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  • SAGE Publications  (19)
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  • SAGE Publications  (19)
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  • 1
    Online Resource
    Online Resource
    The Preference of Place of Death and its Predictors Among Terminally Ill Patients With Cancer and Their Caregivers in China
    SAGE Publications ; 2015
    In:  American Journal of Hospice and Palliative Medicine® Vol. 32, No. 8 ( 2015-12), p. 835-840
    Details
    In: American Journal of Hospice and Palliative Medicine®, SAGE Publications, Vol. 32, No. 8 ( 2015-12), p. 835-840
    Abstract: To describe the preference of place of death among Chinese patients with cancer and their caregivers and to identify factors associated with the preference. Methods: A prospective questionnaire research was conducted in terminally ill patients with cancer and their caregivers. Questions included sociodemographic characteristics and information about patients’ diseases and patients’ preference of place of death. Results: Home (53.64%) was the first choice for 522 patients, 51.34% of participated caregivers chose home as the preferred place of death, and patient–caregiver dyads achieved 84.10% agreement. Patients who lived in rural area, with lower education level and lived with relatives, expressed more preference to die at home. Conclusion: This study described information about the preference of place of death and its potential predictive factors in terminally ill patients with cancer in mainland of China.
    Type of Medium: Online Resource
    ISSN: 1049-9091 , 1938-2715
    URL: Article
    DOI: 10.1177/1049909114542647
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2236674-X
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  • 2
    Online Resource
    Online Resource
    Preparation and characterization of antimicrobial cotton fabrics via N-halamine chitosan derivative/poly(2-acrylamide-2-methylpropane sulfonic acid sodium salt) self-assembled composite films
    SAGE Publications ; 2016
    In:  Journal of Industrial Textiles Vol. 46, No. 4 ( 2016-11), p. 1039-1052
    Details
    In: Journal of Industrial Textiles, SAGE Publications, Vol. 46, No. 4 ( 2016-11), p. 1039-1052
    Abstract: Layer-by-layer self-assembly technology was introduced with adsorption of oppositely charged polycations and polyanions. The composite thin film consisting of quaternized chitosan derivative/poly(2-acrylamide-2-methylpropane sulfonic acid sodium salt) was created on the surface of cotton fabrics by using this method without much damage for breaking strength of swatches. The oxidative chlorine of five bilayers deposited on the swatches could reach 0.25%. The treated cotton fabrics exposure to dilute household bleach possessed excellent antimicrobial property, which could inactivate 100% of Staphylococcus aureus and Escherichia coli O157:H7 bacteria with a contact time of 1 min. The chemical surface modification, surface morphology, washing stability, storage stability, and mechanical property of the modified swatches were characterized and confirmed by Fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, stability measurement, and tensile strength test, respectively.
    Type of Medium: Online Resource
    ISSN: 1528-0837 , 1530-8057
    URL: Article
    DOI: 10.1177/1528083715612232
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2095351-3
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  • 3
    Online Resource
    Online Resource
    Diffusion kurtosis imaging assessment of the response to radiotherapy in a VX2 bone tumor model: an animal study
    SAGE Publications ; 2022
    In:  Acta Radiologica Vol. 63, No. 2 ( 2022-02), p. 182-191
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 63, No. 2 ( 2022-02), p. 182-191
    Abstract: Neoadjuvant radiotherapy plays a vital role in the treatment of malignant bone tumors, and non-invasive imaging methods are needed to evaluate the response to treatment. Purpose To assess the value of diffusion kurtosis imaging (DKI) for monitoring early response to radiotherapy in malignant bone tumors. Material and Methods Treatment response was evaluated in a rabbit VX2 bone tumor model (n = 35) using magnetic resonance imaging (MRI), DKI, and histopathologic examinations. Subjects were divided into three groups: pre-treatment, post-treatment, and control groups. The post-treatment group was subclassified into good response and poor response groups according to the results of histopathologic examination. Apparent diffusion coefficient (ADC) and DKI parameters (mean diffusion coefficient [MD] and mean kurtosis [MK]) were recorded. The relationship between ADC, DKI parameters, and histopathologic changes after radiotherapy was determined using Pearson’s correlation coefficient. The diagnostic performance of these parameters was assessed using receiver operating characteristic analysis. Results MD in the good response group was higher after treatment than before treatment ( P  〈  0.001) and higher than that in the poor response group ( P = 0.009). MD was highly correlated with tumor cell density and apoptosis rate (r = −0.771, P  〈  0.001 and r = 0.625, P  〈  0.001, respectively). MD was superior to other parameters for determining the curative effect of radiotherapy, with a sensitivity of 75.0%, specificity of 100.0%, and area under the curve of 0.917 ( P  〈  0.001). Conclusion The correlations between MD, tumor cell density, and apoptosis suggest that MD could be useful for assessing the early response to radiotherapy in rabbit VX2 malignant bone tumors.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185121989519
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2024579-8
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  • 4
    Online Resource
    Online Resource
    Preparation and characterization of a novel bacterial cellulose/chitosan bio-hydrogel
    SAGE Publications ; 2017
    In:  Nanomaterials and Nanotechnology Vol. 7 ( 2017-01-01), p. 184798041770717-
    Details
    In: Nanomaterials and Nanotechnology, SAGE Publications, Vol. 7 ( 2017-01-01), p. 184798041770717-
    Abstract: Composites of chitosan chloride and bacterial cellulose were successfully prepared by in situ method. Composites of bacterial cellulose/chitosan and pristine bacterial cellulose were investigated by means of scanning electron microscope, atomic force microscope, Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and bacteriostatic test. The crystallization of bacterial cellulose was interfered and weakened by the chitosan chloride included in the growth media, resulting in lower crystallinity index and thermal stability. And interaction between two polymers is verified by the thermal gravimetric analysis. The ultrafine nanofibril network structure of bacterial cellulose was retained by the composites, while the diameters were larger and the aperture inside were smaller than those of pristine bacterial cellulose, as shown through scanning electron microscope and atomic force microscope figures. The antimicrobial effects were enhanced by the increasing concentration of chitosan in composites. All the characteristics of the composites provide evidence for the miscibility of chitosan and cellulose. Their biocompatibility is proved through our published data. It is strongly indicated that bacterial cellulose–chitosan nanocomposites have great potential in tissue engineering or pharmaceutical applications in the near future.
    Type of Medium: Online Resource
    ISSN: 1847-9804 , 1847-9804
    URL: Article
    DOI: 10.1177/1847980417707172
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2618730-9
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  • 5
    Online Resource
    Online Resource
    MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by Activating WNT/β-Catenin Signal via ST7L
    SAGE Publications ; 2020
    In:  Technology in Cancer Research & Treatment Vol. 19 ( 2020-01-01), p. 153303382094580-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 19 ( 2020-01-01), p. 153303382094580-
    Abstract: Pancreatic cancer is an aggressive type of cancer with poor prognosis, short survival rate, and high mortality. Drug resistance is a major cause of treatment failure in the disease. MiR-331-3p has been reported to play an important role in several cancers. We previously showed that miR-331-3p is upregulated in pancreatic cancer and promotes pancreatic cancer cell proliferation and epithelial-to-mesenchymal transition–mediated metastasis by targeting ST7L. However, it is uncertain whether miR-331-3p is involved in drug resistance. Methods: We investigated the relationship between miR-331-3p and pancreatic cancer drug resistance. As part of this, microRNA mimics or inhibitors were transfected into pancreatic cancer cells. Quantitative polymerase chain reaction was used to detect miR-331-3p expression, and flow cytometry was used to detect cell apoptosis. The Cell Counting Kit-8 assay was used to measure the IC50 values of gemcitabine in pancreatic cancer cells. The expression of multidrug resistance protein 1, multidrug resistance-related protein 1, breast cancer resistance protein, β-Catenin, c-Myc, Cyclin D1, Bcl-2, and Caspase-3 was evaluated by Western blotting. Results: We confirmed that miR-331-3p is upregulated in gemcitabine-treated pancreatic cancer cells and plasma from chemotherapy patients. We also confirmed that miR-331-3p inhibition decreased drug resistance by regulating cell apoptosis and multidrug resistance protein 1, multidrug resistance-related protein 1, and breast cancer resistance protein expression in pancreatic cancer cells, whereas miR-331-3p overexpression had the opposite effect. We further demonstrated that miR-331-3p effects in drug resistance were partially reversed by ST7L overexpression. In addition, overexpression of miR-331-3p activated Wnt/β-catenin signaling in pancreatic cancer cells, and ST7L overexpression restored activation of Wnt/β-catenin signaling. Conclusions: Taken together, our data demonstrate that miR-331-3p contributes to drug resistance by activating Wnt/β-catenin signaling via ST7L in pancreatic cancer cells. These data provide a theoretical basis for new targeted therapies in the future.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033820945801
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 6
    Online Resource
    Online Resource
    Evaluating the Scope of Malignant Bone Tumor Using ADC Measurement on ADC Map
    SAGE Publications ; 2019
    In:  Technology in Cancer Research & Treatment Vol. 18 ( 2019-01-01), p. 153303381985326-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 18 ( 2019-01-01), p. 153303381985326-
    Abstract: It is very important for surgeons to know the accurate borders of malignant bone tumors before they can precisely resect the tumors. The objective of the study is to investigate the usefulness of apparent diffusion coefficient value for estimating the extent of malignant bone tumor. Methods: VX2 tumor fragments were implanted into the tibiae of 30 rabbits. After 4 weeks, magnetic resonance plain scans were performed and then tumor specimens were cut into sagittal sections and partitioned into histology slices for dot-to-dot comparisons with microscopic findings. The sizes of the tumors measured separately on specimen, conventional magnetic resonance imaging sequences, and diffusion-weighted imaging (by measuring apparent diffusion coefficient value on apparent diffusion coefficient mapping) were compared statistically with each other. Results: The mean tumor sizes measured on specimen and apparent diffusion coefficient mapping (by calculating apparent diffusion coefficient value) were 5.20 ± 0.89 cm and 5.31 ± 0.87 cm, respectively; there was no significant difference between the 2 ( P 〉 .05). The tumor sizes measured on T1WI, T2WI, T2WI with fat suppression were 4.82 ± 0.87 cm, 5.58 ± 0.87 cm, 5.63 ± 0.85 cm, respectively, and these values were significantly different from that measured on specimen (5.20 ± 0.89 cm, P 〈 .05). Conclusion: The extent of the VX2 malignant bone tumor can be estimated accurately by measurement of apparent diffusion coefficient value.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033819853267
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2146365-7
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  • 7
    Online Resource
    Online Resource
    Risk Factors for Mortality in Chinese Patients on Continuous Ambulatory Peritoneal Dialysis
    SAGE Publications ; 2015
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 35, No. 2 ( 2015-03), p. 199-205
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 35, No. 2 ( 2015-03), p. 199-205
    Abstract: The intent of this study was to evaluate the clinical outcome and risk factors affecting mortality of the continuous ambulatory peritoneal dialysis (CAPD) patients in a single peritoneal dialysis (PD) center over a period of 10 years. Patients and methods We retrospectively analyzed patients on PD from June 2001 to June 2011. The clinical and biochemical data were collected from the medical records. Clinical variables included gender, age at the start of PD, smoking status, body mass index (BMI), cause of end-stage renal disease (ESRD), presence of diabetes mellitus and blood pressure. Biochemical variables included hemoglobin, urine volume, residual renal function (RRF), serum albumin, blood urea nitrogen (BUN), creatinine, total cholesterol, triglyceride, comorbidities, and outcomes. Survival curves were made by the Kaplan-Meier method. Univariate and multivariate analyses to identify mortality risk factors were performed using the Cox proportional hazard regression model. Results A total of 421 patients were enrolled, 269 of whom were male (63.9%). The mean age at the start of PD was 57.9 ± 14.8 years. Chronic glomerulonephritis was the most common cause of ESRD (39.4%). Estimation of patient survival by Kaplan-Meier was 92.5%, 80.2%, 74.4%, and 55.7% at 1, 3, 5, and 10 years, respectively. Patient survival was associated with age (hazard ratio [HR] : 1.641 [1.027 – 2.622], p = 0.038), cardiovascular disease (HR: 1.731 [1.08 – 2.774] , p = 0.023), hypertriglyceridemia (HR: 1.782 [1.11 – 2.858], p = 0.017) in the Cox proportional hazards model analysis. Estimation of technique survival by Kaplan-Meier was 86.7%, 68.8%, 55.7%, and 37.4% at 1, 3, 5, and 10 years, respectively. In the Cox proportional hazards model analysis, age (HR: 1.672 [1.176 – 2.377] , p = 0.004) and hypertriglyceridemia (HR: 1.511 [1.050 – 2.174], p = 0.026) predicted technique failure. Conclusion The PD patients in our center exhibited comparable or even superior patient survival and technical survival rates, compared with reports from other centers in China and other countries.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.3747/pdi.2013.00164
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2075957-5
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  • 8
    Online Resource
    Online Resource
    Antibacterial wound dressing from chitosan/polyethylene oxide nanofibers mats embedded with silver nanoparticles
    SAGE Publications ; 2015
    In:  Journal of Biomaterials Applications Vol. 29, No. 8 ( 2015-03), p. 1086-1095
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 29, No. 8 ( 2015-03), p. 1086-1095
    Abstract: Novel antibacterial nanomaterials have been developed for biomedical applications. The present study involves the preparation and properties of antibacterial nanofibers from chitosan/polyethylene oxide electrospun nanofibers incorporated with silver nanoparticles. Silver nanoparticles were efficiently synthesized in situ after ultra violet (UV) with AgNO 3 as precursor and chitosan/polyethylene oxide as reducing agent and protecting agent, respectively. Then the resultant solutions were electrospun into nanofibers. The formation of silver nanoparticles was confirmed with ultraviolet visible (UV-vis) and transmission electron microscopy (TEM), and the electrospun nanofibers were characterized by scanning electron microscopy and energy dispersive X-ray. The resultant fibers exhibited uniform morphology with silver nanoparticles distributed throughout the fiber. Also, the fibers showed certain tensile strength and excellent antibacterial activity against Gram-positive ( Staphylococcus aureus) and Gram-negative ( Escherichia coli) bacteria. Sustained release of silver nanoparticles from fibers could last for over 72 h. The silver-containing chitosan/polyethylene oxide nanofibers showed excellent cytocompatibility.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328214554665
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 9
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    Online Resource
    Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging
    SAGE Publications ; 2021
    In:  Journal of Biomaterials Applications Vol. 35, No. 7 ( 2021-02), p. 857-868
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 35, No. 7 ( 2021-02), p. 857-868
    Abstract: In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a narrow distribution. The size of the Au@CS-PMPC NPs, as well as the size of the embedded gold NPs, might be well-controlled by adjusting the feeding ratio between chitosan and HAuCl 4 . Furthermore, the Au@CS-PMPC NPs showed increased colloidal stability, high drug loading content, pH-responsive drug release, excellent biocompatibility and bright fluorescence emission. The results demonstrated that Au@CS-PMPC NPs showed a great potential for tumor therapy via the combination advantages of pH-sensitive controlled drug release and cellular fluorescence imaging.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328220952594
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Expression of IL17A in endometrial carcinoma and effects of IL17A on biological behaviour in Ishikawa cells
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 9 ( 2020-09), p. 030006052095056-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 9 ( 2020-09), p. 030006052095056-
    Abstract: A growing body of evidence suggests chronic inflammation triggers the process of endometrial carcinogenesis. Interleukin (IL) 17A is an important proinflammatory factor involved in the tumour angiogenesis processes of many solid tumours. This study aimed to characterize the function of IL17A in endometrioid-type endometrial carcinoma. Methods Levels of IL17A in human endometrial tissues were analysed by immunohistochemistry. In vitro proliferation and migration were analysed in Ishikawa cells treated with IL17A, using cell counting kit-8, wound healing and transwell assays. Western blots were used to analyse levels of oestrogen receptor (ER)α and ERβ proteins in Ishikawa cells treated with IL17A. Results IL17A levels were significantly higher in endometrial carcinoma tissues than in endometrial hyperplasic tissues. Significantly increased proliferation and migration was observed in Ishikawa cells treated with IL17A versus controls. Investigation of the molecular mechanism revealed that IL17A treatment upregulated the ERα/ERβ protein ratio in Ishikawa cells. Conclusions IL17A may be an important proinflammatory factor involved in promoting endometrial carcinogenesis.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520950563
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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