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  • 1
    Online Resource
    Online Resource
    A framework for practically effective creation of postprocessors for 5-axis CNC machines with all possible configurations and working mechanisms
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications
    Abstract: The 5-axis CNC (Computer Numerical Control) machining plays an important role in manufacturing, especially in making parts of complex shapes such as turbine or propeller blades. However, there are always challenges of generating 5-axis CNC machining programs when working with different 5-axis CNC machines of various structures; and 5-axis CNC programs must be automatically generated by CNC postprocessors which calculate the inverse kinematics and convert the Cutter Location data to the CNC programs that are used for operating 5-axis CNC machines. Since the family of 5-axis CNC machines has a wide spectrum of machine configurations, with hundreds of mechanisms of 5 degrees of freedom, it is therefore practically challenging for engineers and CNC machine operators to create CNC postprocessors for specific 5-axis CNC machines. It is more challenging to create CNC postprocessors if engineers or CNC operators do not have strong backgrounds and professional skills in mathematical modeling and kinematics of machines. This paper presents a universal and intuitive framework and practical guidance to create CNC postprocessors for all 5-axis CNC machines, with the focus on a novel mathematical formulation of inverse kinematics of three main groups of 5-axis CNC machines. The case studies of creating CNC postprocessors with the commercially available 5-axis CNC machines were successfully demonstrated, in which the simulation scenarios and experiments were implemented to verify the created CNC postprocessors. The proposed frameworks and guides for generating CNC postprocessors can be conveniently and effectively applied in industrial practices, without the required strong backgrounds and skills for engineers or CNC operators in mathematical modeling and kinematics of machines, especially mathematical modeling of multibody systems.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    URL: Article
    DOI: 10.1177/09544054231179314
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2032745-6
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  • 2
    Online Resource
    Online Resource
    Hairy Root Cultures of Eurycoma longifolia and Production of Anti-inflammatory 9-Methoxycanthin-6-one
    SAGE Publications ; 2018
    In:  Natural Product Communications Vol. 13, No. 5 ( 2018-05), p. 1934578X1801300-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 13, No. 5 ( 2018-05), p. 1934578X1801300-
    Abstract: The content of bioactive alkaloid 9-methoxycanthin-6-one in the roots of Eurycoma longifolia is rather small. In the current study, a high yield of 9-methoxycanthin-6-one was obtained from transgenic hairy roots (1.139 ± 0.20% dry weight, DW) compared to wild roots (0.164 ± 0.25% DW) of E. longifolia. Three liquid basal media supplemented with 3% sucrose were tested for the growth and accumulation of 9-methoxycanthin-6-one. The fastest growth was obtained in the Shenck and Hildebrandt (SH) medium while the highest 9-methoxycanthin-6-one content was observed in McCown's woody plant (WP) medium. In this study, compared to controls, the production of 9-methoxycanthin-6-one was increased by the maximum of 2.6 and 4.0 times after the addition of jasmonic acid and yeast extract, respectively, into hairy root cultures. In addition, pro-inflammatory cytokines IL-6 and TNF-α were significantly inhibited by 9-methoxycanthin-6-one in lipopolysaccharide-stimulated murine RAW264.7 cells, peritoneal macrophages and human THP-1 macrophages These results suggest that the elicited hairy root culture of E. longifolia is an alternative system for the production of an abundant source of anti-inflammatory 9-methoxycanthin-6-one.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1801300507
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Physical Activity During Pregnancy and Postpartum Low Back Pain: A Prospective Cohort Study in Vietnam
    SAGE Publications ; 2019
    In:  Asia Pacific Journal of Public Health Vol. 31, No. 8 ( 2019-11), p. 701-709
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 31, No. 8 ( 2019-11), p. 701-709
    Abstract: Low back pain (LBP) is a universal public health problem for all age groups, related to the upright stance of humans. Postpartum LBP is more common and can lead to limitations to women’s daily activity. Knowledge about preventing postpartum LBP is limited, and the relationship between prenatal physical activity (PA) and LBP remains inconclusive. We conducted a prospective cohort study of 1807 singleton pregnant Vietnamese women to investigate the association between prenatal PA and postpartum LBP using logistic regression analyses. The prevalence of postpartum LBP was 12.3% (n = 222). Women reporting LBP spent more hours sitting per week. Relative to the lowest level of total PA, the highest level was associated with reduced odds of postpartum LBP (odds ratio = 0.55; 95% confidence interval = 0.38-0.80). Inverse associations with LBP were also observed for light intensity, moderate-to-vigorous intensity, household/caregiving, occupational, and transportation activities. Overall, prenatal PA was inversely associated with postpartum LBP in Vietnamese women.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539519890148
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2394975-2
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