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  • SAGE Publications  (76)
  • 1
    Online Resource
    Online Resource
    Associations of RPEL1 and miR-1307 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in Chinese systemic lupus erythematosus patients
    SAGE Publications ; 2022
    In:  Lupus Vol. 31, No. 14 ( 2022-12), p. 1735-1743
    Details
    In: Lupus, SAGE Publications, Vol. 31, No. 14 ( 2022-12), p. 1735-1743
    Abstract: Our present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients. Methods Initially, 1000 participants (500 SLE cases and 500 controls) were recruited for the case–control study. Then, 429 cases who received GCs were followed through 12 weeks to explore GCs efficacy, depression, anxiety, and HRQoL. We selected the iMLDR technique for genotyping: RPEL1: rs4917385 (G/T) and miR-1307: rs7911488 (A/G). Results The minor G allele of rs7911488 reduced the risk of SLE ( p = .024). Four haplotypes consisting of rs4917385 and rs7911488 were associated with SLE susceptibility ( p 〈 .025). Both rs4917385 and rs7911488 were associated with anxiety symptoms and physical function (PF) in SLE patients ( p 〈 .025). The rs4917385 was associated with depression and its improvement. No statistical significance was found between RPEL1 and miR-1307 gene polymorphisms with GCs efficacy. Meanwhile, additive interaction analysis showed a significant association between RPEL1 and miR-1307 gene polymorphisms with tea consumption in anxiety. Conclusion RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) might be related to SLE susceptibility in Chinese population. Additionally, the two polymorphisms were possibly associated with depression, anxiety, and HRQoL in Chinese SLE population.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/09612033221131182
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2008035-9
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  • 2
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    Tannins and Antioxidant Activities of the Walnut ( Juglans regia ) Pellicle
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 12 ( 2015-12), p. 1934578X1501001-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 12 ( 2015-12), p. 1934578X1501001-
    Abstract: The total phenolic content and antioxidant activities of the acetone extract and derived fractions from the walnut ( Juglans regia) pellicle were estimated. The BuOH fraction exhibited the strongest antioxidant activity with the highest phenolic content. A phytochemical investigation of this fraction led to the isolation of three tannins, 2,3-hexahydroxydiphenoylglucose (1), pedunculagin (2) and 2,3,4,6-tetragalloylglucose (3). Pedunculagin showed high content and powerful activity, which implied that this compound plays an important role in the antioxidant activity of the walnut pellicle.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501001232
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 3
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    Fracturing curve and its corresponding gas productivity of coalbed methane wells in the Zhengzhuang block, southern Qinshui Basin, North China
    SAGE Publications ; 2020
    In:  Energy Exploration & Exploitation Vol. 38, No. 5 ( 2020-09), p. 1387-1408
    Details
    In: Energy Exploration & Exploitation, SAGE Publications, Vol. 38, No. 5 ( 2020-09), p. 1387-1408
    Abstract: Hydraulic fracturing has been widely used in low permeability coalbed methane reservoirs to enhance gas production. To better evaluate the hydraulic fracturing curve and its effect on gas productivity, geological and engineering data of 265 development coalbed methane wells and 14 appraisal coalbed methane wells in the Zhengzhuang block were investigated. Based on the regional geologic research and statistical analysis, the microseismic monitoring results, in-situ stress parameters, and gas productivity were synthetically evaluated. The results show that hydraulic fracturing curves can be divided into four types (descending type, stable type, wavy type, and ascending type) according to the fracturing pressure and fracture morphology, and the distributions of different type curves have direct relationship with geological structure. The vertical in-situ stress is greater than the closure stress in the Zhengzhuang block, but there is anomaly in the aggregation areas of the wavy and ascending fracturing curves, which is the main reason for the development of multi-directional propagated fractures. The fracture azimuth is consistent with the regional maximum principle in-situ stress direction (NE–NEE direction). Furthermore, the 265 fracturing curves indicate that the coalbed methane wells owned descending, and stable-type fracturing curves possibly have better fracturing effect considering the propagation pressure gradient (F P ) and instantaneous shut-in pressure (P ISI ). Two fracturing-productivity patterns are summarized according to 61 continuous production wells with different fracturing type and their plane distribution, which indicates that the fracturing effect of different fracturing curve follows the pattern: descending type  〉  stable type  〉  wavy type  〉  ascending type.
    Type of Medium: Online Resource
    ISSN: 0144-5987 , 2048-4054
    URL: Article
    DOI: 10.1177/0144598720923820
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2026571-2
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  • 4
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    A Survey of the Residents of Zhejiang, China on the Knowledge and Awareness of Community Cardiopulmonary Resuscitation and Expectation of the Emergency Medical Service
    SAGE Publications ; 2014
    In:  Hong Kong Journal of Emergency Medicine Vol. 21, No. 4 ( 2014-07), p. 237-248
    Details
    In: Hong Kong Journal of Emergency Medicine, SAGE Publications, Vol. 21, No. 4 ( 2014-07), p. 237-248
    Abstract: To investigate the opinions and expectations of residents from Zhejiang Province on the prehospital emergency medical services (EMS). To evaluate the differences among main urban areas, county-level areas and rural areas in Zhejiang Province. To provide objective data for relevant departments to make further improvement and promote balanced development of the pre-hospital EMS cause. Methods The study was conducted from 1st April 2011 to 30th December 2011. It was carried out in 11 cities and 1,650 residents were included by stratified random sampling method. The survey mainly focused on residents' expectations of EMS and residents' knowledge of emergency skills, the emergency response time, the actions of EMS dispatchers, the fees charged for EMS. Pearson's Chi-Square Test was also used to compare the differences of the current status and residents' expectations of EMS among main urban areas, county-level areas and rural areas. Results The survey showed that the top four emergency skills most needed by residents are cardiopulmonary resuscitation (CPR), bandaging to stop bleeding, first aids for heatstroke and drowning. Trauma patients account for 37.5% (95% CI: 35.08-39.92%) of all those who received EMS service, ranking the first place. While the percentage receiving “wound care” was rated as the most needed emergency skill. There were statistically significant differences in the rate of knowing CPR, independently conducting CPR and emergency response time less than 5 minutes among main urban areas, county-level areas and rural areas in Zhejiang Province. Conclusions Residents of Zhejiang Province lack knowledge and awareness of emergency skills. Their mastery and expectation of emergency skills vary greatly from rural areas to urban areas. Trauma patients have become the main receiver of EMS in these three different regions. The emergency response time, as well as the services provided by EMS dispatchers, is far below the expectation of residents. In addition, the majority of respondents expect EMS to send patients to the nearest hospital and most of the trained paramedics are qualified for the pre-hospital care. (Hong Kong j.emerg.med. 2014;21:237-248)
    Type of Medium: Online Resource
    ISSN: 1024-9079 , 2309-5407
    URL: Article
    DOI: 10.1177/102490791402100406
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2917387-5
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  • 5
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    Effects and Safety of Allogenic Mesenchymal Stem Cell Intravenous Infusion in Active Ankylosing Spondylitis Patients who Failed NSAIDs: A 20-Week Clinical Trial
    SAGE Publications ; 2014
    In:  Cell Transplantation Vol. 23, No. 10 ( 2014-10), p. 1293-1303
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 23, No. 10 ( 2014-10), p. 1293-1303
    Abstract: Our objective was to evaluate the feasibility, safety, and efficacy of intravenous (IV) infusion of allogenic mesenchymal stem cells (MSCs) in ankylosing spondylitis (AS) patients who are refractory to or cannot tolerate the side effects of nonsteroidal anti-inflammatory drugs (NSAIDs). AS patients enrolled in this study received four IV infusions of MSCs on days 0, 7, 14, and 21. The percentage of ASAS20 responders (the primary endpoint) at the fourth week and the mean ASAS20 response duration (the secondary endpoint) were used to assess treatment response to MSC infusion and duration of the therapeutic effects. Ankylosing Spondylitis Disease Activity Score Containing C-reactive Protein (ASDAS-CRP) and other preestablished evaluation indices were also adopted to evaluate the clinical effects. Magnetic resonance imaging (MRI) was performed to detect changes of bone marrow edema in the spine. The safety of this treatment was also evaluated. Thirty-one patients were included, and the percentage of ASAS20 responders reached 77.4% at the fourth week, and the mean ASAS20 response duration was 7.1 weeks. The mean ASDAS-CRP score decreased from 3.6 ± 0.6 to 2.4 ± 0.5 at the fourth week and then increased to 3.2 ± 0.8 at the 20th week. The average total inflammation extent (TIE) detected by MRI decreased from 533,482.5 at baseline to 480,692.3 at the fourth week ( p 〉 0.05) and 400,547.2 at the 20th week ( p 〈 0.05). No adverse effects were noted. IV infusion of MSCs is a feasible, safe, and promising treatment for patients with AS.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368913X667727
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2020466-8
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  • 6
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    Esophageal Carcinosarcoma: Analysis of Clinical Features and Prognosis of 24 Cases and a Literature Review
    SAGE Publications ; 2021
    In:  Cancer Control Vol. 28 ( 2021-01-01), p. 107327482110048-
    Details
    In: Cancer Control, SAGE Publications, Vol. 28 ( 2021-01-01), p. 107327482110048-
    Abstract: Esophageal carcinosarcoma (ECS) is a rare malignant tumor that accounts for only 0.5%-2.8% of all esophageal malignancies. As most current studies are case reports, the relationship between clinical features and prognosis remains controversial. Methods: We investigated the clinical features and prognosis of 24 patients with ECS in a single center from 2006 to 2018. There were 18 male and 6 female patients aged 52-82 years with a median age of 62.5 years. In addition, we included 9 studies on ECS from PubMed and a literature review. Results: The median follow-up time of the 24 patients was 70.5 (range, 10-156)months. The 3-year and 5-year survival rates were 83.3% and 70.8%, respectively. Among the 24 patients, none of the 10 (41.7%) stage T 1 cancer patients had lymph node metastasis; however, lymph node metastasis was noted in 8 (57.1%) stage T 2-4 cancer patients. The literature review revealed that 211 patients had a 5-year survival rate of 11.8%-68.2%, and 54.5%-95.8% study participants had early stage ECS. Although the information provided in the literature review is limited, it appears to be a characteristic of the early stage of the disease and predicts better prognosis when ECS is diagnosed, which is similar to the result of the current study. Conclusion: Our results indicate that ECS has a favorable prognosis, even among patients with early stage ECS who undergo radical esophagectomy with lymph node dissection. Because of the low incidence of ECS, further studies with more cases need to investigate this rare malignancy.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1073-2748
    URL: Article
    DOI: 10.1177/10732748211004886
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2004182-2
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  • 7
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    The Natural Compound Gambogic Acid Radiosensitizes Nasopharyngeal Carcinoma Cells under Hypoxic Conditions
    SAGE Publications ; 2016
    In:  Tumori Journal Vol. 102, No. 2 ( 2016-03), p. 135-143
    Details
    In: Tumori Journal, SAGE Publications, Vol. 102, No. 2 ( 2016-03), p. 135-143
    Abstract: Hypoxia is an important factor that causes decreased local disease control as well as increased distant metastases and resistance to radiotherapy in patients with advanced nasopharyngeal carcinoma (NPC). Gambogic acid (GA), the major active ingredient of gamboge, exerts antitumor effects in vitro and in vivo. However, the molecular mechanism by which GA inhibits tumor radioresistance remains unclear. The present study aimed to investigate the radiosensitizing effects of GA on NPC and explore the underlying mechanisms. Materials and methods CNE-1 and CNE-2 cells exposed to hypoxia and radiation were treated with GA at different concentrations. CCK-8 assay, clonogenic assay, and flow cytometry were performed to analyze cell proliferation, colony formation, apoptosis, and cell cycle. The expression levels of hypoxia-inducible factor-1α (HIF-1α), Bcl-2, Bax, caspase-3, cyclin B1/p-cdc2 and γ-H2AX were assessed using Western blot and/or immunofluorescence analysis. Results Results of the CCK-8 assay, clonogenic assay, and flow cytometry showed that treatment of NPC cells with growth-suppressive concentrations of GA resulted in G2/M phase arrest and apoptosis. Western blot analysis demonstrated that GA-induced cell cycle arrest and apoptosis in CNE-2 cells was associated with upregulated expression of caspase-3 and Bax and downregulated expression of Bcl-2 and cyclin B1/p-cdc2 in hypoxia. Treatment with GA markedly decreased the expression of HIF-1α under hypoxic conditions. Conclusions The results of this study suggest that GA efficiently radiosensitizes NPC cells and the effect may be significant in hypoxic conditions.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.5301/tj.5000411
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 8
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    A comparison and review of three sets of classification criteria for systemic lupus erythematosus for distinguishing systemic lupus erythematosus from pure mucocutaneous manifestations in the lupus disease spectrum
    SAGE Publications ; 2020
    In:  Lupus Vol. 29, No. 14 ( 2020-12), p. 1854-1865
    Details
    In: Lupus, SAGE Publications, Vol. 29, No. 14 ( 2020-12), p. 1854-1865
    Abstract: Although the original purpose of the systemic lupus erythematosus (SLE) classification criteria was to distinguish SLE from other mimic diseases, and to facilitate sample selection in scientific research, they have become widely used as diagnostic criteria in clinical situations. It is not known yet if regarding classification criteria as diagnostic criteria, what problems might be encountered? This is the first study comparing the three sets of classification criteria for SLE, the 1997 American College of Rheumatology (ACR’97), 2012 Systemic Lupus International Collaborating Clinics (SLICC’12) and 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR’19), for their ability to distinguish patients with SLE from patients with pure mucocutaneous manifestations (isolated cutaneous lupus erythematosus without internal disease, i-CLE) in the lupus disease spectrum. 1,865 patients with SLE and 232 patients with i-CLE were recruited from a multicenter study. We found that, due to low specificity, none of the three criteria are adept at distinguishing patients with SLE from patients with i-CLE. SLICC’12 performed best among the original three criteria, but if a positive ANA was removed as an entry criterion, EULAR/ACR’19 would performed better. A review of previous studies that compared the three sets of criteria was presented in this work.
    Type of Medium: Online Resource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203320959716
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
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  • 9
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    Costimulation blockade by combining CTLA4Ig with anti-CD40L mAb markedly inhibits the inflammatory response of experimental autoimmune myocarditis
    SAGE Publications ; 2017
    In:  European Journal of Inflammation Vol. 15, No. 1 ( 2017-04), p. 28-34
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 15, No. 1 ( 2017-04), p. 28-34
    Abstract: The aim of this study was to investigate the effect of costimulation blockade with cytotoxic T-lymphocyte-associated-antigen 4-immunoglobulin (CTLA4Ig) and anti-CD40L monoclonal antibody (anti-CD40L mAb) on an experimental autoimmune myocarditis (EAM) mouse model. Characteristics of myocardial tissue were observed by hematoxylin and eosin (H & E) staining. The messenger RNA (mRNA) levels of CTLA4, CD40L, IFN-γ, and IL-4 were detected by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR). Serum concentrations of IFN-γ and IL-4 were determined by ELISA. After immune intervention, the inflammatory score, mRNA levels of CTLA4 and CD40L, and IFN-γ level were decreased. Furthermore, these parameters in the combinational intervention group (blockade by CTLA4Ig and anti-CD40L mAb) were significantly decreased, compared to the single intervention group (blockade by CTLA4Ig or anti-CD40L mAb). However, after costimulation, blockade serum IL-4 levels were increased. Therefore, costimulation blockade by combination CTLA4Ig and anti-CD40L mAb could more effectively inhibit the inflammatory response of EAM than single use of CTLA4Ig or anti-CD40L mAb.
    Type of Medium: Online Resource
    ISSN: 2058-7392 , 2058-7392
    URL: Article
    DOI: 10.1177/1721727X16686980
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2584683-8
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  • 10
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    Application of Bayesian Regularization Criterion in near Field Acoustic Holography Based on Equivalent Source Method
    SAGE Publications ; 2015
    In:  Noise & Vibration Worldwide Vol. 46, No. 6 ( 2015-06), p. 20-28
    Details
    In: Noise & Vibration Worldwide, SAGE Publications, Vol. 46, No. 6 ( 2015-06), p. 20-28
    Abstract: In order to choose an optimal regularization parameter for near field acoustic holography (NAH) based on equivalent source method (ESM), Bayesian regularization criterion method was introduced to solve the inverse problem. Comparison simulations were conducted with generalized cross validation method (GCV), L-curve method and Hald regularization formula method at various sound source frequencies, hologram distances, and Signal-to-Noise Ratios (SNR). The results show that GCV, L-curve, and Hald regularization formula method cannot achieve the optimal regularization parameter at large hologram distances, high noise levels, high frequencies and input SNR errors. However, Bayesian regularization criterion method is not affected by these restrictions and has excellent reconstruction performance in wide frequency band. Further experiment validates the correctness and effectiveness of the application of Bayesian regularization criterion method in ESM-based NAH, thus providing a new guidance for the solving of inverse problem in ESM-based NAH.
    Type of Medium: Online Resource
    ISSN: 0957-4565 , 2048-4062
    URL: Article
    DOI: 10.1260/0957-4565.46.6.20
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2022675-5
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