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  • SAGE Publications  (12)
  • 1
    Online Resource
    Online Resource
    Irreversible electroporation ablation against subcutaneously implanted VX 2 tumors in rabbits: findings of shearwave ultrasound elastography
    SAGE Publications ; 2021
    In:  Scottish Medical Journal Vol. 66, No. 1 ( 2021-02), p. 23-28
    Details
    In: Scottish Medical Journal, SAGE Publications, Vol. 66, No. 1 ( 2021-02), p. 23-28
    Abstract: This study aimed to evaluate stiffness changes of rabbit subcutaneous VX 2 tumors before and after irreversible electroporation (IRE) ablationby shearwave ultrasound elastography (SWE). Methods IRE was performed on 20 subcutaneously implanted VX 2 tumors in rabbits (R-SIVX 2 ). Tumor stiffness was measured by SWE at different time points (before IRE,120minutes after IRE,7 days after IRE and 14 days after IRE). Results Before IRE, the mean stiffness (E mean ) of tumors was (10.45 ± 1.07) KPa. 120 minutes after I RE, the E mean of tumors obviously rose to (70.53 ± 9.87) KPa. 7 days after IRE, the E mean of tumors decreased to (40.22 ± 9.01) KPa. 14 days after IRE, the E mean of tumors was (15.17 ± 1.00) KPa. A clear boundary was observed between the ablation area and the normal tissues in the pathological results. Conclusions The stiffness of the VX 2 tumors experienced a first rise process and tend to be normal in the procedure of IRE. SWE could provide tissue stiffness information of different IRE ablation period as a non-invasive method.
    Type of Medium: Online Resource
    ISSN: 0036-9330 , 2045-6441
    URL: Article
    DOI: 10.1177/0036933020954178
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2141765-9
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  • 2
    Online Resource
    Online Resource
    Characterizing vibration responses of a handheld workpiece and the hand–arm system
    SAGE Publications ; 2021
    In:  Journal of Low Frequency Noise, Vibration and Active Control Vol. 40, No. 2 ( 2021-06), p. 802-822
    Details
    In: Journal of Low Frequency Noise, Vibration and Active Control, SAGE Publications, Vol. 40, No. 2 ( 2021-06), p. 802-822
    Abstract: The objective of this study is to characterize the vibration responses of a handheld workpiece and the hand–arm system, which is an important step toward identifying and developing effective methods and technologies for controlling the vibration exposures to workers performing the grinding of handheld workpieces. This study established a method for measuring the vibration responses of the entire workpiece–hand–arm system; the vibration exposure of a worker holding and pressing a typical workpiece against a sanding belt or grinding wheel in order to shape the workpiece was simulated. This method was applied to measure the apparent mass and vibration transmissibility of the system under two different feed forces (15 N and 30 N) and six simulated grinding interfaces with different stiffness values. A major resonance was observed in each transmissibility spectrum of the workpiece, which was correlated with the major resonance of the impedance of the entire system. This resonant frequency depended primarily on the workpiece mass and the grinding interface stiffness, but the hand–arm system could substantially affect the resonance magnitude. The feed force also significantly affected the resonance frequency and magnitude. While increasing the feed force increased the overall vibration transmissibility on the hand–arm system, the transmissibility with respect to the workpiece was not significantly affected by the interface conditions. The implications of the results are discussed.
    Type of Medium: Online Resource
    ISSN: 1461-3484 , 2048-4046
    URL: Article
    DOI: 10.1177/1461348420934617
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2025887-2
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  • 3
    Online Resource
    Online Resource
    Stem Cell Marker Aldehyde Dehydrogenase 1 (ALDH1)-Expressing Cells are Enriched in Triple-Negative Breast Cancer
    SAGE Publications ; 2013
    In:  The International Journal of Biological Markers Vol. 28, No. 4 ( 2013-10), p. 357-364
    Details
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 28, No. 4 ( 2013-10), p. 357-364
    Abstract: The stem cell marker ALDH1 has been of particular interest to scientists since it has been successfully used as a marker to isolate cancer stem cells from breast cancers. However, little is known, especially in Chinese breast cancer patients, on whether ALDH1 enrichment is prevalent in certain subtypes of breast cancer. In this study, we performed flow cytometry and immunohistochemistry to measure the expression of ALDH1 in 10 breast cancer cell lines and in a set of tissue microarrays consisting of 101 breast cancer tissues from the Chinese population. The 101 breast cancer tissues included 4 cancer subtypes defined on bases of their ER, PR, and HER2 statuses: triple-negative (25 cases), luminal A (33 cases), luminal B (16 cases) and HER2-overexpressing (HER2-OE, 27 cases). We found that ALDH1 was expressed in 25 of the 101 cases of breast cancer tissues. When the analysis was stratified, we found that the expression of ALDH1 varied significantly among the 4 subtypes, with a higher expression in triple-negative breast cancer (TNBC, p=0.003) than in the other 3 subtypes. In a series of breast cancer cell lines, we also confirmed that ALDH1 activity was mainly found in TNBC cell lines compared with non-TNBC ones (15.6%±2.45% vs 5.5%±2.58%, p=0.026). These data support the concept that the expression of ALDH1 is higher in TNBC than non-TNBC, which may be clinically meaningful for a better understanding of the poor prognosis of TNBC patients.
    Type of Medium: Online Resource
    ISSN: 1724-6008 , 1724-6008
    URL: Article
    DOI: 10.5301/JBM.5000048
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 1475778-3
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  • 4
    Online Resource
    Online Resource
    Exploring the mechanism of the excellent catalytic activity of NiFe-layered double hydroxides in oxygen evolution reactions by modifying the iron content
    SAGE Publications ; 2022
    In:  Journal of Chemical Research Vol. 46, No. 3 ( 2022-03), p. 174751982211035-
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 46, No. 3 ( 2022-03), p. 174751982211035-
    Abstract: Layered double hydroxides are very promising catalysts for water splitting, in particular NiFe-layered double hydroxide, which has attracted significant attention due to its excellent catalytic activity in oxygen evolution reactions using alkaline electrolytes. In this work, samples with different molar ratios of Ni to Fe are prepared by a typical hydrothermal method to study the effect of iron on the catalytic properties of NiFe-layered double hydroxide. All the NiFe-layered double hydroxides exhibit much better oxygen evolution reaction activity than NiOOH, while increasing the iron content slightly affects the activity, which implies that only Fe ions at some specific site contribute to the oxygen evolution reaction activity. The NiFe-layered double hydroxide with a 4:1 molar ratio of Ni to Fe shows the best oxygen evolution reaction catalytic performance, and requires only an overpotential of 176 mV to afford a current of 10 mA cm −2 in 1.0 M KOH, and exhibits a much lower Tafel slope (51 mV dec −1 ). This work also studies the effect of iron on the electronic structure of nickel and reveals the mechanism behind the excellent oxygen evolution reaction catalytic properties of NiFe-layered double hydroxide.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.1177/17475198221103519
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 3010810-X
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  • 5
    Online Resource
    Online Resource
    Elevated Krüppel-like factor 5 expression in spatiotemporal mouse lungs is similar to human congenital cystic adenomatoid malformation of the lungs
    SAGE Publications ; 2018
    In:  Journal of International Medical Research Vol. 46, No. 7 ( 2018-07), p. 2856-2865
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 46, No. 7 ( 2018-07), p. 2856-2865
    Abstract: The study aimed to investigate the role of high Krüppel-like factor 5 (KLF5) expression on the pathogenesis of congenital cystic adenomatoid malformation of the lungs (CCAML) in mice. Methods A mouse model of high KLF5 expression in the lungs was established. KLF5 expression and the pulmonary lumen diameter were examined by immunohistochemistry to determine a successful model. Basement membrane damage and activity of matrix metalloproteinase-9 (MMP-9) were examined. After an adenovirus carrying KLF5 gene transfection in lung adenocarcinoma (H441) was created, changes in expression and activity of MMP-9 were determined. Results In a mouse model with high KLF5 expression, the pulmonary lumen was markedly enlarged, indicating establishment of CCAML. The basement membrane was degraded, and MMP-9 activity was significantly higher in the model group compared with the control group. Moreover, mice in a cellular model after transfection also showed higher MMP-9 activity than did controls. Conclusion High KLF5 expression may play a pivotal role in the pathogenesis of CCAML, partly through regulating the activity of MMP-9.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060518774998
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2082422-1
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  • 6
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    Online Resource
    Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis
    SAGE Publications ; 2015
    In:  Experimental Biology and Medicine Vol. 240, No. 12 ( 2015-12), p. 1672-1681
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 240, No. 12 ( 2015-12), p. 1672-1681
    Abstract: Many studies have shown that natural dietary agents, in combination with chemical agents, can improve the therapeutic response of cancers to chemotherapy and reduce the associated side-effects. In the present study, we investigated the therapeutic potential and mechanisms of anticancer effects for the combination of 5-fluorouracil (5-FU) and resveratrol (Res). In these studies, we employed the cancer cell lines TE-1 and A431 and an animal model of skin cancer. The presented results provide the first evidence that Res can enhance the anti-tumor potency of 5-FU by inducing S-phase arrest. The combination of Res and 5-FU demonstrates synergistic efficacy, causing tumor regression in a two-stage model of mouse skin carcinogenesis induced by DMBA and TPA. There was clear evidence of Res augmenting the growth inhibitory effect of 5-FU on the TE-1 and A431 cancer cells in vitro. In the in vivo studies, the tumor regression rate in the combination group increased significantly after four weeks of treatment ( P  〈  0.01). The combination of 5-FU and Res significantly increased the percentage of apoptotic cells and the level of activated caspase-3, cleaved PARP and p53 proteins as well as increased the Bax/Bcl-2 ratio. In conclusion, the 5-FU/Res combination enabled a more effective inhibition of cell growth and the induction of apoptosis in cancer cells than 5-FU alone. The results of this study suggest that chemotherapy using natural dietary agents with chemical agents represents a superior cancer treatment option.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370215573396
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2020856-X
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  • 7
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    Online Resource
    D-dimer as a thrombus biomarker for predicting 2-year mortality after percutaneous coronary intervention
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Chronic Disease Vol. 11 ( 2020-01), p. 204062232090430-
    Details
    In: Therapeutic Advances in Chronic Disease, SAGE Publications, Vol. 11 ( 2020-01), p. 204062232090430-
    Abstract: D-dimer has predictive value for mortality in some diseases. This study aimed to evaluate the correlation between D-dimer and mortality in patients undergoing percutaneous coronary intervention (PCI). Methods: We examined 10,724 consecutive patients who underwent PCI between January 2013 and December 2013. The primary endpoint was all-cause mortality, and the secondary endpoint was cardiac mortality. Patients were divided according to the median D-dimer level of 0.28 μg/ml. Multivariable model were including age, sex, and risk factors after stepwise selection. Results: After a 2-year follow up, 8565 patients with D-dimer data were analyzed. There were 116 (1.35%) all-cause deaths and 64 (0.75%) cardiac deaths. D-dimer levels were significantly higher in the all-cause mortality group [0.42 (0.29, 0.68) μg/ml] and cardiac mortality group [0.48 (0.30, 0.81) μg/ml] than in the survival group [0.28 (0.20, 0.41) μg/ml] (both p  〈  0.001). Multivariate-adjusted Cox hazard analysis showed that high D-dimer levels (⩾0.28 μg/ml) were significantly associated with all-cause mortality in the total population [hazard ratio (HR): 2.35, 95% confidence interval (CI): 1.44–3.84, p = 0.001], acute coronary syndrome (ACS) subgroup (HR: 1.91, 95% CI: 1.08–3.38, p = 0.027), and stable coronary artery disease (SCAD) subgroup (HR: 3.82, 95% CI: 1.45–10.10, p = 0.007). High D-dimer levels were significantly associated with cardiac mortality in the total population (HR: 3.44, 95% CI: 1.61–7.36, p = 0.001) and the ACS subgroup (HR: 3.33, 95% CI: 1.38–8.03, p = 0.007), but not in the SCAD subgroup (HR: 3.68, 95% CI: 0.80–16.91, p = 0.094). Conclusions: D-dimer levels are independently associated with 2-year all-cause mortality and cardiac mortality in patients undergoing PCI.
    Type of Medium: Online Resource
    ISSN: 2040-6223 , 2040-6231
    URL: Article
    DOI: 10.1177/2040622320904302
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2554816-5
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  • 8
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    Online Resource
    Prognostic Value of the PARIS Thrombotic Risk Score for 2-Year Mortality After Percutaneous Coronary Intervention
    SAGE Publications ; 2019
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 25 ( 2019-01-01), p. 107602961985363-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 25 ( 2019-01-01), p. 107602961985363-
    Abstract: The Patterns of non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) thrombotic risk score is a novel score for predicting the risk of coronary thrombotic events after percutaneous coronary intervention (PCI). We assessed the prognostic value of this score for mortality in patients with PCI. In this prospective, observational study, we enrolled 10 724 consecutive patients underwent PCI. The primary end point was all-cause death and the secondary end point was major adverse cardiovascular and cerebrovascular events (MACCE) as a composite of all-cause death, myocardial infarction, revascularization, stent thrombosis, or stroke. Among 9782 patients without in-hospital events, a total of 97 deaths and 1002 MACCE occurred during the 2-year follow-up. The mortality risk of patients in the high-risk group was 2.31 times higher than that in the low-risk group (hazard ratio, 2.31; P = .001). This risk score showed prognostic value in evaluating mortality (area under the receiver operating characteristic curve [AUROC], 0.607; 95% confidence interval [CI] , 0.551-0.663) and MACCE (AUROC, 0.544; 95% CI, 0.526-0.563; both P 〈 .001). The prognostic value of mortality was higher than that of MACCE (Z = 2.09, P = .04). The PARIS thrombotic risk score shows modest prognostic value for mortality and MACCE, and the prognostic value of mortality is better than that of MACCE.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029619853638
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2230591-9
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  • 9
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    Chronic Myelogenous Leukemia Presenting in Blast Phase with Nodal, Bilineal Myeloid Sarcoma and T-Lymphoblastic Lymphoma in a Child
    SAGE Publications ; 2013
    In:  Pediatric and Developmental Pathology Vol. 16, No. 2 ( 2013-03), p. 91-96
    Details
    In: Pediatric and Developmental Pathology, SAGE Publications, Vol. 16, No. 2 ( 2013-03), p. 91-96
    Abstract: A 14-year-old boy presented with chronic myelogenous leukemia (CML) in blast phase with segregated extramedullary (nodal) myeloid sarcoma and T-lymphoblastic lymphoma. Immunohistochemical stains performed on the lymphadenectomy sample demonstrated T lymphoblasts in the lymph nodes and myeloblasts in the adjacent soft tissue. Fluorescence in situ hybridization performed on paraffin sections confirmed that both T-lymphoblast and myeloblast populations were positive for the t(9;22) BCR/ABL1 translocation. Subsequent flow cytometry analysis of the bone marrow showed expanded populations of abnormal myeloblasts and T lymphoblasts diagnostic of blast phase CML. To the best of our knowledge, bilineal blast phase of CML with segregated extramedullary T lymphoblasts and myeloblasts has not been reported.
    Type of Medium: Online Resource
    ISSN: 1093-5266 , 1615-5742
    URL: Article
    DOI: 10.2350/12-07-1230-CR.1
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 1480654-X
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  • 10
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    Impact of Diabetes Mellitus on Percutaneous Coronary Intervention in Chinese Patients: A Large Single-Center Data
    SAGE Publications ; 2018
    In:  Angiology Vol. 69, No. 6 ( 2018-07), p. 540-547
    Details
    In: Angiology, SAGE Publications, Vol. 69, No. 6 ( 2018-07), p. 540-547
    Abstract: To investigate the impact of diabetic status on 2-year clinical outcomes in Chinese patients undergoing contemporary percutaneous coronary intervention (PCI) treatment. Methods and Results: A total of 10 724 consecutive patients underwent PCI at Fu Wai Hospital were prospectively collected. Two-year clinical outcomes were compared between patients with and without diabetes mellitus (DM). Diabetic patients had more baseline clinical risks and more extensive coronary disease. During 2-year follow-up, the rates of all-cause death, myocardial infarction (MI), revascularization, and major adverse cardiac events (MACE) were significantly higher in DM group. After multivariable-adjusted Cox regression analysis, DM was an independent risk factor for MACE but not for the individual components of MACE. After performing propensity score matching, rates of all-cause death, MI, revascularization, stroke, stent thrombosis, and MACE were not significantly different between the 2 groups, and DM was not predictive of MACE and any clinical adverse outcomes. Conclusions: Diabetic patients who underwent PCI had worse prognosis including death and repeat revascularization during 2-year follow-up, but DM was not an independent risk factor for adverse clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319717735226
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2065911-8
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