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  • 1
    Online Resource
    Online Resource
    Intraneural Perineurioma of the Median Nerve: Case Report and Literature Review
    SAGE Publications ; 2010
    In:  HAND Vol. 5, No. 3 ( 2010-09), p. 286-293
    Details
    In: HAND, SAGE Publications, Vol. 5, No. 3 ( 2010-09), p. 286-293
    Abstract: Intraneural perineurioma is a benign peripheral nerve sheath tumor of perineurial cell origin. We present the case of an intraneural perineurioma of the median nerve in a 23-year-old woman which posed a diagnostic challenge. Ultrasonography was found to be a quick, easy, and effective screening tool for identifying the source of the deficit followed by MRI to further elucidate the lesion. We discuss surgical management options for optimizing functional outcomes when addressing such lesions.
    Type of Medium: Online Resource
    ISSN: 1558-9447 , 1558-9455
    URL: Article
    DOI: 10.1007/s11552-009-9228-1
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2316440-2
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  • 2
    Online Resource
    Online Resource
    Improved Chondrotoxic Profile of Liposomal Bupivacaine Compared With Standard Bupivacaine After Intra-articular Infiltration in a Porcine Model
    SAGE Publications ; 2018
    In:  The American Journal of Sports Medicine Vol. 46, No. 1 ( 2018-01), p. 66-71
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 46, No. 1 ( 2018-01), p. 66-71
    Abstract: Increasingly, liposomal bupivacaine is being used with multimodal pain management strategies. In vitro investigations have shown decreased chondrotoxicity profiles for liposomal bupivacaine; however, there is no evidence regarding its in vivo effects. Hypothesis/Purpose: This study sought to investigate the in vivo chondrotoxicity of liposomal bupivacaine, hypothesizing that there would be increased chondrocyte viability after exposure to liposomal bupivacaine when compared with standard bupivacaine. Study Design: Controlled laboratory study. Methods: Eight juvenile, female Yorkshire cross piglets underwent a lateral stifle joint injection with either 1.3% liposomal bupivacaine or 0.5% bupivacaine. Injections were performed on one joint per animal with no injection to the contralateral knee, which served as the control. Chondrocyte viability was assessed 1 week after injection with a live-dead staining protocol and histologic examination. Results: Significant chondrocyte death was seen with the live-dead staining in the bupivacaine group (33% nonviable cells) in comparison with liposomal bupivacaine (6.2%) and control (5.8%) groups ( P 〈 .01). However, histologic examination showed no differences in chondral surface integrity, fibrillation, and chondrocyte viability. Conclusion: Liposomal bupivacaine was found to be safe for intra-articular injection in this animal model. Although bupivacaine demonstrated decreased chondrocyte viability on a cellular level, histologically there were no changes. This study highlights the dichotomy between fluorescent staining and histologic appearance of articular chondrocytes in short-term analyses of viability. Clinical Relevance: This study supports the peri-articular application of liposomal bupivacaine in the setting of preserved articular cartilage. A single injection of standard bupivacaine did not produce histologic changes in the articular cartilage.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546517732558
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 3
    Online Resource
    Online Resource
    Induction of Interferon-γ-Inducible Protein 10 by SARS-CoV Infection, Interferon Alfacon 1 and Interferon Inducer in Human Bronchial Epithelial Calu-3 Cells and BALB/c Mice
    SAGE Publications ; 2010
    In:  Antiviral Chemistry and Chemotherapy Vol. 20, No. 4 ( 2010-04), p. 169-177
    Details
    In: Antiviral Chemistry and Chemotherapy, SAGE Publications, Vol. 20, No. 4 ( 2010-04), p. 169-177
    Abstract: The pathogenesis of severe acute respiratory syndrome coronavirus (SARS-CoV) is poorly understood. Several mechanisms involving both direct effects on target cells and indirect effects via the immune system might exist. SARS-CoV has been shown in vitro to induce changes of cytokines and chemokines in various human and animal cells. We previously reported that interferon (IFN) alfacon-1 was more active against SARS-CoV infection in human bronchial epithelial Calu-3 cells than in African green monkey kidney epithelial cells on day 3 post-infection. Methods: In the current study, we first evaluated the efficacy of IFN-alfacon 1 in Calu-3 cells during the first 7 days of virus infection. We then used the two-antibody sandwich ELISA method to detect IFN-γ-inducible protein 10 (IP-10). We further evaluated the efficacy of antivirals directed against SARS-CoV infection in BALB/c mice. Results: A potent, prolonged inhibition of SARS-CoV replication in Calu-3 cells with IFN-alfacon 1 was observed. Furthermore, IP-10, an IFN-inducible leukocyte chemoattractant, was detected in Calu-3 cells after SARS-CoV infection. Interestingly, IP-10 expression was shown to be significantly increased when SARS-CoV-infected Calu-3 cells were treated with IFN alfacon-1. IP-10 expression was detected in the lungs of SARS-CoV-infected BALB/c mice. Significantly high levels of mouse IP-10 in BALB/c mice was also detected when SARS-CoV-infected mice were treated with the interferon inducer, polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine and carboxymethyl cellulose (poly IC:LC). Treatment with poly IC:LC by intranasal route were effective in protecting mice against a lethal infection with mouse-adapted SARS-CoV and reduced the viral lung titres. Conclusion: Our data might provide an important insight into the mechanism of pathogenesis of SARS-CoV and these properties might be therapeutically advantageous.
    Type of Medium: Online Resource
    ISSN: 2040-2066 , 2040-2066
    URL: Article
    DOI: 10.3851/IMP1477
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2130088-4
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  • 4
    Online Resource
    Online Resource
    Percutaneous intervention in peripheral artery disease improves calf muscle phosphocreatine recovery kinetics: A pilot study
    SAGE Publications ; 2012
    In:  Vascular Medicine Vol. 17, No. 1 ( 2012-02), p. 3-9
    Details
    In: Vascular Medicine, SAGE Publications, Vol. 17, No. 1 ( 2012-02), p. 3-9
    Abstract: We hypothesized that percutaneous intervention in the affected lower extremity artery would improve calf muscle perfusion and cellular metabolism in patients with claudication and peripheral artery disease (PAD) as measured by magnetic resonance imaging (MRI) and spectroscopy (MRS). Ten patients with symptomatic PAD (mean ± SD: age 57 ± 9 years; ankle–brachial index (ABI) 0.62 ± 0.17; seven males) were studied 2 months before and 10 months after lower extremity percutaneous intervention. Calf muscle phosphocreatine recovery time constant (PCr) in the revascularized leg was measured by 31 P MRS immediately after symptom-limited exercise on a 1.5-T scanner. Calf muscle perfusion was measured using first-pass gadolinium-enhanced MRI at peak exercise. A 6-minute walk and treadmill test were performed. The PCr recovery time constant improved significantly following intervention (91 ± 33 s to 52 ± 34 s, p 〈 0.003). Rest ABI also improved (0.62 ± 0.17 to 0.93 ± 0.25, p 〈 0.003). There was no difference in MRI-measured tissue perfusion or exercise parameters, although the study was underpowered for these endpoints. In conclusion, in this pilot study, successful large vessel percutaneous intervention in patients with symptomatic claudication, results in improved ABI and calf muscle phosphocreatine recovery kinetics.
    Type of Medium: Online Resource
    ISSN: 1358-863X , 1477-0377
    URL: Article
    DOI: 10.1177/1358863X11431837
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2027562-6
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  • 5
    Online Resource
    Online Resource
    Practices, Perceptions, and Concerns of Primary Care Physicians about Opioid Dependence Associated with the Treatment of Chronic Pain
    SAGE Publications ; 2012
    In:  Substance Abuse Vol. 33, No. 2 ( 2012-04), p. 103-113
    Details
    In: Substance Abuse, SAGE Publications, Vol. 33, No. 2 ( 2012-04), p. 103-113
    Abstract: When prescribing opioids to treat chronic pain, physicians face the dilemma of balancing effective pain management while avoiding iatrogenic opioid addiction. Through mailed surveys, the current study assessed concerns, perceptions, and practices of primary care physicians related to this dilemma. Of the 35 (43%) physicians that replied, 32 (91.4%) reported to prescribe opioids for pain. Twenty-six (81.3%) physicians mentioned that “legitimate pain” was the main reason why most patients who are opioid dependent begin using opioids. Most physicians (71.5%) rated their knowledge/comfort of treatment/management of opioid dependence as being low. Although these physicians believed training is essential to learning about the risks involved with chronic pain and opioid dependence, many of these physicians evaluated their own medical training in these areas as unsatisfactory. Training programs may better equip primary care physicians when addressing the treatment of chronic pain and addiction to opioids.
    Type of Medium: Online Resource
    ISSN: 0889-7077 , 1547-0164
    URL: Article
    DOI: 10.1080/08897077.2011.630944
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2018838-9
    SSG: 5,2
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  • 6
    Online Resource
    Online Resource
    Glennon Brothers: Old Dogs Need to Learn New Tricks
    SAGE Publications ; 2017
    In:  Entrepreneurship Theory and Practice Vol. 41, No. 3 ( 2017-05), p. 455-468
    Details
    In: Entrepreneurship Theory and Practice, SAGE Publications, Vol. 41, No. 3 ( 2017-05), p. 455-468
    Abstract: This case study presents the story of Glennon Brothers, a third–generation family–owned sawmilling business in Ireland. As the firm evolved through the organizational life cycle and the complexity of firm operations increased, a different style of management was required to navigate the family business to the next stage. The brothers needed to move from being managers to managing managers. This case study highlights how coleaders can become comfortable with each other and unintentionally overlook the need to change their managerial priorities in line with the business's evolution.
    Type of Medium: Online Resource
    ISSN: 1042-2587 , 1540-6520
    URL: Article
    DOI: 10.1111/etap.12208
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2069619-X
    SSG: 3,2
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  • 7
    Online Resource
    Online Resource
    Big boots to fill—the next generation continuing differently
    SAGE Publications ; 2016
    In:  The International Journal of Entrepreneurship and Innovation Vol. 17, No. 2 ( 2016-05), p. 133-139
    Details
    In: The International Journal of Entrepreneurship and Innovation, SAGE Publications, Vol. 17, No. 2 ( 2016-05), p. 133-139
    Abstract: This case history describes the challenge facing Carlos García, the third-generation successor of a Spanish family business, as he takes over the reins of Hispalis and prepares to continue the business ‘differently’. In two generations, Hispalis has morphed into a global conglomerate, with a portfolio of business ventures in multiple industries and countries. The case history facilitates discussion of business and family issues and is appropriate for beginning-level undergraduate students in the areas of entrepreneurial leadership, family business, strategic management and corporate governance.
    Type of Medium: Online Resource
    ISSN: 1465-7503 , 2043-6882
    URL: Article
    DOI: 10.1177/1465750316648581
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2023523-9
    SSG: 3,2
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  • 8
    Online Resource
    Online Resource
    Effect of Interferon-Alpha and Interferon-Inducers on West Nile Virus in Mouse and Hamster Animal Models
    SAGE Publications ; 2004
    In:  Antiviral Chemistry and Chemotherapy Vol. 15, No. 2 ( 2004-04), p. 67-75
    Details
    In: Antiviral Chemistry and Chemotherapy, SAGE Publications, Vol. 15, No. 2 ( 2004-04), p. 67-75
    Abstract: The recent West Nile virus (WNV) outbreak in the United States has increased the need to identify effective therapies. Studies were conducted in cell culture and in rodent animal models to determine the efficacy of interferon-alpha (IFN-α), interferon (IFN) inducers and ribavirin, alone or in combination with IFN, in treating WNV. Intraperitoneal injection of IFN-α B/D (qd for 7 days), polyIpolyC(12)U [Ampligen (every other day for 7 days)] and topically applied imiquimod (qd for 7 days), administered from 1 day before viral challenge, were effective in protecting, respectively, 100%, 100% and 70% of BALB/c mice from mortality induced by subcutaneous injection of WNV. When IFN-α B/D or Ampligen treatments were delayed to 4–6 h before viral challenge in mice, efficacy was greatly diminished. Infected Syrian golden hamsters treated with interferon alphacon-1 (Infergen) and Ampligen 4–6 h before viral challenge gained more weight and had a greater survival than saline-treated animals. A combination study of subcutaneously administered Infergen (5 to 0.05 μg/kg/day) and ribavirin (75 to 7.5 mg/kg/day) in 〉 7 week old hamsters demonstrated that Infergen was slightly efficacious in reducing mortality and disease signs; however, it was not synergistic in its antiviral effects when combined with ribavirin. Ribavirin treatment alone increased mortality of infected hamsters. The reduced mortality correlated with reduced plasma viraemia. Since WNV-infected patients have already been treated with IFN and ribavirin and future clinical trials have been suggested, this first report of IFN alone or in combination with ribavirin in WNV-infected animal models might provide useful information for subsequent treatment of patients.
    Type of Medium: Online Resource
    ISSN: 2040-2066 , 2040-2066
    URL: Article
    DOI: 10.1177/095632020401500202
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2130088-4
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