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  • SAGE Publications  (10)
  • 1
    Online Resource
    Online Resource
    Effects and Safety of Allogenic Mesenchymal Stem Cell Intravenous Infusion in Active Ankylosing Spondylitis Patients who Failed NSAIDs: A 20-Week Clinical Trial
    SAGE Publications ; 2014
    In:  Cell Transplantation Vol. 23, No. 10 ( 2014-10), p. 1293-1303
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 23, No. 10 ( 2014-10), p. 1293-1303
    Abstract: Our objective was to evaluate the feasibility, safety, and efficacy of intravenous (IV) infusion of allogenic mesenchymal stem cells (MSCs) in ankylosing spondylitis (AS) patients who are refractory to or cannot tolerate the side effects of nonsteroidal anti-inflammatory drugs (NSAIDs). AS patients enrolled in this study received four IV infusions of MSCs on days 0, 7, 14, and 21. The percentage of ASAS20 responders (the primary endpoint) at the fourth week and the mean ASAS20 response duration (the secondary endpoint) were used to assess treatment response to MSC infusion and duration of the therapeutic effects. Ankylosing Spondylitis Disease Activity Score Containing C-reactive Protein (ASDAS-CRP) and other preestablished evaluation indices were also adopted to evaluate the clinical effects. Magnetic resonance imaging (MRI) was performed to detect changes of bone marrow edema in the spine. The safety of this treatment was also evaluated. Thirty-one patients were included, and the percentage of ASAS20 responders reached 77.4% at the fourth week, and the mean ASAS20 response duration was 7.1 weeks. The mean ASDAS-CRP score decreased from 3.6 ± 0.6 to 2.4 ± 0.5 at the fourth week and then increased to 3.2 ± 0.8 at the 20th week. The average total inflammation extent (TIE) detected by MRI decreased from 533,482.5 at baseline to 480,692.3 at the fourth week ( p 〉 0.05) and 400,547.2 at the 20th week ( p 〈 0.05). No adverse effects were noted. IV infusion of MSCs is a feasible, safe, and promising treatment for patients with AS.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368913X667727
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2020466-8
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  • 2
    Online Resource
    Online Resource
    Robust fault-tolerant tracking control for a class of nonlinear systems based on position measurements only
    SAGE Publications ; 2016
    In:  Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering Vol. 230, No. 6 ( 2016-12), p. 486-497
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, SAGE Publications, Vol. 230, No. 6 ( 2016-12), p. 486-497
    Abstract: The problem of trajectory tracking for a class of nonlinear systems in the presence of un-modeled dynamics, parameter variations and even the actuator faults is investigated in this paper. A novel fault-tolerant control scheme is proposed by combining the nominal model-based controller and time-delay controller, which are adopted to achieve the real-time dynamic compensation and guarantee the robust stability of the controlled systems, respectively. Moreover, high-quality differential signals are unavailable in the presence of disturbances and measurement noise, which limit the performance of closed-loop systems in practice. Therefore, an extended state observer (ESO) is introduced to obtain high-quality differential signal estimations based on position measurements only. Furthermore, the effectiveness of the proposed novel control scheme is verified by testing in the spacecraft attitude tracking system.
    Type of Medium: Online Resource
    ISSN: 0954-4089 , 2041-3009
    URL: Article
    DOI: 10.1177/0954408915576290
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2024897-0
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  • 3
    Online Resource
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    Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Neurological Disorders Vol. 13 ( 2020-01), p. 175628641989808-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 13 ( 2020-01), p. 175628641989808-
    Abstract: Diagnostic criteria for multiple sclerosis have evolved over time, with the most recent being the 2017 McDonald criteria. Evidence is lacking regarding the validity of the 2017 McDonald criteria among the Asian population. Therefore, this study aims to evaluate the diagnostic performance of the 2017 McDonald criteria in Chinese patients with clinically isolated syndrome (CIS). Methods: A total of 93 patients with initial findings suggestive of CIS in a tertiary hospital in China from 2012 to 2017 were included in this retrospective study. Baseline and follow-up data were reviewed. Diagnostic performance (sensitivity, specificity, accuracy), was assessed and survival analysis was performed for the 2017 and 2010 McDonald criteria respectively. Results: Among the 93 Chinese patients with CIS, 57 were female (61.3%) and the median (interquartile range) age of onset was 37 (31.3–41.8) years. The 2017 McDonald criteria displayed a higher sensitivity (75.0% versus 14.6%, p  〈  0.0001), lower specificity (47.1% versus 100.0%, p  〈  0.05) but an overall higher accuracy (67.7% versus 36.9%, p  〈  0.0001) when compared with the 2010 iteration. The novel criteria allow for a better detection of MS at baseline (40.8% versus 9.9%, p  〈  0.0001). Conclusion: The 2017 McDonald criteria had a higher sensitivity but lower specificity than the 2010 iteration. Overall it facilitated an earlier and more accurate diagnosis of multiple sclerosis in Chinese patients with CIS.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/1756286419898083
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2442245-9
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  • 4
    Online Resource
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    Clinical impact of the tumor immune microenvironment in completely resected stage IIIA(N2) non-small cell lung cancer based on an immunological score approach
    SAGE Publications ; 2021
    In:  Therapeutic Advances in Medical Oncology Vol. 13 ( 2021-01), p. 175883592098497-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 13 ( 2021-01), p. 175883592098497-
    Abstract: Completely resected stage IIIA(N2) non-small cell lung cancer (NSCLC) comprises a heterogeneous population according to discrepancies in survival prognosis. Accumulating evidence suggests that tumor-infiltrating lymphocytes (TILs) are clinically significant, despite a lack of consensus regarding the immunological score (IS) in NSCLC. Here, we determined the prognostic value of the immune microenvironment as an IS in a uniform cohort of patients with completely resected stage IIIA(N2) NSCLC. Methods: Consecutive patients with pathologically confirmed stage IIIA(N2) NSCLC and who underwent complete resection (2005–2012) were retrospectively reviewed. Tissue microarrays (TMAs) were constructed from surgical paraffin-embedded primary lung tumor specimen. For each case, two representative regions from the tumor center (CT) and two from the invasive margin (IM) containing the highest density of lymphocytes were selected. Densities of CD3+, CD45RO+, and CD8+ lymphocytes were assessed using immunohistochemistry (IHC) by specialized pathologists according to predefined scoring scales. Patients were classified according to IS definition based on TIL type, density, and distribution, and relationships between IS and prognosis were evaluated. Results: Patients ( N = 288) with complete IHC-based TMA spots were included. Univariate analyses showed that CD3+ T cell density was associated with neither overall survival (OS) nor distant metastasis-free survival (DMFS), whereas CD45RO+ T cell density in the IM was a significant prognostic factor for DMFS ( p = 0.02) and was predictive of OS ( p = 0.05). Combined CD45RO+ and CD8+ cell infiltration in tumor regions (CT and IM) significantly improved IS prognostic impact. Multivariate analyses revealed IS as an independent prognostic predictor for both DMFS ( p = 0.001) and OS ( p = 0.002). Conclusion: The proposed IS might provide valuable prognostic information, including prediction of DMFS and OS in stage IIIA(N2) NSCLC patients. Larger patient cohorts are needed to validate this IS classification, which might assist with accurate risk stratification and treatment decisions.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920984975
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2503443-1
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  • 5
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    Online Resource
    Fabrication and Characterization of Heterostructural CoFe2O4/ Pb(Zr0.52Ti0.48)O3 Nanofibers by Electrospinning
    SAGE Publications ; 2010
    In:  Journal of Composite Materials Vol. 44, No. 17 ( 2010-08), p. 2135-2144
    Details
    In: Journal of Composite Materials, SAGE Publications, Vol. 44, No. 17 ( 2010-08), p. 2135-2144
    Abstract: Heterostructural CoFe 2 O 4 /Pb(Zr 0.52 Ti 0.48 )O 3 composite nanofibers with diameters about 100 nm were prepared by electrospinning. The thermal decomposition process, structure and morphology of the precursor composite fibers and the calcined CoFe 2 O 4 /Pb(Zr 0.52 Ti 0.48 )O 3 nanofibers were investigated by thermogravimetric and differential scanning calorimetry (TG-DSC), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and high-resolution TEM (HRTEM). It is found that just the spinel CoFe 2 O 4 (CFO) and perovskite Pb(Zr 0.52 Ti 0.48 )O 3 (PZT) phases coexist in the composite CFO/PZT nanofibers obtained at calcination temperature of 950 ° C. The grain sizes of CFO and PZT increase with the calcination temperature whilst the grain growth process would be limited due to the separation effects for these two phases. When the grain sizes of CFO and PZT in the nanofiber reach about the size range of the nanofiber diameter, these grains are alternatively distributed along the nanofiber length direction and the well-defined heterostructure is formed between these nanograins of CFO and PZT.
    Type of Medium: Online Resource
    ISSN: 0021-9983 , 1530-793X
    URL: Article
    DOI: 10.1177/0021998310369587
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 160490-9
    detail.hit.zdb_id: 2081924-9
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  • 6
    Online Resource
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    Short segment myelitis as the initial and only manifestation of aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorders
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Neurological Disorders Vol. 13 ( 2020-01), p. 175628641989859-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 13 ( 2020-01), p. 175628641989859-
    Abstract: Short segment myelitis (SSM, 〈 3 vertebral segments) is an under-recognized initial manifestation of neuromyelitis optica spectrum disorders (NMOSD). Though infrequent, failure to recognize SSM in patients with NMOSD would lead to incorrect diagnosis and treatment. Therefore, delineation of features of NMOSD-associated SSM is of paramount importance. Objective: Our study aimed to determine the demographic, clinical and radiological features of NMOSD-associated SSM, and compare those with NMOSD-associated longitudinally extensive transverse myelitis (LETM) and multiple sclerosis (MS)-associated SSM, respectively. Methods: Chinese patients presenting initially only with acute myelitis and diagnosed with NMOSD ( n = 46) and MS ( n = 11) were included. Clinical, serological, imaging and disability data were collected. Mann–Whitney U test or two-tailed Fisher’s exact tests were used to analyse the data. Results: Of the 46 enrolled NMOSD patients, 34 (74%) collectively had 38 LETM lesions, while 12 (26%) had 14 SSM lesions. When compared with LETM, NMOSD presenting with SSM were more likely to have a delayed diagnosis and a lower level of disability at nadir during the first attack. T1-weighted imaging hypointensity was more prominent in NMOSD-associated LETM lesions than NMOSD-associated SSM lesions. When compared with MS-associated SSM, NMOSD-associated SSM lesions were more likely to be centrally located, grey matter involving and transversally extensive on axial imaging and spanned no less than 2 vertebral segments on sagittal imaging. Conclusion: These findings suggest that SSM does not preclude the possibility of a NMOSD diagnosis. Testing for serum aquaporin-4 immunoglobulin G (AQP4-IgG) and careful study of lesions on spinal cord magnetic resonance imaging could aid in an earlier and correct diagnosis.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/1756286419898594
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2442245-9
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  • 7
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    Dynamic finite cylindrical cavity-expansion models for cellular steel tube confined concrete targets normally impacted by rigid sharp-nosed projectiles
    SAGE Publications ; 2021
    In:  International Journal of Protective Structures Vol. 12, No. 4 ( 2021-12), p. 517-540
    Details
    In: International Journal of Protective Structures, SAGE Publications, Vol. 12, No. 4 ( 2021-12), p. 517-540
    Abstract: Cellular steel-tube-confined concrete (CSTCC) targets show improved anti-penetration performance over single-cell STCC targets due to the confinement effect of surrounding cells on the impacted cell. Dynamic finite cylindrical cavity-expansion (FCCE) models including radial confinement effect were developed to predict the depth of penetration (DOP) for CSTCC targets normally penetrated by rigid sharp-nosed projectiles, and stiffness of radial confinement was achieved with the elastic solution of infinite cylindrical shell in Winkler medium. Steady responses of dynamic FCCE models were obtained on the assumption of incompressibility of concrete, failure of comminuted zone with Heok–Brown criterion and two possible response modes of the confined concrete in the impacted cell. Furthermore, a DOP model for CSTCC targets normally impacted by rigid projectiles was also proposed on the basis of the dynamic FCCE approximate model. Lastly, relevant penetration tests of CSTCC targets normally penetrated by 12.7 mm armor piecing projectile (APP) were taken as examples to validate the dynamic FCCE models and the corresponding DOP model. The results show that the DOP results based on dynamic FCCE model agree well with those of the CSTCC targets normally penetrated by rigid conical or other sharp-nosed projectiles.
    Type of Medium: Online Resource
    ISSN: 2041-4196 , 2041-420X
    URL: Article
    DOI: 10.1177/20414196211027288
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2548257-9
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  • 8
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    Efficacy and safety of immunosuppressive therapy in myelin oligodendrocyte glycoprotein antibody–associated disease: a systematic review and meta-analysis
    SAGE Publications ; 2021
    In:  Therapeutic Advances in Neurological Disorders Vol. 14 ( 2021-01), p. 175628642110541-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 14 ( 2021-01), p. 175628642110541-
    Abstract: A considerable number of patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) will experience a relapse, but the effect of maintenance therapies on re-attack rates is currently unknown. Objective: To investigate the efficacy and safety of immunosuppressive therapy for preventing disease relapses in patients with MOGAD, including rituximab (RTX), mycophenolate mofetil (MMF), and azathioprine (AZA). Methods: English-language studies published prior to August 31, 2020, were searched in the NCBI (PubMed), ISI Web of Science, and the Cochrane Library databases. Patient characteristics, treatment regimens, outcome measures, and adverse effects were retrieved. Results: We enrolled 11 studies in the final meta-analysis, including 346 patients with MOGAD. RTX therapy was demonstrated to result in reduced mean annualized relapse rate (ARR) by 1.35 (95% confidence interval (CI): 0.85–1.85) and reduced mean Expanded Disability Status Scale score by 0.80 (95% CI: 0.53–1.08) in patients with MOGAD. MMF therapy was associated with the mean ARR decreasing by 0.83 (95% CI: 0.31–1.35), and AZA was related to the mean ARR decreasing by 1.71 (95% CI: 0.83–2.58). The reported discontinuation rates of RTX, MMF, and AZA therapy due to adverse effects were 3/197 (1.52%), 3/39 (7.69%), and 4/37 (10.81%), respectively. Conclusion: The study provided evidence to support the efficacy of RTX, MMF, and AZA on the preventive treatment in patients with MOGAD. However, large randomized controlled trials are still needed in the future.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/17562864211054157
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2442245-9
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  • 9
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    Activation and expression of μ-calpain in dorsal root contributes to RTX-induced mechanical allodynia
    SAGE Publications ; 2017
    In:  Molecular Pain Vol. 13 ( 2017-01), p. 174480691771916-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 13 ( 2017-01), p. 174480691771916-
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1177/1744806917719169
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2174252-2
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  • 10
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    Evaluation of brain and spinal cord lesion distribution criteria at disease onset in distinguishing NMOSD from MS and MOG antibody-associated disorder
    SAGE Publications ; 2021
    In:  Multiple Sclerosis Journal Vol. 27, No. 6 ( 2021-05), p. 871-882
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 27, No. 6 ( 2021-05), p. 871-882
    Abstract: To validate the recently proposed imaging criteria in distinguishing aquaporin-4 antibody (AQP4-ab)-seropositive neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody-associated disorder (MOG-AD) at disease onset in a Chinese population. Methods: We enrolled 241 patients in this retrospective study, including 143 AQP4-ab-seropositive NMOSD, 73 MS, and 25 MOG-AD. Cacciaguerra’s criteria were described as fulfillment of at least 2/5 conditions including the absence of the combined juxtacortical/cortical lesions, the presence of longitudinal extensive transverse myelitis (LETM) lesions, the presence of periependymal-lateral ventricles lesions, the absence of Dawson’s fingers lesions, and the absence of periventricular lesions. Results: Fulfillment of at least 3/5 conditions was able to differentiate NMOSD from MS with a good diagnostic performance (accuracy = 0.92, sensitivity = 0.91, specificity = 0.93), yet failed to differentiate NMOSD from MOG-AD. LETM lesions showed the highest accuracy (0.78), sensitivity (0.70), and specificity (0.97) for NMSOD. Conclusion: Our research suggested the utility of Cacciaguerra’s criteria in a Chinese population at disease onset. A better diagnostic performance in NMOSD could be attained with at least 3/5 conditions fulfilled. Yet their utility in distinguishing NMOSD from MOG-AD was limited.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458520939008
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2008225-3
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