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  • 1
    Online Resource
    Online Resource
    Tin Protoporphyrin IX Used in Control of Heme Metabolism in Humans Effectively Inhibits HIV-1 Infection
    SAGE Publications ; 1994
    In:  Antiviral Chemistry and Chemotherapy Vol. 5, No. 5 ( 1994-10), p. 322-330
    Details
    In: Antiviral Chemistry and Chemotherapy, SAGE Publications, Vol. 5, No. 5 ( 1994-10), p. 322-330
    Abstract: Recent observations indicated that several porphyrins bound to the V3 loop of the envelope glycoprotein gp120 of the human immunodeficiency virus type 1 (HIV-1) and inhibited infection of cells by HIV-1. The tin derivative of protoporphyrin IX (Sn-PTP-IX) has already been used clinically in humans to suppress hyperbilirubinemia. It was therefore of interest to determine whether Sn-PTP-IX has anti-HIV-1 activity. It is demonstrated here that Sn-PTP-IX effectively inhibited infection by several HIV-1 isolates (HIB, MN, RF, SF-2 and two isolates resistant to azidothymidine). This was surprising, since earlier studies indicated that incorporation of other metals into porphyrins markedly decreased their antiviral activity. Sn-PTP-IX blocked the binding to gp120 of anti-V3-loop-specific antibodies and of monoclonal antibodies specific for the CD4 binding site on gp120. The latter effect appeared to be allosteric and was not observed with a deletion mutant of gp 120 lacking the V3 loop sequence. This suggests that Sn-PTP-IX binds to the V3 loop and distorts the native conformation of the HIV-1 envelope, thereby preventing infection. These results merit the consideration of Sn-PTP-IX as a prophylactic and chemotherapeutic agent against HIV-1.
    Type of Medium: Online Resource
    ISSN: 2040-2066 , 2040-2066
    URL: Article
    DOI: 10.1177/095632029400500506
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1994
    detail.hit.zdb_id: 2130088-4
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  • 2
    Online Resource
    Online Resource
    Screening and Identification of Antibiotic Resistant Gene int1 in Coliforms Isolated From Drinking Water
    SAGE Publications ; 2022
    In:  Air, Soil and Water Research Vol. 15 ( 2022-01), p. 117862212210847-
    Details
    In: Air, Soil and Water Research, SAGE Publications, Vol. 15 ( 2022-01), p. 117862212210847-
    Abstract: Antibiotic-resistance genes carried by coliforms in drinking water is a concerning issue for public health in Bangladesh. This research was carried out to identify coliforms in drinking water and to understand the importance of the int1 gene of coliforms in the spread of resistance to bacterial antibiotics through consumption of contaminated water. A total of 31 drinking water samples were collected from restaurants ( n = 18), health center ( n = 9), and residences ( n = 4) located in Chattogram City, Bangladesh. The isolation and identification of coliforms was performed on selective media with a combination of biochemical and molecular analysis. PCR amplification of the LacZ, uidA and int1 genes was carried out for the identification of the coliform and fecal coliform and antibiotic resistant gene, respectively. Antimicrobial susceptibility test was performed according to the Kirby-Bauer disk diffusion method with McFarland standard against three selective antibiotics including co-trimoxazole, ciprofloxacin, and ampicillin. Of 31 drinking water samples, coliforms were detected within 32% ( n = 10) of the water samples, nine samples were collected in restaurants and one sample in a residence. But no coliform was detected in the drinking water of the health center. Among the identified coliforms, the prevalence of fecal coliforms and the int1 gene was 60% ( n = 6) and 40% ( n = 4), relatively. All isolates containing the int1 microbial-resistance gene were resistant to ampicillin.This study shows that drinking water consumed in different restaurants located in Chattogram, Bangladesh is contaminated by antibiotic-resistant gene bearing coliforms that not only increase the risk of water-borne disease, but also may be the major cause of antibiotic resistance transmission in this part of Bangladesh.
    Type of Medium: Online Resource
    ISSN: 1178-6221 , 1178-6221
    URL: Article
    DOI: 10.1177/11786221221084715
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2488152-1
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  • 3
    Online Resource
    Online Resource
    Friction and wear characteristics of ceramics composite under multidirectional motions
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 236, No. 5 ( 2022-05), p. 867-880
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 236, No. 5 ( 2022-05), p. 867-880
    Abstract: The friction and wear characteristics of stainless steel diffused with Si-based ceramics were investigated using pin-and-disc configuration under reciprocation motion, rotational motion, and simultaneous motion. The pin material was diffused by the combination of 60% Ti 2 O 3 , 30% Al 2 O 3 , and 10% Si 2 O 3 . Experiments have been carried out both in diffused and non-diffused conditions. Both the friction coefficient and wear rate have been possible to reduce by diffused pin material. The effects of both friction coefficient and wear rate have been studied on ceramics composites at different pin-and-disc motions. Experiments were conducted underpin motions of 0.15–0.25 m/s, disc motions of 0.5–0.6 m/s, and normal loads of 2.5–3.5 N. A relation was found among friction, wear and surface hardness of the composite. The friction coefficient and wear resistance were improved of stainless steel diffused with ceramics. Scanning electron microscopic analysis was performed to observe the morphology of ceramic and pin material.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    URL: Article
    DOI: 10.1177/13506501211042146
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2032767-5
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  • 4
    Online Resource
    Online Resource
    A feedback controller for milling chatter vibration control using a new response matrix
    SAGE Publications ; 2022
    In:  Journal of Vibration and Control Vol. 28, No. 9-10 ( 2022-05), p. 998-1010
    Details
    In: Journal of Vibration and Control, SAGE Publications, Vol. 28, No. 9-10 ( 2022-05), p. 998-1010
    Abstract: A chatter mark is a result of irregular vibration that affects the milling process, which results in poor surface finish, reduced work quality, machine impairment, and high production cost. This work presents an active feedback controller design using a new response matrix to suppress the free vibration in the milling process. The proposed controller considers feed rate, tooth passing frequency, and time-varying dynamic milling force coefficients. A milling experiment verifies the effect of the proposed method. The method provides a reliable way of tackling chatter vibration in an industrial process. The procedure is technically and economically beneficial.
    Type of Medium: Online Resource
    ISSN: 1077-5463 , 1741-2986
    URL: Article
    DOI: 10.1177/1077546320988201
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2070247-4
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  • 5
    Online Resource
    Online Resource
    Experimental analysis of aluminum alloy under solid particle erosion process
    SAGE Publications ; 2016
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 230, No. 12 ( 2016-12), p. 1516-1541
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 230, No. 12 ( 2016-12), p. 1516-1541
    Abstract: The erosion behaviors of aluminum alloy have been evaluated practically at different test conditions under ambient temperature. Irregular silica sand (SiO 2 ) is used as an erodent within the range of 300–600 µm. The impact velocity within 30–50 m/s, impact angle 15–90°, and stand-off distance 15–25 mm considered as related parameters. The maximum level of erosion is obtained at impact angle 15° which indicates the ductile manner of the tested alloy. The higher the impact velocity, the higher the erosion rate as almost linear fashion is observed. Mass loss of aluminum alloy reduces with the increase of stand-off distance. A dimensional analysis, erosion efficiency (η) and relationship between friction and erosion indicate the prominent correlation. The test results are designated using Taguchi’s concept to ensure the minimization of observations for clarification of results in alternative process. ANOVA data analysis is considered to signify the interaction of tested parameters as well as identifying most influencing operating parameter. S/N ratio indicates that there are 2.92% deviations estimated between predicted and experimental results. To elaborately analyze the results, GMDH method is mentioned. After erosion process of the tested composite, the damage propagation on the surfaces is examined using SEM for confirming wear mechanisms. The elemental composition of eroded test samples at varying percentage of aluminum is analyzed by energy dispersive X-ray spectroscopy analysis.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    URL: Article
    DOI: 10.1177/1350650116639466
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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  • 6
    Online Resource
    Online Resource
    Estimation of the friction coefficient in turning process of metals through model experiment
    SAGE Publications ; 2018
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 232, No. 6 ( 2018-06), p. 685-692
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 232, No. 6 ( 2018-06), p. 685-692
    Abstract: An in-procedure tribometer is analyzed to assess the friction during orthogonal turning process at cutting rates of up to 300 m/min to determine genuine cutting procedure conditions. The examined tribometer consists of a spring preloaded tungsten carbide with (5% to 8%) cobalt pin with the rounded tip mounted behind the bleeding edge and in contact with the naturally produced workpiece plane. The pin preload is fitted by feed power or force. A 3D-feed force measuring gadget in the obsession of the pin facilitates the assessment of the friction coefficient from tangential and typical strengths. Tests indicate considerably diverse results while reaching new and oxidized planes as well as diminishing friction coefficients as the cutting velocity increases. In general, greater graphite content decreases the friction coefficient and the temperature inclines in the wear pin. A uniform scattering of graphite particles in steel composites enhance their irritating resistance. Moreover, the wear rates for these amalgams are lower than those for similar combinations without graphite. Plane or surface equality is the key predictor of roughness. Plane inequality decreases as cutting speed increases and vice versa.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    URL: Article
    DOI: 10.1177/1350650117726463
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2032767-5
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  • 7
    Online Resource
    Online Resource
    A Prospective Study of the Treatment of Fractures of the Little Finger Metacarpal Shaft with a Short Hand Cast
    SAGE Publications ; 2004
    In:  Journal of Hand Surgery Vol. 29, No. 3 ( 2004-06), p. 214-217
    Details
    In: Journal of Hand Surgery, SAGE Publications, Vol. 29, No. 3 ( 2004-06), p. 214-217
    Abstract: This prospective study describes the use of a short hand cast, which leaves the finger metacarpophalangeal and wrist joint free, for angularly displaced little finger metacarpal shaft fractures which require reduction. Twenty-seven patients with a mean age of 25 (range, 16–39) years with little finger or combined ring and little finger displaced metacarpal shaft fractures were prospectively recruited. All were treated by closed fracture reduction and immobilization in the cast. Patients were followed up at 1 week, 4 weeks, and between 6 and 12 months. At each of these follow-up visits posteroanterior and lateral radiographs of the metacarpals were performed to assess angulation of the fracture. The mean initial angulation of the 17 little finger metacarpal fractures with complete follow up was 40° (range, 20–60°). Their mean final angulation at 6 to 12 months was 8°. The fracture reduction was lost in three patients in whom the final angular deformities were 15° (one patient) and 20° (two patients).
    Type of Medium: Online Resource
    ISSN: 0266-7681
    URL: Article
    DOI: 10.1016/J.JHSB.2004.02.020
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2376920-8
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