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  • 1
    Online Resource
    Online Resource
    Ku86 alleviates human umbilical vein endothelial cellular apoptosis and senescence induced by a low dose of ionizing radiation
    SAGE Publications ; 2019
    In:  Journal of International Medical Research Vol. 47, No. 2 ( 2019-02), p. 893-904
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 47, No. 2 ( 2019-02), p. 893-904
    Abstract: The aim of this study was to observe the effect of Ku86 on cellular senescence and apoptosis induced by various doses of ionizing radiation in human umbilical vein endothelial cells (HUVECs). Methods Senescence-associated β-galactosidase activity was detected to evaluate cell senescence. Apoptosis was determined by flow cytometry and a caspase enzyme determination kit. p16 Ink4a , Sirt1, superoxide dismutase 2 (SOD2), xanthine oxidase (XOD), and Bcl-2 protein expression levels were measured by western blotting. Results Low doses of ionizing radiation induced cellular senescence and apoptosis in a dose-dependent manner. The Ku86 protein was negatively correlated with ionization intensity. After transfection of Ku86 with a vector (pcDNA 3.1), or interference with siRNA (si-Ku86), apoptosis/senescence and related protein expression were observed. Western blot results revealed that this induction of senescence was associated with activated Sirt1 and SOD2, and downregulation of p16 Ink4a and XOD in 0.2 Gy ionizing radiation. The expression levels of apoptosis-associated proteins, such as Bcl-2, cleaved caspase-3, caspase-8, and caspase-9, were significantly altered in both the presence and absence of Ku86 with ionizing radiation (0.2 Gy). Conclusions Our study revealed that Ku86 overexpression inhibits HUVEC apoptosis and senescence induced by low doses of ionizing radiation.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060518805302
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2082422-1
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  • 2
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    An Energy-Efficient Multipath Routing Algorithm Based on Ant Colony Optimization for Wireless Sensor Networks
    SAGE Publications ; 2015
    In:  International Journal of Distributed Sensor Networks Vol. 11, No. 6 ( 2015-06-01), p. 642189-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 11, No. 6 ( 2015-06-01), p. 642189-
    Abstract: An energy-efficient ACO-based multipath routing algorithm (EAMR) is proposed for energy-constrained wireless sensor networks. EAMR is a hybrid multipath algorithm, which is reactive in path discovery and proactive in route maintenance. EAMR has improvement and innovation in the ant packet structure, pheromone update formula, pheromone update mode, and the mechanism of multipath. Average energy consumption and congestion of path make pheromone update formula more reasonable. Incremental pheromone update mode may easily lead to local optimum. The pheromone will be thoroughly updated when a node receives a backward ant. EAMR makes an innovation in multipath mechanism which becomes more reasonable to multipath between source node and destination node. Probabilistic routing mechanism is designed to make stream flow into network more balanced. The simulation results show that the proposed algorithm achieves an improvement in energy efficiency, packet delivery ratio, and end-to-end delay.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1155/2015/642189
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2192922-1
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  • 3
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    Hierarchical control of soft manipulators towards unstructured interactions
    SAGE Publications ; 2021
    In:  The International Journal of Robotics Research Vol. 40, No. 1 ( 2021-01), p. 411-434
    Details
    In: The International Journal of Robotics Research, SAGE Publications, Vol. 40, No. 1 ( 2021-01), p. 411-434
    Abstract: Performing daily interaction tasks such as opening doors and pulling drawers in unstructured environments is a challenging problem for robots. The emergence of soft-bodied robots brings a new perspective to solving this problem. In this paper, inspired by humans performing interaction tasks through simple behaviors, we propose a hierarchical control system for soft arms, in which the low-level controller achieves motion control of the arm tip, the high-level controller controls the behaviors of the arm based on the low-level controller, and the top-level planner chooses what behaviors should be taken according to tasks. To realize the motion control of the soft arm in interacting with environments, we propose two control methods. The first is a feedback control method based on a simplified Jacobian model utilizing the motion laws of the soft arm that are not affected by environments during interaction. The second is a control method based on [Formula: see text]-learning, in which we present a novel method to increase training data by setting virtual goals. We implement the hierarchical control system on a platform with the Honeycomb Pneumatic Networks Arm (HPN Arm) and validate the effectiveness of this system on a series of typical daily interaction tasks, which demonstrates this proposed hierarchical control system could render the soft arms to perform interaction tasks as simply as humans, without force sensors or accurate models of the environments. This work provides a new direction for the application of soft-bodied arms and offers a new perspective for the physical interactions between robots and environments.
    Type of Medium: Online Resource
    ISSN: 0278-3649 , 1741-3176
    URL: Article
    DOI: 10.1177/0278364920979367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2015221-8
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  • 4
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    Milk and Egg Are Risk Factors for Adverse Effects of Capecitabine-Based Chemotherapy in Chinese Colorectal Cancer Patients
    SAGE Publications ; 2022
    In:  Integrative Cancer Therapies Vol. 21 ( 2022-01), p. 153473542211054-
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 21 ( 2022-01), p. 153473542211054-
    Abstract: Chemotherapy-induced adverse effects (CIAEs) remain a challenging problem due to their high incidences and negative impacts on treatment in Chinese colorectal cancer (CRC) patients. We aimed to identify risk factors and predictive markers for CIAEs using food/nutrition data in CRC patients receiving post-operative capecitabine-based chemotherapy. Methods: Food/nutrition data from 130 Chinese CRC patients were analyzed. Univariate and multivariate analyses were used to identify CIAE-related food/nutrition factors. Prediction models were constructed based on the combination of these factors. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the discrimination ability of models. Results: A total of 20 food/nutrition factors associated with CIAEs were identified in the univariate analysis after adjustments for total energy and potential confounding factors. Based on multivariate analysis, we found that, among these factors, dessert, eggs, poultry, and milk were associated with several CIAEs. Most importantly, poultry was an overall protective factor; milk and egg were risk factors for hand-foot syndrome (HFS) and bone marrow suppression (BMS), respectively. Developed multivariate models in predicting grade 1 to 3 CIAEs and grade 2/3 CIAEs both had good discrimination (AUROC values from 0.671 to 0.778, 0.750 to 0.946 respectively), which had potential clinical application value in the early prediction of CIAEs, especially for more severe CIAEs. Conclusions: Our findings suggest that patients with high milk and egg intakes should be clinically instructed to control their corresponding dietary intake to reduce the likelihood of developing HFS and BMS during capecitabine-based chemotherapy, respectively. Trial registration: ClinicalTrials.gov Identifier: NCT03030508.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/15347354221105485
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2101248-9
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  • 5
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    Robots serve humans in public places— KeJia robot as a shopping assistant
    SAGE Publications ; 2017
    In:  International Journal of Advanced Robotic Systems Vol. 14, No. 3 ( 2017-05), p. 172988141770356-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 14, No. 3 ( 2017-05), p. 172988141770356-
    Type of Medium: Online Resource
    ISSN: 1729-8814 , 1729-8814
    URL: Article
    DOI: 10.1177/1729881417703569
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2202393-8
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  • 6
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    Using mixed methods to design service quality evaluation indicator system of railway container multimodal transport
    SAGE Publications ; 2020
    In:  Science Progress Vol. 103, No. 1 ( 2020-01), p. 003685041989049-
    Details
    In: Science Progress, SAGE Publications, Vol. 103, No. 1 ( 2020-01), p. 003685041989049-
    Abstract: Multimodal transport can bring the technical and economic advantages in different transportation modes into full play. While ensuring the level of service, it can reduce energy consumption and transport costs. Governments of most countries are actively promoting it. Therefore, it has become a research hot spot. Being a green, fast, and all-day transport mode, railways play an important role in multimodal transport. This article aims to analyze a multimodal transport service quality indicator system involving railways from the perspectives of customers, multimodal service providers, and governments. Qualitative and quantitative research methods were adopted to analyze the secondhand data of academic papers, government policy, and industry reports to clarify the quality characteristics of multimodal transport services. Using grounded theory and to analyze firsthand data from in-depth interviews with multimodal transport practitioners, 25 evaluation indicators of container multimodal transport service quality were chosen to be the evaluation index system. To test and improve the evaluation scale, 270 valid questionnaires were analyzed using SPSS 24.0 and AMOS 21.0 software, including reliability analysis, exploratory factor analysis, and confirmatory factor analysis. The results show that all the indicators meet the standard requirements and have good reliability and validity.
    Type of Medium: Online Resource
    ISSN: 0036-8504 , 2047-7163
    URL: Article
    DOI: 10.1177/0036850419890491
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2483680-1
    detail.hit.zdb_id: 2199376-2
    SSG: 11
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  • 7
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    Chemical Constituents and Antimicrobial Activities of Canthium horridum
    SAGE Publications ; 2010
    In:  Natural Product Communications Vol. 5, No. 6 ( 2010-06), p. 1934578X1000500-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 5, No. 6 ( 2010-06), p. 1934578X1000500-
    Abstract: Bioassay-guided isolation studies of the extract of Canthium horridum Bl. stem led to the isolation of ten compounds: (+)-syringaresinol (1), scoparone (2), scopoletin (3), 3′-methoxy-4′-hydroxy- trans-cinnamaldehyde (4), sinapic aldehyde (5), syringic acid (6), mannitol (7), vanillic acid 4- O-β-D-glucopyranoside (8), β-daucosterol (9), and β-sitosterol (10). Compounds 1-10 were reported for the first time from this species, and compounds 1, 4, 5, 6, and 8 from the genus. The antimicrobial activities of the isolated compounds were studied; 6 had the highest activity against Bacillus subtilis, but 1 showed good activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. Compounds 2, 4 and 6 also inhibited the growth of these three bacteria. None of the compounds demonstrated inhibitory activity against Aspergillus niger.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1000500620
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 8
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    Variation of voids and inter-layer shear strength of advanced polymer-matrix composites at different pressures with high-pressure microwave
    SAGE Publications ; 2019
    In:  Journal of Engineered Fibers and Fabrics Vol. 14 ( 2019-01), p. 155892501986395-
    Details
    In: Journal of Engineered Fibers and Fabrics, SAGE Publications, Vol. 14 ( 2019-01), p. 155892501986395-
    Abstract: Due to its rapid and volumetric heating capabilities, microwave heating has been conceived as an alternative cost-effective route for curing advanced polymer-matrix composites. Different curing pressures were applied to the pre-impregnated laminates of advanced polymer-matrix composites in a given high-pressure microwave curing process. The variation of voids’ shapes in the advanced polymer-matrix composites was revealed, and the shear failure mechanism of advanced polymer-matrix composites with different porosity was analyzed. During the shear failure process of the advanced polymer-matrix composites, sounds ceaselessly occur. The experiment results of the optical digital microscopy, the scanning electron microscope, and the inter-laminar shear properties test showed that in high-pressure microwave curing process, pressure was not only the main factor that affects the porosity and the mechanical properties but also influences the bonding strength of the resin and the carbon fiber interface significantly. There is a threshold value for the effect of curing pressure on porosity and inter-laminar shear strength of advanced polymer-matrix composites. The internal relationship among porosity, inter-laminar shear strength, and curing pressure of advanced polymer-matrix composites could be summarized as a piecewise power function.
    Type of Medium: Online Resource
    ISSN: 1558-9250 , 1558-9250
    URL: Article
    DOI: 10.1177/1558925019863958
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2393988-6
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  • 9
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    Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) in the Perioperative Mode of Day Ward
    SAGE Publications ; 2022
    In:  The American Surgeon Vol. 88, No. 12 ( 2022-12), p. 2928-2931
    Details
    In: The American Surgeon, SAGE Publications, Vol. 88, No. 12 ( 2022-12), p. 2928-2931
    Type of Medium: Online Resource
    ISSN: 0003-1348 , 1555-9823
    URL: Article
    DOI: 10.1177/0003134820951461
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 10
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    Relationships between physiological characteristics and match demands in elite-level male field hockey players
    SAGE Publications ; 2021
    In:  International Journal of Sports Science & Coaching Vol. 16, No. 4 ( 2021-08), p. 985-993
    Details
    In: International Journal of Sports Science & Coaching, SAGE Publications, Vol. 16, No. 4 ( 2021-08), p. 985-993
    Abstract: This study investigated the physical characteristics, match demands and their relationships in elite-level male field hockey players (n = 23; 24 ± 3 years). Testing data were collected to investigate the physiological profiles of the players, while match demands were quantified with GPS data over 26 matches. There were significant differences (p =  〈 0.05) between positional groups for pull ups, relative and absolute lower body strength, and body composition. Average total match distance for all the players was (5420 ± 1518 m). There were significant differences between positional groups for defenders (5770 ± 1419 m) vs strikers (4739 ± 1409 m) and midfielders (5549 ± 1545 m) vs strikers. The most high-speed-running ( 〉 4.5 ms −1 ) distance was covered by midfielders (950 ± 275 m) and strikers (908 ± 284 m). Midfielders (116 ± 15 m min) and strikers (120 ± 20 m min) achieved higher intensities during matches compared to defenders (105 ± 13 m min). There were small differences between positional groups for physiological variables, but large variation between positional groups for match demands. There was a significant negative relationship between 2.4 km time trial vs high-speed running (p =  〈 0.05), player load.min and match speed (p =  〈 0.001). Also, there was a negative association between repeat sprint ability total time and high-speed running distance (p =  〈 0.02) and match speed (p =  〈 0.02). The countermovement jump height was associated with match speed (p =  〈 0.05) and there was a negative relationship between body fat % and match speed (p =  〈 0.02). When considering key performance indicators while using GPS devices, match speed (m.min) provides the most valuable information in field hockey players.
    Type of Medium: Online Resource
    ISSN: 1747-9541 , 2048-397X
    URL: Article
    DOI: 10.1177/1747954121998065
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2237333-0
    SSG: 31
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