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  • 1
    Online Resource
    Online Resource
    Consensus statement on diagnosis and treatment of cervical ossification of posterior longitudinal ligament from Asia Pacific Spine Society (APSS) 2020
    SAGE Publications ; 2020
    In:  Journal of Orthopaedic Surgery Vol. 28, No. 3 ( 2020-05-01), p. 230949902097521-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 28, No. 3 ( 2020-05-01), p. 230949902097521-
    Abstract: The study aimed to develop an evidence-based expert consensus statement on diagnosis and treatment of cervical ossification posterior longitudinal ligament (OPLL). Method: Delphi method was used to perform such survey, and the panel members from Asia Pacific Spine Society (APSS) 2020 were invited to answer the open-ended questions in rounds 1 and 2. Then the results were summarized and developed into a Likert-style questionnaire for voting in round 3, and the level of agreement was defined as 80%. In the whole process, we conducted a systematic literature search on evidence for each statement. Results: Cervical OPLL can cause various degrees of neurological symptoms, an it’s thought to be more common in Asia population. CT reconstruction is an important imaging examination to assist diagnosis and guide surgical choice. Segmental, continuous, mixed, and focal type is the most widely used classification system. The non-surgical treatment is recommended for patients with no or mild clinical symptoms, or irreversible neurological damage, or failed surgical decompression, or condition cannot tolerant surgery, or refusing surgery. As OPLL may continue to develop gradually, surgical treatment would be considered in their course inevitably. The surgical choice should depend on various conditions, such as involved levels, thickness, and type of OPLL, skill-experiences of surgeons, which are listed and discussed in the article. Conclusion: In this statement, we describe the clinical features, classifications, and diagnostic criteria of cervical OPLL, and review various surgical methods (such as their indications, complications), and provide a guideline on their choice strategy.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499020975213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2128854-9
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  • 2
    Online Resource
    Online Resource
    Urothelial Carcinomas of the Urinary Bladder With Plasmacytoid or Rhabdoid Features and Tendency of Epithelial-Mesenchymal Transition in 3 Dogs
    SAGE Publications ; 2018
    In:  Veterinary Pathology Vol. 55, No. 5 ( 2018-09), p. 673-677
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 55, No. 5 ( 2018-09), p. 673-677
    Abstract: Plasmacytoid and rhabdoid variants of urothelial carcinomas (UCs) of the urinary bladder have been described in humans with plasma cell–like or rhabdoid cellular appearance and aggressive clinical outcome. Canine UC of the bladder is generally classified as papillary/nonpapillary and infiltrating/noninfiltrating with limited information regarding other histological patterns. We report 3 cases of UC of the urinary bladder showing a unique discohesive cellular morphology with malignant behavior resembling the human plasmacytoid and rhabdoid variants of UC, which may raise some difficulties in diagnosis. Epithelial-mesenchymal transition and reduced E-cadherin expression were revealed by immunohistochemistry in 2 cases, possibly explaining the discohesive and invasive behavior of the tumor cells. The findings broaden the morphological spectrum as well as the distinct clinical features of canine UC of the urinary bladder.
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1177/0300985818771151
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2106608-5
    SSG: 22
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  • 3
    Online Resource
    Online Resource
    Tertiary hospital nurses’ ethical sensitivity and its influencing factors: A cross-sectional study
    SAGE Publications ; 2022
    In:  Nursing Ethics Vol. 29, No. 1 ( 2022-02), p. 104-113
    Details
    In: Nursing Ethics, SAGE Publications, Vol. 29, No. 1 ( 2022-02), p. 104-113
    Abstract: High ethical sensitivity positively affects the quality of nursing care; nevertheless, Chinese nurses’ ethical sensitivity and the factors influencing it have not been described. Research objectives: The purpose of this study was to describe ethical sensitivity and to explore factors influencing it among Chinese-registered nurses, to help nursing administrators improve nurses’ ethical sensitivity, build harmony between nurses and patients, and promote the patients’ health. Research design: This was a descriptive, cross-sectional study. Participants and research context: We recruited 500 nurses from several departments in three tertiary hospitals. The Chinese Moral Sensitivity Questionnaire–Revised version and the Jefferson Scale of Empathy-Health Professionals were used to assess the nurses’ ethical sensitivity and empathy ability, respectively. Fifteen sociodemographic variables were included in the questionnaires. Ethical considerations: Informed consent was obtained from the participants regarding participation and data storage and handling. This program has been examined and supported by the research center of medical ethics and professional ethics of Guilin Medical University. The Approval No. was 2016RWYB04. The whole research process is conducted strictly according to ethical requirements. Results: The valid response rate was 84.40% ( n = 422). The total score of Chinese Moral Sensitivity Questionnaire–Revised was 35.82 ± 8.17. The subscale scores of moral responsibility and strength and sense of moral burden were 21.50 ± 4.91 and 14.33 ± 3.98, respectively. Significant differences were found among age groups, gender, years of working, category of profession, and quality of family communication regarding nurses’ ethical sensitivity ( p 〈 0.05). Regression analysis showed that the main factors influencing nurses’ ethical sensitivity were gender, years of working, quality of family communication, career satisfaction, and empathic ability. Discussion: Our findings suggest that Chinese nurses’ ethical sensitivity in tertiary hospitals in Guilin is at a medium level. Conclusion: The director of nursing schools and hospitals in China should pay attention to nurses’ ethical sensitivity and should intensify education and training to improve nurses’ ethical sensitivity. Further studies should focus on interventions aimed at improving Chinese nurses’ ethical sensitivity.
    Type of Medium: Online Resource
    ISSN: 0969-7330 , 1477-0989
    URL: Article
    DOI: 10.1177/09697330211005103
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2031461-9
    SSG: 0
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  • 4
    Online Resource
    Online Resource
    Study of the Anchorage Connections for Buckling Restrained Braces Part 1: Experimental Investigation
    SAGE Publications ; 2013
    In:  Advances in Structural Engineering Vol. 16, No. 4 ( 2013-04), p. 759-771
    Details
    In: Advances in Structural Engineering, SAGE Publications, Vol. 16, No. 4 ( 2013-04), p. 759-771
    Abstract: This is the first of the two companion papers dealing with anchorage connection for buckling restrained braces (BRBs) used in reinforced concrete frames. In this paper, configuration details of an anchorage connection are proposed. Eight comparative specimens are designed to investigate the monotonic and cyclic behaviors of the proposed connection under tension/compression, shear and combined tension/compression and shear conditions. Test results indicate that static and hysteretic behaviors of the connection under tension/compression are much better than those under shear. In order to guarantee the energy dissipation of BRBs, the connection should work in elastic state to prevent low cycle fatigue failure and to reduce the deformation of the anchorage connections. Furthermore, the design method of the anchorage connections presented in the related Chinese codes (GB 50010–2010 and GB 50011–2010) is examined against the test results. It is found that the code method is accurate enough for predicting the load-bearing capacity of the connections under mere tension and mere shear condition, but is too conservative for prediction under combined tension and shear. At last, the design suggestion is proposed for the anchorage connection against the test results. Due to limitation of the test results, theoretical study is carried out in Part 2 of the companion papers.
    Type of Medium: Online Resource
    ISSN: 1369-4332 , 2048-4011
    URL: Article
    DOI: 10.1260/1369-4332.16.4.759
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2026561-X
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  • 5
    Online Resource
    Online Resource
    Using nerve segment insert grafting to reconstruct neural pathways of brain-derived paralysis
    SAGE Publications ; 2017
    In:  Translational Neuroscience and Clinics Vol. 3, No. 4 ( 2017), p. 188-195
    Details
    In: Translational Neuroscience and Clinics, SAGE Publications, Vol. 3, No. 4 ( 2017), p. 188-195
    Type of Medium: Online Resource
    ISSN: 2096-0441
    URL: Article
    DOI: 10.18679/CN11-6030/R.2017.028
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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  • 6
    Online Resource
    Online Resource
    Perioperative Deep Vein Thrombosis in Patients With Lower Extremity Fractures: An Observational Study
    SAGE Publications ; 2020
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 26 ( 2020-01-01), p. 107602962093027-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 26 ( 2020-01-01), p. 107602962093027-
    Abstract: This study aimed to investigate deep vein thrombosis (DVT) in patients with lower extremity fractures who received anticoagulation treatment in the perioperative stage. We collected the patients’ clinical data and diagnosed DVT using Doppler ultrasonography. Preoperative, postoperative, and 1-month postoperative examinations were performed. The patients were divided into thrombosis and non-thrombosis groups according to ultrasonographic findings. A total of 404 patients were included in the study. The preoperative, postoperative, and 1-month postoperative incidence rates were, respectively, 35%, 55%, and 40% for DVT and 12%, 22%, and 20% for DVT in the uninjured contralateral lower extremity. The incidence of perioperative DVT decreased over time from 223 (55%) to 161 (40%). Multivariate analysis revealed that the independent risk factors for preoperative that of DVT were age (odds ratio [OR]: 1.03; 95% CI: 1.01-1.04; P = .000); postoperative that of DVT were age (OR: 1.04; 95% CI: 1.03-1.05; P = .000), blood loss (OR: 1.001; 95% CI: 1.000-1.002; P = .018), and American Society of Anesthesiologists classification (OR: 2.07; 95% CI: 1.16-3.72; P = .014); and 1-month postoperative that of DVT were age (OR: 1.05; 95% CI: 1.03-1.07; P = .000), respectively. In conclusion, the incidence of perioperative DVT decreased over time in patients who received anticoagulation treatment. Age was an important risk factor for perioperative DVT.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029620930272
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2230591-9
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  • 7
    Online Resource
    Online Resource
    Deep vein thrombosis in the lower extremities after femoral neck fracture: A retrospective observational study
    SAGE Publications ; 2020
    In:  Journal of Orthopaedic Surgery Vol. 28, No. 1 ( 2020-01-01), p. 230949901990117-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 28, No. 1 ( 2020-01-01), p. 230949901990117-
    Abstract: The actual incidence of deep vein thrombosis (DVT) in femoral neck fractures is underestimated. This study aimed to investigate the incidence of DVT in the lower extremities after femoral neck fracture before and after operation. Methods: The clinical data of patients with femoral neck fractures treated at Xi’an Honghui Hospital between July 1, 2016, and December 31, 2018, were collected. The patients were examined with ultrasonography before and after operation and divided into thrombosis and non-thrombosis groups according to their ultrasonographic results. The incidence of DVT was reported as a percentage. Results: The incidence rates of preoperative and postoperative DVT were 32% and 56%, respectively. DVT on the uninjured side constituted 45% of all preoperative DVT and 43% of all postoperative DVT. Peripheral DVT constituted 90% and 84% of all preoperative and postoperative DVT, respectively. Diabetes was an independent risk factor of preoperative DVT. Blood loss was an independent risk factor of postoperative DVT, and open reduction and internal fixation surgical procedure was independent protective factor of postoperative DVT as compared with hemiarthroplasty and total hip replacement. Conclusions: The incidence rates of preoperative and postoperative DVT in the patients with femoral neck fracture were high, and orthopedists should pay more attention to DVT as a complication.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499019901172
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2128854-9
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  • 8
    Online Resource
    Online Resource
    Relationship between use of screws and acetabular cup stability in total hip arthroplasty: a meta-analysis
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 2 ( 2020-02), p. 030006052090364-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 2 ( 2020-02), p. 030006052090364-
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520903649
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 9
    Online Resource
    Online Resource
    Deep Vein Thrombosis in the Uninjured Lower Extremity: A Retrospective Study of 1454 Patients With Lower Extremity Fractures
    SAGE Publications ; 2021
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 27 ( 2021-01-01), p. 107602962098686-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 27 ( 2021-01-01), p. 107602962098686-
    Abstract: The purpose of this study was to identify patients at higher risk of deep venous thrombosis (DVT) in the uninjured lower extremity both preoperatively and postoperatively in patients with lower extremity fractures. We collected the clinical data of patients with lower extremities fractures who presented at Xi’an Honghui Hospital between 1 July, 2015 and 31 October, 2017. Doppler ultrasonography was used to diagnose the DVT. Patients were examined pre- and postoperatively. The patients were divided into thrombosis group and no thrombosis group according to the preoperative and postoperative ultrasonography results. The thrombosis group was defined as patients with DVT in the uninjured lower extremity and the no thrombosis group was defined as patients without DVT in the uninjured lower extremity. This study enrolled 1454 patients who met the inclusion criteria. The incidence of preoperative DVT in the uninjured lower extremity was 9.63% whereas the postoperative incidence was 20.29%. Age (OR = 0.965, 95 CI%: 0.954-0.977; P ≤ 0.001) and female (OR = 0.667, 95% CI: 0.451-0.986, P = 0.042) were independent risk factors for preoperative DVT in the uninjured lower extremity. Blood loss (OR = 0.997, 95 CI%: 0.995-1.000; P = 0.020), D-dimer level at admission (OR = 0.941, 95 CI%: 0.887-0.999; P = 0.045), and postoperative day 5 D-dimer level (OR = 0.889, 95 CI%: 0.819-0.965; P = 0.005), were independent risk factors for postoperative DVT in the uninjured lower extremity. For the patients with lower extremity fractures, age and female were associated with the preoperative DVT in the uninjured lower extremity. Blood loss, D-dimer at admission and postoperative day 5 D-dimer were associated with the postoperative DVT in the uninjured lower extremity.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029620986862
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2230591-9
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  • 10
    Online Resource
    Online Resource
    Post-treatment with glycyrrhizin can attenuate hepatic mitochondrial damage induced by acetaminophen in mice
    SAGE Publications ; 2021
    In:  Experimental Biology and Medicine Vol. 246, No. 10 ( 2021-05), p. 1219-1227
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 246, No. 10 ( 2021-05), p. 1219-1227
    Abstract: Overdose of acetaminophen (APAP) is responsible for the most cases of acute liver failure worldwide. Hepatic mitochondrial damage mediated by neuronal nitric oxide synthase- (nNOS) induced liver protein tyrosine nitration plays a critical role in the pathophysiology of APAP hepatotoxicity. It has been reported that pre-treatment or co-treatment with glycyrrhizin can protect against hepatotoxicity through prevention of hepatocellular apoptosis. However, the majority of APAP-induced acute liver failure cases are people intentionally taking the drug to commit suicide. Any preventive treatment is of little value in practice. In addition, the hepatocellular damage induced by APAP is considered to be oncotic necrosis rather than apoptosis. In the present study, our aim is to investigate if glycyrrhizin can be used therapeutically and the underlying mechanisms of APAP hepatotoxicity protection. Hepatic damage was induced by 300 mg/kg APAP in balb/c mice, followed with administration of 40, 80, or 160 mg/kg glycyrrhizin 90 min later. Mice were euthanized and harvested at 6 h post-APAP. Compared with model controls, glycyrrhizin post-treatment attenuated hepatic mitochondrial and hepatocellular damages, as indicated by decreased serum glutamate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase activities as well as ameliorated mitochondrial swollen, distortion, and hepatocellular necrosis. Notably, 80 mg/kg glycyrrhizin inhibited hepatic nNOS activity and its mRNA and protein expression levels by 16.9, 14.9, and 28.3%, respectively. These results were consistent with the decreased liver nitric oxide content and liver protein tyrosine nitration indicated by 3-nitrotyrosine staining. Moreover, glycyrrhizin did not affect the APAP metabolic activation, and the survival rate of ALF mice was increased by glycyrrhizin. The present study indicates that post-treatment with glycyrrhizin can dose-dependently attenuate hepatic mitochondrial damage and inhibit the up-regulation of hepatic nNOS induced by APAP. Glycyrrhizin shows promise as drug for the treatment of APAP hepatotoxicity.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370220977823
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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