of pipelines. This article carries out an experimental research to figure out the transient changes. First of all, under the condition of using the pig with 231 g and the injection pressure of 0.3 MPa, the hydraulic pulse increases from 0.31 to 0.54 MPa as the liquid level rises from 1 to 8 m. And at the liquid level of 8 m, the injection pressure grows from 0.3 to 0.75 MPa and the hydraulic pulse from 0.54 to 0.95 MPa. When the interception air mass is located at the blind side of the pipeline’s end, the injection pressure is 0.75 MPa, and the hydraulic pulse decreases from 4.9 to 3.21 MPa with the increase in the void fraction. The maximum hydraulic pressure generates when the air pocket is located at the rear end of the drainage system (4.9 MPa) is far higher than that when the air pocket is located in front of the pig (1.0 MPa). Therefore, it is necessary to minimize the generation of trapped air pockets at the rear end of the pipeline system to ensure safety.
    Type of Medium: Online Resource
    ISSN: 0036-8504 , 2047-7163
    URL: Article
    DOI: 10.1177/0036850419884452
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2483680-1
    detail.hit.zdb_id: 2199376-2
    SSG: 11
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  • 4
    Online Resource
    Online Resource
    MicroRNA-34a alleviates steroid-induced avascular necrosis of femoral head by targeting Tgif2 through OPG/RANK/RANKL signaling pathway
    SAGE Publications ; 2017
    In:  Experimental Biology and Medicine Vol. 242, No. 12 ( 2017-06), p. 1234-1243
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 242, No. 12 ( 2017-06), p. 1234-1243
    Abstract: The study aims to investigate the effect of microRNA-34a (miR-34a) targeting Tgif2 on steroid-induced avascular necrosis of femoral head (SANFH) by regulating OPG/RANK/RANKL signaling pathway. SD rats were divided into normal control and model (RNAKL rat models) groups. The model group was further assigned into model control, negative control, miR-34a mimics and miR-34a inhibitors groups. QRT-PCR was applied to detect miR-34a, Tgif2, OPG, RANK and RNAKL mRNA expressions. Femoral head tissues were collected for Micro-CT scanning and HE staining. QRT-PCR and Western blotting were used to detect expressions of miR-34a, Tgif2, OPG, RANK, RANKL and Runx2, OPN and OC in bone tissues. Dual-luciferase reporter gene assay was used to testify the target relationship between miR-34a and Tgif2. Compared with the normal control group, the model group showed increased Tgif2, RANK and RANKL mRNA expressions, but decreased miR-34a and OPG mRNA expressions. Tgif2 mRNA expression was negatively correlated with miR-34a and OPG mRNA expressions. Micro-CT showed cystic degeneration of femoral head, with decreased bone volume/total volume (BV/TV), bone surface area/bone volume and trabecular number in the model control group compared with the normal control group. Compared with the model control group, the miR-34a mimics group showed increased BV/TV and trabecular thickness and Runx2, OPN and OC expressions, while the parameters decreased in the miR-34a inhibitors group. Compared with the normal control group, the other groups showed increased Tgif2, RANK and RANKL expressions but decreased miR-34a and OPG expressions. Compared with the model control group, Tgif2, RANK and RANKL expressions decreased and miR-34a and OPG expressions increased in the miR-34a mimics group, while the miR-34a inhibitors group had a reverse trend in contrast to the miR-34a mimics group. Tgif2 is a target gene of miR-34a. In conclusion, miR-34a can alleviate SANFH through targeting Tgif2 and further regulating OPG/RANK/RANKL signaling pathway. Impact statement miR-34a can alleviate SANFH through targeting Tgif2 and further regulating OPG/RANK/RANKL signaling pathway, which can be used as a new theoretical basis for SANFH treatment.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370217703975
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 5
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    Online Resource
    Bioinformatics analysis on differentially expressed genes between colorectal adenoma and colorectal adenocarcinoma
    SAGE Publications ; 2022
    In:  Scottish Medical Journal Vol. 67, No. 4 ( 2022-11), p. 178-188
    Details
    In: Scottish Medical Journal, SAGE Publications, Vol. 67, No. 4 ( 2022-11), p. 178-188
    Abstract: Colorectal adenoma (CRA) is the main cause of the progression of Colorectal adenocarcinoma (COAD). Therefore, it is very important to accurately reveal its developmental mechanism. Methods Differential expression genes (DEGs) in three microarray datasets were screened using GEO and GEO2R. R packages were used for gene ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) path enrichment analysis. Hub genes screened by STRING, Cytoscape and CytoHubba were used. R was used for DEGs of hub genes, and Gene Expression Profiling Interactive Analysis (GEPIA2) database was used for prognostic Analysis. R-packet were used to analyze tumor pathology, tumour, lymph-nodes, and metastases (TNM) staging, enrichment, immune invasion and prognosis. Results Among the 66 genes, including 36 up-regulated and 30 down-regulated genes. Survival analysis showed that COL1A1, COL5A2, COL5A1 and secreted protein acidic and rich in cysteine (SPARC) were associated with disease-free survival in patients. The four genes were related to tumor pathological stage, TNM stage and immune invasion. COL1A1 and COL5A2 were highly expressed in chromatin modification and cellular senescence. Low expression of COL5A1 and SPARC was significantly enriched in neutrophil degranulation and Wp VegfavegFR2 signaling pathways. Conclusions Obviously, these four key genes can serve as important targets for early diagnosis, treatment, immunity and prognosis of CRA to COAD.
    Type of Medium: Online Resource
    ISSN: 0036-9330 , 2045-6441
    URL: Article
    DOI: 10.1177/00369330221122306
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2141765-9
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  • 6
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    Anthraquinones from the Roots of Prismatomeris Tetrandra
    SAGE Publications ; 2010
    In:  Natural Product Communications Vol. 5, No. 8 ( 2010-08), p. 1934578X1000500-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 5, No. 8 ( 2010-08), p. 1934578X1000500-
    Abstract: A new anthraquinone compound, 1,3-dihydroxy-6-methoxy-2-methoxymethyl-9,10-anthraquinone (1), along with four known analogues (2–5) were isolated from the roots of Prismatomeris tetrandra. Their structures were elucidated on the basis of spectroscopic analysis. Among these compounds, lucidin ω-methyl ether (4) and lucidin ω-ethyl ether (5) were isolated from this genus for the first time. Compound 1 showed weak cytotoxic activity against A549 and LAC cell lines.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1000500821
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 7
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    Two New Secondary Metabolites from Tephrosia purpurea
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 6 ( 2015-06), p. 1934578X1501000-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 6 ( 2015-06), p. 1934578X1501000-
    Abstract: Further investigation of Tephrosia purpurea led to the isolation of a new prenylated flavone, isoglabratephrin B (1) and a new 1,2-ethanedione benzofuran derivative, purpdione B (2). The structures of the new isolates were elucidated on the basis of extensive spectroscopic analysis.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501000631
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 8
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    Advanced rotor temperature estimation of permanent magnet synchronous machines for electric vehicles
    SAGE Publications ; 2020
    In:  Advances in Mechanical Engineering Vol. 12, No. 6 ( 2020-06), p. 168781402091874-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 12, No. 6 ( 2020-06), p. 168781402091874-
    Abstract: The actual power capacity of permanent magnet synchronous machine for electric vehicles is usually limited by rotor temperature, and rotor overheating is one of the major reasons for permanent magnet synchronous machine failure. Therefore, an approach of rotor temperature estimation is proposed to improve motor peak power utilization and protect permanent magnet synchronous machine from serious demagnetization due to thermal damage. A real-time iterative algorithm is provided based on the equivalent thermal model for rotor temperature. First, the heat generating principle of each part as well as the power flow transferring of the motor system is analyzed. Second, rotor temperature model is built based on the conservation of energy loss from the stator and real-time superposition of temperature variation rate for the rotor. Finally, the motor performance test bench is built to validate the proposed algorithm and numerical models are also constructed to simplify estimation parameters for rotor temperature model. The algorithm accuracy is improved and verified by optimizing control parameters with given environment temperature and power load. The experimental result shows that the maximum error between actual test value and estimation value is within ±10°C, and it meets the requirement of algorithm accuracy and also benefits on system performance and manufacture cost efficiently.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814020918742
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2501620-9
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  • 9
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    MiR-100 Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion and Enhances Chemosensitivity by Targeting IGFIR
    SAGE Publications ; 2016
    In:  Technology in Cancer Research & Treatment Vol. 15, No. 5 ( 2016-10), p. NP40-NP48
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 15, No. 5 ( 2016-10), p. NP40-NP48
    Abstract: MicroRNAs are highly conserved noncoding RNA that negatively modulate protein expression at a posttranscriptional and/or translational level. MicroRNAs play an important role in the development and progression of human cancers, including osteosarcoma. Recent studies have shown that miR-100 was downregulated in many cancers; however, the role of miR-100 in human osteosarcoma has not been totally elucidated. In this study, we demonstrate that the expression of miR-100 was significantly downregulated in human osteosarcoma tissues compared to the adjacent tissues. Enforced expression of miR-100 inhibited cell proliferation, migration, and invasion abilities of osteosarcoma cells, U-2OS, and MG-63. Additionally, miR-100 also sensitized osteosarcoma cells to cisplatin and promoted apoptosis. Furthermore, overexpression of miR-100 decreased the expression of insulin-like growth factor I receptor and inhibited PI3K/AKT and MAPK/ERK signaling. In human clinical specimens, insulin-like growth factor I receptor was inversely correlated with miR-100 in osteosarcoma tissues. Collectively, our results demonstrate that miR-100 is a tumor suppressor microRNA and indicate its potential application for the treatment of osteosarcoma in future.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533034615601281
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 10
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    Measuring smartphone usage and task switching with log tracking and self-reports
    SAGE Publications ; 2019
    In:  Mobile Media & Communication Vol. 7, No. 1 ( 2019-01), p. 3-23
    Details
    In: Mobile Media & Communication, SAGE Publications, Vol. 7, No. 1 ( 2019-01), p. 3-23
    Abstract: Smartphones offer multimedia convergence in a single device, ubiquitous access to media, and constant connections with others. The rapid rise of smartphone use calls for more scholarly attention paid to users’ media usage and time expenditure. This study aims to (a) understand smartphone usage patterns by examining time spent using smartphones and task switching between mobile applications (apps), and (b) test the validity of self-reported measures of these behaviors by comparing self-reports with log data from the smartphone. Data were collected from 50 participants over 1 week. Results show that on average participants spent 2 hours 39 minutes on their smartphone and made 101 app switches per day. Among other findings, social networking was the most used app category, age was a significant demographic factor, and participants, especially heavy smartphone users, overestimated their mobile app usage. Theoretical and practical implications of these findings are discussed.
    Type of Medium: Online Resource
    ISSN: 2050-1579 , 2050-1587
    URL: Article
    DOI: 10.1177/2050157918761491
    RVK:
    MN 1000
    RVK:
    AP 10790.6
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2684519-2
    detail.hit.zdb_id: 2686704-7
    SSG: 24,1
    SSG: 3,4
    SSG: 3,5
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