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  • 1
    Online Resource
    Online Resource
    Prevalence and Risk Factors for Abnormal Liver Stiffness in HIV-infected Patients without Viral Hepatitis Coinfection: Role of Didanosine
    SAGE Publications ; 2010
    In:  Antiviral Therapy Vol. 15, No. 5 ( 2010-07), p. 753-763
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 15, No. 5 ( 2010-07), p. 753-763
    Abstract: Unexpected cases of severe liver disease in HIV-infected patients have been reported and an association with didanosine (ddI) has been suggested. Transient elastography (TE) might detect patients harbouring such a condition. Our objective was to search for the presence of abnormal liver stiffness (LS) in a cohort of HIV-infected patients without HBV or HCV coinfection and to assess the related factors. Methods A cross-sectional prospective study was conducted. LS was assessed by TE in 258 HIV-infected patients without HBV or HCV coinfection and with no evidence of acute hepatotoxicity or other origins of liver disease. LS values ≥7.2 kPa were considered abnormal. Multivariate analyses were performed to identify factors associated with abnormal LS. Results Abnormal LS was observed in 29 (11.2%) patients. A total of 18 (16.4%) patients previously treated with ddI and 11 (7.4%) of those who never received ddI had LS values ≥7.2 kPa ( P=0.02). The prevalence of abnormal LS was higher in patients previously treated with abacavir than in those who had never received abacavir (15 [21.7%] versus 14 [7.4%] ; P=0.001). After multivariate analyses, age (adjusted odds ratio [AOR] 1.05, 95% confidence interval [CI] 1.002-1.1; P=0.004) alcohol intake 〉 50 g/day (AOR 7.2, 95% CI 2.6-19.7; P 〈 0.0001), CD4 + T-cell count 〈 200 cells/ml (AOR 3.4, 95% CI 1.06-11.007; P=0.03), time on ddI treatment (AOR 1.31, 95% CI 1.12-1.52; P=0.001) and previous abacavir exposure (AOR 3.01, 95% CI 1.18-7.67; P=0.02) were independently associated with abnormal LS. Conclusions The prevalence of abnormal LS in HIV-infected patients without HBV or HCV coinfection is substantial. Long-term exposure to ddI is a major cause of liver damage in these patients.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP1612
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
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    SSG: 15,3
    Location Call Number Limitation Availability
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  • 2
    Online Resource
    Online Resource
    School Culture Change in the Making : Leadership Factors That Matter
    SAGE Publications ; 2007
    In:  Urban Education Vol. 42, No. 6 ( 2007-11), p. 616-637
    Details
    In: Urban Education, SAGE Publications, Vol. 42, No. 6 ( 2007-11), p. 616-637
    Abstract: The urban elementary school profiled in this case study was considered low performing based on state-mandated assessment scores from the time the school opened its doors in 1998 until very recently, putting the school on academic watch under the terms of the No Child Left Behind Act. However, in recent years the school realized a significant turnaround with the placement of a proactive principal and internal specialized supports accompanied by district office support. Survey data on school culture measures demonstrate an improvement in professional communities of practice, collaborative leadership, and evidence-based practice. This case study provides evidence that leadership coupled with multiple and coherent district supports can result in dramatic change at a school in a short period.
    Type of Medium: Online Resource
    ISSN: 0042-0859 , 1552-8340
    URL: Article
    DOI: 10.1177/0042085907304906
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2067136-2
    SSG: 5,3
    Location Call Number Limitation Availability
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  • 3
    Online Resource
    Online Resource
    Acute hepatitis C virus infection and direct-acting antiviral drugs: Perfect combination to eliminate the epidemic?
    SAGE Publications ; 2021
    In:  International Journal of STD & AIDS Vol. 32, No. 13 ( 2021-11), p. 1257-1260
    Details
    In: International Journal of STD & AIDS, SAGE Publications, Vol. 32, No. 13 ( 2021-11), p. 1257-1260
    Abstract: Early diagnosis and treatment of incident cases of hepatitis C virus (HCV) infection is fundamental to eliminate HCV in HIV-positive patients. From January 2016 to December 2019, we attended 40 episodes of acute HCV infection (AHC) in 35 subjects (9 reinfections) who were coinfected with HIV. The patients were treated with direct-acting antiviral agents (DAAs) in seven hospitals in Andalusia, Spain. All were men who have sex with men (MSM), mean age was 42.9 (±8.3) years and median time of HIV infection was 46.6 months (IQR: 20.4–67.2). All received antiretroviral therapy and had undetectable HIV viral load (except 2 with 65 and 68 copies/mL); median CD4 count was 632 cells/mm 3 (IQR: 553–896). Over half (74.3%) also had another concomitant sexually transmitted infection, syphilis (48.6%) being the most common. AHC was asymptomatic in 32 cases (80%). Genotypic distribution was G1a 65%, G4 32.5% and G1b 3%. Median time to DAA was 6 weeks (IQR: 4.3–18.3) and median baseline HCV RNA was 6.1 Log (IQR: 5.6–6.5). DAA regimens were SOF/LDV (19 episodes), SOF/VEL (14), ELB/GZV (5) and GLP/PIB (2). All presented sustained viral response and none discontinued due to adverse effects. In conclusion, early treatment with DAA in AHC patients proved effective and safe. It could be an excellent strategy to eliminate HCV infection in HIV-coinfected MSM.
    Type of Medium: Online Resource
    ISSN: 0956-4624 , 1758-1052
    URL: Article
    DOI: 10.1177/09564624211033756
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2009782-7
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  • 4
    Online Resource
    Online Resource
    Data in the making, political struggle, and epistemic (in)justice: Asian and Asian Americans as early responders to the COVID-19 pandemic in the United States
    SAGE Publications ; 2024
    In:  New Media & Society
    Details
    In: New Media & Society, SAGE Publications
    Abstract: The COVID-19 pandemic exposed the limits of big data to guide decision-making in times of crisis. As people navigated daily life, they were confronted with the reality that data were often not yet material but rather in-the-making. Drawing upon critical and feminist lenses and participatory methodologies, this study investigates the data stories of nine people of Asian descent living in the United States. Findings illustrate how participants navigated within and across time, space, activity, media, epistemology, race, and politics to produce lively data assemblages. These data stories guided social-distancing and mask-wearing weeks before official US policy even as participants lived in constant fear of dehumanizing racist and xenophobic violence. This study advances theorizing about data practices for human knowing and learning with media, racial and epistemic (in)justice, and community action. It also advances participatory research as a site of epistemic resistance and activism.
    Type of Medium: Online Resource
    ISSN: 1461-4448 , 1461-7315
    URL: Article
    DOI: 10.1177/14614448231226400
    RVK:
    MN 1000
    RVK:
    AP 10792.2
    RVK:
    AP 10790.6
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
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    detail.hit.zdb_id: 2684519-2
    detail.hit.zdb_id: 2016312-5
    detail.hit.zdb_id: 2686704-7
    SSG: 24,1
    SSG: 3,4
    SSG: 3,5
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  • 5
    Online Resource
    Online Resource
    Hemodialysis Catheter Breakage in an Infant
    SAGE Publications ; 2022
    In:  The Journal of Vascular Access
    Details
    In: The Journal of Vascular Access, SAGE Publications
    Abstract: A 3-month-old male infant was admitted to our unit due to acute decompensation of chronic kidney disease of unknown etiology. Further investigation led to the diagnosis of primary hyperoxaluria type 1. As the patient did not recover, hemodialysis was initiated with a non-tunneled femoral catheter. A tunneled Hickman catheter was placed in the internal jugular vein. The patient experienced moderate intradialytic exit-site bleeding and catheter malfunction, which initially responded to pressure and postural changes. During the third session, the patient suffered cardiopulmonary arrest. After stabilization, a chest hematoma was identified. Fluoroscopy revealed a catheter breakage. Despite initial stabilization, the patient developed septic shock due to Pseudomonas aeruginosa and died several days later. Hemodialysis is sometimes necessary in children under 24 months with chronic kidney disease. Vascular access is a major challenge in these patients due to lack of appropriate catheter sizes and high complication rates. Hemodialysis catheter fracture is an uncommon complication, and diagnosis can be difficult when the breakage involves the subcutaneous segment. Persistent intradialytic bleeding and mechanical malfunction should raise suspicion of this complication and should elicit catheter revision under fluoroscopy. Without prompt diagnosis, catheter breakage may have fatal consequences, as in our case.
    Type of Medium: Online Resource
    ISSN: 1129-7298 , 1724-6032
    URL: Article
    DOI: 10.1177/11297298221086854
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2079292-X
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