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  • SAGE Publications  (19)
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  • SAGE Publications  (19)
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  • 1
    Online Resource
    Online Resource
    Downregulation of Clock in circulatory system leads to an enhancement of fibrinolysis in mice
    SAGE Publications ; 2011
    In:  Experimental Biology and Medicine Vol. 236, No. 9 ( 2011-09), p. 1078-1084
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 236, No. 9 ( 2011-09), p. 1078-1084
    Abstract: As a main component of circadian genes, clock plays not only an important role in circadian rhythm but also in the regulation of many physiological systems. The dysfunction of clock genes is associated with the development of various disorders. Many studies have investigated the association between clock genes and blood coagulation and the fibrinolytic system. The present study was designed to investigate the effect of downregulation of circulatory Clock on blood coagulation and fibrinolysis at the initial stage of active phase in male mice. Downregulation of the expression of the Clock gene by siRNA and, subsequently, its effect on the thrombotic potential and the expression of relative coagulative and/or fibrinolytic factors were investigated. It was found that the Clock interfered mice were less liable to thrombosis and showed prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) at Zeitgeber time (ZT) 15. Meanwhile, these mice also showed an increase in factor VII (FVII) and a decrease in thrombomodulin (TM) and plasminogen activator inhibitor 1 (PAI-1) at ZT 15 at both transcriptional and translational levels. PT, APTT and mRNA expressions of fvii, tm and pai-1 were analyzed with the least-squares fit of a 24-h cosine function by single cosinor method; no circadian rhythm was determined in PT and APTT, and a higher amplitude of fvii in the Clock RNAi group was found with a circadian phase shift, while lower amplitudes of tm and pai-1 were found in the Clock RNAi group with nearly no phase shift. All these results suggest that downregulation of the Clock gene in circulatory system has an effect on factors involved in both blood coagulation and fibrinolysis resulting in an enhancement in mice. This may be considered as an indication that Clock regulates thrombotic homeostasis through the fibrinolytic system.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1258/ebm.2011.010322
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    TA15 and inconel 625 bimetallic structures additive manufacturing and phased array ultrasonic testing
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 236, No. 15 ( 2022-08), p. 8444-8448
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 236, No. 15 ( 2022-08), p. 8444-8448
    Abstract: Additive manufacturing of bimetallic structures has become a hotspot in recent years. However, the interfaces of bimetallic structures are always the weaknesses, and cracks always occur at the interfaces. Three bimetallic samples of TA15 and Inconel 625 were manufactured by laser metal deposition, and the effect of laser power on the manufacturing quality was analyzed. Then phased array ultrasonic testing (PAUT) technique was applied for crack detection for the three samples, and metallographic analysis was employed to verify detection results. The results showed that the increase of laser power can eliminate macro-cracks at the interface of the bimetallic sample, and micro-cracks at the interface can be detected by PAUT.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/09544062221080325
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2024890-8
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  • 3
    Online Resource
    Online Resource
    Evaluation on the compliance with secondary prevention and influence factors of ischemic stroke in Hainan province, China
    SAGE Publications ; 2014
    In:  Vascular Vol. 22, No. 3 ( 2014-06), p. 181-187
    Details
    In: Vascular, SAGE Publications, Vol. 22, No. 3 ( 2014-06), p. 181-187
    Abstract: Survivors of ischemic stroke are still at a significant risk for recurrence. Numerous effective strategies for the secondary prevention of ischemic stroke have now been established; however, these guidelines are not widely known. In this retrospective, a multicenter study was conducted from January 2011 to February 2012 in 10 general hospitals, which included 1300 elderly patients who had previously been diagnosed with ischemic stroke and re-admitted to hospitals. Logistic regression models were fitted to determine the relationship between compliance with secondary prevention therapy and each variable of interest. The treatment rates of antihypertensive, antiplatelet and lipid-lowering therapy were only 56.3%, 48.9% and 19.6%, respectively. Multivariate analysis presented that cardiovascular risk factors would motivate patients with hypertension and hyperlipidemia to receive corresponding treatments. However, it is worth noting that they did not influence the use of antiplatelet therapy. In addition, high education, health education and insurance promote the use of secondary prevention in patients. In conclusion, the importance of antiplatelet therapy should not be ignored any more. Besides, health education will raise patients’ attention to ischemic stroke.
    Type of Medium: Online Resource
    ISSN: 1708-5381 , 1708-539X
    URL: Article
    DOI: 10.1177/1708538113484022
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2143006-8
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  • 4
    Online Resource
    Online Resource
    An analysis method of pressure characteristic for cylindrical intershaft gas film seal considering centrifugal expansion, rotor misalignment, and precession
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 236, No. 5 ( 2022-05), p. 935-945
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 236, No. 5 ( 2022-05), p. 935-945
    Abstract: To improve the weaknesses of large leakage and wear of dual-rotor intershaft labyrinth seal in aero-engines, the cylindrical gas film seal of metal rubber with a compliant feature is proposed to substitute this conventional seal. According to the dual-rotor operating condition, an analysis method of gas film pressure is presented considering the complex condition of rotor tilt, centrifugal expansion effect, and rotor circular precession. The characteristics of gas film pressure distribution are computed and comparisons are conducted in a complex operating state that the tilt rotor is in forward/backward circular precession under a homodromous/counter-rotating condition with/without the influence of centrifugal expansion. Besides, the formation mechanism of the gas film pressure caused by rotor rotational direction and circular precession direction is revealed. Also, the influence of rotor speed and seal ring speed on gas film pressure is analyzed when the rotor is tilted. The results indicate that for the dual-rotor cylindrical gas film seal with high rotating speed, the rotor tilt and centrifugal expansion effect have significant influence on the gas film pressure distribution, and the rotors’ rotational direction as well as rotor circular precession direction determines the maximum gas film pressure distribution area. The maximum pressure under a homodromous condition with backward precession is the highest; the maximum pressure under a homodromous condition with forward precession is the lowest. The former is 1.33% and 1.68% higher than the latter, respectively, with/without consideration of centrifugal expansion. The study method, which is generally suitable for the cylindrical gas film seal with single-rotor/dual-rotor, lays the foundation of performance analysis under complex operating conditions.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    URL: Article
    DOI: 10.1177/13506501211039793
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2032767-5
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  • 5
    Online Resource
    Online Resource
    A Novel Approach for Assessing the Progression of Deep Venous Thrombosis by Area of Venous Thrombus in Ultrasonic Elastography
    SAGE Publications ; 2014
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 20, No. 3 ( 2014-04), p. 311-317
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 20, No. 3 ( 2014-04), p. 311-317
    Abstract: Exact age determination of deep venous thrombosis (DVT) is important for an appropriate treatment. The purpose of this present study is to assess the age of acute DVT with the area of venous thrombi in elasticity imaging during the thrombosis procession. The thrombus area is obtained from a specially designed program. It was applied to clot specimens induced in human great saphenous (n = 15) at selected time points following the initiation of thrombosis. The relative mean proportion of blood clots was 50.01% ± 12.44% at day 1; 69.94% ± 8.19% at day 3; 81.93% ± 6.15% at day 6; and 92.37% ± 4.06% at day 9. The results indicated that the thrombus area increased significantly over time, while the normalized strain values inside the thrombus changed only a little. The pathological analyses also showed the same results. Therefore, we conclude that the area of venous thrombi in elasticity imaging may be a novel function for acute DVT staging.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029612461066
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2230591-9
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  • 6
    Online Resource
    Online Resource
    The composite sandwich structure of dNCPs polyelectrolyte multilayers induced the osteogenic differentiation of PDLSCs in vitro
    SAGE Publications ; 2020
    In:  Journal of Applied Biomaterials & Functional Materials Vol. 18 ( 2020-01), p. 228080002094271-
    Details
    In: Journal of Applied Biomaterials & Functional Materials, SAGE Publications, Vol. 18 ( 2020-01), p. 228080002094271-
    Abstract: This study reported about the fabrication of dentin non-collagenous proteins (dNCPs) polyelectrolyte multilayers and evaluated its osteogenic potential. The composite sandwich structure of dNCPs polyelectrolyte multilayers was generated on the surface of polycaprolactone electrospinning membranes by the Layer-by-Layer self-assembly technique. The dNCPs-coated membranes comprised the experimental group and the non-coated membranes acted as the control. Nanofiber morphologies of both membranes were observed under scanning electron microscope. The release of dNCPs was evaluated by ELISA kit. Periodontal ligament stem cells (PDLSCs) were seeded on both membranes. The morphology changes and proliferation of cells were tested. The expressions of osteogenic-related genes and proteins were evaluated by RT-PCR, alkaline phosphatase (ALP) activity assay, and immunofluorescence staining. dNCPs-coated membranes displayed significantly different fiber morphology than the non-coated membranes. A stable release of dentin phosphoprotein was maintained from day 4 to day 15 in the experimental group. Cells on dNCPs-coated membranes were found to have cuboidal or polygonal shapes. The proliferative rate of cells was significantly lower in the experimental group from day 4 to day 9 ( p 〈 0.05). However, cells on the dNCPs-coated membranes demonstrated a significantly higher ALP content and expression levels of osteogenic gene and proteins than the controls ( p 〈 0.05). These results indicated that dNCPs polyelectrolyte multilayers could induce the osteogenic differentiation of PDLSCs in vitro.
    Type of Medium: Online Resource
    ISSN: 2280-8000 , 2280-8000
    URL: Article
    DOI: 10.1177/2280800020942719
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2673624-X
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  • 7
    Online Resource
    Online Resource
    Navigating autonomous vehicles in uncertain environments with distributional reinforcement learning
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, SAGE Publications
    Abstract: Navigation in complex urban environments is very difficult, mainly due to perceptual uncertainty caused by obstructions in the field of view. The perceptual uncertainty is mainly due to sensors obstructed by obstacles. This has a significant impact on the safety of autonomous vehicles. Existing approaches based on partially observable Markov decision processes or reinforcement learning for the uncertainty problem may lead to conservative planning and expensive computation. We propose caution-driven networks combined with distributional reinforcement learning fully parameterized quantile function, which termed Intrinsic caution module – fully parameterized quantile function (ICM-FQF). The method is also applied in the continuous action space. The method is used to evaluate two challenging scenarios, pedestrians crossing with occlusion and a unsignalized intersection with a limited field of view. The algorithm is trained and evaluated using the CARLA simulator. Compared to conventional RL algorithms, the method makes smarter decisions and reduces the rate of collisions.
    Type of Medium: Online Resource
    ISSN: 0954-4070 , 2041-2991
    URL: Article
    DOI: 10.1177/09544070231186841
    RVK:
    ZO 4200
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2032754-7
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  • 8
    Online Resource
    Online Resource
    Improved multi-wavelet denoising with neighboring coefficients of cutting force for application in the load spectrum of computer numerical control lathe
    SAGE Publications ; 2018
    In:  Advances in Mechanical Engineering Vol. 10, No. 2 ( 2018-02), p. 168781401875467-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 10, No. 2 ( 2018-02), p. 168781401875467-
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814018754674
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2501620-9
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  • 9
    Online Resource
    Online Resource
    Management of thoracogastric airway fistula after esophagectomy for esophageal cancer: A systematic literature review
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 5 ( 2020-05), p. 030006052092602-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 5 ( 2020-05), p. 030006052092602-
    Abstract: Thoracogastric airway fistula (TGAF) is a serious complication of esophagectomy for esophageal cancer. We conducted a systematic review of the appropriate therapeutic options for acquired TGAF. Methods We performed a literature search to identify relevant studies from PubMed, EMBASE, and Web of Science using the search terms “gastric airway fistula”, “gastrotracheal fistula”, “gastrobronchial fistula”, “tracheogastric fistula”, “bronchogastric fistula”, “esophageal cancer”, and “esophagectomy”. Result Twenty-four studies (89 patients) were selected for analysis. Cough was the main clinical presentation of TGAF. The main bronchus was the most common place for fistulas (53/89), and 29 fistulas occurred in the trachea. Almost 73% (65/89) of patients underwent non-surgical treatment of whom 87.7% (57/65) received initial fistula closure. Twenty-three patients underwent surgery, including 19 (82.6%) with initial closure. The 1-, 2-, 3-, 6-, and 9-month survival rates in patients who underwent surgical repair were 95.65%, 95.65%, 82.61%, 72.73%, and 38.10%, respectively, and the equivalent survival rates in patients with tracheal stent placement were 91.67%, 86.67%, 71.67%, 36.96%, and 13.33%, respectively. Conclusion TGAF should be suspected in patients with persistent cough, especially in a recumbent position or associated with food intake. Individualized treatment should be emphasized based on the general condition of each patient.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520926025
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 10
    Online Resource
    Online Resource
    Effects of a health promotion program on medication adherence to antiplatelet therapy among ischemic stroke patients in Hainan Province, China
    SAGE Publications ; 2017
    In:  Vascular Vol. 25, No. 3 ( 2017-06), p. 242-248
    Details
    In: Vascular, SAGE Publications, Vol. 25, No. 3 ( 2017-06), p. 242-248
    Abstract: Survivors of ischemic stroke are still at a significant risk for recurrence. Antiplatelet agents are the treatment of first choice for long-term secondary prevention of vascular events. This study aims to assess a health promotion program on medication adherence to antiplatelet therapy among ischemic stroke patients in Hainan province, China. In five hospitals from the intervention group, four highly experienced physicians trained 62 neurologists, who in turn trained 613 stroke patients to improve their awareness and adherence to antiplatelet therapy. Physicians and patients of the control group received usual stroke management programs. After one-year follow-up, the proportion of patients who took the antiplatelet therapy increased significantly in the intervention group, reaching 73.2%, with a pre–post difference between two arms of 22.9% ( P  〈  0.01). There was also a significant net increase in the proportion of patients with awareness of antiplatelet therapy (24.4%, P  〈  0.01). Multivariate analysis illustrated health promotion program, higher education, annual household income, insurance, and medical status affected antiplatelet drug use in stroke patients. In conclusion, the health promotion program, based on a train-the-trainer approach, showed positive effects on awareness of and adherence to antiplatelet therapy, which has the potential to be scaled up to other resource-limited areas.
    Type of Medium: Online Resource
    ISSN: 1708-5381 , 1708-539X
    URL: Article
    DOI: 10.1177/1708538116666159
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2143006-8
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